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UniProtKB - Q8IWI9 (MGAP_HUMAN)

Entry version 161 (25 May 2022)
Sequence version 4 (05 Jun 2019)
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Protein

MAX gene-associated protein

Gene

MGA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi84 – 260T-boxPROSITE-ProRule annotationAdd BLAST177

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IWI9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8953750, Transcriptional Regulation by E2F6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8IWI9

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8IWI9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MAX gene-associated protein
Alternative name(s):
MAX dimerization protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MGA
Synonyms:KIAA0518, MAD5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14010, MGA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616061, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IWI9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000174197

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23269

MalaCards human disease database

More...MalaCardsi		MGA

Open Targets

More...OpenTargetsi		ENSG00000174197

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134976336

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IWI9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MGA

Domain mapping of disease mutations (DMDM)

More...DMDMi		527504082

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003426921 – 3065MAX gene-associated proteinAdd BLAST3065

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki323Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki329Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki349Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki432Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki460Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki465Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki482Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei534PhosphoserineCombined sources1
Cross-linki570Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei607PhosphoserineCombined sources1
Cross-linki613Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei645PhosphoserineCombined sources1
Cross-linki654Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki791Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki817Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki826Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei851PhosphoserineCombined sources1
Modified residuei924PhosphoserineCombined sources1
Cross-linki928Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki990Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1091Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1140Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1199Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1207Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1208PhosphoserineCombined sources1
Modified residuei1430PhosphoserineCombined sources1
Modified residuei1457PhosphoserineCombined sources1
Cross-linki1461Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1502Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1985Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1992Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2135Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2159Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2194Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2206Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2238Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2265Omega-N-methylarginineCombined sources1
Cross-linki2284Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2378Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2457Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2532Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2541PhosphoserineCombined sources1
Cross-linki2546Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2629Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2679Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2698Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2784Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2910PhosphoserineCombined sources1
Modified residuei2921PhosphoserineCombined sources1
Modified residuei2978PhosphoserineCombined sources1
Cross-linki3041Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IWI9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IWI9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IWI9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IWI9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IWI9

PeptideAtlas

More...PeptideAtlasi		Q8IWI9

PRoteomics IDEntifications database

More...PRIDEi		Q8IWI9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		17160
27509

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q8IWI9

GlyConnect protein glycosylation platform

More...GlyConnecti		2859, 1 O-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8IWI9, 6 sites, 1 O-linked glycan (6 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IWI9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IWI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000174197, Expressed in corpus callosum and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IWI9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IWI9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000174197, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAX. Requires dimerization with MAX for E-box binding (By similarity).

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.

Interacts with ZMYND11.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116870, 157 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8IWI9

Database of interacting proteins

More...DIPi		DIP-57615N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q8IWI9

Protein interaction database and analysis system

More...IntActi		Q8IWI9, 104 interactors

Molecular INTeraction database

More...MINTi		Q8IWI9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000219905

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IWI9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IWI9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2423 – 2474bHLHPROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni259 – 322DisorderedSequence analysisAdd BLAST64
Regioni604 – 653DisorderedSequence analysisAdd BLAST50
Regioni881 – 911DisorderedSequence analysisAdd BLAST31
Regioni971 – 990DisorderedSequence analysisAdd BLAST20
Regioni1246 – 1332DisorderedSequence analysisAdd BLAST87
Regioni1380 – 1429DisorderedSequence analysisAdd BLAST50
Regioni1488 – 1517DisorderedSequence analysisAdd BLAST30
Regioni1905 – 1927DisorderedSequence analysisAdd BLAST23
Regioni1967 – 2029DisorderedSequence analysisAdd BLAST63
Regioni2258 – 2316DisorderedSequence analysisAdd BLAST59
Regioni2576 – 2595DisorderedSequence analysisAdd BLAST20
Regioni2668 – 2709DisorderedSequence analysisAdd BLAST42
Regioni2944 – 2968DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1111 – 1147Sequence analysisAdd BLAST37
Coiled coili2817 – 2841Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi262 – 276Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi277 – 294Polar residuesSequence analysisAdd BLAST18
Compositional biasi632 – 648Polar residuesSequence analysisAdd BLAST17
Compositional biasi971 – 988Polar residuesSequence analysisAdd BLAST18
Compositional biasi1254 – 1276Polar residuesSequence analysisAdd BLAST23
Compositional biasi1293 – 1310Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1311 – 1328Polar residuesSequence analysisAdd BLAST18
Compositional biasi1492 – 1514Polar residuesSequence analysisAdd BLAST23
Compositional biasi1972 – 1998Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi2299 – 2316Acidic residuesSequence analysisAdd BLAST18
Compositional biasi2577 – 2595Polar residuesSequence analysisAdd BLAST19
Compositional biasi2675 – 2705Basic and acidic residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3585, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156269

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000469_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IWI9

Identification of Orthologs from Complete Genome Data

More...OMAi		FQRKATH

Database of Orthologous Groups

More...OrthoDBi		1201455at2759

TreeFam database of animal gene trees

More...TreeFami		TF106341

Family and domain databases

Conserved Domains Database

More...CDDi		cd00182, TBOX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.820, 1 hit
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
IPR037935, MAX_gene-associated_protein
IPR032060, MGA_dom
IPR008967, p53-like_TF_DNA-bd
IPR046360, T-box_DNA-bd
IPR036960, T-box_sf
IPR001699, TF_T-box
IPR018186, TF_T-box_CS

The PANTHER Classification System

More...PANTHERi		PTHR11267, PTHR11267, 1 hit
PTHR11267:SF32, PTHR11267:SF32, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16059, DUF4801, 1 hit
PF00010, HLH, 1 hit
PF00907, T-box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00937, TBOX

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00353, HLH, 1 hit
SM00425, TBOX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47459, SSF47459, 1 hit
SSF49417, SSF49417, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50888, BHLH, 1 hit
PS01264, TBOX_2, 1 hit
PS50252, TBOX_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IWI9-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEKQQIILA NQDGGTVAGA APTFFVILKQ PGNGKTDQGI LVTNQDACAL 
        60         70         80         90        100
ASSVSSPVKS KGKICLPADC TVGGITVTLD NNSMWNEFYH RSTEMILTKQ 
       110        120        130        140        150
GRRMFPYCRY WITGLDSNLK YILVMDISPV DNHRYKWNGR WWEPSGKAEP 
       160        170        180        190        200
HVLGRVFIHP ESPSTGHYWM HQPVSFYKLK LTNNTLDQEG HIILHSMHRY 
       210        220        230        240        250
LPRLHLVPAE KAVEVIQLNG PGVHTFTFPQ TEFFAVTAYQ NIQITQLKID 
       260        270        280        290        300
YNPFAKGFRD DGLNNKPQRD GKQKNSSDQE GNNISSSSGH RVRLTEGQGS 
       310        320        330        340        350
EIQPGDLDPL SRGHETSGKG LEKTSLNIKR DFLGFMDTDS ALSEVPQLKQ 
       360        370        380        390        400
EISECLIASS FEDDSRVASP LDQNGSFNVV IKEEPLDDYD YELGECPEGV 
       410        420        430        440        450
TVKQEETDEE TDVYSNSDDD PILEKQLKRH NKVDNPEADH LSSKWLPSSP 
       460        470        480        490        500
SGVAKAKMFK LDTGKMPVVY LEPCAVTRST VKISELPDNM LSTSRKDKSS 
       510        520        530        540        550
MLAELEYLPT YIENSNETAF CLGKESENGL RKHSPDLRVV QKYPLLKEPQ 
       560        570        580        590        600
WKYPDISDSI STERILDDSK DSVGDSLSGK EDLGRKRTTM LKIATAAKVV 
       610        620        630        640        650
NANQNASPNV PGKRGRPRKL KLCKAGRPPK NTGKSLISTK NTPVSPGSTF 
       660        670        680        690        700
PDVKPDLEDV DGVLFVSFES KEALDIHAVD GTTEESSSLQ ASTTNDSGYR 
       710        720        730        740        750
ARISQLEKEL IEDLKTLRHK QVIHPGLQEV GLKLNSVDPT MSIDLKYLGV 
       760        770        780        790        800
QLPLAPATSF PFWNLTGTNP ASPDAGFPFV SRTGKTNDFT KIKGWRGKFH 
       810        820        830        840        850
SASASRNEGG NSESSLKNRS AFCSDKLDEY LENEGKLMET SMGFSSNAPT 
       860        870        880        890        900
SPVVYQLPTK STSYVRTLDS VLKKQSTISP STSYSLKPHS VPPVSRKAKS 
       910        920        930        940        950
QNRQATFSGR TKSSYKSILP YPVSPKQKYS HVILGDKVTK NSSGIISENQ 
       960        970        980        990       1000
ANNFVVPTLD ENIFPKQISL RQAQQQQQQQ QGSRPPGLSK SQVKLMDLED 
      1010       1020       1030       1040       1050
CALWEGKPRT YITEERADVS LTTLLTAQAS LKTKPIHTII RKRAPPCNND 
      1060       1070       1080       1090       1100
FCRLGCVCSS LALEKRQPAH CRRPDCMFGC TCLKRKVVLV KGGSKTKHFQ 
      1110       1120       1130       1140       1150
RKAAHRDPVF YDTLGEEARE EEEGIREEEE QLKEKKKRKK LEYTICETEP 
      1160       1170       1180       1190       1200
EQPVRHYPLW VKVEGEVDPE PVYIPTPSVI EPMKPLLLPQ PEVLSPTVKG 
      1210       1220       1230       1240       1250
KLLTGIKSPR SYTPKPNPVI REEDKDPVYL YFESMMTCAR VRVYERKKED 
      1260       1270       1280       1290       1300
QRQPSSSSSP SPSFQQQTSC HSSPENHNNA KEPDSEQQPL KQLTCDLEDD 
      1310       1320       1330       1340       1350
SDKLQEKSWK SSCNEGESSS TSYMHQRSPG GPTKLIEIIS DCNWEEDRNK 
      1360       1370       1380       1390       1400
ILSILSQHIN SNMPQSLKVG SFIIELASQR KSRGEKNPPV YSSRVKISMP 
      1410       1420       1430       1440       1450
SCQDQDDMAE KSGSETPDGP LSPGKMEDIS PVQTDALDSV RERLHGGKGL 
      1460       1470       1480       1490       1500
PFYAGLSPAG KLVAYKRKPS SSTSGLIQVA SNAKVAASRK PRTLLPSTSN 
      1510       1520       1530       1540       1550
SKMASSSGTA TNRPGKNLKA FVPAKRPIAA RPSPGGVFTQ FVMSKVGALQ 
      1560       1570       1580       1590       1600
QKIPGVSTPQ TLAGTQKFSI RPSPVMVVTP VVSSEPVQVC SPVTAAVTTT 
      1610       1620       1630       1640       1650
TPQVFLENTT AVTPMTAISD VETKETTYSS GATTTGVVEV SETNTSTSVT 
      1660       1670       1680       1690       1700
STQSTATVNL TKTTGITTPV ASVAFPKSLV ASPSTITLPV ASTASTSLVV 
      1710       1720       1730       1740       1750
VTAAASSSMV TTPTSSLGSV PIILSGINGS PPVSQRPENA AQIPVATPQV 
      1760       1770       1780       1790       1800
SPNTVKRAGP RLLLIPVQQG SPTLRPVSNT QLQGHRMVLQ PVRSPSGMNL 
      1810       1820       1830       1840       1850
FRHPNGQIVQ LLPLHQLRGS NTQPNLQPVM FRNPGSVMGI RLPAPSKPSE 
      1860       1870       1880       1890       1900
TPPSSTSSSA FSVMNPVIQA VGSSSAVNVI TQAPSLLSSG ASFVSQAGTL 
      1910       1920       1930       1940       1950
TLRISPPEPQ SFASKTGSET KITYSSGGQP VGTASLIPLQ SGSFALLQLP 
      1960       1970       1980       1990       2000
GQKPVPSSIL QHVASLQMKR ESQNPDQKDE TNSIKREQET KKVLQSEGEA 
      2010       2020       2030       2040       2050
VDPEANVIKQ NSGAATSEET LNDSLEDRGD HLDEECLPEE GCATVKPSEH 
      2060       2070       2080       2090       2100
SCITGSHTDQ DYKDVNEEYG ARNRKSSKEK VAVLEVRTIS EKASNKTVQN 
      2110       2120       2130       2140       2150
LSKVQHQKLG DVKVEQQKGF DNPEENSSEF PVTFKEESKF ELSGSKVMEQ 
      2160       2170       2180       2190       2200
QSNLQPEAKE KECGDSLEKD RERWRKHLKG PLTRKCVGAS QECKKEADEQ 
      2210       2220       2230       2240       2250
LIKETKTCQE NSDVFQQEQG ISDLLGKSGI TEDARVLKTE CDSWSRISNP 
      2260       2270       2280       2290       2300
SAFSIVPRRA AKSSRGNGHF QGHLLLPGEQ IQPKQEKKGG RSSADFTVLD 
      2310       2320       2330       2340       2350
LEEDDEDDNE KTDDSIDEIV DVVSDYQSEE VDDVEKNNCV EYIEDDEEHV 
      2360       2370       2380       2390       2400
DIETVEELSE EINVAHLKTT AAHTQSFKQP SCTHISADEK AAERSRKAPP 
      2410       2420       2430       2440       2450
IPLKLKPDYW SDKLQKEAEA FAYYRRTHTA NERRRRGEMR DLFEKLKITL 
      2460       2470       2480       2490       2500
GLLHSSKVSK SLILTRAFSE IQGLTDQADK LIGQKNLLTR KRNILIRKVS 
      2510       2520       2530       2540       2550
SLSGKTEEVV LKKLEYIYAK QQALEAQKRK KKMGSDEFDI SPRISKQQEG 
      2560       2570       2580       2590       2600
SSASSVDLGQ MFINNRRGKP LILSRKKDQA TENTSPLNTP HTSANLVMTP 
      2610       2620       2630       2640       2650
QGQLLTLKGP LFSGPVVAVS PDLLESDLKP QVAGSAVALP ENDDLFMMPR 
      2660       2670       2680       2690       2700
IVNVTSLATE GGLVDMGGSK YPHEVPDSKP SDHLKDTVRN EDNSLEDKGR 
      2710       2720       2730       2740       2750
ISSRGNRDGR VTLGPTQVFL ANKDSGYPQI VDVSNMQKAQ EFLPKKISGD 
      2760       2770       2780       2790       2800
MRGIQYKWKE SESRGERVKS KDSSFHKLKM KDLKDSSIEM ELRKVTSAIE 
      2810       2820       2830       2840       2850
EAALDSSELL TNMEDEDDTD ETLTSLLNEI AFLNQQLNDD SVGLAELPSS 
      2860       2870       2880       2890       2900
MDTEFPGDAR RAFISKVPPG SRATFQVEHL GTGLKELPDV QGESDSISPL 
      2910       2920       2930       2940       2950
LLHLEDDDFS ENEKQLAEPA SEPDVLKIVI DSEIKDSLLS NKKAIDGGKN 
      2960       2970       2980       2990       3000
TSGLPAEPES VSSPPTLHMK TGLENSNSTD TLWRPMPKLA PLGLKVANPS 
      3010       3020       3030       3040       3050
SDADGQSLKV MPCLAPIAAK VGSVGHKMNL TGNDQEGRES KVMPTLAPVV 
      3060 
AKLGNSGASP SSAGK
Length:3,065
Mass (Da):336,159
Last modified:June 5, 2019 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i430B04B7ED92B4A8
GO
Isoform 2 (identifier: Q8IWI9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1529-1737: Missing.

Show »
Length:2,856
Mass (Da):315,219
Checksum:iE79165E8AF0C9FE6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BP52H3BP52_HUMAN
MAX gene-associated protein
MGA
1,097Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8C8P5L8A0A8C8P5L8_HUMAN
MAX gene-associated protein
MGA
2,574Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BU53H3BU53_HUMAN
MAX gene-associated protein
MGA
1,174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8C8NNX8A0A8C8NNX8_HUMAN
MAX gene-associated protein
MGA
1,021Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14186 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14543 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti266K → N in BAB14186 (PubMed:14702039).Curated1
Sequence conflicti742S → R in BAB14186 (PubMed:14702039).Curated1
Sequence conflicti1383R → P in AAI36660 (PubMed:15489334).Curated1
Sequence conflicti2230Missing in BAB14543 (PubMed:14702039).Curated1
Sequence conflicti2365A → T in BAB14543 (PubMed:14702039).Curated1
Sequence conflicti2744P → L in AAI36660 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044341338T → A. Corresponds to variant dbSNP:rs3803348EnsemblClinVar.1
Natural variantiVAR_044342716T → S. Corresponds to variant dbSNP:rs2178004Ensembl.1
Natural variantiVAR_0443431270C → R. Corresponds to variant dbSNP:rs17677811Ensembl.1
Natural variantiVAR_0572681523P → A. Corresponds to variant dbSNP:rs17677991Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0601771529 – 1737Missing in isoform 2. Add BLAST209

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC016134 Genomic DNA No translation available.
AC073657 Genomic DNA No translation available.
BC136659 mRNA Translation: AAI36660.1
AK022696 mRNA Translation: BAB14186.1 Different initiation.
AK023360 mRNA Translation: BAB14543.1 Different initiation.
AB011090 mRNA Translation: BAA25444.1
AL050181 mRNA Translation: CAB43310.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55959.1 [Q8IWI9-4]
CCDS55960.1 [Q8IWI9-3]

Protein sequence database of the Protein Information Resource

More...PIRi		T00081

NCBI Reference Sequences

More...RefSeqi		NP_001074010.2, NM_001080541.2 [Q8IWI9-3]
NP_001157745.1, NM_001164273.1 [Q8IWI9-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000219905.13; ENSP00000219905.7; ENSG00000174197.18
ENST00000566586.6; ENSP00000456141.1; ENSG00000174197.18 [Q8IWI9-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23269

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23269

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000219905.13; ENSP00000219905.7; NM_001164273.2; NP_001157745.1

UCSC genome browser

More...UCSCi		uc010ucy.2, human [Q8IWI9-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016134 Genomic DNA No translation available.
AC073657 Genomic DNA No translation available.
BC136659 mRNA Translation: AAI36660.1
AK022696 mRNA Translation: BAB14186.1 Different initiation.
AK023360 mRNA Translation: BAB14543.1 Different initiation.
AB011090 mRNA Translation: BAA25444.1
AL050181 mRNA Translation: CAB43310.1
CCDSiCCDS55959.1 [Q8IWI9-4]
CCDS55960.1 [Q8IWI9-3]
PIRiT00081
RefSeqiNP_001074010.2, NM_001080541.2 [Q8IWI9-3]
NP_001157745.1, NM_001164273.1 [Q8IWI9-4]

3D structure databases

SMRiQ8IWI9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116870, 157 interactors
CORUMiQ8IWI9
DIPiDIP-57615N
ELMiQ8IWI9
IntActiQ8IWI9, 104 interactors
MINTiQ8IWI9
STRINGi9606.ENSP00000219905

PTM databases

CarbonylDBiQ8IWI9
GlyConnecti2859, 1 O-Linked glycan (1 site)
GlyGeniQ8IWI9, 6 sites, 1 O-linked glycan (6 sites)
iPTMnetiQ8IWI9
PhosphoSitePlusiQ8IWI9

Genetic variation databases

BioMutaiMGA
DMDMi527504082

Proteomic databases

EPDiQ8IWI9
jPOSTiQ8IWI9
MassIVEiQ8IWI9
MaxQBiQ8IWI9
PaxDbiQ8IWI9
PeptideAtlasiQ8IWI9
PRIDEiQ8IWI9
ProteomicsDBi17160
27509

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		6067, 84 antibodies from 16 providers

Genome annotation databases

EnsembliENST00000219905.13; ENSP00000219905.7; ENSG00000174197.18
ENST00000566586.6; ENSP00000456141.1; ENSG00000174197.18 [Q8IWI9-3]
GeneIDi23269
KEGGihsa:23269
MANE-SelectiENST00000219905.13; ENSP00000219905.7; NM_001164273.2; NP_001157745.1
UCSCiuc010ucy.2, human [Q8IWI9-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23269
DisGeNETi23269

GeneCards: human genes, protein and diseases

More...GeneCardsi		MGA
HGNCiHGNC:14010, MGA
HPAiENSG00000174197, Tissue enhanced (brain)
MalaCardsiMGA
MIMi616061, gene
neXtProtiNX_Q8IWI9
OpenTargetsiENSG00000174197
PharmGKBiPA134976336
VEuPathDBiHostDB:ENSG00000174197

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3585, Eukaryota
GeneTreeiENSGT00940000156269
HOGENOMiCLU_000469_1_0_1
InParanoidiQ8IWI9
OMAiFQRKATH
OrthoDBi1201455at2759
TreeFamiTF106341

Enzyme and pathway databases

PathwayCommonsiQ8IWI9
ReactomeiR-HSA-8953750, Transcriptional Regulation by E2F6
SignaLinkiQ8IWI9
SIGNORiQ8IWI9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23269, 42 hits in 1101 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MGA, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23269
PharosiQ8IWI9, Tbio

Protein Ontology

More...PROi		PR:Q8IWI9
RNActiQ8IWI9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000174197, Expressed in corpus callosum and 241 other tissues
ExpressionAtlasiQ8IWI9, baseline and differential
GenevisibleiQ8IWI9, HS

Family and domain databases

CDDicd00182, TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
IPR037935, MAX_gene-associated_protein
IPR032060, MGA_dom
IPR008967, p53-like_TF_DNA-bd
IPR046360, T-box_DNA-bd
IPR036960, T-box_sf
IPR001699, TF_T-box
IPR018186, TF_T-box_CS
PANTHERiPTHR11267, PTHR11267, 1 hit
PTHR11267:SF32, PTHR11267:SF32, 1 hit
PfamiView protein in Pfam
PF16059, DUF4801, 1 hit
PF00010, HLH, 1 hit
PF00907, T-box, 1 hit
PRINTSiPR00937, TBOX
SMARTiView protein in SMART
SM00353, HLH, 1 hit
SM00425, TBOX, 1 hit
SUPFAMiSSF47459, SSF47459, 1 hit
SSF49417, SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit
PS01264, TBOX_2, 1 hit
PS50252, TBOX_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGAP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWI9
Secondary accession number(s): B9EGR5
, E7ENI0, F5H7K2, Q9H8R3, Q9H9N7, Q9UG69, Q9Y4E9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 5, 2019
Last modified: May 25, 2022
This is version 161 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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