SCN4B

Functionⁱ

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.1 Publication

GO - Molecular functionⁱ

ion channel binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17592081
sodium channel regulator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 24297919
voltage-gated ion channel activity Source: UniProtKB-KW
voltage-gated sodium channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12930796
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17592081

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

AV node cell action potential
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17592081
cardiac muscle cell action potential involved in contraction
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17592081
cardiac muscle contraction
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17592081
membrane depolarization during cardiac muscle cell action potential
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17592081
positive regulation of sodium ion transport
Source: BHF-UCL
Inferred from direct assayⁱ
- 17592081
regulation of heart rate by cardiac conduction
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17592081
regulation of sodium ion transmembrane transporter activity
Source: UniProtKB
Inferred from direct assayⁱ
- 24297919
regulation of ventricular cardiac muscle cell membrane repolarization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17592081
sodium ion transmembrane transport
Source: BHF-UCL
Inferred from direct assayⁱ
- 20226894
sodium ion transport
Source: UniProtKB
Inferred from direct assayⁱ
- 12930796

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Sodium channel, Voltage-gated channel
Biological process	Ion transport, Sodium transport, Transport
Ligand	Sodium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-445095 Interaction between L1 and Ankyrins R-HSA-5576892 Phase 0 - rapid depolarisation

Reactomeⁱ

R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5576892 Phase 0 - rapid depolarisation

Protein family/group databases

TCDBⁱ	8.A.17.2.2 the na(+) channel auxiliary subunit Beta1-Beta4 (sca-Beta) family

TCDBⁱ

8.A.17.2.2 the na(+) channel auxiliary subunit Beta1-Beta4 (sca-Beta) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium channel subunit beta-4
Gene namesⁱ	Name:SCN4B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000177098.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10592 SCN4B
MIMⁱ	608256 gene
neXtProtⁱ	NX_Q8IWT1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	31 – 162	ExtracellularSequence analysisAdd BLAST	132
Transmembraneⁱ	163 – 183	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	184 – 228	CytoplasmicSequence analysisAdd BLAST	45

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Long QT syndrome 10 (LQT10)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_043488	179	L → F in LQT10; increase in late sodium current. 1 PublicationCorresponds to variant dbSNP:rs121434386EnsemblClinVar.		1

Atrial fibrillation, familial, 17 (ATFB17)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	58	C → A: Abolishes regulation of channel activity. 1 Publication		1
Mutagenesisⁱ	131	C → A or W: Decreases protein stability. Causes conformation changes that impair interaction with the alpha subunit. 1 Publication		1

Keywords - Diseaseⁱ

Atrial fibrillation, Disease mutation, Long QT syndrome

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6330
GeneReviewsⁱ	SCN4B
MalaCards human disease database More...MalaCardsⁱ	SCN4B
MIMⁱ	611819 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000177098
Orphanetⁱ	334 Familial atrial fibrillation 101016 Romano-Ward syndrome
PharmGKBⁱ	PA35007

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00313 Valproic Acid DB00909 Zonisamide

DrugBankⁱ

DB00313 Valproic Acid
DB00909 Zonisamide

Polymorphism and mutation databases

BioMutaⁱ	SCN4B
DMDMⁱ	57012701

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 30	Sequence analysisAdd BLAST		30
ChainⁱPRO_0000014937	31 – 228	Sodium channel subunit beta-4Add BLAST		198

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	45	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	53 ↔ 131	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	58	Interchain; with alpha subunitPROSITE-ProRule annotation1 Publication
Glycosylationⁱ	71	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	113	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

Contains an interchain disulfide bond with SCN2A.

N-glycosylated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q8IWT1
PeptideAtlas More...PeptideAtlasⁱ	Q8IWT1
PRIDEⁱ	Q8IWT1
ProteomicsDBⁱ	70889 70890 [Q8IWT1-2]

PTM databases

iPTMnetⁱ	Q8IWT1
PhosphoSitePlusⁱ	Q8IWT1

Miscellaneous databases

PMAP-CutDBⁱ	Q8IWT1

PMAP-CutDBⁱ

Q8IWT1

Expressionⁱ

Tissue specificityⁱ

Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000177098 Expressed in 175 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_SCN4B
ExpressionAtlasⁱ	Q8IWT1 baseline and differential
Genevisibleⁱ	Q8IWT1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA017293

HPAⁱ

HPA017293

Interactionⁱ

Subunit structureⁱ

Component of the voltage-sensitive sodium channel complex that consists of an ion-conducting pore-forming alpha subunit and one or more regulatory beta subunits. Heterooligomer with SCN2A; disulfide-linked.1 Publication

GO - Molecular functionⁱ

ion channel binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17592081

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112235, 1 interactor
STRINGⁱ	9606.ENSP00000322460

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	32 – 34	Combined sources	3
Beta strandⁱ	40 – 44	Combined sources	5
Beta strandⁱ	49 – 51	Combined sources	3
Turnⁱ	58 – 60	Combined sources	3
Beta strandⁱ	62 – 71	Combined sources	10
Beta strandⁱ	76 – 86	Combined sources	11
Beta strandⁱ	92 – 96	Combined sources	5
Beta strandⁱ	101 – 103	Combined sources	3
Beta strandⁱ	116 – 118	Combined sources	3
Helixⁱ	123 – 125	Combined sources	3
Beta strandⁱ	127 – 135	Combined sources	9
Helixⁱ	136 – 138	Combined sources	3
Beta strandⁱ	140 – 143	Combined sources	4
Beta strandⁱ	147 – 152	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8IWT1
SMRⁱ	Q8IWT1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	31 – 148	Ig-like C2-typeAdd BLAST		118

Sequence similaritiesⁱ

Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family. [View classification]Curated

Keywords - Domainⁱ

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IXQZ Eukaryota ENOG4111PJ2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000141020
HOGENOMⁱ	HOG000048715
HOVERGENⁱ	HBG056581
InParanoidⁱ	Q8IWT1
KEGG Orthology (KO) More...KOⁱ	K04848
OMAⁱ	REKKKEC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MQV
PhylomeDBⁱ	Q8IWT1
TreeFamⁱ	TF331728

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set IPR000920 Myelin_P0-rel
PANTHERⁱ	PTHR13869 PTHR13869, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q8IWT1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGAGDGGKA PARWLGTGLL GLFLLPVTLS LEVSVGKATD IYAVNGTEIL 
        60         70         80         90        100
LPCTFSSCFG FEDLHFRWTY NSSDAFKILI EGTVKNEKSD PKVTLKDDDR 
       110        120        130        140        150
ITLVGSTKEK MNNISIVLRD LEFSDTGKYT CHVKNPKENN LQHHATIFLQ 
       160        170        180        190        200
VVDRLEEVDN TVTLIILAVV GGVIGLLILI LLIKKLIIFI LKKTREKKKE 
       210        220 
CLVSSSGNDN TENGLPGSKA EEKPPSKV

Length:228

Mass (Da):24,969

Last modified:March 1, 2003 - v1

Checksum:ⁱ2F17E1210E8EFEF8

GO

Isoform 2 (identifier: Q8IWT1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-110: Missing.

« Hide

        10         20         30         40         50
MNNISIVLRD LEFSDTGKYT CHVKNPKENN LQHHATIFLQ VVDRLEEVDN 
        60         70         80         90        100
TVTLIILAVV GGVIGLLILI LLIKKLIIFI LKKTREKKKE CLVSSSGNDN 
       110 
TENGLPGSKA EEKPPSKV

Note: No experimental confirmation available.

Show »

Length:118

Mass (Da):13,104

Checksum:ⁱ171185D98FAB28ED

GO

Isoform 3 (identifier: Q8IWT1-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
21-155: GLFLLPVTLS...TIFLQVVDRL → V

« Hide

        10         20         30         40         50
MPGAGDGGKA PARWLGTGLL VEEVDNTVTL IILAVVGGVI GLLILILLIK 
        60         70         80         90 
KLIIFILKKT REKKKECLVS SSGNDNTENG LPGSKAEEKP PSKV

Note: Gene prediction based on EST data.

Show »

Length:94

Mass (Da):9,876

Checksum:ⁱ5E474827FFA2FA01

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	40	D → Y in AAH35017 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_071317	162	V → G in ATFB17. 1 PublicationCorresponds to variant dbSNP:rs587777559EnsemblClinVar.	1
Natural variantⁱVAR_071318	166	I → L in ATFB17. 1 PublicationCorresponds to variant dbSNP:rs587777560EnsemblClinVar.	1
Natural variantⁱVAR_043488	179	L → F in LQT10; increase in late sodium current. 1 PublicationCorresponds to variant dbSNP:rs121434386EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_053913	1 – 110	Missing in isoform 2. CuratedAdd BLAST		110
Alternative sequenceⁱVSP_046971	21 – 155	GLFLL…VVDRL → V in isoform 3. CuratedAdd BLAST		135

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY149967 mRNA Translation: AAN74584.1 AP002800 Genomic DNA No translation available. BC035017 mRNA Translation: AAH35017.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44744.1 [Q8IWT1-3] CCDS8389.1 [Q8IWT1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001135820.1, NM_001142348.1 [Q8IWT1-3] NP_001135821.1, NM_001142349.1 [Q8IWT1-2] NP_777594.1, NM_174934.3 [Q8IWT1-1]
UniGeneⁱ	Hs.65239

Genome annotation databases

Ensemblⁱ	ENST00000324727; ENSP00000322460; ENSG00000177098 [Q8IWT1-1] ENST00000529878; ENSP00000436343; ENSG00000177098 [Q8IWT1-3]
GeneIDⁱ	6330
KEGGⁱ	hsa:6330
UCSC genome browser More...UCSCⁱ	uc001pse.4 human [Q8IWT1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IWT1	Sodium channel beta-4 subunit		HUMAN		228	UniRef100_Q8IWT1
SCN4B isoform 2		PANTR		228
Uncharacterized protein		PANPA		228
Q8IWT1-2	Sodium channel subunit beta-4 isoform 1		MACMU		118	UniRef100_H9EN52
Sodium voltage-gated channel beta subunit 4		PANTR		118
Uncharacterized protein		PANPA		118
UPI00045E3B32		CHLSB		262
Q8IWT1-3	SCN4B isoform 1		PANTR		94	UniRef100_H2Q4V5
Uncharacterized protein		PANPA		94

Protein	Similar proteins		Species	Score	Length	Source
Q8IWT1	Sodium channel beta-4 subunit		HUMAN		228	UniRef90_Q8IWT1
SCN4B isoform 2		PANTR		228
Uncharacterized protein		PANPA		228
Uncharacterized protein		MACNE		270
Uncharacterized protein (Fragment)		MACMU		118
+18
Q8IWT1-2	Sodium channel subunit beta-4 isoform 1		MACMU		118	UniRef90_H9EN52
Sodium voltage-gated channel beta subunit 4		PANTR		118
Uncharacterized protein		PANPA		118
UPI00045E3B32		CHLSB		262
Q8IWT1-3	SCN4B isoform 1		PANTR		94	UniRef90_H2Q4V5
Uncharacterized protein		PANPA		94
Uncharacterized protein		PROCO		94
Sodium voltage-gated channel beta subunit 4		SAIBB		94
Sodium voltage-gated channel beta subunit 4		CALJA		94
+16

Protein	Similar proteins		Species	Score	Length	Source
Q8IWT1	Sodium channel beta-4 subunit		HUMAN		228	UniRef50_Q8IWT1
SCN4B isoform 2		PANTR		228
Uncharacterized protein		PANPA		228
Uncharacterized protein		MACNE		270
Uncharacterized protein (Fragment)		MACMU		118
+63
Q8IWT1-3	Uncharacterized protein		ANOCA		115	UniRef50_H9GCJ7
Uncharacterized protein		FELCA		94
Sodium voltage-gated channel beta subunit 4		GORGO		94
Sodium voltage-gated channel beta subunit 4		CALJA		94
Uncharacterized protein		Cebus capucinus imitator		94
+18

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY149967 mRNA Translation: AAN74584.1 AP002800 Genomic DNA No translation available. BC035017 mRNA Translation: AAH35017.1
CCDSⁱ	CCDS44744.1 [Q8IWT1-3] CCDS8389.1 [Q8IWT1-1]
RefSeqⁱ	NP_001135820.1, NM_001142348.1 [Q8IWT1-3] NP_001135821.1, NM_001142349.1 [Q8IWT1-2] NP_777594.1, NM_174934.3 [Q8IWT1-1]
UniGeneⁱ	Hs.65239

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4MZ2	X-ray	1.72	A	32-157	[»]
	4MZ3	X-ray	1.74	A/B	32-157	[»]
	5XAW	X-ray	2.10	A/B	30-152	[»]
ProteinModelPortalⁱ	Q8IWT1
SMRⁱ	Q8IWT1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112235, 1 interactor
STRINGⁱ	9606.ENSP00000322460

Chemistry databases

DrugBankⁱ	DB00313 Valproic Acid DB00909 Zonisamide

DrugBankⁱ

DB00313 Valproic Acid
DB00909 Zonisamide

Protein family/group databases

TCDBⁱ	8.A.17.2.2 the na(+) channel auxiliary subunit Beta1-Beta4 (sca-Beta) family

TCDBⁱ

8.A.17.2.2 the na(+) channel auxiliary subunit Beta1-Beta4 (sca-Beta) family

PTM databases

iPTMnetⁱ	Q8IWT1
PhosphoSitePlusⁱ	Q8IWT1

Polymorphism and mutation databases

BioMutaⁱ	SCN4B
DMDMⁱ	57012701

Proteomic databases

PaxDbⁱ	Q8IWT1
PeptideAtlasⁱ	Q8IWT1
PRIDEⁱ	Q8IWT1
ProteomicsDBⁱ	70889 70890 [Q8IWT1-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000324727; ENSP00000322460; ENSG00000177098 [Q8IWT1-1] ENST00000529878; ENSP00000436343; ENSG00000177098 [Q8IWT1-3]
GeneIDⁱ	6330
KEGGⁱ	hsa:6330
UCSCⁱ	uc001pse.4 human [Q8IWT1-1]

Organism-specific databases

CTDⁱ	6330
DisGeNETⁱ	6330
EuPathDBⁱ	HostDB:ENSG00000177098.8
GeneCardsⁱ	SCN4B
GeneReviewsⁱ	SCN4B
HGNCⁱ	HGNC:10592 SCN4B
HPAⁱ	HPA017293
MalaCardsⁱ	SCN4B
MIMⁱ	608256 gene 611819 phenotype
neXtProtⁱ	NX_Q8IWT1
OpenTargetsⁱ	ENSG00000177098
Orphanetⁱ	334 Familial atrial fibrillation 101016 Romano-Ward syndrome
PharmGKBⁱ	PA35007
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IXQZ Eukaryota ENOG4111PJ2 LUCA
GeneTreeⁱ	ENSGT00900000141020
HOGENOMⁱ	HOG000048715
HOVERGENⁱ	HBG056581
InParanoidⁱ	Q8IWT1
KOⁱ	K04848
OMAⁱ	REKKKEC
OrthoDBⁱ	EOG091G0MQV
PhylomeDBⁱ	Q8IWT1
TreeFamⁱ	TF331728

Enzyme and pathway databases

Reactomeⁱ	R-HSA-445095 Interaction between L1 and Ankyrins R-HSA-5576892 Phase 0 - rapid depolarisation

Reactomeⁱ

R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5576892 Phase 0 - rapid depolarisation

Miscellaneous databases

ChiTaRSⁱ	SCN4B human
GeneWikiⁱ	SCN4B
GenomeRNAiⁱ	6330
PMAP-CutDBⁱ	Q8IWT1
Protein Ontology More...PROⁱ	PR:Q8IWT1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000177098 Expressed in 175 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_SCN4B
ExpressionAtlasⁱ	Q8IWT1 baseline and differential
Genevisibleⁱ	Q8IWT1 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set IPR000920 Myelin_P0-rel
PANTHERⁱ	PTHR13869 PTHR13869, 1 hit
Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SCN4B_HUMAN
Accessionⁱ	Q8IWT1Primary (citable) accession number: Q8IWT1 Secondary accession number(s): E9PPT5, Q6PIG5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
	Last sequence update:	March 1, 2003
	Last modified:	October 10, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8IWT1 (SCN4B_HUMAN)

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Sodium channel subunit beta-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ