Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coiled-coil domain-containing protein 28A

Gene

CCDC28A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-91 is the initiator. The first 90 residues are not conserved and orthologous sequences, including rat and mouse ones, contain a stop codon upstream of the conserved methionine.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 28A
Alternative name(s):
CCRL1AP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC28A
Synonyms:C6orf80
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000024862.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21098 CCDC28A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615353 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IWP9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving CCDC28A has been identified in acute leukemias. Translocation t(6;11)(q24.1;p15.5) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 13 to CCDC28A exon 2. Ectopic expression of NUP98-CCDC28A in mouse promotes the proliferative capacity and self-renewal potential of hematopoietic progenitors and rapidly induced fatal myeloproliferative neoplasms and defects in the differentiation of the erythro-megakaryocytic lineage.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei76 – 77Breakpoint for translocation to form NUP98-CCDC28A2

Organism-specific databases

DisGeNET

More...
DisGeNETi
25901

Open Targets

More...
OpenTargetsi
ENSG00000024862

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134939277

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC28A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68052352

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000894111 – 274Coiled-coil domain-containing protein 28AAdd BLAST274

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IWP9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IWP9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IWP9

PeptideAtlas

More...
PeptideAtlasi
Q8IWP9

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWP9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70876

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8IWP9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IWP9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IWP9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000024862 Expressed in 233 organ(s), highest expression level in anterior cingulate cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_CCDC28A

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IWP9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IWP9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055125

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117408, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IWP9, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000332716

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IWP9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IWP9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili234 – 263Sequence analysisAdd BLAST30

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJUP Eukaryota
ENOG4111KYE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044870

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231321

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG061498

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IWP9

Identification of Orthologs from Complete Genome Data

More...
OMAi
MPEDQRK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0PBD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IWP9

TreeFam database of animal gene trees

More...
TreeFami
TF323549

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025271 DUF4061

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13270 DUF4061, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8IWP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRAEPRATL GEQEKAGLPL GAWRLYLLRH FRKQTELRRS GSRDVTGALL
60 70 80 90 100
VAAAVASEAV GSLRVAEGGP NTLLLQVLRS WPWCNKELKT MEERKVKRRS
110 120 130 140 150
PKSFSAHCTQ VVNAKKNAIP VSKSTGFSNP ASQSTSQRPK LKRVMKEKTK
160 170 180 190 200
PQGGEGKGAQ STPIQHSFLT DVSDVQEMER GLLSLLNDFH SGKLQAFGNE
210 220 230 240 250
CSIEQMEHVR GMQEKLARLN LELYGELEEL PEDKRKTASD SNLDRLLSDL
260 270
EELNSSIQKL HLADAQDVPN TSAS
Length:274
Mass (Da):30,367
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2C6F97AE9854108
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DUJ5B4DUJ5_HUMAN
cDNA FLJ60164, highly similar to Co...
CCDC28A
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05074442S → Y. Corresponds to variant dbSNP:rs34538642Ensembl.1
Natural variantiVAR_05074582P → L. Corresponds to variant dbSNP:rs2273510Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY167571 mRNA Translation: AAN87344.1
AL121834 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47910.1
CH471051 Genomic DNA Translation: EAW47911.1
BC013019 mRNA Translation: AAH13019.2
BC080566 mRNA Translation: AAH80566.1
BC108717 mRNA Translation: AAI08718.1
AL050197 mRNA Translation: CAB43315.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5192.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T08802

NCBI Reference Sequences

More...
RefSeqi
NP_056254.1, NM_015439.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.412019

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332797; ENSP00000332716; ENSG00000024862
ENST00000611852; ENSP00000479060; ENSG00000024862

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25901

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25901

UCSC genome browser

More...
UCSCi
uc003qie.3 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY167571 mRNA Translation: AAN87344.1
AL121834 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47910.1
CH471051 Genomic DNA Translation: EAW47911.1
BC013019 mRNA Translation: AAH13019.2
BC080566 mRNA Translation: AAH80566.1
BC108717 mRNA Translation: AAI08718.1
AL050197 mRNA Translation: CAB43315.1
CCDSiCCDS5192.1
PIRiT08802
RefSeqiNP_056254.1, NM_015439.2
UniGeneiHs.412019

3D structure databases

ProteinModelPortaliQ8IWP9
SMRiQ8IWP9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117408, 19 interactors
IntActiQ8IWP9, 8 interactors
STRINGi9606.ENSP00000332716

PTM databases

iPTMnetiQ8IWP9
PhosphoSitePlusiQ8IWP9

Polymorphism and mutation databases

BioMutaiCCDC28A
DMDMi68052352

Proteomic databases

EPDiQ8IWP9
MaxQBiQ8IWP9
PaxDbiQ8IWP9
PeptideAtlasiQ8IWP9
PRIDEiQ8IWP9
ProteomicsDBi70876
TopDownProteomicsiQ8IWP9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332797; ENSP00000332716; ENSG00000024862
ENST00000611852; ENSP00000479060; ENSG00000024862
GeneIDi25901
KEGGihsa:25901
UCSCiuc003qie.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25901
DisGeNETi25901
EuPathDBiHostDB:ENSG00000024862.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC28A
HGNCiHGNC:21098 CCDC28A
HPAiHPA055125
MIMi615353 gene
neXtProtiNX_Q8IWP9
OpenTargetsiENSG00000024862
PharmGKBiPA134939277

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJUP Eukaryota
ENOG4111KYE LUCA
GeneTreeiENSGT00500000044870
HOGENOMiHOG000231321
HOVERGENiHBG061498
InParanoidiQ8IWP9
OMAiMPEDQRK
OrthoDBiEOG091G0PBD
PhylomeDBiQ8IWP9
TreeFamiTF323549

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC28A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25901

Protein Ontology

More...
PROi
PR:Q8IWP9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000024862 Expressed in 233 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_CCDC28A
ExpressionAtlasiQ8IWP9 baseline and differential
GenevisibleiQ8IWP9 HS

Family and domain databases

InterProiView protein in InterPro
IPR025271 DUF4061
PfamiView protein in Pfam
PF13270 DUF4061, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC28A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWP9
Secondary accession number(s): E1P591
, Q32NC7, Q66K67, Q96E23, Q9Y430
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again