Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho GTPase-activating protein 12

Gene

ARHGAP12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8IWW6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 12
Alternative name(s):
Rho-type GTPase-activating protein 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165322.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16348 ARHGAP12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610577 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IWW6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
94134

Open Targets

More...
OpenTargetsi
ENSG00000165322

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24957

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117238

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567131 – 846Rho GTPase-activating protein 12Add BLAST846

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei165PhosphoserineCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei230PhosphothreonineCombined sources1
Modified residuei231PhosphothreonineCombined sources1
Modified residuei240PhosphoserineCombined sources1
Modified residuei243PhosphotyrosineCombined sources1
Modified residuei592PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IWW6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IWW6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IWW6

PeptideAtlas

More...
PeptideAtlasi
Q8IWW6

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWW6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70913
70914 [Q8IWW6-2]
70915 [Q8IWW6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IWW6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IWW6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165322 Expressed in 227 organ(s), highest expression level in buccal mucosa cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_ARHGAP12

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IWW6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IWW6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000412

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125122, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IWW6, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345808

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IWW6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IWW6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 74SH3PROSITE-ProRule annotationAdd BLAST63
Domaini265 – 298WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini358 – 391WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini463 – 575PHPROSITE-ProRule annotationAdd BLAST113
Domaini656 – 844Rho-GAPPROSITE-ProRule annotationAdd BLAST189

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQ9D Eukaryota
ENOG410ZTHP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153530

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005328

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IWW6

KEGG Orthology (KO)

More...
KOi
K20636

Identification of Orthologs from Complete Genome Data

More...
OMAi
DFQSPGD

Database of Orthologous Groups

More...
OrthoDBi
EOG091G164H

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IWW6

TreeFam database of animal gene trees

More...
TreeFami
TF329345

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12070 SH3_ARHGAP12, 1 hit
cd00201 WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035491 ARHGAP12_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR001202 WW_dom
IPR036020 WW_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 1 hit
PF00620 RhoGAP, 1 hit
PF14604 SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit
SM00456 WW, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF51045 SSF51045, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit
PS50020 WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IWW6-1) [UniParc]FASTAAdd to basket
Also known as: ARHGAP12b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKMADRSGKI IPGQVYIEVE YDYEYEAKDR KIVIKQGERY ILVKKTNDDW
60 70 80 90 100
WQVKPDENSK AFYVPAQYVK EVTRKALMPP VKQVAGLPNN STKIMQSLHL
110 120 130 140 150
QRSTENVNKL PELSSFGKPS SSVQGTGLIR DANQNFGPSY NQGQTVNLSL
160 170 180 190 200
DLTHNNGKFN NDSHSPKVSS QNRTRSFGHF PGPEFLDVEK TSFSQEQSCD
210 220 230 240 250
SAGEGSERIH QDSESGDELS SSSTEQIRAT TPPNQGRPDS PVYANLQELK
260 270 280 290 300
ISQSALPPLP GSPAIQINGE WETHKDSSGR CYYYNRGTQE RTWKPPRWTR
310 320 330 340 350
DASISKGDFQ NPGDQELLSS EENYYSTSYS QSDSQCGSPP RGWSEELDER
360 370 380 390 400
GHTLYTSDYT NEKWLKHVDD QGRQYYYSAD GSRSEWELPK YNASSQQQRE
410 420 430 440 450
IIKSRSLDRR LQEPIVLTKW RHSTIVLDTN DKESPTASKP CFPENESSPS
460 470 480 490 500
SPKHQDTASS PKDQEKYGLL NVTKIAENGK KVRKNWLSSW AVLQGSSLLF
510 520 530 540 550
TKTQGSSTSW FGSNQSKPEF TVDLKGATIE MASKDKSSKK NVFELKTRQG
560 570 580 590 600
TELLIQSDND TVINDWFKVL SSTINNQAVE TDEGIEEEIP DSPGIEKHDK
610 620 630 640 650
EKEQKDPKKL RSFKVSSIDS SEQKKTKKNL KKFLTRRPTL QAVREKGYIK
660 670 680 690 700
DQVFGSNLAN LCQRENGTVP KFVKLCIEHV EEHGLDIDGI YRVSGNLAVI
710 720 730 740 750
QKLRFAVNHD EKLDLNDSKW EDIHVITGAL KMFFRELPEP LFTFNHFNDF
760 770 780 790 800
VNAIKQEPRQ RVAAVKDLIR QLPKPNQDTM QILFRHLRRV IENGEKNRMT
810 820 830 840
YQSIAIVFGP TLLKPEKETG NIAVHTVYQN QIVELILLEL SSIFGR
Length:846
Mass (Da):96,254
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i274CF06B47F02DDC
GO
Isoform 2 (identifier: Q8IWW6-2) [UniParc]FASTAAdd to basket
Also known as: ARHGAP12a

The sequence of this isoform differs from the canonical sequence as follows:
     433-462: Missing.

Show »
Length:816
Mass (Da):93,114
Checksum:iA948E9F7904B8DC7
GO
Isoform 3 (identifier: Q8IWW6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-363: Missing.
     458-462: Missing.

Show »
Length:794
Mass (Da):90,403
Checksum:i330029A7C1C294B3
GO
Isoform 4 (identifier: Q8IWW6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-462: Missing.

Show »
Length:841
Mass (Da):95,784
Checksum:i5C07E44111C30C1C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q1RLN5Q1RLN5_HUMAN
ARHGAP12 protein
ARHGAP12
799Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5D8H0Y5D8_HUMAN
Rho GTPase-activating protein 12
ARHGAP12
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70K → R in CAD38926 (PubMed:17974005).Curated1
Sequence conflicti760Q → P in CAD38926 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024454442F → S. Corresponds to variant dbSNP:rs2808096Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010326317 – 363Missing in isoform 3. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_010327433 – 462Missing in isoform 2. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_010328458 – 462Missing in isoform 3 and isoform 4. 2 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY033594 mRNA Translation: AAK52311.1
AY033595 mRNA Translation: AAK52312.1
AL390715 Genomic DNA No translation available.
AL834250 mRNA Translation: CAD38926.2
AL137485 mRNA Translation: CAB70766.1
CH471072 Genomic DNA Translation: EAW85980.1
CH471072 Genomic DNA Translation: EAW85983.1
CH471072 Genomic DNA Translation: EAW85985.1
BC051811 mRNA Translation: AAH51811.1
BC094719 mRNA Translation: AAH94719.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59214.1 [Q8IWW6-3]
CCDS59215.1 [Q8IWW6-2]
CCDS59216.1 [Q8IWW6-4]
CCDS7170.1 [Q8IWW6-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46471

NCBI Reference Sequences

More...
RefSeqi
NP_001257624.1, NM_001270695.1 [Q8IWW6-4]
NP_001257625.1, NM_001270696.1 [Q8IWW6-2]
NP_001257626.1, NM_001270697.1
NP_001257627.1, NM_001270698.1
NP_001257628.1, NM_001270699.1 [Q8IWW6-3]
NP_060757.4, NM_018287.6 [Q8IWW6-1]
XP_005252701.1, XM_005252644.1 [Q8IWW6-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.499264
Hs.741991

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311380; ENSP00000310984; ENSG00000165322 [Q8IWW6-3]
ENST00000344936; ENSP00000345808; ENSG00000165322 [Q8IWW6-1]
ENST00000375250; ENSP00000364399; ENSG00000165322 [Q8IWW6-2]
ENST00000396144; ENSP00000379448; ENSG00000165322 [Q8IWW6-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
94134

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:94134

UCSC genome browser

More...
UCSCi
uc001ivy.3 human [Q8IWW6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033594 mRNA Translation: AAK52311.1
AY033595 mRNA Translation: AAK52312.1
AL390715 Genomic DNA No translation available.
AL834250 mRNA Translation: CAD38926.2
AL137485 mRNA Translation: CAB70766.1
CH471072 Genomic DNA Translation: EAW85980.1
CH471072 Genomic DNA Translation: EAW85983.1
CH471072 Genomic DNA Translation: EAW85985.1
BC051811 mRNA Translation: AAH51811.1
BC094719 mRNA Translation: AAH94719.1
CCDSiCCDS59214.1 [Q8IWW6-3]
CCDS59215.1 [Q8IWW6-2]
CCDS59216.1 [Q8IWW6-4]
CCDS7170.1 [Q8IWW6-1]
PIRiT46471
RefSeqiNP_001257624.1, NM_001270695.1 [Q8IWW6-4]
NP_001257625.1, NM_001270696.1 [Q8IWW6-2]
NP_001257626.1, NM_001270697.1
NP_001257627.1, NM_001270698.1
NP_001257628.1, NM_001270699.1 [Q8IWW6-3]
NP_060757.4, NM_018287.6 [Q8IWW6-1]
XP_005252701.1, XM_005252644.1 [Q8IWW6-3]
UniGeneiHs.499264
Hs.741991

3D structure databases

ProteinModelPortaliQ8IWW6
SMRiQ8IWW6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125122, 11 interactors
IntActiQ8IWW6, 7 interactors
STRINGi9606.ENSP00000345808

PTM databases

iPTMnetiQ8IWW6
PhosphoSitePlusiQ8IWW6

Polymorphism and mutation databases

DMDMi47117238

Proteomic databases

EPDiQ8IWW6
MaxQBiQ8IWW6
PaxDbiQ8IWW6
PeptideAtlasiQ8IWW6
PRIDEiQ8IWW6
ProteomicsDBi70913
70914 [Q8IWW6-2]
70915 [Q8IWW6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311380; ENSP00000310984; ENSG00000165322 [Q8IWW6-3]
ENST00000344936; ENSP00000345808; ENSG00000165322 [Q8IWW6-1]
ENST00000375250; ENSP00000364399; ENSG00000165322 [Q8IWW6-2]
ENST00000396144; ENSP00000379448; ENSG00000165322 [Q8IWW6-4]
GeneIDi94134
KEGGihsa:94134
UCSCiuc001ivy.3 human [Q8IWW6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
94134
DisGeNETi94134
EuPathDBiHostDB:ENSG00000165322.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARHGAP12
HGNCiHGNC:16348 ARHGAP12
HPAiHPA000412
MIMi610577 gene
neXtProtiNX_Q8IWW6
OpenTargetsiENSG00000165322
PharmGKBiPA24957

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQ9D Eukaryota
ENOG410ZTHP LUCA
GeneTreeiENSGT00940000153530
HOVERGENiHBG005328
InParanoidiQ8IWW6
KOiK20636
OMAiDFQSPGD
OrthoDBiEOG091G164H
PhylomeDBiQ8IWW6
TreeFamiTF329345

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
SignaLinkiQ8IWW6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARHGAP12 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
94134

Protein Ontology

More...
PROi
PR:Q8IWW6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165322 Expressed in 227 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_ARHGAP12
ExpressionAtlasiQ8IWW6 baseline and differential
GenevisibleiQ8IWW6 HS

Family and domain databases

CDDicd12070 SH3_ARHGAP12, 1 hit
cd00201 WW, 1 hit
Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035491 ARHGAP12_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00620 RhoGAP, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit
SM00456 WW, 2 hits
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF51045 SSF51045, 2 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit
PS50020 WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWW6
Secondary accession number(s): B1ANY0
, B1ANY1, B1ANY2, Q504X1, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: December 5, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again