Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 162 (08 May 2019)
Sequence version 4 (30 Nov 2010)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

GRIP and coiled-coil domain-containing protein 2

Gene

GCC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8IWJ2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GRIP and coiled-coil domain-containing protein 2
Alternative name(s):
185 kDa Golgi coiled-coil protein
Short name:
GCC185
CLL-associated antigen KW-11
CTCL tumor antigen se1-1
Ran-binding protein 2-like 4
Short name:
RanBP2L4
Renal carcinoma antigen NY-REN-53
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GCC2
Synonyms:KIAA0336, RANBP2L4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23218 GCC2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612711 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IWJ2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1588I → A: Slightly decreases RAB6A binding affinity. Decreases RAB9A binding affinity by 2-fold. Strongly decreases RAB6A or RAB9A binding affinity and abolishes Golgi localization; when associated with A-1595. 1 Publication1
Mutagenesisi1595L → A: Decreases RAB6A binding affinity by 2-fold. Strongly decreases RAB9A binding affinity. Strongly decreases RAB6A or RAB9A binding affinity and abolishes Golgi localization; when associated with A-1588. 1 Publication1
Mutagenesisi1618Y → A: No effect on interaction with RAB6A and RAB9A. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9648

Open Targets

More...
OpenTargetsi
ENSG00000135968

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134876902

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GCC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104307

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001900741 – 1684GRIP and coiled-coil domain-containing protein 2Add BLAST1684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei14PhosphothreonineCombined sources1
Modified residuei236PhosphoserineCombined sources1
Modified residuei1483PhosphoserineCombined sources1
Modified residuei1487PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IWJ2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IWJ2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IWJ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IWJ2

PeptideAtlas

More...
PeptideAtlasi
Q8IWJ2

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWJ2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70862
70863 [Q8IWJ2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IWJ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IWJ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135968 Expressed in 231 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IWJ2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IWJ2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035849
HPA035850

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts (via GRIP domain) with RAB6A (preferentially in its GTP-bound form). May interact (RAB6A-dependent) with ARL1; according to PubMed:19703403, RAB6A and ARL1 are not involved in GCC2 Golgi localization as proposed by PubMed:18243103. Interacts (probably via GRIP domain) with RAB9A (preferentially in its GTP-bound form). Interacts with CLASP1 and CLASP2; recruits both proteins to membranes of the TGN. Interacts with STX16.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115006, 36 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IWJ2, 21 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000307939

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11684
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IWJ2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8IWJ2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1609 – 1659GRIPPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1574 – 1684Mediates interaction with RAB9AAdd BLAST111
Regioni1574 – 1613Mediates interaction with RAB6AAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili110 – 1618Sequence analysisAdd BLAST1509

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Extended rod-like protein with coiled-coil domains.

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUCE Eukaryota
ENOG410Y42S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183078

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060191

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IWJ2

KEGG Orthology (KO)

More...
KOi
K20282

Identification of Orthologs from Complete Genome Data

More...
OMAi
EEREQHM

Database of Orthologous Groups

More...
OrthoDBi
200498at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IWJ2

TreeFam database of animal gene trees

More...
TreeFami
TF332907

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032023 GCC2_Rab_bind
IPR000237 GRIP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01465 GRIP, 1 hit
PF16704 Rab_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00755 Grip, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50913 GRIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IWJ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDLVQDGVA SPATPGTGKS KLETLPKEDL IKFAKKQMML IQKAKSRCTE
60 70 80 90 100
LEKEIEELRS KPVTEGTGDI IKALTERLDA LLLEKAETEQ QCLSLKKENI
110 120 130 140 150
KMKQEVEDSV TKMGDAHKEL EQSHINYVKE IENLKNELMA VRSKYSEDKA
160 170 180 190 200
NLQKQLEEAM NTQLELSEQL KFQNNSEDNV KKLQEEIEKI RPGFEEQILY
210 220 230 240 250
LQKQLDATTD EKKETVTQLQ NIIEANSQHY QKNINSLQEE LLQLKAIHQE
260 270 280 290 300
EVKELMCQIE ASAKEHEAEI NKLNELKENL VKQCEASEKN IQKKYECELE
310 320 330 340 350
NLRKATSNAN QDNQICSILL QENTFVEQVV NEKVKHLEDT LKELESQHSI
360 370 380 390 400
LKDEVTYMNN LKLKLEMDAQ HIKDEFFHER EDLEFKINEL LLAKEEQGCV
410 420 430 440 450
IEKLKSELAG LNKQFCYTVE QHNREVQSLK EQHQKEISEL NETFLSDSEK
460 470 480 490 500
EKLTLMFEIQ GLKEQCENLQ QEKQEAILNY ESLREIMEIL QTELGESAGK
510 520 530 540 550
ISQEFESMKQ QQASDVHELQ QKLRTAFTEK DALLETVNRL QGENEKLLSQ
560 570 580 590 600
QELVPELENT IKNLQEKNGV YLLSLSQRDT MLKELEGKIN SLTEEKDDFI
610 620 630 640 650
NKLKNSHEEM DNFHKKCERE ERLILELGKK VEQTIQYNSE LEQKVNELTG
660 670 680 690 700
GLEETLKEKD QNDQKLEKLM VQMKVLSEDK EVLSAEVKSL YEENNKLSSE
710 720 730 740 750
KKQLSRDLEV FLSQKEDVIL KEHITQLEKK LQLMVEEQDN LNKLLENEQV
760 770 780 790 800
QKLFVKTQLY GFLKEMGSEV SEDSEEKDVV NVLQAVGESL AKINEEKCNL
810 820 830 840 850
AFQRDEKVLE LEKEIKCLQE ESVVQCEELK SLLRDYEQEK VLLRKELEEI
860 870 880 890 900
QSEKEALQSD LLEMKNANEK TRLENQNLLI QVEEVSQTCS KSEIHNEKEK
910 920 930 940 950
CFIKEHENLK PLLEQKELRD RRAELILLKD SLAKSPSVKN DPLSSVKELE
960 970 980 990 1000
EKIENLEKEC KEKEEKINKI KLVAVKAKKE LDSSRKETQT VKEELESLRS
1010 1020 1030 1040 1050
EKDQLSASMR DLIQGAESYK NLLLEYEKQS EQLDVEKERA NNFEHRIEDL
1060 1070 1080 1090 1100
TRQLRNSTLQ CETINSDNED LLARIETLQS NAKLLEVQIL EVQRAKAMVD
1110 1120 1130 1140 1150
KELEAEKLQK EQKIKEHATT VNELEELQVQ LQKQKKQLQK TMQELELVKK
1160 1170 1180 1190 1200
DAQQTTLMNM EIADYERLMK ELNQKLTNKN NKIEDLEQEI KIQKQKQETL
1210 1220 1230 1240 1250
QEEITSLQSS VQQYEEKNTK IKQLLVKTKK ELADSKQAET DHLILQASLK
1260 1270 1280 1290 1300
GELEASQQQV EVYKIQLAEI TSEKHKIHEH LKTSAEQHQR TLSAYQQRVT
1310 1320 1330 1340 1350
ALQEECRAAK AEQATVTSEF ESYKVRVHNV LKQQKNKSMS QAETEGAKQE
1360 1370 1380 1390 1400
REHLEMLIDQ LKIKLQDSQN NLQINVSELQ TLQSEHDTLL ERHNKMLQET
1410 1420 1430 1440 1450
VSKEAELREK LCSIQSENMM MKSEHTQTVS QLTSQNEVLR NSFRDQVRHL
1460 1470 1480 1490 1500
QEEHRKTVET LQQQLSKMEA QLFQLKNEPT TRSPVSSQQS LKNLRERRNT
1510 1520 1530 1540 1550
DLPLLDMHTV TREEGEGMET TDTESVSSAS TYTQSLEQLL NSPETKLEPP
1560 1570 1580 1590 1600
LWHAEFTKEE LVQKLSSTTK SADHLNGLLR ETEATNAILM EQIKLLKSEI
1610 1620 1630 1640 1650
RRLERNQERE KSAANLEYLK NVLLQFIFLK PGSERERLLP VINTMLQLSP
1660 1670 1680
EEKGKLAAVA QGEEENASRS SGWASYLHSW SGLR
Length:1,684
Mass (Da):195,910
Last modified:November 30, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83B6135D9EB9440D
GO
Isoform 2 (identifier: Q8IWJ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-45: LETLPKEDLIKFAKKQMMLIQKAK → NWRKKLKNSDQNLLLKELVILLRH
     46-1684: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:45
Mass (Da):5,043
Checksum:i01BB22944C997E56
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZW2B8ZZW2_HUMAN
GRIP and coiled-coil domain-contain...
GCC2
916Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8ZZA5B8ZZA5_HUMAN
GRIP and coiled-coil domain-contain...
GCC2
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYJ9H7BYJ9_HUMAN
GRIP and coiled-coil domain-contain...
GCC2
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C010H7C010_HUMAN
GRIP and coiled-coil domain-contain...
GCC2
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQE0U3KQE0_HUMAN
GRIP and coiled-coil domain-contain...
GCC2
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KPU4U3KPU4_HUMAN
GRIP and coiled-coil domain-contain...
GCC2
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG34902 differs from that shown. Reason: Frameshift at positions 694, 700, 937 and 940.Curated
The sequence AAH37774 differs from that shown. Wrong choice of CDS.Curated
The sequence AAI46790 differs from that shown. Wrong choice of CDS.Curated
The sequence AAL99918 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAX88838 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA20794 differs from that shown. Wrong choice of CDS.Curated
The sequence EAW53882 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0466351134Q → E1 PublicationCorresponds to variant dbSNP:rs2718698Ensembl.1
Natural variantiVAR_0161011298R → G. Corresponds to variant dbSNP:rs1061202Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04010622 – 45LETLP…IQKAK → NWRKKLKNSDQNLLLKELVI LLRH in isoform 2. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_04010746 – 1684Missing in isoform 2. 2 PublicationsAdd BLAST1639

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB002334 mRNA Translation: BAA20794.2 Sequence problems.
AC012487 Genomic DNA Translation: AAX88838.1 Sequence problems.
AC068941 Genomic DNA No translation available.
CH471182 Genomic DNA Translation: EAW53882.1 Sequence problems.
BC037774 mRNA Translation: AAH37774.1 Sequence problems.
BC146789 mRNA Translation: AAI46790.1 Sequence problems.
AF432211 mRNA Translation: AAL99918.1 Different initiation.
AF273042 mRNA Translation: AAG34902.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33268.1 [Q8IWJ2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_852118.1, NM_181453.3
XP_006712934.1, XM_006712871.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000309863; ENSP00000307939; ENSG00000135968 [Q8IWJ2-1]
ENST00000482325; ENSP00000419969; ENSG00000135968 [Q8IWJ2-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9648

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9648

UCSC genome browser

More...
UCSCi
uc002tec.4 human [Q8IWJ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002334 mRNA Translation: BAA20794.2 Sequence problems.
AC012487 Genomic DNA Translation: AAX88838.1 Sequence problems.
AC068941 Genomic DNA No translation available.
CH471182 Genomic DNA Translation: EAW53882.1 Sequence problems.
BC037774 mRNA Translation: AAH37774.1 Sequence problems.
BC146789 mRNA Translation: AAI46790.1 Sequence problems.
AF432211 mRNA Translation: AAL99918.1 Different initiation.
AF273042 mRNA Translation: AAG34902.1 Frameshift.
CCDSiCCDS33268.1 [Q8IWJ2-1]
RefSeqiNP_852118.1, NM_181453.3
XP_006712934.1, XM_006712871.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BBPX-ray3.00D/E/F1547-1612[»]
SMRiQ8IWJ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115006, 36 interactors
IntActiQ8IWJ2, 21 interactors
STRINGi9606.ENSP00000307939

PTM databases

iPTMnetiQ8IWJ2
PhosphoSitePlusiQ8IWJ2

Polymorphism and mutation databases

BioMutaiGCC2
DMDMi313104307

Proteomic databases

EPDiQ8IWJ2
jPOSTiQ8IWJ2
MaxQBiQ8IWJ2
PaxDbiQ8IWJ2
PeptideAtlasiQ8IWJ2
PRIDEiQ8IWJ2
ProteomicsDBi70862
70863 [Q8IWJ2-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309863; ENSP00000307939; ENSG00000135968 [Q8IWJ2-1]
ENST00000482325; ENSP00000419969; ENSG00000135968 [Q8IWJ2-3]
GeneIDi9648
KEGGihsa:9648
UCSCiuc002tec.4 human [Q8IWJ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9648
DisGeNETi9648

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GCC2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0023314
HGNCiHGNC:23218 GCC2
HPAiHPA035849
HPA035850
MIMi612711 gene
neXtProtiNX_Q8IWJ2
OpenTargetsiENSG00000135968
PharmGKBiPA134876902

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IUCE Eukaryota
ENOG410Y42S LUCA
GeneTreeiENSGT00950000183078
HOGENOMiHOG000060191
InParanoidiQ8IWJ2
KOiK20282
OMAiEEREQHM
OrthoDBi200498at2759
PhylomeDBiQ8IWJ2
TreeFamiTF332907

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
SIGNORiQ8IWJ2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GCC2 human
EvolutionaryTraceiQ8IWJ2

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GCC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9648

Protein Ontology

More...
PROi
PR:Q8IWJ2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135968 Expressed in 231 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ8IWJ2 baseline and differential
GenevisibleiQ8IWJ2 HS

Family and domain databases

InterProiView protein in InterPro
IPR032023 GCC2_Rab_bind
IPR000237 GRIP_dom
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
PF16704 Rab_bind, 1 hit
SMARTiView protein in SMART
SM00755 Grip, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWJ2
Secondary accession number(s): A6H8X8
, O15045, Q4ZG46, Q8TDH3, Q9H2G8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: November 30, 2010
Last modified: May 8, 2019
This is version 162 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again