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Entry version 163 (08 May 2019)
Sequence version 2 (04 Jan 2005)
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Protein

Cullin-9

Gene

CUL9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi2070Zinc 1PROSITE-ProRule annotation1
Metal bindingi2073Zinc 1PROSITE-ProRule annotation1
Metal bindingi2088Zinc 2PROSITE-ProRule annotation1
Metal bindingi2090Zinc 2; via pros nitrogenPROSITE-ProRule annotation1
Metal bindingi2093Zinc 1PROSITE-ProRule annotation1
Metal bindingi2096Zinc 1PROSITE-ProRule annotation1
Metal bindingi2115Zinc 2PROSITE-ProRule annotation1
Metal bindingi2120Zinc 2PROSITE-ProRule annotation1
Metal bindingi2160Zinc 3PROSITE-ProRule annotation1
Metal bindingi2166Zinc 3PROSITE-ProRule annotation1
Metal bindingi2181Zinc 3PROSITE-ProRule annotation1
Metal bindingi2184Zinc 3PROSITE-ProRule annotation1
Metal bindingi2189Zinc 4PROSITE-ProRule annotation1
Metal bindingi2192Zinc 4PROSITE-ProRule annotation1
Metal bindingi2198Zinc 4; via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi2203Zinc 4PROSITE-ProRule annotation1
Metal bindingi2236Zinc 5PROSITE-ProRule annotation1
Metal bindingi2239Zinc 5PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2249PROSITE-ProRule annotation1
Metal bindingi2254Zinc 5PROSITE-ProRule annotation1
Metal bindingi2257Zinc 5PROSITE-ProRule annotation1
Metal bindingi2262Zinc 6PROSITE-ProRule annotation1
Metal bindingi2265Zinc 6PROSITE-ProRule annotation1
Metal bindingi2273Zinc 6; via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi2279Zinc 6PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1363 – 1370ATPSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri2070 – 2120RING-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri2140 – 2203IBR-typePROSITE-ProRule annotationAdd BLAST64
Zinc fingeri2236 – 2265RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8951664 Neddylation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8IWT3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cullin-9
Short name:
CUL-9
Alternative name(s):
UbcH7-associated protein 1
p53-associated parkin-like cytoplasmic protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CUL9
Synonyms:H7AP1, KIAA0708, PARC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15982 CUL9

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607489 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IWT3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23113

Open Targets

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OpenTargetsi
ENSG00000112659

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA164718328

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CUL9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
57015409

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001198151 – 2517Cullin-9Add BLAST2517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei976PhosphoserineCombined sources1
Modified residuei1457PhosphoserineCombined sources1
Modified residuei2436PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

In vitro, self-ubiquitination in the presence of E1, E2 and ubiquitin.
Neddylated.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IWT3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IWT3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IWT3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IWT3

PeptideAtlas

More...
PeptideAtlasi
Q8IWT3

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWT3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70891
70892 [Q8IWT3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IWT3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IWT3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed in all tissues with highest expression in testis brain and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000112659 Expressed in 217 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8IWT3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IWT3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA016434
HPA052004

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a Cul9-RING complex at least composed of CUL9 and RBX1. Interacts with CUL7: interaction with CUL7 component of the 3M complex leads to inhibition of CUL9 activity. The CUL7-CUL9 heterodimer seems to interact specifically with TP53. Forms a complex with p53/TP53 in the cytoplasm of unstressed cells. Interacts with UBCH7 and UBCH8.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TP53P046374EBI-311123,EBI-366083

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116736, 15 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8IWT3

Protein interaction database and analysis system

More...
IntActi
Q8IWT3, 9 interactors

Molecular INTeraction database

More...
MINTi
Q8IWT3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000252050

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12517
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IWT3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8IWT3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1143 – 1322DOCPROSITE-ProRule annotationAdd BLAST180

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2066 – 2283TRIAD supradomainPROSITE-ProRule annotationAdd BLAST218

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1649 – 1691Sequence analysisAdd BLAST43
Coiled coili2365 – 2385Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1661 – 1689Glu-richAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The IBR domain is required for interaction with UBCH7 and UBCH8.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cullin family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2070 – 2120RING-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri2140 – 2203IBR-typePROSITE-ProRule annotationAdd BLAST64
Zinc fingeri2236 – 2265RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1815 Eukaryota
ENOG410XP9Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153954

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8IWT3

KEGG Orthology (KO)

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KOi
K11970

Identification of Orthologs from Complete Genome Data

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OMAi
QDTEHMD

Database of Orthologous Groups

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OrthoDBi
469819at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IWT3

TreeFam database of animal gene trees

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TreeFami
TF101154

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.30.30, 1 hit
2.60.120.260, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR016024 ARM-type_fold
IPR021097 CPH_domain
IPR031222 CUL9
IPR016157 Cullin_CS
IPR016158 Cullin_homology
IPR036317 Cullin_homology_sf
IPR001373 Cullin_N
IPR019559 Cullin_neddylation_domain
IPR008979 Galactose-bd-like_sf
IPR002867 IBR_dom
IPR014722 Rib_L2_dom2
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

The PANTHER Classification System

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PANTHERi
PTHR22771:SF2 PTHR22771:SF2, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF03256 ANAPC10, 1 hit
PF11515 Cul7, 1 hit
PF00888 Cullin, 1 hit
PF01485 IBR, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01337 APC10, 1 hit
SM00884 Cullin_Nedd8, 1 hit
SM00647 IBR, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 1 hit
SSF49785 SSF49785, 1 hit
SSF75632 SSF75632, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01256 CULLIN_1, 1 hit
PS50069 CULLIN_2, 1 hit
PS51284 DOC, 1 hit
PS51873 TRIAD, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IWT3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVGERHAGDL MVPLGPRLQA YPEELIRQRP GHDGHPEYLI RWSVLKCGEV
60 70 80 90 100
GKVGVEEGKA EHILMWLSAP EVYANCPGLL GERALSKGLQ HEPAGVSGSF
110 120 130 140 150
PRDPGGLDEV AMGEMEADVQ ALVRRAARQL AESGTPSLTA AVLHTIHVLS
160 170 180 190 200
AYASIGPLTG VFRETGALDL LMHMLCNPEP QIRRSAGKML QALAAHDAGS
210 220 230 240 250
RAHVLLSLSQ QDGIEQHMDF DSRYTLLELF AETTSSEEHC MAFEGIHLPQ
260 270 280 290 300
IPGKLLFSLV KRYLCVTSLL DQLNSSPELG AGDQSSPCAT REKSRGQREL
310 320 330 340 350
EFSMAVGNLI SELVRSMGWA RNLSEQGMSP PRPTRSIFQP YISGPSLLLP
360 370 380 390 400
TIVTTPRRQG WVFRQRSEFS SRSGYGEYVQ QTLQPGMRVR MLDDYEEISA
410 420 430 440 450
GDEGEFRQSN NGIPPVQVFW QSTGRTYWVH WHMLEILGPE EATEDKASAA
460 470 480 490 500
VEKGAGATVL GTAFPSWDWN PMDGLYPLPY LQPEPQKNER VGYLTQAEWW
510 520 530 540 550
ELLFFIKKLD LCEQQPIFQN LWKNLDETLG EKALGEISVS VEMAESLLQV
560 570 580 590 600
LSSRFEGSTL NDLLNSQIYT KYGLLSNEPS SSSTSRNHSC TPDPEEESKS
610 620 630 640 650
EASFSEEETE SLKAKAEAPK TEAEPTKTRT ETPMAQSDSQ LFNQLLVTEG
660 670 680 690 700
MTLPTEMKEA ASEMARALRG PGPRSSLDQH VAAVVATVQI SSLDTNLQLS
710 720 730 740 750
GLSALSQAVE EVTERDHPLV RPDRSLREKL VKMLVELLTN QVGEKMVVVQ
760 770 780 790 800
ALRLLYLLMT KHEWRPLFAR EGGIYAVLVC MQEYKTSVLV QQAGLAALKM
810 820 830 840 850
LAVASSSEIP TFVTGRDSIH SLFDAQMTRE IFASIDSATR PGSESLLLTV
860 870 880 890 900
PAAVILMLNT EGCSSAARNG LLLLNLLLCN HHTLGDQIIT QELRDTLFRH
910 920 930 940 950
SGIAPRTEPM PTTRTILMML LNRYSEPPGS PERAALETPI IQGQDGSPEL
960 970 980 990 1000
LIRSLVGGPS AELLLDLERV LCREGSPGGA VRPLLKRLQQ ETQPFLLLLR
1010 1020 1030 1040 1050
TLDAPGPNKT LLLSVLRVIT RLLDFPEAMV LPWHEVLEPC LNCLSGPSSD
1060 1070 1080 1090 1100
SEIVQELTCF LHRLASMHKD YAVVLCCLGA KEILSKVLDK HSAQLLLGCE
1110 1120 1130 1140 1150
LRDLVTECEK YAQLYSNLTS SILAGCIQMV LGQIEDHRRT HQPINIPFFD
1160 1170 1180 1190 1200
VFLRHLCQGS SVEVKEDKCW EKVEVSSNPH RASKLTDHNP KTYWESNGST
1210 1220 1230 1240 1250
GSHYITLHMH RGVLVRQLTL LVASEDSSYM PARVVVFGGD STSCIGTELN
1260 1270 1280 1290 1300
TVNVMPSASR VILLENLNRF WPIIQIRIKR CQQGGIDTRV RGVEVLGPKP
1310 1320 1330 1340 1350
TFWPLFREQL CRRTCLFYTI RAQAWSRDIA EDHRRLLQLC PRLNRVLRHE
1360 1370 1380 1390 1400
QNFADRFLPD DEAAQALGKT CWEALVSPLV QNITSPDAEG VSALGWLLDQ
1410 1420 1430 1440 1450
YLEQRETSRN PLSRAASFAS RVRRLCHLLV HVEPPPGPSP EPSTRPFSKN
1460 1470 1480 1490 1500
SKGRDRSPAP SPVLPSSSLR NITQCWLSVV QEQVSRFLAA AWRAPDFVPR
1510 1520 1530 1540 1550
YCKLYEHLQR AGSELFGPRA AFMLALRSGF SGALLQQSFL TAAHMSEQFA
1560 1570 1580 1590 1600
RYIDQQIQGG LIGGAPGVEM LGQLQRHLEP IMVLSGLELA TTFEHFYQHY
1610 1620 1630 1640 1650
MADRLLSFGS SWLEGAVLEQ IGLCFPNRLP QLMLQSLSTS EELQRQFHLF
1660 1670 1680 1690 1700
QLQRLDKLFL EQEDEEEKRL EEEEEEEEEE EAEKELFIED PSPAISILVL
1710 1720 1730 1740 1750
SPRCWPVSPL CYLYHPRKCL PTEFCDALDR FSSFYSQSQN HPVLDMGPHR
1760 1770 1780 1790 1800
RLQWTWLGRA ELQFGKQILH VSTVQMWLLL KFNQTEEVSV ETLLKDSDLS
1810 1820 1830 1840 1850
PELLLQALVP LTSGNGPLTL HEGQDFPHGG VLRLHEPGPQ RSGEALWLIP
1860 1870 1880 1890 1900
PQAYLNVEKD EGRTLEQKRN LLSCLLVRIL KAHGEKGLHI DQLVCLVLEA
1910 1920 1930 1940 1950
WQKGPNPPGT LGHTVAGGVA CTSTDVLSCI LHLLGQGYVK RRDDRPQILM
1960 1970 1980 1990 2000
YAAPEPMGPC RGQADVPFCG SQSETSKPSP EAVATLASLQ LPAGRTMSPQ
2010 2020 2030 2040 2050
EVEGLMKQTV RQVQETLNLE PDVAQHLLAH SHWGAEQLLQ SYSEDPEPLL
2060 2070 2080 2090 2100
LAAGLCVHQA QAVPVRPDHC PVCVSPLGCD DDLPSLCCMH YCCKSCWNEY
2110 2120 2130 2140 2150
LTTRIEQNLV LNCTCPIADC PAQPTGAFIR AIVSSPEVIS KYEKALLRGY
2160 2170 2180 2190 2200
VESCSNLTWC TNPQGCDRIL CRQGLGCGTT CSKCGWASCF NCSFPEAHYP
2210 2220 2230 2240 2250
ASCGHMSQWV DDGGYYDGMS VEAQSKHLAK LISKRCPSCQ APIEKNEGCL
2260 2270 2280 2290 2300
HMTCAKCNHG FCWRCLKSWK PNHKDYYNCS AMVSKAARQE KRFQDYNERC
2310 2320 2330 2340 2350
TFHHQAREFA VNLRNRVSAI HEVPPPRSFT FLNDACQGLE QARKVLAYAC
2360 2370 2380 2390 2400
VYSFYSQDAE YMDVVEQQTE NLELHTNALQ ILLEETLLRC RDLASSLRLL
2410 2420 2430 2440 2450
RADCLSTGME LLRRIQERLL AILQHSAQDF RVGLQSPSVE AWEAKGPNMP
2460 2470 2480 2490 2500
GSQPQASSGP EAEEEEEDDE DDVPEWQQDE FDEELDNDSF SYDESENLDQ
2510
ETFFFGDEEE DEDEAYD
Length:2,517
Mass (Da):281,229
Last modified:January 4, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42387A55DCC52EAF
GO
Isoform 2 (identifier: Q8IWT3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     418-527: Missing.

Note: No experimental confirmation available.
Show »
Length:2,407
Mass (Da):268,362
Checksum:iF41FAF09CC71656C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PEZ1E9PEZ1_HUMAN
Cullin-9
CUL9
2,489Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA00H0YA00_HUMAN
Cullin-9
CUL9
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8H9H0Y8H9_HUMAN
Cullin-9
CUL9
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC85207 differs from that shown. Intron retention.Curated
The sequence BAC86090 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti527E → G in CAH18696 (PubMed:17974005).Curated1
Sequence conflicti663E → K in AAN61516 (PubMed:12526791).Curated1
Sequence conflicti1171E → K in CAH18328 (PubMed:17974005).Curated1
Sequence conflicti1230M → T in CAH18328 (PubMed:17974005).Curated1
Sequence conflicti1268N → S in CAH18328 (PubMed:17974005).Curated1
Sequence conflicti1277R → H in CAH18328 (PubMed:17974005).Curated1
Sequence conflicti1830 – 1857Missing in CAH18696 (PubMed:17974005).CuratedAdd BLAST28
Sequence conflicti2049L → P in CAH18696 (PubMed:17974005).Curated1
Sequence conflicti2058 – 2059HQ → PL in CAH18696 (PubMed:17974005).Curated2
Sequence conflicti2345V → VV in EAX04163 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0488442058H → P. Corresponds to variant dbSNP:rs2273709Ensembl.1
Natural variantiVAR_0488452180T → I. Corresponds to variant dbSNP:rs11962520Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009573418 – 527Missing in isoform 2. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY145132 mRNA Translation: AAN61516.1
AJ318215 mRNA Translation: CAC85756.1
CR749511 mRNA Translation: CAH18328.1
CR749841 mRNA Translation: CAH18696.1
AL133375 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04163.1
AK125228 mRNA Translation: BAC86090.1 Sequence problems.
AK129649 mRNA Translation: BAC85207.1 Sequence problems.
AB014608 mRNA Translation: BAA31683.3
BC002879 mRNA Translation: AAH02879.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4890.1 [Q8IWT3-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00350

NCBI Reference Sequences

More...
RefSeqi
NP_055904.1, NM_015089.3 [Q8IWT3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000252050; ENSP00000252050; ENSG00000112659 [Q8IWT3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23113

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23113

UCSC genome browser

More...
UCSCi
uc003ouk.4 human [Q8IWT3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145132 mRNA Translation: AAN61516.1
AJ318215 mRNA Translation: CAC85756.1
CR749511 mRNA Translation: CAH18328.1
CR749841 mRNA Translation: CAH18696.1
AL133375 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04163.1
AK125228 mRNA Translation: BAC86090.1 Sequence problems.
AK129649 mRNA Translation: BAC85207.1 Sequence problems.
AB014608 mRNA Translation: BAA31683.3
BC002879 mRNA Translation: AAH02879.2
CCDSiCCDS4890.1 [Q8IWT3-1]
PIRiT00350
RefSeqiNP_055904.1, NM_015089.3 [Q8IWT3-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JUFNMR-A366-466[»]
SMRiQ8IWT3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116736, 15 interactors
CORUMiQ8IWT3
IntActiQ8IWT3, 9 interactors
MINTiQ8IWT3
STRINGi9606.ENSP00000252050

PTM databases

iPTMnetiQ8IWT3
PhosphoSitePlusiQ8IWT3

Polymorphism and mutation databases

BioMutaiCUL9
DMDMi57015409

Proteomic databases

EPDiQ8IWT3
jPOSTiQ8IWT3
MaxQBiQ8IWT3
PaxDbiQ8IWT3
PeptideAtlasiQ8IWT3
PRIDEiQ8IWT3
ProteomicsDBi70891
70892 [Q8IWT3-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252050; ENSP00000252050; ENSG00000112659 [Q8IWT3-1]
GeneIDi23113
KEGGihsa:23113
UCSCiuc003ouk.4 human [Q8IWT3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23113
DisGeNETi23113

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CUL9
HGNCiHGNC:15982 CUL9
HPAiHPA016434
HPA052004
MIMi607489 gene
neXtProtiNX_Q8IWT3
OpenTargetsiENSG00000112659
PharmGKBiPA164718328

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1815 Eukaryota
ENOG410XP9Y LUCA
GeneTreeiENSGT00940000153954
InParanoidiQ8IWT3
KOiK11970
OMAiQDTEHMD
OrthoDBi469819at2759
PhylomeDBiQ8IWT3
TreeFamiTF101154

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
SIGNORiQ8IWT3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CUL9 human
EvolutionaryTraceiQ8IWT3

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PARC_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23113

Protein Ontology

More...
PROi
PR:Q8IWT3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112659 Expressed in 217 organ(s), highest expression level in testis
ExpressionAtlasiQ8IWT3 baseline and differential
GenevisibleiQ8IWT3 HS

Family and domain databases

Gene3Di2.30.30.30, 1 hit
2.60.120.260, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR016024 ARM-type_fold
IPR021097 CPH_domain
IPR031222 CUL9
IPR016157 Cullin_CS
IPR016158 Cullin_homology
IPR036317 Cullin_homology_sf
IPR001373 Cullin_N
IPR019559 Cullin_neddylation_domain
IPR008979 Galactose-bd-like_sf
IPR002867 IBR_dom
IPR014722 Rib_L2_dom2
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR22771:SF2 PTHR22771:SF2, 1 hit
PfamiView protein in Pfam
PF03256 ANAPC10, 1 hit
PF11515 Cul7, 1 hit
PF00888 Cullin, 1 hit
PF01485 IBR, 2 hits
SMARTiView protein in SMART
SM01337 APC10, 1 hit
SM00884 Cullin_Nedd8, 1 hit
SM00647 IBR, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49785 SSF49785, 1 hit
SSF75632 SSF75632, 1 hit
PROSITEiView protein in PROSITE
PS01256 CULLIN_1, 1 hit
PS50069 CULLIN_2, 1 hit
PS51284 DOC, 1 hit
PS51873 TRIAD, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUL9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWT3
Secondary accession number(s): O75188
, Q5TCY3, Q68CP2, Q68D92, Q8N3W9, Q9BU56
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: January 4, 2005
Last modified: May 8, 2019
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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