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Entry version 143 (31 Jul 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Protein unc-45 homolog B

Gene

UNC45B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone, Developmental protein
Biological processDifferentiation, Myogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein unc-45 homolog B
Short name:
Unc-45B
Alternative name(s):
SMUNC45
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UNC45B
Synonyms:CMYA4, UNC45
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14304 UNC45B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611220 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IWX7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cataract 43 (CTRCT43)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073375805R → W in CTRCT43. 1 PublicationCorresponds to variant dbSNP:rs370424081EnsemblClinVar.1

Keywords - Diseasei

Cataract, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
146862

MalaCards human disease database

More...
MalaCardsi
UNC45B
MIMi616279 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000141161

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98991 Early-onset nuclear cataract
441447 Early-onset posterior subcapsular cataract

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26655

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UNC45B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762485

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002498921 – 931Protein unc-45 homolog BAdd BLAST931

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IWX7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IWX7

PeptideAtlas

More...
PeptideAtlasi
Q8IWX7

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWX7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70922 [Q8IWX7-1]
70923 [Q8IWX7-2]
70924 [Q8IWX7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IWX7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IWX7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in eye lens tissues.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from 43-day and 54-day embryonic eye development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141161 Expressed in 75 organ(s), highest expression level in left ventricle myocardium

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IWX7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017861

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HSP90 in an ATP-independent manner (By similarity).

Interacts with UBE4B; the interaction may target UNC45B for proteasomal degradation (PubMed:17369820).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90AB1P082382EBI-9363363,EBI-352572

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127021, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IWX7, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000268876

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IWX7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati6 – 39TPR 1Add BLAST34
Repeati43 – 76TPR 2Add BLAST34
Repeati77 – 110TPR 3Add BLAST34
Repeati169 – 208ARM 1Add BLAST40
Repeati211 – 250ARM 2Add BLAST40
Repeati751 – 790ARM 3Add BLAST40

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4151 Eukaryota
ENOG410XQNT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157654

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000285994

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8IWX7

KEGG Orthology (KO)

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KOi
K21991

Identification of Orthologs from Complete Genome Data

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OMAi
LCNAYEK

Database of Orthologous Groups

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OrthoDBi
1059433at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8IWX7

TreeFam database of animal gene trees

More...
TreeFami
TF314096

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 2 hits
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR024660 UCS_central_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11701 UNC45-central, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185 ARM, 4 hits
SM00028 TPR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IWX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEVEAVQLK EEGNRHFQLQ DYKAATNSYS QALKLTKDKA LLATLYRNRA
60 70 80 90 100
ACGLKTESYV QAASDASRAI DINSSDIKAL YRRCQALEHL GKLDQAFKDV
110 120 130 140 150
QRCATLEPRN QNFQEMLRRL NTSIQEKLRV QFSTDSRVQK MFEILLDENS
160 170 180 190 200
EADKREKAAN NLIVLGREEA GAEKIFQNNG VALLLQLLDT KKPELVLAAV
210 220 230 240 250
RTLSGMCSGH QARATVILHA VRIDRICSLM AVENEEMSLA VCNLLQAIID
260 270 280 290 300
SLSGEDKREH RGKEEALVLD TKKDLKQITS HLLDMLVSKK VSGQGRDQAL
310 320 330 340 350
NLLNKNVPRK DLAIHDNSRT IYVVDNGLRK ILKVVGQVPD LPSCLPLTDN
360 370 380 390 400
TRMLASILIN KLYDDLRCDP ERDHFRKICE EYITGKFDPQ DMDKNLNAIQ
410 420 430 440 450
TVSGILQGPF DLGNQLLGLK GVMEMMVALC GSERETDQLV AVEALIHAST
460 470 480 490 500
KLSRATFIIT NGVSLLKQIY KTTKNEKIKI RTLVGLCKLG SAGGTDYGLR
510 520 530 540 550
QFAEGSTEKL AKQCRKWLCN MSIDTRTRRW AVEGLAYLTL DADVKDDFVQ
560 570 580 590 600
DVPALQAMFE LAKAGTSDKT ILYSVATTLV NCTNSYDVKE VIPELVQLAK
610 620 630 640 650
FSKQHVPEEH PKDKKDFIDM RVKRLLKAGV ISALACMVKA DSAILTDQTK
660 670 680 690 700
ELLARVFLAL CDNPKDRGTI VAQGGGKALI PLALEGTDVG KVKAAHALAK
710 720 730 740 750
IAAVSNPDIA FPGERVYEVV RPLVRLLDTQ RDGLQNYEAL LGLTNLSGRS
760 770 780 790 800
DKLRQKIFKE RALPDIENYM FENHDQLRQA ATECMCNMVL HKEVQERFLA
810 820 830 840 850
DGNDRLKLVV LLCGEDDDKV QNAAAGALAM LTAAHKKLCL KMTQVTTQWL
860 870 880 890 900
EILQRLCLHD QLSVQHRGLV IAYNLLAADA ELAKKLVESE LLEILTVVGK
910 920 930
QEPDEKKAEV VQTARECLIK CMDYGFIKPV S
Length:931
Mass (Da):103,733
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4F457349AAEAB76
GO
Isoform 2 (identifier: Q8IWX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     485-565: Missing.

Show »
Length:850
Mass (Da):94,850
Checksum:i879D62CB12BB7E1C
GO
Isoform 3 (identifier: Q8IWX7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     564-565: Missing.

Note: No experimental confirmation available.
Show »
Length:929
Mass (Da):103,605
Checksum:i5FEF624AF6E24D38
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02750660V → I1 PublicationCorresponds to variant dbSNP:rs16970659Ensembl.1
Natural variantiVAR_052630199A → V. Corresponds to variant dbSNP:rs35749208Ensembl.1
Natural variantiVAR_052631377K → R. Corresponds to variant dbSNP:rs41389545Ensembl.1
Natural variantiVAR_035870496D → H in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_073375805R → W in CTRCT43. 1 PublicationCorresponds to variant dbSNP:rs370424081EnsemblClinVar.1
Natural variantiVAR_027507852I → N. Corresponds to variant dbSNP:rs11654824Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020586485 – 565Missing in isoform 2. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_020587564 – 565Missing in isoform 3. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF539794 mRNA Translation: AAO13384.1
BC101062 mRNA Translation: AAI01063.1
BC101063 mRNA Translation: AAI01064.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11292.1 [Q8IWX7-1]
CCDS45648.1 [Q8IWX7-3]
CCDS76993.1 [Q8IWX7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001028748.1, NM_001033576.1 [Q8IWX7-3]
NP_001253981.1, NM_001267052.1 [Q8IWX7-3]
NP_001295210.1, NM_001308281.1 [Q8IWX7-2]
NP_775259.1, NM_173167.3 [Q8IWX7-1]
XP_016879723.1, XM_017024234.1 [Q8IWX7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000268876; ENSP00000268876; ENSG00000141161 [Q8IWX7-1]
ENST00000394570; ENSP00000378071; ENSG00000141161 [Q8IWX7-3]
ENST00000591048; ENSP00000468335; ENSG00000141161 [Q8IWX7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
146862

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:146862

UCSC genome browser

More...
UCSCi
uc002hja.3 human [Q8IWX7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF539794 mRNA Translation: AAO13384.1
BC101062 mRNA Translation: AAI01063.1
BC101063 mRNA Translation: AAI01064.1
CCDSiCCDS11292.1 [Q8IWX7-1]
CCDS45648.1 [Q8IWX7-3]
CCDS76993.1 [Q8IWX7-2]
RefSeqiNP_001028748.1, NM_001033576.1 [Q8IWX7-3]
NP_001253981.1, NM_001267052.1 [Q8IWX7-3]
NP_001295210.1, NM_001308281.1 [Q8IWX7-2]
NP_775259.1, NM_173167.3 [Q8IWX7-1]
XP_016879723.1, XM_017024234.1 [Q8IWX7-2]

3D structure databases

SMRiQ8IWX7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127021, 15 interactors
IntActiQ8IWX7, 10 interactors
STRINGi9606.ENSP00000268876

PTM databases

iPTMnetiQ8IWX7
PhosphoSitePlusiQ8IWX7

Polymorphism and mutation databases

BioMutaiUNC45B
DMDMi74762485

Proteomic databases

EPDiQ8IWX7
PaxDbiQ8IWX7
PeptideAtlasiQ8IWX7
PRIDEiQ8IWX7
ProteomicsDBi70922 [Q8IWX7-1]
70923 [Q8IWX7-2]
70924 [Q8IWX7-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268876; ENSP00000268876; ENSG00000141161 [Q8IWX7-1]
ENST00000394570; ENSP00000378071; ENSG00000141161 [Q8IWX7-3]
ENST00000591048; ENSP00000468335; ENSG00000141161 [Q8IWX7-2]
GeneIDi146862
KEGGihsa:146862
UCSCiuc002hja.3 human [Q8IWX7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
146862
DisGeNETi146862

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UNC45B
HGNCiHGNC:14304 UNC45B
HPAiHPA017861
MalaCardsiUNC45B
MIMi611220 gene
616279 phenotype
neXtProtiNX_Q8IWX7
OpenTargetsiENSG00000141161
Orphaneti98991 Early-onset nuclear cataract
441447 Early-onset posterior subcapsular cataract
PharmGKBiPA26655

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4151 Eukaryota
ENOG410XQNT LUCA
GeneTreeiENSGT00940000157654
HOGENOMiHOG000285994
InParanoidiQ8IWX7
KOiK21991
OMAiLCNAYEK
OrthoDBi1059433at2759
PhylomeDBiQ8IWX7
TreeFamiTF314096

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
UNC45B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
146862

Protein Ontology

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PROi
PR:Q8IWX7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000141161 Expressed in 75 organ(s), highest expression level in left ventricle myocardium
GenevisibleiQ8IWX7 HS

Family and domain databases

Gene3Di1.25.10.10, 2 hits
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR024660 UCS_central_dom
PfamiView protein in Pfam
PF11701 UNC45-central, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 4 hits
SM00028 TPR, 3 hits
SUPFAMiSSF48371 SSF48371, 2 hits
SSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUN45B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWX7
Secondary accession number(s): Q495Q8, Q495Q9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 1, 2003
Last modified: July 31, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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