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Entry version 147 (12 Aug 2020)
Sequence version 2 (10 Jun 2008)
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Protein

Zinc transporter 8

Gene

SLC30A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein homodimerization activity Source: BHF-UCL
  • zinc ion binding Source: BHF-UCL
  • zinc ion transmembrane transporter activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IWU4

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-264876, Insulin processing
R-HSA-435368, Zinc efflux and compartmentalization by the SLC30 family

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.4.3.5, the cation diffusion facilitator (cdf) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc transporter 8
Short name:
ZnT-8
Alternative name(s):
Solute carrier family 30 member 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC30A8
Synonyms:ZNT8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164756.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20303, SLC30A8

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611145, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IWU4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 79CytoplasmicSequence analysisAdd BLAST79
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 103ExtracellularSequence analysis3
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 140CytoplasmicSequence analysisAdd BLAST16
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 175ExtracellularSequence analysisAdd BLAST14
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 217CytoplasmicSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 245ExtracellularSequence analysis7
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 369CytoplasmicSequence analysisAdd BLAST103

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNET

More...
DisGeNETi
169026

MalaCards human disease database

More...
MalaCardsi
SLC30A8
MIMi125853, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000164756

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134915546

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IWU4, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC30A8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
190358866

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002817401 – 369Zinc transporter 8Add BLAST369

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IWU4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8IWU4

PeptideAtlas

More...
PeptideAtlasi
Q8IWU4

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWU4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70895 [Q8IWU4-1]
70896 [Q8IWU4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IWU4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IWU4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive.5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164756, Expressed in islet of Langerhans and 93 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8IWU4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IWU4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164756, Tissue enriched (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8IWU4
With#Exp.IntAct
ANK1 - isoform Mu17 [P16157-17]3EBI-10262251,EBI-941819
AQP6 [Q13520]3EBI-10262251,EBI-13059134
ARL8B [Q9NVJ2]3EBI-10262251,EBI-718376
ATP13A1 - isoform C [Q9HD20-3]3EBI-10262251,EBI-12069500
BCL2L13 [Q9BXK5]3EBI-10262251,EBI-747430
BIK [Q13323]3EBI-10262251,EBI-700794
BSND [Q8WZ55]3EBI-10262251,EBI-7996695
C16orf58 [Q96GQ5]3EBI-10262251,EBI-8636004
CCL4 [P13236]3EBI-10262251,EBI-2873970
CD99L2 [Q8TCZ2]3EBI-10262251,EBI-2824782
CGRRF1 [Q99675]3EBI-10262251,EBI-2130213
CLDN6 [P56747]3EBI-10262251,EBI-12955011
CMTM7 [Q96FZ5]3EBI-10262251,EBI-2807956
CPLX4 [Q7Z7G2]3EBI-10262251,EBI-18013275
CREB3L1 [Q96BA8]9EBI-10262251,EBI-6942903
DERL1 [Q9BUN8]3EBI-10262251,EBI-398977
EBP [Q15125]3EBI-10262251,EBI-3915253
ELOVL4 [Q9GZR5]3EBI-10262251,EBI-18535450
ERGIC3 [Q9Y282]3EBI-10262251,EBI-781551
ERVFRD-1 [P60508]3EBI-10262251,EBI-17973325
FAM209A [Q5JX71]3EBI-10262251,EBI-18304435
FAM210B [Q96KR6]3EBI-10262251,EBI-18938272
FAXDC2 [Q96IV6]3EBI-10262251,EBI-12142299
FNDC9 [Q8TBE3]3EBI-10262251,EBI-12142257
GPR37L1 [O60883]3EBI-10262251,EBI-2927498
GPR42 [O15529]3EBI-10262251,EBI-18076404
GRM2 [Q14416]3EBI-10262251,EBI-10232876
HMG20A [Q9NP66]3EBI-10262251,EBI-740641
HMOX2 [P30519]3EBI-10262251,EBI-712096
HSD17B11 [Q8NBQ5]3EBI-10262251,EBI-1052304
JSRP1 [Q96MG2]3EBI-10262251,EBI-11305455
LEUTX [A8MZ59]3EBI-10262251,EBI-17490413
MUC1 - isoform Y-LSP [P15941-11]3EBI-10262251,EBI-17263240
NKG7 [Q16617]3EBI-10262251,EBI-3919611
ORMDL1 [Q9P0S3]3EBI-10262251,EBI-1054848
OTULINL [Q9NUU6]3EBI-10262251,EBI-6916492
PCNA [P12004]3EBI-10262251,EBI-358311
PGRMC2 [O15173]3EBI-10262251,EBI-1050125
PKMYT1 - isoform 2 [Q99640-2]3EBI-10262251,EBI-12257782
PLN [P26678]3EBI-10262251,EBI-692836
PTPN9 [P43378]3EBI-10262251,EBI-742898
REEP4 [Q9H6H4]3EBI-10262251,EBI-7545592
REEP6 - isoform 2 [Q96HR9-2]3EBI-10262251,EBI-14065960
RELL2 [Q8NC24]3EBI-10262251,EBI-10269209
RMDN3 [Q96TC7]3EBI-10262251,EBI-1056589
RTN3 - isoform 3 [O95197-3]3EBI-10262251,EBI-11525735
SAR1A [Q9NR31]3EBI-10262251,EBI-3920694
SCN3B [Q9NY72]3EBI-10262251,EBI-17247926
SELENOK [Q9Y6D0]3EBI-10262251,EBI-9679163
SFT2D1 [Q8WV19]3EBI-10262251,EBI-2854842
SFT2D2 [O95562]3EBI-10262251,EBI-4402330
SLC18A1 - isoform 3 [P54219-3]3EBI-10262251,EBI-17595455
SLC30A3 [Q99726]3EBI-10262251,EBI-10294651
SLC39A2 [Q9NP94]3EBI-10262251,EBI-12898013
SPAG4 [Q9NPE6]3EBI-10262251,EBI-10819434
SSMEM1 [Q8WWF3]3EBI-10262251,EBI-17280858
SYS1 [Q8N2H4]3EBI-10262251,EBI-13075176
SYT2 [Q8N9I0]3EBI-10262251,EBI-8032987
THAP4 [Q8WY91]3EBI-10262251,EBI-726691
THSD7B [C9JKN6]3EBI-10262251,EBI-17192156
TMEM11 [P17152]3EBI-10262251,EBI-723946
TMEM139 [Q8IV31]3EBI-10262251,EBI-7238458
TMEM14B [Q9NUH8]3EBI-10262251,EBI-8638294
TMEM208 [Q9BTX3]3EBI-10262251,EBI-12876824
TMEM237 - isoform 2 [Q96Q45-2]3EBI-10262251,EBI-10982110
TMEM50A [O95807]3EBI-10262251,EBI-12903814
TMEM52B [Q4KMG9]3EBI-10262251,EBI-18178701
TMEM80 [Q96HE8]3EBI-10262251,EBI-11742770
TMEM9 [Q9P0T7]3EBI-10262251,EBI-723976
TSPAN2 [O60636]3EBI-10262251,EBI-3914288
VAMP1 - isoform 2 [P23763-3]3EBI-10262251,EBI-12097582
VAMP2 [P63027]3EBI-10262251,EBI-520113
YIPF4 [Q9BSR8]3EBI-10262251,EBI-751253
YIPF6 [Q96EC8]3EBI-10262251,EBI-751210
ZFYVE27 [Q5T4F4]3EBI-10262251,EBI-3892947
Spike glycoprotein E1 (PRO_0000041304) from Rubella virus (strain M33).2EBI-10262251,EBI-11477759

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127975, 2 interactors

Protein interaction database and analysis system

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IntActi
Q8IWU4, 76 interactors

Molecular INTeraction database

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MINTi
Q8IWU4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000415011

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IWU4, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi197 – 205HXXXXX[HY]NH-motif9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1482, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160706

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013430_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IWU4

KEGG Orthology (KO)

More...
KOi
K14695

Identification of Orthologs from Complete Genome Data

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OMAi
FNIIMGL

Database of Orthologous Groups

More...
OrthoDBi
820567at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IWU4

TreeFam database of animal gene trees

More...
TreeFami
TF313382

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1510.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002524, Cation_efflux
IPR036837, Cation_efflux_CTD_sf
IPR027469, Cation_efflux_TMD_sf
IPR033572, ZnT-8

The PANTHER Classification System

More...
PANTHERi
PTHR11562:SF37, PTHR11562:SF37, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01545, Cation_efflux, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF160240, SSF160240, 1 hit
SSF161111, SSF161111, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01297, CDF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IWU4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFLERTYLV NDKAAKMYAF TLESVELQQK PVNKDQCPRE RPEELESGGM
60 70 80 90 100
YHCHSGSKPT EKGANEYAYA KWKLCSASAI CFIFMIAEVV GGHIAGSLAV
110 120 130 140 150
VTDAAHLLID LTSFLLSLFS LWLSSKPPSK RLTFGWHRAE ILGALLSILC
160 170 180 190 200
IWVVTGVLVY LACERLLYPD YQIQATVMII VSSCAVAANI VLTVVLHQRC
210 220 230 240 250
LGHNHKEVQA NASVRAAFVH ALGDLFQSIS VLISALIIYF KPEYKIADPI
260 270 280 290 300
CTFIFSILVL ASTITILKDF SILLMEGVPK SLNYSGVKEL ILAVDGVLSV
310 320 330 340 350
HSLHIWSLTM NQVILSAHVA TAASRDSQVV RREIAKALSK SFTMHSLTIQ
360
MESPVDQDPD CLFCEDPCD
Length:369
Mass (Da):40,755
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45926FADCEE18FF3
GO
Isoform 2 (identifier: Q8IWU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Show »
Length:320
Mass (Da):35,053
Checksum:i5D6EE4250AFD9492
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RG87E5RG87_HUMAN
Solute carrier family 30 member 8
SLC30A8
87Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LPF3A0A096LPF3_HUMAN
Zinc transporter 8
SLC30A8
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LNR0A0A096LNR0_HUMAN
Zinc transporter 8
SLC30A8
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18Y → H in AAM80562 (PubMed:15331542).Curated1
Sequence conflicti123L → S in ABQ59023 (PubMed:17974005).Curated1
Sequence conflicti222L → P in CAD28545 (PubMed:17974005).Curated1
Sequence conflicti302S → C in CAD28545 (PubMed:17974005).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Variant Trp-325 is a risk factor that confers susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM) [MIMi:125853].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031258325R → Q. Corresponds to variant dbSNP:rs16889462Ensembl.1
Natural variantiVAR_031259325R → W1 PublicationCorresponds to variant dbSNP:rs13266634Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0240251 – 49Missing in isoform 2. 3 PublicationsAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY117411 mRNA Translation: AAM80562.1
AK298294 mRNA Translation: BAG60552.1
AL713790 mRNA Translation: CAD28545.1
EF560713 mRNA Translation: ABQ59023.1
AC027419 Genomic DNA No translation available.
AC084114 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91968.1
BC126446 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55272.1 [Q8IWU4-2]
CCDS6322.1 [Q8IWU4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001166282.1, NM_001172811.1 [Q8IWU4-2]
NP_001166284.1, NM_001172813.1 [Q8IWU4-2]
NP_001166285.1, NM_001172814.1 [Q8IWU4-2]
NP_001166286.1, NM_001172815.2 [Q8IWU4-2]
NP_776250.2, NM_173851.2 [Q8IWU4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000427715; ENSP00000407505; ENSG00000164756 [Q8IWU4-2]
ENST00000456015; ENSP00000415011; ENSG00000164756 [Q8IWU4-1]
ENST00000519688; ENSP00000431069; ENSG00000164756 [Q8IWU4-2]
ENST00000521243; ENSP00000428545; ENSG00000164756 [Q8IWU4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
169026

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:169026

UCSC genome browser

More...
UCSCi
uc003yog.3, human [Q8IWU4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY117411 mRNA Translation: AAM80562.1
AK298294 mRNA Translation: BAG60552.1
AL713790 mRNA Translation: CAD28545.1
EF560713 mRNA Translation: ABQ59023.1
AC027419 Genomic DNA No translation available.
AC084114 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91968.1
BC126446 mRNA No translation available.
CCDSiCCDS55272.1 [Q8IWU4-2]
CCDS6322.1 [Q8IWU4-1]
RefSeqiNP_001166282.1, NM_001172811.1 [Q8IWU4-2]
NP_001166284.1, NM_001172813.1 [Q8IWU4-2]
NP_001166285.1, NM_001172814.1 [Q8IWU4-2]
NP_001166286.1, NM_001172815.2 [Q8IWU4-2]
NP_776250.2, NM_173851.2 [Q8IWU4-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127975, 2 interactors
IntActiQ8IWU4, 76 interactors
MINTiQ8IWU4
STRINGi9606.ENSP00000415011

Chemistry databases

DrugBankiDB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

Protein family/group databases

TCDBi2.A.4.3.5, the cation diffusion facilitator (cdf) family

PTM databases

iPTMnetiQ8IWU4
PhosphoSitePlusiQ8IWU4

Polymorphism and mutation databases

BioMutaiSLC30A8
DMDMi190358866

Proteomic databases

jPOSTiQ8IWU4
PaxDbiQ8IWU4
PeptideAtlasiQ8IWU4
PRIDEiQ8IWU4
ProteomicsDBi70895 [Q8IWU4-1]
70896 [Q8IWU4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
42965, 195 antibodies

The DNASU plasmid repository

More...
DNASUi
169026

Genome annotation databases

EnsembliENST00000427715; ENSP00000407505; ENSG00000164756 [Q8IWU4-2]
ENST00000456015; ENSP00000415011; ENSG00000164756 [Q8IWU4-1]
ENST00000519688; ENSP00000431069; ENSG00000164756 [Q8IWU4-2]
ENST00000521243; ENSP00000428545; ENSG00000164756 [Q8IWU4-2]
GeneIDi169026
KEGGihsa:169026
UCSCiuc003yog.3, human [Q8IWU4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
169026
DisGeNETi169026
EuPathDBiHostDB:ENSG00000164756.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC30A8
HGNCiHGNC:20303, SLC30A8
HPAiENSG00000164756, Tissue enriched (pancreas)
MalaCardsiSLC30A8
MIMi125853, phenotype
611145, gene
neXtProtiNX_Q8IWU4
OpenTargetsiENSG00000164756
PharmGKBiPA134915546

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1482, Eukaryota
GeneTreeiENSGT00940000160706
HOGENOMiCLU_013430_0_1_1
InParanoidiQ8IWU4
KOiK14695
OMAiFNIIMGL
OrthoDBi820567at2759
PhylomeDBiQ8IWU4
TreeFamiTF313382

Enzyme and pathway databases

PathwayCommonsiQ8IWU4
ReactomeiR-HSA-264876, Insulin processing
R-HSA-435368, Zinc efflux and compartmentalization by the SLC30 family

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
169026, 3 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC30A8, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC30A8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
169026
PharosiQ8IWU4, Tbio

Protein Ontology

More...
PROi
PR:Q8IWU4
RNActiQ8IWU4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164756, Expressed in islet of Langerhans and 93 other tissues
ExpressionAtlasiQ8IWU4, baseline and differential
GenevisibleiQ8IWU4, HS

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR002524, Cation_efflux
IPR036837, Cation_efflux_CTD_sf
IPR027469, Cation_efflux_TMD_sf
IPR033572, ZnT-8
PANTHERiPTHR11562:SF37, PTHR11562:SF37, 1 hit
PfamiView protein in Pfam
PF01545, Cation_efflux, 1 hit
SUPFAMiSSF160240, SSF160240, 1 hit
SSF161111, SSF161111, 1 hit
TIGRFAMsiTIGR01297, CDF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNT8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWU4
Secondary accession number(s): A0AVP9
, A5YM39, B4DPE0, Q8TCL3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 10, 2008
Last modified: August 12, 2020
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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