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UniProtKB - Q8IWI9 (MGAP_HUMAN)

Protein

MAX gene-associated protein

Gene

MGA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi84 – 260T-boxPROSITE-ProRule annotationAdd BLAST177

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-8953750 Transcriptional Regulation by E2F6
SIGNORiQ8IWI9

Names & Taxonomyi

Protein namesi
Recommended name:
MAX gene-associated protein
Alternative name(s):
MAX dimerization protein 5
Gene namesi
Name:MGA
Synonyms:KIAA0518, MAD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000174197.16
HGNCiHGNC:14010 MGA
MIMi616061 gene
neXtProtiNX_Q8IWI9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23269
OpenTargetsiENSG00000174197
PharmGKBiPA134976336

Polymorphism and mutation databases

BioMutaiMGA
DMDMi527504082

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003426921 – 3026MAX gene-associated proteinAdd BLAST3026

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki323Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki329Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki349Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki432Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki460Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki465Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki482Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei534PhosphoserineCombined sources1
Cross-linki570Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei607PhosphoserineCombined sources1
Cross-linki613Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei645PhosphoserineCombined sources1
Cross-linki654Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki791Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki817Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki826Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei851PhosphoserineCombined sources1
Modified residuei924PhosphoserineCombined sources1
Cross-linki928Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki990Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1091Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1140Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1199Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1207Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1208PhosphoserineCombined sources1
Modified residuei1430PhosphoserineCombined sources1
Modified residuei1457PhosphoserineCombined sources1
Cross-linki1461Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1502Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1946Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1953Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2064Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2074Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2096Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2100Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2107Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2155Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2199Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2226Omega-N-methylarginineCombined sources1
Cross-linki2245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2374Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2418Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2493Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2502PhosphoserineCombined sources1
Cross-linki2507Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2590Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2640Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2659Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki2745Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2871PhosphoserineCombined sources1
Modified residuei2882PhosphoserineCombined sources1
Modified residuei2939PhosphoserineCombined sources1
Cross-linki3002Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 3 (identifier: Q8IWI9-3)
Modified residuei1552Asymmetric dimethylarginineCombined sources1
Modified residuei1566Asymmetric dimethylarginineCombined sources1
Isoform 4 (identifier: Q8IWI9-4)
Modified residuei1761Asymmetric dimethylarginineCombined sources1
Modified residuei1775Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IWI9
MaxQBiQ8IWI9
PaxDbiQ8IWI9
PeptideAtlasiQ8IWI9
PRIDEiQ8IWI9
ProteomicsDBi70860
70861 [Q8IWI9-2]

PTM databases

CarbonylDBiQ8IWI9
iPTMnetiQ8IWI9
PhosphoSitePlusiQ8IWI9

Expressioni

Gene expression databases

BgeeiENSG00000174197 Expressed in 229 organ(s), highest expression level in corpus callosum
CleanExiHS_MGA
ExpressionAtlasiQ8IWI9 baseline and differential
GenevisibleiQ8IWI9 HS

Organism-specific databases

HPAiHPA042278
HPA058183

Interactioni

Subunit structurei

Interacts with MAX. Requires dimerization with MAX for E-box binding (By similarity). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ZMYND11.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAXP612444EBI-2815196,EBI-751711

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi116870, 60 interactors
CORUMiQ8IWI9
DIPiDIP-57615N
ELMiQ8IWI9
IntActiQ8IWI9, 47 interactors
MINTiQ8IWI9
STRINGi9606.ENSP00000219905

Structurei

3D structure databases

ProteinModelPortaliQ8IWI9
SMRiQ8IWI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2384 – 2435bHLHPROSITE-ProRule annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1111 – 1147Sequence analysisAdd BLAST37
Coiled coili2778 – 2802Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi967 – 981Gln-richAdd BLAST15
Compositional biasi1255 – 1263Poly-Ser9
Compositional biasi1594 – 1714Thr-richAdd BLAST121

Domaini

Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00900000140847
HOGENOMiHOG000113578
HOVERGENiHBG108131
InParanoidiQ8IWI9
OMAiMQEAQEF
OrthoDBiEOG091G0I8R
TreeFamiTF106341

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR032060 DUF4801
IPR036638 HLH_DNA-bd_sf
IPR037935 MAX_gene-associated_protein
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 2 hits
PTHR11267:SF32 PTHR11267:SF32, 2 hits
PfamiView protein in Pfam
PF16059 DUF4801, 1 hit
PF00010 HLH, 1 hit
PF00907 T-box, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00425 TBOX, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IWI9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEKQQIILA NQDGGTVAGA APTFFVILKQ PGNGKTDQGI LVTNQDACAL 
        60         70         80         90        100
ASSVSSPVKS KGKICLPADC TVGGITVTLD NNSMWNEFYH RSTEMILTKQ 
       110        120        130        140        150
GRRMFPYCRY WITGLDSNLK YILVMDISPV DNHRYKWNGR WWEPSGKAEP 
       160        170        180        190        200
HVLGRVFIHP ESPSTGHYWM HQPVSFYKLK LTNNTLDQEG HIILHSMHRY 
       210        220        230        240        250
LPRLHLVPAE KAVEVIQLNG PGVHTFTFPQ TEFFAVTAYQ NIQITQLKID 
       260        270        280        290        300
YNPFAKGFRD DGLNNKPQRD GKQKNSSDQE GNNISSSSGH RVRLTEGQGS 
       310        320        330        340        350
EIQPGDLDPL SRGHETSGKG LEKTSLNIKR DFLGFMDTDS ALSEVPQLKQ 
       360        370        380        390        400
EISECLIASS FEDDSRVASP LDQNGSFNVV IKEEPLDDYD YELGECPEGV 
       410        420        430        440        450
TVKQEETDEE TDVYSNSDDD PILEKQLKRH NKVDNPEADH LSSKWLPSSP 
       460        470        480        490        500
SGVAKAKMFK LDTGKMPVVY LEPCAVTRST VKISELPDNM LSTSRKDKSS 
       510        520        530        540        550
MLAELEYLPT YIENSNETAF CLGKESENGL RKHSPDLRVV QKYPLLKEPQ 
       560        570        580        590        600
WKYPDISDSI STERILDDSK DSVGDSLSGK EDLGRKRTTM LKIATAAKVV 
       610        620        630        640        650
NANQNASPNV PGKRGRPRKL KLCKAGRPPK NTGKSLISTK NTPVSPGSTF 
       660        670        680        690        700
PDVKPDLEDV DGVLFVSFES KEALDIHAVD GTTEESSSLQ ASTTNDSGYR 
       710        720        730        740        750
ARISQLEKEL IEDLKTLRHK QVIHPGLQEV GLKLNSVDPT MSIDLKYLGV 
       760        770        780        790        800
QLPLAPATSF PFWNLTGTNP ASPDAGFPFV SRTGKTNDFT KIKGWRGKFH 
       810        820        830        840        850
SASASRNEGG NSESSLKNRS AFCSDKLDEY LENEGKLMET SMGFSSNAPT 
       860        870        880        890        900
SPVVYQLPTK STSYVRTLDS VLKKQSTISP STSYSLKPHS VPPVSRKAKS 
       910        920        930        940        950
QNRQATFSGR TKSSYKSILP YPVSPKQKYS HVILGDKVTK NSSGIISENQ 
       960        970        980        990       1000
ANNFVVPTLD ENIFPKQISL RQAQQQQQQQ QGSRPPGLSK SQVKLMDLED 
      1010       1020       1030       1040       1050
CALWEGKPRT YITEERADVS LTTLLTAQAS LKTKPIHTII RKRAPPCNND 
      1060       1070       1080       1090       1100
FCRLGCVCSS LALEKRQPAH CRRPDCMFGC TCLKRKVVLV KGGSKTKHFQ 
      1110       1120       1130       1140       1150
RKAAHRDPVF YDTLGEEARE EEEGIREEEE QLKEKKKRKK LEYTICETEP 
      1160       1170       1180       1190       1200
EQPVRHYPLW VKVEGEVDPE PVYIPTPSVI EPMKPLLLPQ PEVLSPTVKG 
      1210       1220       1230       1240       1250
KLLTGIKSPR SYTPKPNPVI REEDKDPVYL YFESMMTCAR VRVYERKKED 
      1260       1270       1280       1290       1300
QRQPSSSSSP SPSFQQQTSC HSSPENHNNA KEPDSEQQPL KQLTCDLEDD 
      1310       1320       1330       1340       1350
SDKLQEKSWK SSCNEGESSS TSYMHQRSPG GPTKLIEIIS DCNWEEDRNK 
      1360       1370       1380       1390       1400
ILSILSQHIN SNMPQSLKVG SFIIELASQR KSRGEKNPPV YSSRVKISMP 
      1410       1420       1430       1440       1450
SCQDQDDMAE KSGSETPDGP LSPGKMEDIS PVQTDALDSV RERLHGGKGL 
      1460       1470       1480       1490       1500
PFYAGLSPAG KLVAYKRKPS SSTSGLIQVA SNAKVAASRK PRTLLPSTSN 
      1510       1520       1530       1540       1550
SKMASSSGTA TNRPGKNLKA FVPAKRPIAA RPSPGGVFTQ FVMSKVGALQ 
      1560       1570       1580       1590       1600
QKIPGVSTPQ TLAGTQKFSI RPSPVMVVTP VVSSEPVQVC SPVTAAVTTT 
      1610       1620       1630       1640       1650
TPQVFLENTT AVTPMTAISD VETKETTYSS GATTTGVVEV SETNTSTSVT 
      1660       1670       1680       1690       1700
STQSTATVNL TKTTGITTPV ASVAFPKSLV ASPSTITLPV ASTASTSLVV 
      1710       1720       1730       1740       1750
VTAAASSSMV TTPTSSLGSV PIILSGINGS PPVSQRPENA AQIPVATPQV 
      1760       1770       1780       1790       1800
SPNTVKRAGP RLLHPNGQIV QLLPLHQLRG SNTQPNLQPV MFRNPGSVMG 
      1810       1820       1830       1840       1850
IRLPAPSKPS ETPPSSTSSS AFSVMNPVIQ AVGSSSAVNV ITQAPSLLSS 
      1860       1870       1880       1890       1900
GASFVSQAGT LTLRISPPEP QSFASKTGSE TKITYSSGGQ PVGTASLIPL 
      1910       1920       1930       1940       1950
QSGSFALLQL PGQKPVPSSI LQHVASLQMK RESQNPDQKD ETNSIKREQE 
      1960       1970       1980       1990       2000
TKKVLQSEGE AVDPEANVIK QNSGAATSEE TLNDSLEDRG DHLDEECLPE 
      2010       2020       2030       2040       2050
EGCATVKPSE HSCITGSHTD QDYKDVNEEY GARNRKSSKE KVAVLEVRTI 
      2060       2070       2080       2090       2100
SEKASNKTVQ NLSKVQHQKL GDVKVEQQKG FDNPEENSSE FPVTFKEESK 
      2110       2120       2130       2140       2150
FELSGSKVME QQSNLQPEAK EKECGDSLEK DRERWRKHLK GPLTRKCVGA 
      2160       2170       2180       2190       2200
SQECKKEADE QLIKETKTCQ ENSDVFQQEQ GISDLLGKSG ITEDARVLKT 
      2210       2220       2230       2240       2250
ECDSWSRISN PSAFSIVPRR AAKSSRGNGH FQGHLLLPGE QIQPKQEKKG 
      2260       2270       2280       2290       2300
GRSSADFTVL DLEEDDEDDN EKTDDSIDEI VDVVSDYQSE EVDDVEKNNC 
      2310       2320       2330       2340       2350
VEYIEDDEEH VDIETVEELS EEINVAHLKT TAAHTQSFKQ PSCTHISADE 
      2360       2370       2380       2390       2400
KAAERSRKAP PIPLKLKPDY WSDKLQKEAE AFAYYRRTHT ANERRRRGEM 
      2410       2420       2430       2440       2450
RDLFEKLKIT LGLLHSSKVS KSLILTRAFS EIQGLTDQAD KLIGQKNLLT 
      2460       2470       2480       2490       2500
RKRNILIRKV SSLSGKTEEV VLKKLEYIYA KQQALEAQKR KKKMGSDEFD 
      2510       2520       2530       2540       2550
ISPRISKQQE GSSASSVDLG QMFINNRRGK PLILSRKKDQ ATENTSPLNT 
      2560       2570       2580       2590       2600
PHTSANLVMT PQGQLLTLKG PLFSGPVVAV SPDLLESDLK PQVAGSAVAL 
      2610       2620       2630       2640       2650
PENDDLFMMP RIVNVTSLAT EGGLVDMGGS KYPHEVPDSK PSDHLKDTVR 
      2660       2670       2680       2690       2700
NEDNSLEDKG RISSRGNRDG RVTLGPTQVF LANKDSGYPQ IVDVSNMQKA 
      2710       2720       2730       2740       2750
QEFLPKKISG DMRGIQYKWK ESESRGERVK SKDSSFHKLK MKDLKDSSIE 
      2760       2770       2780       2790       2800
MELRKVTSAI EEAALDSSEL LTNMEDEDDT DETLTSLLNE IAFLNQQLND 
      2810       2820       2830       2840       2850
DSVGLAELPS SMDTEFPGDA RRAFISKVPP GSRATFQVEH LGTGLKELPD 
      2860       2870       2880       2890       2900
VQGESDSISP LLLHLEDDDF SENEKQLAEP ASEPDVLKIV IDSEIKDSLL 
      2910       2920       2930       2940       2950
SNKKAIDGGK NTSGLPAEPE SVSSPPTLHM KTGLENSNST DTLWRPMPKL 
      2960       2970       2980       2990       3000
APLGLKVANP SSDADGQSLK VMPCLAPIAA KVGSVGHKMN LTGNDQEGRE 
      3010       3020 
SKVMPTLAPV VAKLGNSGAS PSSAGK
Length:3,026
Mass (Da):331,836
Last modified:July 24, 2013 - v3
Checksum:i33D363321F6E40CD
GO
Isoform 2 (identifier: Q8IWI9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1790: Missing.
     2488-3026: Missing.

Note: No experimental confirmation available.
Show »
Length:697
Mass (Da):77,234
Checksum:i6F8E87B777DD16BE
GO
Isoform 3 (identifier: Q8IWI9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1529-1763: AARPSPGGVF...TVKRAGPRLL → ENAAQIPVAT...RSPSGMNLFR

Note: No experimental confirmation available.Combined sources
Show »
Length:2,856
Mass (Da):315,219
Checksum:iE79165E8AF0C9FE6
GO
Isoform 4 (identifier: Q8IWI9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1763-1763: L → LLIPVQQGSPTLRPVSNTQLQGHRMVLQPVRSPSGMNLFR

Note: No experimental confirmation available.Combined sources
Show »
Length:3,065
Mass (Da):336,159
Checksum:i430B04B7ED92B4A8
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BTF4H3BTF4_HUMAN
MAX gene-associated protein
MGA
1,138Annotation score:
H3BP52H3BP52_HUMAN
MAX gene-associated protein
MGA
1,086Annotation score:
H3BU53H3BU53_HUMAN
MAX gene-associated protein
MGA
1,174Annotation score:
H3BTN2H3BTN2_HUMAN
MAX gene-associated protein
MGA
83Annotation score:
A0A087X194A0A087X194_HUMAN
MAX gene-associated protein
MGA
61Annotation score:

Sequence cautioni

The sequence BAB14186 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti266K → N in BAB14186 (PubMed:14702039).Curated1
Sequence conflicti742S → R in BAB14186 (PubMed:14702039).Curated1
Sequence conflicti1138R → K in AAH38449 (PubMed:15489334).Curated1
Sequence conflicti2191Missing in BAB14543 (PubMed:14702039).Curated1
Sequence conflicti2326A → T in BAB14543 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044341338T → A. Corresponds to variant dbSNP:rs3803348Ensembl.1
Natural variantiVAR_044342716T → S. Corresponds to variant dbSNP:rs2178004Ensembl.1
Natural variantiVAR_0443431270C → R. Corresponds to variant dbSNP:rs17677811Ensembl.1
Natural variantiVAR_0572681523P → A. Corresponds to variant dbSNP:rs17677991Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0345341 – 1790Missing in isoform 2. 1 PublicationAdd BLAST1790
Alternative sequenceiVSP_0476691529 – 1763AARPS…GPRLL → ENAAQIPVATPQVSPNTVKR AGPRLLLIPVQQGSPTLRPV SNTQLQGHRMVLQPVRSPSG MNLFR in isoform 3. CuratedAdd BLAST235
Alternative sequenceiVSP_0476701763L → LLIPVQQGSPTLRPVSNTQL QGHRMVLQPVRSPSGMNLFR in isoform 4. Curated1
Alternative sequenceiVSP_0345352488 – 3026Missing in isoform 2. 1 PublicationAdd BLAST539

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022696 mRNA Translation: BAB14186.1 Different initiation.
AK023360 mRNA Translation: BAB14543.1
AC016134 Genomic DNA No translation available.
AC073657 Genomic DNA No translation available.
BC038449 mRNA Translation: AAH38449.1
AB011090 mRNA Translation: BAA25444.1
AL050181 mRNA Translation: CAB43310.1
CCDSiCCDS55959.1 [Q8IWI9-4]
CCDS55960.1 [Q8IWI9-3]
PIRiT00081
RefSeqiNP_001074010.2, NM_001080541.2 [Q8IWI9-3]
NP_001157745.1, NM_001164273.1 [Q8IWI9-4]
UniGeneiHs.187569

Genome annotation databases

EnsembliENST00000219905; ENSP00000219905; ENSG00000174197 [Q8IWI9-4]
ENST00000545763; ENSP00000442467; ENSG00000174197 [Q8IWI9-3]
ENST00000566586; ENSP00000456141; ENSG00000174197 [Q8IWI9-3]
ENST00000570161; ENSP00000457035; ENSG00000174197 [Q8IWI9-4]
GeneIDi23269
KEGGihsa:23269
UCSCiuc010ucy.2 human [Q8IWI9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022696 mRNA Translation: BAB14186.1 Different initiation.
AK023360 mRNA Translation: BAB14543.1
AC016134 Genomic DNA No translation available.
AC073657 Genomic DNA No translation available.
BC038449 mRNA Translation: AAH38449.1
AB011090 mRNA Translation: BAA25444.1
AL050181 mRNA Translation: CAB43310.1
CCDSiCCDS55959.1 [Q8IWI9-4]
CCDS55960.1 [Q8IWI9-3]
PIRiT00081
RefSeqiNP_001074010.2, NM_001080541.2 [Q8IWI9-3]
NP_001157745.1, NM_001164273.1 [Q8IWI9-4]
UniGeneiHs.187569

3D structure databases

ProteinModelPortaliQ8IWI9
SMRiQ8IWI9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116870, 60 interactors
CORUMiQ8IWI9
DIPiDIP-57615N
ELMiQ8IWI9
IntActiQ8IWI9, 47 interactors
MINTiQ8IWI9
STRINGi9606.ENSP00000219905

PTM databases

CarbonylDBiQ8IWI9
iPTMnetiQ8IWI9
PhosphoSitePlusiQ8IWI9

Polymorphism and mutation databases

BioMutaiMGA
DMDMi527504082

Proteomic databases

EPDiQ8IWI9
MaxQBiQ8IWI9
PaxDbiQ8IWI9
PeptideAtlasiQ8IWI9
PRIDEiQ8IWI9
ProteomicsDBi70860
70861 [Q8IWI9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219905; ENSP00000219905; ENSG00000174197 [Q8IWI9-4]
ENST00000545763; ENSP00000442467; ENSG00000174197 [Q8IWI9-3]
ENST00000566586; ENSP00000456141; ENSG00000174197 [Q8IWI9-3]
ENST00000570161; ENSP00000457035; ENSG00000174197 [Q8IWI9-4]
GeneIDi23269
KEGGihsa:23269
UCSCiuc010ucy.2 human [Q8IWI9-1]

Organism-specific databases

CTDi23269
DisGeNETi23269
EuPathDBiHostDB:ENSG00000174197.16
GeneCardsiMGA
H-InvDBiHIX0012158
HGNCiHGNC:14010 MGA
HPAiHPA042278
HPA058183
MIMi616061 gene
neXtProtiNX_Q8IWI9
OpenTargetsiENSG00000174197
PharmGKBiPA134976336
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00900000140847
HOGENOMiHOG000113578
HOVERGENiHBG108131
InParanoidiQ8IWI9
OMAiMQEAQEF
OrthoDBiEOG091G0I8R
TreeFamiTF106341

Enzyme and pathway databases

ReactomeiR-HSA-8953750 Transcriptional Regulation by E2F6
SIGNORiQ8IWI9

Miscellaneous databases

ChiTaRSiMGA human
GenomeRNAii23269
PROiPR:Q8IWI9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174197 Expressed in 229 organ(s), highest expression level in corpus callosum
CleanExiHS_MGA
ExpressionAtlasiQ8IWI9 baseline and differential
GenevisibleiQ8IWI9 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR032060 DUF4801
IPR036638 HLH_DNA-bd_sf
IPR037935 MAX_gene-associated_protein
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 2 hits
PTHR11267:SF32 PTHR11267:SF32, 2 hits
PfamiView protein in Pfam
PF16059 DUF4801, 1 hit
PF00010 HLH, 1 hit
PF00907 T-box, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00425 TBOX, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMGAP_HUMAN
AccessioniPrimary (citable) accession number: Q8IWI9
Secondary accession number(s): E7ENI0
, F5H7K2, Q9H8R3, Q9H9N7, Q9UG69, Q9Y4E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 24, 2013
Last modified: November 7, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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