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UniProtKB - Q8IWV2 (CNTN4_HUMAN)

Entry version 150 (17 Jun 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Contactin-4

Gene

CNTN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Contactin-4
Alternative name(s):
Brain-derived immunoglobulin superfamily protein 2
Short name:
BIG-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNTN4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000144619.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:2174 CNTN4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607280 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IWV2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features.1 Publication

Organism-specific databases

DisGeNET

More...DisGeNETi		152330

Open Targets

More...OpenTargetsi		ENSG00000144619

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26688

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IWV2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CNTN4

Domain mapping of disease mutations (DMDM)

More...DMDMi		55976529

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001471119 – 1000Contactin-4Add BLAST982
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000147121001 – 1026Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi50 ↔ 100PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi65N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 194PROSITE-ProRule annotation
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi247 ↔ 295PROSITE-ProRule annotation
Disulfide bondi337 ↔ 384PROSITE-ProRule annotation
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi429 ↔ 477PROSITE-ProRule annotation
Glycosylationi466N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi519 ↔ 576PROSITE-ProRule annotation
Glycosylationi705N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi764N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi858N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi893N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi911N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi929N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi954N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1000GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IWV2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IWV2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IWV2

PeptideAtlas

More...PeptideAtlasi		Q8IWV2

PRoteomics IDEntifications database

More...PRIDEi		Q8IWV2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3420
70904 [Q8IWV2-1]
70905 [Q8IWV2-2]
70906 [Q8IWV2-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1156

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IWV2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IWV2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mainly expressed in brain. Highly expressed in cerebellum and weakly expressed in corpus callosum, caudate nucleus, amygdala and spinal cord. Also expressed in testis, pancreas, thyroid, uterus, small intestine and kidney. Not expressed in skeletal muscle. Isoform 2 is weakly expressed in cerebral cortex.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By retinoic acid, suggesting that it may act in response to differentiating agents.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000144619 Expressed in thoracic aorta and 164 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IWV2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IWV2 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000144619 Tissue enhanced (parathyroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PTPRG.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127444, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q8IWV2, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380602

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IWV2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IWV2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 117Ig-like C2-type 1Add BLAST86
Domaini122 – 207Ig-like C2-type 2Add BLAST86
Domaini225 – 311Ig-like C2-type 3Add BLAST87
Domaini316 – 400Ig-like C2-type 4Add BLAST85
Domaini406 – 493Ig-like C2-type 5Add BLAST88
Domaini497 – 586Ig-like C2-type 6Add BLAST90
Domaini599 – 697Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini702 – 799Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini804 – 899Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini900 – 995Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. Contactin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3513 Eukaryota
ENOG410XSVG LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155198

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005756_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IWV2

KEGG Orthology (KO)

More...KOi		K06762

Identification of Orthologs from Complete Genome Data

More...OMAi		HSGDLIF

Database of Orthologous Groups

More...OrthoDBi		655902at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IWV2

TreeFam database of animal gene trees

More...TreeFami		TF351103

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063 FN3, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033007 Contactin-4
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

The PANTHER Classification System

More...PANTHERi		PTHR12231:SF229 PTHR12231:SF229, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IWV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLPWELLVL QSFILCLADD STLHGPIFIQ EPSPVMFPLD SEEKKVKLNC 
        60         70         80         90        100
EVKGNPKPHI RWKLNGTDVD TGMDFRYSVV EGSLLINNPN KTQDAGTYQC 
       110        120        130        140        150
TATNSFGTIV SREAKLQFAY LDNFKTRTRS TVSVRRGQGM VLLCGPPPHS 
       160        170        180        190        200
GELSYAWIFN EYPSYQDNRR FVSQETGNLY IAKVEKSDVG NYTCVVTNTV 
       210        220        230        240        250
TNHKVLGPPT PLILRNDGVM GEYEPKIEVQ FPETVPTAKG ATVKLECFAL 
       260        270        280        290        300
GNPVPTIIWR RADGKPIARK ARRHKSNGIL EIPNFQQEDA GLYECVAENS 
       310        320        330        340        350
RGKNVARGQL TFYAQPNWIQ KINDIHVAME ENVFWECKAN GRPKPTYKWL 
       360        370        380        390        400
KNGEPLLTRD RIQIEQGTLN ITIVNLSDAG MYQCLAENKH GVIFSNAELS 
       410        420        430        440        450
VIAVGPDFSR TLLKRVTLVK VGGEVVIECK PKASPKPVYT WKKGRDILKE 
       460        470        480        490        500
NERITISEDG NLRIINVTKS DAGSYTCIAT NHFGTASSTG NLVVKDPTRV 
       510        520        530        540        550
MVPPSSMDVT VGESIVLPCQ VTHDHSLDIV FTWSFNGHLI DFDRDGDHFE 
       560        570        580        590        600
RVGGQDSAGD LMIRNIQLKH AGKYVCMVQT SVDRLSAAAD LIVRGPPGPP 
       610        620        630        640        650
EAVTIDEITD TTAQLSWRPG PDNHSPITMY VIQARTPFSV GWQAVSTVPE 
       660        670        680        690        700
LIDGKTFTAT VVGLNPWVEY EFRTVAANVI GIGEPSRPSE KRRTEEALPE 
       710        720        730        740        750
VTPANVSGGG GSKSELVITW ETVPEELQNG RGFGYVVAFR PYGKMIWMLT 
       760        770        780        790        800
VLASADASRY VFRNESVHPF SPFEVKVGVF NNKGEGPFSP TTVVYSAEEE 
       810        820        830        840        850
PTKPPASIFA RSLSATDIEV FWASPLEKNR GRIQGYEVKY WRHEDKEENA 
       860        870        880        890        900
RKIRTVGNQT STKITNLKGS VLYHLAVKAY NSAGTGPSSA TVNVTTRKPP 
       910        920        930        940        950
PSQPPGNIIW NSSDSKIILN WDQVKALDNE SEVKGYKVLY RWNRQSSTSV 
       960        970        980        990       1000
IETNKTSVEL SLPFDEDYII EIKPFSDGGD GSSSEQIRIP KISNAYARGS 
      1010       1020 
GASTSNACTL SAISTIMISL TARSSL
Length:1,026
Mass (Da):113,454
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B53D15665B4287B
GO
Isoform 2 (identifier: Q8IWV2-2) [UniParc]FASTAAdd to basket
Also known as: CNTN4A

The sequence of this isoform differs from the canonical sequence as follows:
     1-744: Missing.

Show »
Length:282
Mass (Da):31,066
Checksum:iFC0BD80B86F9E048
GO
Isoform 3 (identifier: Q8IWV2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-328: Missing.
     555-555: Missing.

Show »
Length:697
Mass (Da):76,527
Checksum:i9984789B5E5334F9
GO
Isoform 4 (identifier: Q8IWV2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-328: Missing.

Show »
Length:698
Mass (Da):76,655
Checksum:iBA1E4A8521B5D6FF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WD58F8WD58_HUMAN
Contactin-4
CNTN4
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JMQ2C9JMQ2_HUMAN
Contactin-4
CNTN4
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIY1C9JIY1_HUMAN
Contactin-4
CNTN4
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JGK9C9JGK9_HUMAN
Contactin-4
CNTN4
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8U1H0Y8U1_HUMAN
Contactin-4
CNTN4
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035507176T → P in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_035508420K → N in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0119611 – 744Missing in isoform 2. 1 PublicationAdd BLAST744
Alternative sequenceiVSP_0442701 – 328Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST328
Alternative sequenceiVSP_011962555Missing in isoform 3. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF464063 mRNA Translation: AAN86141.1
AY090737 mRNA Translation: AAM00025.1
AF549455 mRNA Translation: AAP05786.1
AK314396 mRNA Translation: BAG37020.1
AC018842 Genomic DNA No translation available.
AC022002 Genomic DNA No translation available.
AC022008 Genomic DNA No translation available.
AC024057 Genomic DNA No translation available.
AC026882 Genomic DNA No translation available.
AC066608 Genomic DNA No translation available.
AC087094 Genomic DNA No translation available.
AC087427 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW63874.1
BC026119 mRNA Translation: AAH26119.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2558.1 [Q8IWV2-4]
CCDS43041.1 [Q8IWV2-1]

NCBI Reference Sequences

More...RefSeqi		NP_001193884.1, NM_001206955.1 [Q8IWV2-1]
NP_001193885.1, NM_001206956.1 [Q8IWV2-3]
NP_783200.1, NM_175607.2 [Q8IWV2-1]
NP_783302.1, NM_175613.2 [Q8IWV2-4]
XP_011531727.1, XM_011533425.2 [Q8IWV2-1]
XP_011531728.1, XM_011533426.2
XP_011531729.1, XM_011533427.2 [Q8IWV2-1]
XP_011531730.1, XM_011533428.2 [Q8IWV2-1]
XP_011531731.1, XM_011533429.2 [Q8IWV2-1]
XP_011531732.1, XM_011533430.2 [Q8IWV2-1]
XP_016861271.1, XM_017005782.1 [Q8IWV2-1]
XP_016861272.1, XM_017005783.1 [Q8IWV2-1]
XP_016861273.1, XM_017005784.1 [Q8IWV2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000397459; ENSP00000380600; ENSG00000144619 [Q8IWV2-4]
ENST00000397461; ENSP00000380602; ENSG00000144619 [Q8IWV2-1]
ENST00000418658; ENSP00000396010; ENSG00000144619 [Q8IWV2-1]
ENST00000427331; ENSP00000413642; ENSG00000144619 [Q8IWV2-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		152330

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:152330

UCSC genome browser

More...UCSCi		uc003bpc.4 human [Q8IWV2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF464063 mRNA Translation: AAN86141.1
AY090737 mRNA Translation: AAM00025.1
AF549455 mRNA Translation: AAP05786.1
AK314396 mRNA Translation: BAG37020.1
AC018842 Genomic DNA No translation available.
AC022002 Genomic DNA No translation available.
AC022008 Genomic DNA No translation available.
AC024057 Genomic DNA No translation available.
AC026882 Genomic DNA No translation available.
AC066608 Genomic DNA No translation available.
AC087094 Genomic DNA No translation available.
AC087427 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW63874.1
BC026119 mRNA Translation: AAH26119.1
CCDSiCCDS2558.1 [Q8IWV2-4]
CCDS43041.1 [Q8IWV2-1]
RefSeqiNP_001193884.1, NM_001206955.1 [Q8IWV2-1]
NP_001193885.1, NM_001206956.1 [Q8IWV2-3]
NP_783200.1, NM_175607.2 [Q8IWV2-1]
NP_783302.1, NM_175613.2 [Q8IWV2-4]
XP_011531727.1, XM_011533425.2 [Q8IWV2-1]
XP_011531728.1, XM_011533426.2
XP_011531729.1, XM_011533427.2 [Q8IWV2-1]
XP_011531730.1, XM_011533428.2 [Q8IWV2-1]
XP_011531731.1, XM_011533429.2 [Q8IWV2-1]
XP_011531732.1, XM_011533430.2 [Q8IWV2-1]
XP_016861271.1, XM_017005782.1 [Q8IWV2-1]
XP_016861272.1, XM_017005783.1 [Q8IWV2-1]
XP_016861273.1, XM_017005784.1 [Q8IWV2-1]

3D structure databases

SMRiQ8IWV2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127444, 4 interactors
IntActiQ8IWV2, 5 interactors
STRINGi9606.ENSP00000380602

PTM databases

GlyConnecti1156
iPTMnetiQ8IWV2
PhosphoSitePlusiQ8IWV2

Polymorphism and mutation databases

BioMutaiCNTN4
DMDMi55976529

Proteomic databases

jPOSTiQ8IWV2
MassIVEiQ8IWV2
PaxDbiQ8IWV2
PeptideAtlasiQ8IWV2
PRIDEiQ8IWV2
ProteomicsDBi3420
70904 [Q8IWV2-1]
70905 [Q8IWV2-2]
70906 [Q8IWV2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		9906 183 antibodies

Genome annotation databases

EnsembliENST00000397459; ENSP00000380600; ENSG00000144619 [Q8IWV2-4]
ENST00000397461; ENSP00000380602; ENSG00000144619 [Q8IWV2-1]
ENST00000418658; ENSP00000396010; ENSG00000144619 [Q8IWV2-1]
ENST00000427331; ENSP00000413642; ENSG00000144619 [Q8IWV2-1]
GeneIDi152330
KEGGihsa:152330
UCSCiuc003bpc.4 human [Q8IWV2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		152330
DisGeNETi152330
EuPathDBiHostDB:ENSG00000144619.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		CNTN4
HGNCiHGNC:2174 CNTN4
HPAiENSG00000144619 Tissue enhanced (parathyroid)
MIMi607280 gene
neXtProtiNX_Q8IWV2
OpenTargetsiENSG00000144619
PharmGKBiPA26688

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
GeneTreeiENSGT00940000155198
HOGENOMiCLU_005756_0_0_1
InParanoidiQ8IWV2
KOiK06762
OMAiHSGDLIF
OrthoDBi655902at2759
PhylomeDBiQ8IWV2
TreeFamiTF351103

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		152330 3 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CNTN4 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CNTN4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		152330
PharosiQ8IWV2 Tbio

Protein Ontology

More...PROi		PR:Q8IWV2
RNActiQ8IWV2 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000144619 Expressed in thoracic aorta and 164 other tissues
ExpressionAtlasiQ8IWV2 baseline and differential
GenevisibleiQ8IWV2 HS

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR033007 Contactin-4
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PANTHERiPTHR12231:SF229 PTHR12231:SF229, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNTN4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWV2
Secondary accession number(s): B2RAX3, Q8IX14, Q8TC35
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: June 17, 2020
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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