UniProtKB - Q8IWQ7 (Q8IWQ7_HUMAN)
Protein
Non-specific serine/threonine protein kinase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Cofactori
Mg2+ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 106 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- actin cytoskeleton organization Source: InterPro
- intracellular signal transduction Source: InterPro
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseARBA annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
SignaLinki | Q8IWQ7 |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmARBA annotationPTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
PeptideAtlasi | Q8IWQ7 |
PRIDEi | Q8IWQ7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 77 – 343 | Protein kinaseInterPro annotationAdd BLAST | 267 | |
Domaini | 344 – 414 | AGC-kinase C-terminalInterPro annotationAdd BLAST | 71 | |
Domaini | 918 – 968 | Phorbol-ester/DAG-typeInterPro annotationAdd BLAST | 51 | |
Domaini | 988 – 1107 | PHInterPro annotationAdd BLAST | 120 | |
Domaini | 1133 – 1405 | CNHInterPro annotationAdd BLAST | 273 | |
Domaini | 1477 – 1490 | CRIBInterPro annotationAdd BLAST | 14 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1497 – 1638 | DisorderedSequence analysisAdd BLAST | 142 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 441 – 468 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 482 – 560 | Sequence analysisAdd BLAST | 79 | |
Coiled coili | 568 – 588 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 634 – 739 | Sequence analysisAdd BLAST | 106 | |
Coiled coili | 805 – 825 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 833 – 860 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1508 – 1555 | PolarSequence analysisAdd BLAST | 48 | |
Compositional biasi | 1563 – 1582 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1601 – 1638 | PolarSequence analysisAdd BLAST | 38 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotation, Zinc-fingerARBA annotationPhylogenomic databases
OMAi | KKACPGS |
Family and domain databases
CDDi | cd00029, C1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR001180, CNH_dom IPR000095, CRIB_dom IPR011009, Kinase-like_dom_sf IPR014930, Myotonic_dystrophy_kinase_coil IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR026611, Ser/Thr_kinase_MRCK_alpha |
PANTHERi | PTHR22988:SF31, PTHR22988:SF31, 3 hits |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00780, CNH, 1 hit PF08826, DMPK_coil, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00036, CNH, 1 hit SM00285, PBD, 1 hit SM00233, PH, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50219, CNH, 1 hit PS50108, CRIB, 1 hit PS50003, PH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IWQ7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGEVRLRQL EQFILDGPAQ TNGQCFSVET LLDILICLYD ECNNSPLRRE
60 70 80 90 100
KNILEYLEWA KPFTSKVKQM RLHREDFEIL KVIGRGAFGE VAVVKLKNAD
110 120 130 140 150
KVFAMKILNK WEMLKRAETA CFREERDVLV NGDNKWITTL HYAFQDDNNL
160 170 180 190 200
YLVMDYYVGG DLLTLLSKFE DRLPEDMARF YLAEMVIAID SVHQLHYVHR
210 220 230 240 250
DIKPDNILMD MNGHIRLADF GSCLKLMEDG TVQSSVAVGT PDYISPEILQ
260 270 280 290 300
AMEDGKGRYG PECDWWSLGV CMYEMLYGET PFYAESLVET YGKIMNHKER
310 320 330 340 350
FQFPAQVTDV SENAKDPIRR LICGREHRLG QSGIEDFKKH PFFSGIDWDN
360 370 380 390 400
IRNCEAPYIP EVSSPTDTSN FDVDDDCLKN SETMPPPTHT AFSGHHLPFV
410 420 430 440 450
GFTYTSSCVL SDRSCLRVTA GPTSLDLDVN VQRTLDNNLA TEAYERRIKR
460 470 480 490 500
LEQEKLELSR KLQESTQTVQ ALQYSTVDGP LTASKDLEIK NLKEVIEKLR
510 520 530 540 550
KQVTESSHLE QQLEEANAVR QELDDAFRQI KAYEKQIKTL QQEREDLNKL
560 570 580 590 600
EVHTEALAAE ASKDRKLREQ SEHYSKQLEN ELEGLKQKQI SYSPGVCSIE
610 620 630 640 650
HQQEITKLKT DLEKKSIFYE EELSKREGIH ANEIKNLKKE LHDSEGQQLA
660 670 680 690 700
LNKEIMILKD KLEKTRRESQ SEREEFESEF KQQYEREKVL LTEENKKLTS
710 720 730 740 750
ELDKLTTLYE NLSIHNQQLE EEVKDLADKK ESVAHWEAQI TEIIQWVSDE
760 770 780 790 800
KDARGYLQAL ASKMTEELEA LRNSSLGTRA TDMPWKMRRF AKLDMSARLE
810 820 830 840 850
LQSALDAEIR AKQAIQEELN KVKASNIITE CKLKDSEKKN LELLSEIEQL
860 870 880 890 900
IKDTEELRSE KGIEHQDSQH SFLAFLNTPT DALDQFETVD STPLSVHTPT
910 920 930 940 950
LRKKGCPGST GFPPKRKTHQ FFVKSFTTPT KCHQCTSLMV GLIRQGCSCE
960 970 980 990 1000
VCGFSCHITC VNKAPTTCPV PPEQTKGPLG IDPQKGIGTA YEGHVRIPKP
1010 1020 1030 1040 1050
AGVKKGWQRA LAIVCDFKLF LYDIAEGKAS QPSVVISQVI DMRDEEFSVS
1060 1070 1080 1090 1100
SVLASDVIHA SRKDIPCIFR VTASQLSASN NKCSILMLAD TENEKNKWVG
1110 1120 1130 1140 1150
VLSELHKILK KNKFRDRSVY VPKEAYDSTL PLIKTTQAAA IIDHERIALG
1160 1170 1180 1190 1200
NEEGLFVVHV TKDEIIRVGD NKKIHQIELI PNDQLVAVIS GRNRHVRLFP
1210 1220 1230 1240 1250
MSALDGRETD FYKLSETKGC QTVTSGKVRH GALTCLCVAM KRQVLCYELF
1260 1270 1280 1290 1300
QSKTRHRKFK EIQVPYNVQW MAIFSEQLCV GFQSGFLRYP LNGEGNPYSM
1310 1320 1330 1340 1350
LHSNDHTLSF IAHQPMDAIC AVEISSKEYL LCFNSIGIYT DCQGRRSRQQ
1360 1370 1380 1390 1400
ELMWPANPSS CCYNAPYLSV YSENAVDIFD VNSMEWIQTL PLKKVRPLNN
1410 1420 1430 1440 1450
EGSLNLLGLE TIRLIYFKNK MAEGDELVVP ETSDNSRKQM VRNINNKRRY
1460 1470 1480 1490 1500
SFRVPEEERM QQRREMLRDP EMRNKLISNP TNFNHIAHMG PGDGIQILKD
1510 1520 1530 1540 1550
LPMNPRPQES RTVFSGSVSI PSITKSRPEP GRSMSASSGL SARSSAQNGS
1560 1570 1580 1590 1600
ALKREFSGGS YSAKRQPMPS PSEGSLSSGG MDQGSDAPAR DFDGEDSDSP
1610 1620 1630
RHSTASNSSN LSSPPSPVSP RKTKSLSLES TDRGSWDP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY166586 mRNA Translation: AAN86031.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY166586 mRNA Translation: AAN86031.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q8IWQ7 |
PRIDEi | Q8IWQ7 |
Phylogenomic databases
OMAi | KKACPGS |
Enzyme and pathway databases
SignaLinki | Q8IWQ7 |
Family and domain databases
CDDi | cd00029, C1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR001180, CNH_dom IPR000095, CRIB_dom IPR011009, Kinase-like_dom_sf IPR014930, Myotonic_dystrophy_kinase_coil IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR026611, Ser/Thr_kinase_MRCK_alpha |
PANTHERi | PTHR22988:SF31, PTHR22988:SF31, 3 hits |
Pfami | View protein in Pfam PF00130, C1_1, 1 hit PF00780, CNH, 1 hit PF08826, DMPK_coil, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00036, CNH, 1 hit SM00285, PBD, 1 hit SM00233, PH, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50219, CNH, 1 hit PS50108, CRIB, 1 hit PS50003, PH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IWQ7_HUMAN | |
Accessioni | Q8IWQ7Primary (citable) accession number: Q8IWQ7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |