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Protein

Iron-sulfur cluster co-chaperone protein HscB, mitochondrial

Gene

HSCB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria.1 Publication

Pathwayi: iron-sulfur cluster biosynthesis

This protein is involved in the pathway iron-sulfur cluster biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway iron-sulfur cluster biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41Divalent metal cation1
Metal bindingi44Divalent metal cation1
Metal bindingi58Divalent metal cation1
Metal bindingi61Divalent metal cation1

GO - Molecular functioni

  • ATPase activator activity Source: InterPro
  • chaperone binding Source: GO_Central
  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis
UniPathwayi
UPA00266

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur cluster co-chaperone protein HscB, mitochondrial
Alternative name(s):
DnaJ homolog subfamily C member 20
Hsc20
Gene namesi
Name:HSCB
Synonyms:DNAJC20, HSC20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100209.9
HGNCiHGNC:28913 HSCB
MIMi608142 gene
neXtProtiNX_Q8IWL3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi41C → S: Does not alter subcellular localization; when associated with A-44, A-58 and A-61. 1
Mutagenesisi44C → S: Does not alter subcellular localization; when associated with A-41, A-58 and A-61. 1
Mutagenesisi58C → S: Does not alter subcellular localization; when associated with A-41, A-44 and A-61. 1
Mutagenesisi61C → S: Does not alter subcellular localization; when associated with A-41, A-44 and A-58. 1
Mutagenesisi102 – 104HPD → AAA: Does not interact with HSPA9. Does not inhibit interaction with ISCU. 1 Publication3

Organism-specific databases

OpenTargetsiENSG00000100209
PharmGKBiPA162391621

Polymorphism and mutation databases

BioMutaiHSCB
DMDMi60416441

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000000726230 – 235Iron-sulfur cluster co-chaperone protein HscB, mitochondrialAdd BLAST206

Proteomic databases

EPDiQ8IWL3
MaxQBiQ8IWL3
PaxDbiQ8IWL3
PeptideAtlasiQ8IWL3
PRIDEiQ8IWL3
ProteomicsDBi70870

PTM databases

iPTMnetiQ8IWL3
PhosphoSitePlusiQ8IWL3

Expressioni

Tissue specificityi

Expressed in lung, brain, stomach, spleen, ovary, testis, liver, muscle and heart.2 Publications

Gene expression databases

BgeeiENSG00000100209 Expressed in 197 organ(s), highest expression level in parotid gland
CleanExiHS_HSCB
ExpressionAtlasiQ8IWL3 baseline and differential
GenevisibleiQ8IWL3 HS

Organism-specific databases

HPAiHPA018447
HPA031518

Interactioni

Subunit structurei

Interacts with ISCU and HSPA9.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127276, 12 interactors
DIPiDIP-46570N
IntActiQ8IWL3, 738 interactors
STRINGi9606.ENSP00000216027

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8IWL3
SMRiQ8IWL3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IWL3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 144JAdd BLAST73

Sequence similaritiesi

Belongs to the HscB family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3192 Eukaryota
COG1076 LUCA
GeneTreeiENSGT00390000008206
HOGENOMiHOG000006786
HOVERGENiHBG051931
InParanoidiQ8IWL3
KOiK04082
OMAiHDTAFLM
OrthoDBiEOG091G0O5A
PhylomeDBiQ8IWL3
TreeFamiTF319992

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
1.20.1280.20, 1 hit
HAMAPiMF_00682 HscB, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR004640 HscB
IPR036386 HscB_C_sf
IPR009073 HscB_oligo_C
IPR036869 J_dom_sf
PANTHERiPTHR14021 PTHR14021, 1 hit
PfamiView protein in Pfam
PF07743 HSCB_C, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF47144 SSF47144, 1 hit
TIGRFAMsiTIGR00714 hscB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8IWL3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWRGRAGALL RVWGFWPTGV PRRRPLSCDA ASQAGSNYPR CWNCGGPWGP
60 70 80 90 100
GREDRFFCPQ CRALQAPDPT RDYFSLMDCN RSFRVDTAKL QHRYQQLQRL
110 120 130 140 150
VHPDFFSQRS QTEKDFSEKH STLVNDAYKT LLAPLSRGLY LLKLHGIEIP
160 170 180 190 200
ERTDYEMDRQ FLIEIMEINE KLAEAESEAA MKEIESIVKA KQKEFTDNVS
210 220 230
SAFEQDDFEE AKEILTKMRY FSNIEEKIKL KKIPL
Length:235
Mass (Da):27,422
Last modified:March 1, 2005 - v3
Checksum:i70CF499E58FFD1C2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYH2B0QYH2_HUMAN
Iron-sulfur cluster co-chaperone pr...
HSCB RP3-366L4.2, hCG_40981
143Annotation score:
F8WBY7F8WBY7_HUMAN
Iron-sulfur cluster co-chaperone pr...
HSCB
105Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43N → S in AAN85282 (PubMed:12938016).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04891673Y → C. Corresponds to variant dbSNP:rs17886090Ensembl.1
Natural variantiVAR_048917163I → M. Corresponds to variant dbSNP:rs17884212Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191719 mRNA Translation: AAN85282.1
CR456462 mRNA Translation: CAG30348.1
AL023494 Genomic DNA No translation available.
AL117330 Genomic DNA No translation available.
BC065569 mRNA Translation: AAH65569.1
CCDSiCCDS13845.1
RefSeqiNP_741999.3, NM_172002.4
UniGeneiHs.632780

Genome annotation databases

EnsembliENST00000216027; ENSP00000216027; ENSG00000100209
GeneIDi150274
KEGGihsa:150274
UCSCiuc003aea.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191719 mRNA Translation: AAN85282.1
CR456462 mRNA Translation: CAG30348.1
AL023494 Genomic DNA No translation available.
AL117330 Genomic DNA No translation available.
BC065569 mRNA Translation: AAH65569.1
CCDSiCCDS13845.1
RefSeqiNP_741999.3, NM_172002.4
UniGeneiHs.632780

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BVOX-ray3.00A/B30-235[»]
ProteinModelPortaliQ8IWL3
SMRiQ8IWL3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127276, 12 interactors
DIPiDIP-46570N
IntActiQ8IWL3, 738 interactors
STRINGi9606.ENSP00000216027

PTM databases

iPTMnetiQ8IWL3
PhosphoSitePlusiQ8IWL3

Polymorphism and mutation databases

BioMutaiHSCB
DMDMi60416441

Proteomic databases

EPDiQ8IWL3
MaxQBiQ8IWL3
PaxDbiQ8IWL3
PeptideAtlasiQ8IWL3
PRIDEiQ8IWL3
ProteomicsDBi70870

Protocols and materials databases

DNASUi150274
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216027; ENSP00000216027; ENSG00000100209
GeneIDi150274
KEGGihsa:150274
UCSCiuc003aea.4 human

Organism-specific databases

CTDi150274
EuPathDBiHostDB:ENSG00000100209.9
GeneCardsiHSCB
HGNCiHGNC:28913 HSCB
HPAiHPA018447
HPA031518
MIMi608142 gene
neXtProtiNX_Q8IWL3
OpenTargetsiENSG00000100209
PharmGKBiPA162391621
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3192 Eukaryota
COG1076 LUCA
GeneTreeiENSGT00390000008206
HOGENOMiHOG000006786
HOVERGENiHBG051931
InParanoidiQ8IWL3
KOiK04082
OMAiHDTAFLM
OrthoDBiEOG091G0O5A
PhylomeDBiQ8IWL3
TreeFamiTF319992

Enzyme and pathway databases

UniPathwayi
UPA00266

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis

Miscellaneous databases

ChiTaRSiHSCB human
EvolutionaryTraceiQ8IWL3
GenomeRNAii150274
PROiPR:Q8IWL3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100209 Expressed in 197 organ(s), highest expression level in parotid gland
CleanExiHS_HSCB
ExpressionAtlasiQ8IWL3 baseline and differential
GenevisibleiQ8IWL3 HS

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
1.20.1280.20, 1 hit
HAMAPiMF_00682 HscB, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR004640 HscB
IPR036386 HscB_C_sf
IPR009073 HscB_oligo_C
IPR036869 J_dom_sf
PANTHERiPTHR14021 PTHR14021, 1 hit
PfamiView protein in Pfam
PF07743 HSCB_C, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF47144 SSF47144, 1 hit
TIGRFAMsiTIGR00714 hscB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSC20_HUMAN
AccessioniPrimary (citable) accession number: Q8IWL3
Secondary accession number(s): Q9BWS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 1, 2005
Last modified: November 7, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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