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Entry version 158 (12 Aug 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Zinc finger CCCH domain-containing protein 7A

Gene

ZC3H7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri634 – 656C3H1-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri769 – 797C3H1-type 2PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri857 – 881C2H2-typeAdd BLAST25
Zinc fingeri906 – 928C3H1-type 3PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IWR0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 7A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZC3H7A
Synonyms:ZC3H7, ZC3HDC7
ORF Names:HSPC055
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000122299.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30959, ZC3H7A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IWR0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
29066

Open Targets

More...
OpenTargetsi
ENSG00000122299

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394652

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IWR0, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZC3H7A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68566208

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001063211 – 971Zinc finger CCCH domain-containing protein 7AAdd BLAST971

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei210PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IWR0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IWR0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IWR0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IWR0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IWR0

PeptideAtlas

More...
PeptideAtlasi
Q8IWR0

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWR0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70882 [Q8IWR0-1]
70883 [Q8IWR0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IWR0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IWR0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122299, Expressed in calcaneal tendon and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IWR0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IWR0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000122299, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
118841, 124 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IWR0, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379773

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IWR0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1971
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IWR0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8IWR0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati43 – 76TPR 1Add BLAST34
Repeati89 – 122TPR 2Add BLAST34
Repeati124 – 156TPR 3Add BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili924 – 952Sequence analysisAdd BLAST29

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri634 – 656C3H1-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri769 – 797C3H1-type 2PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri857 – 881C2H2-typeAdd BLAST25
Zinc fingeri906 – 928C3H1-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Coiled coil, Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSHP, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018542

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_135703_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IWR0

Identification of Orthologs from Complete Genome Data

More...
OMAi
ESKQYWQ

Database of Orthologous Groups

More...
OrthoDBi
369231at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IWR0

TreeFam database of animal gene trees

More...
TreeFami
TF329017

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011990, TPR-like_helical_dom_sf
IPR039691, ZC3H7A/B
IPR036236, Znf_C2H2_sf
IPR000571, Znf_CCCH
IPR036855, Znf_CCCH_sf

The PANTHER Classification System

More...
PANTHERi
PTHR14928, PTHR14928, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00642, zf-CCCH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00356, ZnF_C3H1, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit
SSF57667, SSF57667, 1 hit
SSF90229, SSF90229, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50103, ZF_C3H1, 3 hits
PS00028, ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IWR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNVSEERRK RQQNIKEGLQ FIQSPLSYPG TQEQYAVYLR ALVRNLFNEG
60 70 80 90 100
NDVYREHDWN NSISQYTEAL NIADYAKSEE ILIPKEIIEK LYINRIACYS
110 120 130 140 150
NMGFHDKVLE DCNIVLSLNA SNCKALYRKS KALSDLGRYK KAYDAVAKCS
160 170 180 190 200
LAVPQDEHVI KLTQELAQKL GFKIRKAYVR AELSLKSVPG DGATKALNHS
210 220 230 240 250
VEDIEPDLLT PRQEAVPVVS LPAPSFSHEV GSELASVPVM PLTSILPLQV
260 270 280 290 300
EESALPSAVL ANGGKMPFTM PEAFLDDGDM VLGDELDDLL DSAPETNETV
310 320 330 340 350
MPSALVRGPL QTASVSPSMP FSASLLGTLP IGARYAPPPS FSEFYPPLTS
360 370 380 390 400
SLEDFCSSLN SFSMSESKRD LSTSTSREGT PLNNSNSSLL LMNGPGSLFA
410 420 430 440 450
SENFLGISSQ PRNDFGNFFG SAVTKPSSSV TPRHPLEGTH ELRQACQICF
460 470 480 490 500
VKSGPKLMDF TYHANIDHKC KKDILIGRIK NVEDKSWKKI RPRPTKTNYE
510 520 530 540 550
GPYYICKDVA AEEECRYSGH CTFAYCQEEI DVWTLERKGA FSREAFFGGN
560 570 580 590 600
GKINLTVFKL LQEHLGEFIF LCEKCFDHKP RMISKRNKDN STACSHPVTK
610 620 630 640 650
HEFEDNKCLV HILRETTVKY SKIRSFHGQC QLDLCRHEVR YGCLREDECF
660 670 680 690 700
YAHSLVELKV WIMQNETGIS HDAIAQESKR YWQNLEANVP GAQVLGNQIM
710 720 730 740 750
PGFLNMKIKF VCAQCLRNGQ VIEPDKNRKY CSAKARHSWT KDRRAMRVMS
760 770 780 790 800
IERKKWMNIR PLPTKKQMPL QFDLCNHIAS GKKCQYVGNC SFAHSPEERE
810 820 830 840 850
VWTYMKENGI QDMEQFYELW LKSQKNEKSE DIASQSNKEN GKQIHMPTDY
860 870 880 890 900
AEVTVDFHCW MCGKNCNSEK QWQGHISSEK HKEKVFHTED DQYCWQHRFP
910 920 930 940 950
TGYFSICDRY MNGTCPEGNS CKFAHGNAEL HEWEERRDAL KMKLNKARKD
960 970
HLIGPNDNDF GKYSFLFKDL N
Length:971
Mass (Da):110,538
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA62D4EF6BC639181
GO
Isoform 2 (identifier: Q8IWR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-804: Missing.

Show »
Length:167
Mass (Da):19,811
Checksum:i5A672347194A2897
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2K5I3L2K5_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H7A hCG_14614
733Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2N8I3L2N8_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H7A
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L382I3L382_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H7A
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3S2I3L3S2_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H7A
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1Y3I3L1Y3_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H7A
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L282I3L282_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H7A
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L323I3L323_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H7A
328Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3F9I3L3F9_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H7A
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0526323N → S. Corresponds to variant dbSNP:rs1429077Ensembl.1
Natural variantiVAR_05263357H → R. Corresponds to variant dbSNP:rs16958654Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0143831 – 804Missing in isoform 2. 3 PublicationsAdd BLAST804

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY163807 mRNA Translation: AAO06906.1
AF161540 mRNA Translation: AAF29027.1
AK000889 mRNA Translation: BAA91408.1
AK001869 mRNA Translation: BAA91952.1
CH471112 Genomic DNA Translation: EAW85138.1
CH471112 Genomic DNA Translation: EAW85139.1
BC012575 mRNA Translation: AAH12575.1
BC046363 mRNA Translation: AAH46363.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10550.1 [Q8IWR0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_054872.2, NM_014153.3 [Q8IWR0-1]
XP_006720940.1, XM_006720877.2 [Q8IWR0-1]
XP_011520765.1, XM_011522463.1 [Q8IWR0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355758; ENSP00000347999; ENSG00000122299 [Q8IWR0-1]
ENST00000396516; ENSP00000379773; ENSG00000122299 [Q8IWR0-1]
ENST00000575984; ENSP00000459477; ENSG00000122299 [Q8IWR0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29066

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:29066

UCSC genome browser

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UCSCi
uc002dbl.4, human [Q8IWR0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY163807 mRNA Translation: AAO06906.1
AF161540 mRNA Translation: AAF29027.1
AK000889 mRNA Translation: BAA91408.1
AK001869 mRNA Translation: BAA91952.1
CH471112 Genomic DNA Translation: EAW85138.1
CH471112 Genomic DNA Translation: EAW85139.1
BC012575 mRNA Translation: AAH12575.1
BC046363 mRNA Translation: AAH46363.1
CCDSiCCDS10550.1 [Q8IWR0-1]
RefSeqiNP_054872.2, NM_014153.3 [Q8IWR0-1]
XP_006720940.1, XM_006720877.2 [Q8IWR0-1]
XP_011520765.1, XM_011522463.1 [Q8IWR0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D9MNMR-A892-947[»]
SMRiQ8IWR0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118841, 124 interactors
IntActiQ8IWR0, 10 interactors
STRINGi9606.ENSP00000379773

PTM databases

iPTMnetiQ8IWR0
PhosphoSitePlusiQ8IWR0

Polymorphism and mutation databases

BioMutaiZC3H7A
DMDMi68566208

Proteomic databases

EPDiQ8IWR0
jPOSTiQ8IWR0
MassIVEiQ8IWR0
MaxQBiQ8IWR0
PaxDbiQ8IWR0
PeptideAtlasiQ8IWR0
PRIDEiQ8IWR0
ProteomicsDBi70882 [Q8IWR0-1]
70883 [Q8IWR0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
24731, 126 antibodies

The DNASU plasmid repository

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DNASUi
29066

Genome annotation databases

EnsembliENST00000355758; ENSP00000347999; ENSG00000122299 [Q8IWR0-1]
ENST00000396516; ENSP00000379773; ENSG00000122299 [Q8IWR0-1]
ENST00000575984; ENSP00000459477; ENSG00000122299 [Q8IWR0-2]
GeneIDi29066
KEGGihsa:29066
UCSCiuc002dbl.4, human [Q8IWR0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29066
DisGeNETi29066
EuPathDBiHostDB:ENSG00000122299.11

GeneCards: human genes, protein and diseases

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GeneCardsi
ZC3H7A
HGNCiHGNC:30959, ZC3H7A
HPAiENSG00000122299, Low tissue specificity
neXtProtiNX_Q8IWR0
OpenTargetsiENSG00000122299
PharmGKBiPA128394652

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QSHP, Eukaryota
GeneTreeiENSGT00390000018542
HOGENOMiCLU_135703_0_0_1
InParanoidiQ8IWR0
OMAiESKQYWQ
OrthoDBi369231at2759
PhylomeDBiQ8IWR0
TreeFamiTF329017

Enzyme and pathway databases

PathwayCommonsiQ8IWR0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
29066, 14 hits in 882 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZC3H7A, human
EvolutionaryTraceiQ8IWR0

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29066
PharosiQ8IWR0, Tbio

Protein Ontology

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PROi
PR:Q8IWR0
RNActiQ8IWR0, protein

Gene expression databases

BgeeiENSG00000122299, Expressed in calcaneal tendon and 235 other tissues
ExpressionAtlasiQ8IWR0, baseline and differential
GenevisibleiQ8IWR0, HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011990, TPR-like_helical_dom_sf
IPR039691, ZC3H7A/B
IPR036236, Znf_C2H2_sf
IPR000571, Znf_CCCH
IPR036855, Znf_CCCH_sf
PANTHERiPTHR14928, PTHR14928, 1 hit
PfamiView protein in Pfam
PF00642, zf-CCCH, 1 hit
SMARTiView protein in SMART
SM00356, ZnF_C3H1, 3 hits
SUPFAMiSSF48452, SSF48452, 1 hit
SSF57667, SSF57667, 1 hit
SSF90229, SSF90229, 2 hits
PROSITEiView protein in PROSITE
PS50103, ZF_C3H1, 3 hits
PS00028, ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZ3H7A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWR0
Secondary accession number(s): D3DUG5, Q9NPE9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2003
Last modified: August 12, 2020
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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