Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger CCCH domain-containing protein 7A

Gene

ZC3H7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri634 – 656C3H1-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri769 – 797C3H1-type 2PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri857 – 881C2H2-typeAdd BLAST25
Zinc fingeri906 – 928C3H1-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • miRNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • posttranscriptional regulation of gene expression Source: UniProtKB
  • production of miRNAs involved in gene silencing by miRNA Source: UniProtKB

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 7A
Gene namesi
Name:ZC3H7A
Synonyms:ZC3H7, ZC3HDC7
ORF Names:HSPC055
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000122299.11
HGNCiHGNC:30959 ZC3H7A
neXtProtiNX_Q8IWR0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi29066
OpenTargetsiENSG00000122299
PharmGKBiPA128394652

Polymorphism and mutation databases

BioMutaiZC3H7A
DMDMi68566208

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063211 – 971Zinc finger CCCH domain-containing protein 7AAdd BLAST971

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei210PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IWR0
MaxQBiQ8IWR0
PaxDbiQ8IWR0
PeptideAtlasiQ8IWR0
PRIDEiQ8IWR0
ProteomicsDBi70882
70883 [Q8IWR0-2]

PTM databases

iPTMnetiQ8IWR0
PhosphoSitePlusiQ8IWR0

Expressioni

Gene expression databases

BgeeiENSG00000122299
CleanExiHS_ZC3H7A
ExpressionAtlasiQ8IWR0 baseline and differential
GenevisibleiQ8IWR0 HS

Organism-specific databases

HPAiHPA040808
HPA059849

Interactioni

Protein-protein interaction databases

BioGridi118841, 12 interactors
IntActiQ8IWR0, 7 interactors

Structurei

Secondary structure

1971
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi908 – 912Combined sources5
Beta strandi922 – 926Combined sources5
Helixi927 – 940Combined sources14
Turni941 – 943Combined sources3

3D structure databases

ProteinModelPortaliQ8IWR0
SMRiQ8IWR0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IWR0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 76TPR 1Add BLAST34
Repeati89 – 122TPR 2Add BLAST34
Repeati124 – 156TPR 3Add BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili924 – 952Sequence analysisAdd BLAST29

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri634 – 656C3H1-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri769 – 797C3H1-type 2PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri857 – 881C2H2-typeAdd BLAST25
Zinc fingeri906 – 928C3H1-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Coiled coil, Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IDY2 Eukaryota
ENOG41100XQ LUCA
GeneTreeiENSGT00390000018542
HOGENOMiHOG000008703
HOVERGENiHBG058699
InParanoidiQ8IWR0
OMAiEDDQNCW
OrthoDBiEOG091G02K0
PhylomeDBiQ8IWR0
TreeFamiTF329017

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR036236 Znf_C2H2_sf
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF00642 zf-CCCH, 1 hit
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF57667 SSF57667, 1 hit
SSF90229 SSF90229, 2 hits
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 3 hits
PS00028 ZINC_FINGER_C2H2_1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IWR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNVSEERRK RQQNIKEGLQ FIQSPLSYPG TQEQYAVYLR ALVRNLFNEG
60 70 80 90 100
NDVYREHDWN NSISQYTEAL NIADYAKSEE ILIPKEIIEK LYINRIACYS
110 120 130 140 150
NMGFHDKVLE DCNIVLSLNA SNCKALYRKS KALSDLGRYK KAYDAVAKCS
160 170 180 190 200
LAVPQDEHVI KLTQELAQKL GFKIRKAYVR AELSLKSVPG DGATKALNHS
210 220 230 240 250
VEDIEPDLLT PRQEAVPVVS LPAPSFSHEV GSELASVPVM PLTSILPLQV
260 270 280 290 300
EESALPSAVL ANGGKMPFTM PEAFLDDGDM VLGDELDDLL DSAPETNETV
310 320 330 340 350
MPSALVRGPL QTASVSPSMP FSASLLGTLP IGARYAPPPS FSEFYPPLTS
360 370 380 390 400
SLEDFCSSLN SFSMSESKRD LSTSTSREGT PLNNSNSSLL LMNGPGSLFA
410 420 430 440 450
SENFLGISSQ PRNDFGNFFG SAVTKPSSSV TPRHPLEGTH ELRQACQICF
460 470 480 490 500
VKSGPKLMDF TYHANIDHKC KKDILIGRIK NVEDKSWKKI RPRPTKTNYE
510 520 530 540 550
GPYYICKDVA AEEECRYSGH CTFAYCQEEI DVWTLERKGA FSREAFFGGN
560 570 580 590 600
GKINLTVFKL LQEHLGEFIF LCEKCFDHKP RMISKRNKDN STACSHPVTK
610 620 630 640 650
HEFEDNKCLV HILRETTVKY SKIRSFHGQC QLDLCRHEVR YGCLREDECF
660 670 680 690 700
YAHSLVELKV WIMQNETGIS HDAIAQESKR YWQNLEANVP GAQVLGNQIM
710 720 730 740 750
PGFLNMKIKF VCAQCLRNGQ VIEPDKNRKY CSAKARHSWT KDRRAMRVMS
760 770 780 790 800
IERKKWMNIR PLPTKKQMPL QFDLCNHIAS GKKCQYVGNC SFAHSPEERE
810 820 830 840 850
VWTYMKENGI QDMEQFYELW LKSQKNEKSE DIASQSNKEN GKQIHMPTDY
860 870 880 890 900
AEVTVDFHCW MCGKNCNSEK QWQGHISSEK HKEKVFHTED DQYCWQHRFP
910 920 930 940 950
TGYFSICDRY MNGTCPEGNS CKFAHGNAEL HEWEERRDAL KMKLNKARKD
960 970
HLIGPNDNDF GKYSFLFKDL N
Length:971
Mass (Da):110,538
Last modified:March 1, 2003 - v1
Checksum:iA62D4EF6BC639181
GO
Isoform 2 (identifier: Q8IWR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-804: Missing.

Show »
Length:167
Mass (Da):19,811
Checksum:i5A672347194A2897
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0526323N → S. Corresponds to variant dbSNP:rs1429077Ensembl.1
Natural variantiVAR_05263357H → R. Corresponds to variant dbSNP:rs16958654Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0143831 – 804Missing in isoform 2. 3 PublicationsAdd BLAST804

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY163807 mRNA Translation: AAO06906.1
AF161540 mRNA Translation: AAF29027.1
AK000889 mRNA Translation: BAA91408.1
AK001869 mRNA Translation: BAA91952.1
CH471112 Genomic DNA Translation: EAW85138.1
CH471112 Genomic DNA Translation: EAW85139.1
BC012575 mRNA Translation: AAH12575.1
BC046363 mRNA Translation: AAH46363.1
CCDSiCCDS10550.1 [Q8IWR0-1]
RefSeqiNP_054872.2, NM_014153.3 [Q8IWR0-1]
XP_006720940.1, XM_006720877.2 [Q8IWR0-1]
XP_011520765.1, XM_011522463.1 [Q8IWR0-1]
UniGeneiHs.371856

Genome annotation databases

EnsembliENST00000355758; ENSP00000347999; ENSG00000122299 [Q8IWR0-1]
ENST00000396516; ENSP00000379773; ENSG00000122299 [Q8IWR0-1]
ENST00000575984; ENSP00000459477; ENSG00000122299 [Q8IWR0-2]
GeneIDi29066
KEGGihsa:29066
UCSCiuc002dbl.4 human [Q8IWR0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZ3H7A_HUMAN
AccessioniPrimary (citable) accession number: Q8IWR0
Secondary accession number(s): D3DUG5, Q9NPE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 1, 2003
Last modified: July 18, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health