UniProtKB - Q8IWV2 (CNTN4_HUMAN)
Contactin-4
CNTN4
Functioni
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
GO - Molecular functioni
- cell-cell adhesion mediator activity Source: GO_Central
GO - Biological processi
- axonal fasciculation Source: UniProtKB
- axon guidance Source: GO_Central
- axonogenesis Source: UniProtKB
- brain development Source: UniProtKB
- dendrite self-avoidance Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
- negative regulation of neuron differentiation Source: UniProtKB
- nervous system development Source: UniProtKB
- neuron cell-cell adhesion Source: UniProtKB
- neuron projection development Source: UniProtKB
- regulation of synaptic plasticity Source: UniProtKB
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | Q8IWV2 |
Reactomei | R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins |
SignaLinki | Q8IWV2 |
Names & Taxonomyi
Protein namesi | Recommended name: Contactin-4Alternative name(s): Brain-derived immunoglobulin superfamily protein 2 Short name: BIG-2 |
Gene namesi | Name:CNTN4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2174, CNTN4 |
MIMi | 607280, gene |
neXtProti | NX_Q8IWV2 |
VEuPathDBi | HostDB:ENSG00000144619 |
Subcellular locationi
Plasma membrane
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: Reactome
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- anchored component of membrane Source: UniProtKB-KW
- axon Source: GO_Central
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Organism-specific databases
DisGeNETi | 152330 |
OpenTargetsi | ENSG00000144619 |
PharmGKBi | PA26688 |
Miscellaneous databases
Pharosi | Q8IWV2, Tbio |
Genetic variation databases
BioMutai | CNTN4 |
DMDMi | 55976529 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000014711 | 19 – 1000 | Contactin-4Add BLAST | 982 | |
PropeptideiPRO_0000014712 | 1001 – 1026 | Removed in mature formSequence analysisAdd BLAST | 26 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 50 ↔ 100 | PROSITE-ProRule annotation | ||
Glycosylationi | 65 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 90 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 144 ↔ 194 | PROSITE-ProRule annotation | ||
Glycosylationi | 191 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 247 ↔ 295 | PROSITE-ProRule annotation | ||
Disulfide bondi | 337 ↔ 384 | PROSITE-ProRule annotation | ||
Glycosylationi | 370 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 375 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 429 ↔ 477 | PROSITE-ProRule annotation | ||
Glycosylationi | 466 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 519 ↔ 576 | PROSITE-ProRule annotation | ||
Glycosylationi | 705 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 764 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 858 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 893 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 911 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 929 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 954 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 1000 | GPI-anchor amidated serineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
jPOSTi | Q8IWV2 |
MassIVEi | Q8IWV2 |
PaxDbi | Q8IWV2 |
PeptideAtlasi | Q8IWV2 |
PRIDEi | Q8IWV2 |
ProteomicsDBi | 3420 70904 [Q8IWV2-1] 70905 [Q8IWV2-2] 70906 [Q8IWV2-3] |
PTM databases
GlyConnecti | 1156, 25 N-Linked glycans (7 sites) |
GlyGeni | Q8IWV2, 14 sites, 27 N-linked glycans (7 sites) |
iPTMneti | Q8IWV2 |
PhosphoSitePlusi | Q8IWV2 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000144619, Expressed in thoracic aorta and 182 other tissues |
ExpressionAtlasi | Q8IWV2, baseline and differential |
Genevisiblei | Q8IWV2, HS |
Organism-specific databases
HPAi | ENSG00000144619, Tissue enhanced (parathyroid) |
Interactioni
Subunit structurei
Interacts with PTPRG.
1 PublicationGO - Molecular functioni
- cell-cell adhesion mediator activity Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 127444, 5 interactors |
IntActi | Q8IWV2, 5 interactors |
STRINGi | 9606.ENSP00000380602 |
Miscellaneous databases
RNActi | Q8IWV2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 117 | Ig-like C2-type 1Add BLAST | 86 | |
Domaini | 122 – 207 | Ig-like C2-type 2Add BLAST | 86 | |
Domaini | 225 – 311 | Ig-like C2-type 3Add BLAST | 87 | |
Domaini | 316 – 400 | Ig-like C2-type 4Add BLAST | 85 | |
Domaini | 406 – 493 | Ig-like C2-type 5Add BLAST | 88 | |
Domaini | 497 – 586 | Ig-like C2-type 6Add BLAST | 90 | |
Domaini | 599 – 697 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 702 – 799 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 804 – 899 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 900 – 995 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 96 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 685 – 710 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 886 – 907 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG3513, Eukaryota |
GeneTreei | ENSGT00940000155198 |
HOGENOMi | CLU_005756_0_0_1 |
InParanoidi | Q8IWV2 |
OMAi | KICKAYT |
OrthoDBi | 655902at2759 |
PhylomeDBi | Q8IWV2 |
TreeFami | TF351103 |
Family and domain databases
CDDi | cd00063, FN3, 4 hits |
Gene3Di | 2.60.40.10, 10 hits |
InterProi | View protein in InterPro IPR043204, Basigin-like IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
PANTHERi | PTHR10075, PTHR10075, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF07679, I-set, 3 hits |
SMARTi | View protein in SMART SM00060, FN3, 4 hits SM00409, IG, 6 hits SM00408, IGc2, 5 hits |
SUPFAMi | SSF48726, SSF48726, 6 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS50835, IG_LIKE, 6 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRLPWELLVL QSFILCLADD STLHGPIFIQ EPSPVMFPLD SEEKKVKLNC
60 70 80 90 100
EVKGNPKPHI RWKLNGTDVD TGMDFRYSVV EGSLLINNPN KTQDAGTYQC
110 120 130 140 150
TATNSFGTIV SREAKLQFAY LDNFKTRTRS TVSVRRGQGM VLLCGPPPHS
160 170 180 190 200
GELSYAWIFN EYPSYQDNRR FVSQETGNLY IAKVEKSDVG NYTCVVTNTV
210 220 230 240 250
TNHKVLGPPT PLILRNDGVM GEYEPKIEVQ FPETVPTAKG ATVKLECFAL
260 270 280 290 300
GNPVPTIIWR RADGKPIARK ARRHKSNGIL EIPNFQQEDA GLYECVAENS
310 320 330 340 350
RGKNVARGQL TFYAQPNWIQ KINDIHVAME ENVFWECKAN GRPKPTYKWL
360 370 380 390 400
KNGEPLLTRD RIQIEQGTLN ITIVNLSDAG MYQCLAENKH GVIFSNAELS
410 420 430 440 450
VIAVGPDFSR TLLKRVTLVK VGGEVVIECK PKASPKPVYT WKKGRDILKE
460 470 480 490 500
NERITISEDG NLRIINVTKS DAGSYTCIAT NHFGTASSTG NLVVKDPTRV
510 520 530 540 550
MVPPSSMDVT VGESIVLPCQ VTHDHSLDIV FTWSFNGHLI DFDRDGDHFE
560 570 580 590 600
RVGGQDSAGD LMIRNIQLKH AGKYVCMVQT SVDRLSAAAD LIVRGPPGPP
610 620 630 640 650
EAVTIDEITD TTAQLSWRPG PDNHSPITMY VIQARTPFSV GWQAVSTVPE
660 670 680 690 700
LIDGKTFTAT VVGLNPWVEY EFRTVAANVI GIGEPSRPSE KRRTEEALPE
710 720 730 740 750
VTPANVSGGG GSKSELVITW ETVPEELQNG RGFGYVVAFR PYGKMIWMLT
760 770 780 790 800
VLASADASRY VFRNESVHPF SPFEVKVGVF NNKGEGPFSP TTVVYSAEEE
810 820 830 840 850
PTKPPASIFA RSLSATDIEV FWASPLEKNR GRIQGYEVKY WRHEDKEENA
860 870 880 890 900
RKIRTVGNQT STKITNLKGS VLYHLAVKAY NSAGTGPSSA TVNVTTRKPP
910 920 930 940 950
PSQPPGNIIW NSSDSKIILN WDQVKALDNE SEVKGYKVLY RWNRQSSTSV
960 970 980 990 1000
IETNKTSVEL SLPFDEDYII EIKPFSDGGD GSSSEQIRIP KISNAYARGS
1010 1020
GASTSNACTL SAISTIMISL TARSSL
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JMQ2 | C9JMQ2_HUMAN | Contactin-4 | CNTN4 | 116 | Annotation score: | ||
F8WD58 | F8WD58_HUMAN | Contactin-4 | CNTN4 | 232 | Annotation score: | ||
C9JIY1 | C9JIY1_HUMAN | Contactin-4 | CNTN4 | 137 | Annotation score: | ||
C9JGK9 | C9JGK9_HUMAN | Contactin-4 | CNTN4 | 54 | Annotation score: | ||
H0Y8U1 | H0Y8U1_HUMAN | Contactin-4 | CNTN4 | 143 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035507 | 176 | T → P in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_035508 | 420 | K → N in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011961 | 1 – 744 | Missing in isoform 2. 1 PublicationAdd BLAST | 744 | |
Alternative sequenceiVSP_044270 | 1 – 328 | Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 328 | |
Alternative sequenceiVSP_011962 | 555 | Missing in isoform 3. Curated | 1 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000397459.6; ENSP00000380600.2; ENSG00000144619.15 [Q8IWV2-4] ENST00000397461.5; ENSP00000380602.1; ENSG00000144619.15 ENST00000418658.6; ENSP00000396010.1; ENSG00000144619.15 ENST00000427331.5; ENSP00000413642.1; ENSG00000144619.15 |
GeneIDi | 152330 |
KEGGi | hsa:152330 |
MANE-Selecti | ENST00000418658.6; ENSP00000396010.1; NM_175607.3; NP_783200.1 |
UCSCi | uc003bpc.4, human [Q8IWV2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
AlphaFoldDBi | Q8IWV2 |
SMRi | Q8IWV2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127444, 5 interactors |
IntActi | Q8IWV2, 5 interactors |
STRINGi | 9606.ENSP00000380602 |
PTM databases
GlyConnecti | 1156, 25 N-Linked glycans (7 sites) |
GlyGeni | Q8IWV2, 14 sites, 27 N-linked glycans (7 sites) |
iPTMneti | Q8IWV2 |
PhosphoSitePlusi | Q8IWV2 |
Genetic variation databases
BioMutai | CNTN4 |
DMDMi | 55976529 |
Proteomic databases
jPOSTi | Q8IWV2 |
MassIVEi | Q8IWV2 |
PaxDbi | Q8IWV2 |
PeptideAtlasi | Q8IWV2 |
PRIDEi | Q8IWV2 |
ProteomicsDBi | 3420 70904 [Q8IWV2-1] 70905 [Q8IWV2-2] 70906 [Q8IWV2-3] |
Protocols and materials databases
Antibodypediai | 9906, 199 antibodies from 31 providers |
DNASUi | 152330 |
Genome annotation databases
Ensembli | ENST00000397459.6; ENSP00000380600.2; ENSG00000144619.15 [Q8IWV2-4] ENST00000397461.5; ENSP00000380602.1; ENSG00000144619.15 ENST00000418658.6; ENSP00000396010.1; ENSG00000144619.15 ENST00000427331.5; ENSP00000413642.1; ENSG00000144619.15 |
GeneIDi | 152330 |
KEGGi | hsa:152330 |
MANE-Selecti | ENST00000418658.6; ENSP00000396010.1; NM_175607.3; NP_783200.1 |
UCSCi | uc003bpc.4, human [Q8IWV2-1] |
Organism-specific databases
CTDi | 152330 |
DisGeNETi | 152330 |
GeneCardsi | CNTN4 |
HGNCi | HGNC:2174, CNTN4 |
HPAi | ENSG00000144619, Tissue enhanced (parathyroid) |
MIMi | 607280, gene |
neXtProti | NX_Q8IWV2 |
OpenTargetsi | ENSG00000144619 |
PharmGKBi | PA26688 |
VEuPathDBi | HostDB:ENSG00000144619 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3513, Eukaryota |
GeneTreei | ENSGT00940000155198 |
HOGENOMi | CLU_005756_0_0_1 |
InParanoidi | Q8IWV2 |
OMAi | KICKAYT |
OrthoDBi | 655902at2759 |
PhylomeDBi | Q8IWV2 |
TreeFami | TF351103 |
Enzyme and pathway databases
PathwayCommonsi | Q8IWV2 |
Reactomei | R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins |
SignaLinki | Q8IWV2 |
Miscellaneous databases
BioGRID-ORCSi | 152330, 12 hits in 1068 CRISPR screens |
ChiTaRSi | CNTN4, human |
GeneWikii | CNTN4 |
GenomeRNAii | 152330 |
Pharosi | Q8IWV2, Tbio |
PROi | PR:Q8IWV2 |
RNActi | Q8IWV2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144619, Expressed in thoracic aorta and 182 other tissues |
ExpressionAtlasi | Q8IWV2, baseline and differential |
Genevisiblei | Q8IWV2, HS |
Family and domain databases
CDDi | cd00063, FN3, 4 hits |
Gene3Di | 2.60.40.10, 10 hits |
InterProi | View protein in InterPro IPR043204, Basigin-like IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
PANTHERi | PTHR10075, PTHR10075, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 2 hits PF07679, I-set, 3 hits |
SMARTi | View protein in SMART SM00060, FN3, 4 hits SM00409, IG, 6 hits SM00408, IGc2, 5 hits |
SUPFAMi | SSF48726, SSF48726, 6 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS50835, IG_LIKE, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CNTN4_HUMAN | |
Accessioni | Q8IWV2Primary (citable) accession number: Q8IWV2 Secondary accession number(s): B2RAX3, Q8IX14, Q8TC35 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families