UniProtKB - Q8IWI9 (MGAP_HUMAN)
MAX gene-associated protein
MGA
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 84 – 260 | T-boxPROSITE-ProRule annotationAdd BLAST | 177 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- protein dimerization activity Source: InterPro
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cell fate specification Source: GO_Central
- negative regulation of G0 to G1 transition Source: Reactome
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q8IWI9 |
Reactomei | R-HSA-8953750, Transcriptional Regulation by E2F6 |
SIGNORi | Q8IWI9 |
Names & Taxonomyi
Protein namesi | Recommended name: MAX gene-associated proteinAlternative name(s): MAX dimerization protein 5 |
Gene namesi | Name:MGA Synonyms:KIAA0518, MAD5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000174197.16 |
HGNCi | HGNC:14010, MGA |
MIMi | 616061, gene |
neXtProti | NX_Q8IWI9 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- MLL1 complex Source: UniProtKB
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: Reactome
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 23269 |
OpenTargetsi | ENSG00000174197 |
PharmGKBi | PA134976336 |
Miscellaneous databases
Pharosi | Q8IWI9, Tbio |
Polymorphism and mutation databases
BioMutai | MGA |
DMDMi | 527504082 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000342692 | 1 – 3065 | MAX gene-associated proteinAdd BLAST | 3065 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 4 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 178 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 323 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 329 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 349 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 432 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 460 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 465 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 482 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 534 | PhosphoserineCombined sources | 1 | |
Cross-linki | 570 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 607 | PhosphoserineCombined sources | 1 | |
Cross-linki | 613 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 645 | PhosphoserineCombined sources | 1 | |
Cross-linki | 654 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 785 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 791 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 817 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 826 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 851 | PhosphoserineCombined sources | 1 | |
Modified residuei | 924 | PhosphoserineCombined sources | 1 | |
Cross-linki | 928 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 990 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1091 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1140 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1162 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1199 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1207 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1208 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1430 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1457 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1461 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1502 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1985 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1992 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2103 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2113 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2135 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2139 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2146 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2159 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2194 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2206 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2238 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 2265 | Omega-N-methylarginineCombined sources | 1 | |
Cross-linki | 2284 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2378 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2413 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2457 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2532 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 2541 | PhosphoserineCombined sources | 1 | |
Cross-linki | 2546 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2629 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2679 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2698 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 2784 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 2910 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2921 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2978 | PhosphoserineCombined sources | 1 | |
Cross-linki | 3041 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8IWI9 |
jPOSTi | Q8IWI9 |
MassIVEi | Q8IWI9 |
MaxQBi | Q8IWI9 |
PaxDbi | Q8IWI9 |
PeptideAtlasi | Q8IWI9 |
PRIDEi | Q8IWI9 |
ProteomicsDBi | 17160 27509 |
PTM databases
CarbonylDBi | Q8IWI9 |
GlyConnecti | 2859, 1 O-Linked glycan (1 site) |
iPTMneti | Q8IWI9 |
PhosphoSitePlusi | Q8IWI9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000174197, Expressed in corpus callosum and 240 other tissues |
ExpressionAtlasi | Q8IWI9, baseline and differential |
Genevisiblei | Q8IWI9, HS |
Organism-specific databases
HPAi | ENSG00000174197, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MAX. Requires dimerization with MAX for E-box binding (By similarity).
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.
Interacts with ZMYND11.
By similarity2 PublicationsBinary interactionsi
Q8IWI9
With | #Exp. | IntAct |
---|---|---|
MAX [P61244] | 4 | EBI-2815196,EBI-751711 |
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 116870, 85 interactors |
CORUMi | Q8IWI9 |
DIPi | DIP-57615N |
ELMi | Q8IWI9 |
IntActi | Q8IWI9, 66 interactors |
MINTi | Q8IWI9 |
STRINGi | 9606.ENSP00000219905 |
Miscellaneous databases
RNActi | Q8IWI9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2423 – 2474 | bHLHPROSITE-ProRule annotationAdd BLAST | 52 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1111 – 1147 | Sequence analysisAdd BLAST | 37 | |
Coiled coili | 2817 – 2841 | Sequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 967 – 981 | Gln-richAdd BLAST | 15 | |
Compositional biasi | 1255 – 1263 | Poly-Ser | 9 | |
Compositional biasi | 1594 – 1714 | Thr-richAdd BLAST | 121 |
Domaini
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3585, Eukaryota |
GeneTreei | ENSGT00940000156269 |
HOGENOMi | CLU_000469_1_0_1 |
InParanoidi | Q8IWI9 |
OMAi | KERWRKH |
OrthoDBi | 1201455at2759 |
TreeFami | TF106341 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit cd00182, TBOX, 1 hit |
Gene3Di | 2.60.40.820, 1 hit 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR032060, DUF4801 IPR036638, HLH_DNA-bd_sf IPR037935, MAX_gene-associated_protein IPR008967, p53-like_TF_DNA-bd IPR036960, T-box_sf IPR001699, TF_T-box IPR018186, TF_T-box_CS |
PANTHERi | PTHR11267, PTHR11267, 2 hits PTHR11267:SF32, PTHR11267:SF32, 2 hits |
Pfami | View protein in Pfam PF16059, DUF4801, 1 hit PF00010, HLH, 1 hit PF00907, T-box, 1 hit |
PRINTSi | PR00937, TBOX |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00425, TBOX, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS01264, TBOX_2, 1 hit PS50252, TBOX_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEKQQIILA NQDGGTVAGA APTFFVILKQ PGNGKTDQGI LVTNQDACAL
60 70 80 90 100
ASSVSSPVKS KGKICLPADC TVGGITVTLD NNSMWNEFYH RSTEMILTKQ
110 120 130 140 150
GRRMFPYCRY WITGLDSNLK YILVMDISPV DNHRYKWNGR WWEPSGKAEP
160 170 180 190 200
HVLGRVFIHP ESPSTGHYWM HQPVSFYKLK LTNNTLDQEG HIILHSMHRY
210 220 230 240 250
LPRLHLVPAE KAVEVIQLNG PGVHTFTFPQ TEFFAVTAYQ NIQITQLKID
260 270 280 290 300
YNPFAKGFRD DGLNNKPQRD GKQKNSSDQE GNNISSSSGH RVRLTEGQGS
310 320 330 340 350
EIQPGDLDPL SRGHETSGKG LEKTSLNIKR DFLGFMDTDS ALSEVPQLKQ
360 370 380 390 400
EISECLIASS FEDDSRVASP LDQNGSFNVV IKEEPLDDYD YELGECPEGV
410 420 430 440 450
TVKQEETDEE TDVYSNSDDD PILEKQLKRH NKVDNPEADH LSSKWLPSSP
460 470 480 490 500
SGVAKAKMFK LDTGKMPVVY LEPCAVTRST VKISELPDNM LSTSRKDKSS
510 520 530 540 550
MLAELEYLPT YIENSNETAF CLGKESENGL RKHSPDLRVV QKYPLLKEPQ
560 570 580 590 600
WKYPDISDSI STERILDDSK DSVGDSLSGK EDLGRKRTTM LKIATAAKVV
610 620 630 640 650
NANQNASPNV PGKRGRPRKL KLCKAGRPPK NTGKSLISTK NTPVSPGSTF
660 670 680 690 700
PDVKPDLEDV DGVLFVSFES KEALDIHAVD GTTEESSSLQ ASTTNDSGYR
710 720 730 740 750
ARISQLEKEL IEDLKTLRHK QVIHPGLQEV GLKLNSVDPT MSIDLKYLGV
760 770 780 790 800
QLPLAPATSF PFWNLTGTNP ASPDAGFPFV SRTGKTNDFT KIKGWRGKFH
810 820 830 840 850
SASASRNEGG NSESSLKNRS AFCSDKLDEY LENEGKLMET SMGFSSNAPT
860 870 880 890 900
SPVVYQLPTK STSYVRTLDS VLKKQSTISP STSYSLKPHS VPPVSRKAKS
910 920 930 940 950
QNRQATFSGR TKSSYKSILP YPVSPKQKYS HVILGDKVTK NSSGIISENQ
960 970 980 990 1000
ANNFVVPTLD ENIFPKQISL RQAQQQQQQQ QGSRPPGLSK SQVKLMDLED
1010 1020 1030 1040 1050
CALWEGKPRT YITEERADVS LTTLLTAQAS LKTKPIHTII RKRAPPCNND
1060 1070 1080 1090 1100
FCRLGCVCSS LALEKRQPAH CRRPDCMFGC TCLKRKVVLV KGGSKTKHFQ
1110 1120 1130 1140 1150
RKAAHRDPVF YDTLGEEARE EEEGIREEEE QLKEKKKRKK LEYTICETEP
1160 1170 1180 1190 1200
EQPVRHYPLW VKVEGEVDPE PVYIPTPSVI EPMKPLLLPQ PEVLSPTVKG
1210 1220 1230 1240 1250
KLLTGIKSPR SYTPKPNPVI REEDKDPVYL YFESMMTCAR VRVYERKKED
1260 1270 1280 1290 1300
QRQPSSSSSP SPSFQQQTSC HSSPENHNNA KEPDSEQQPL KQLTCDLEDD
1310 1320 1330 1340 1350
SDKLQEKSWK SSCNEGESSS TSYMHQRSPG GPTKLIEIIS DCNWEEDRNK
1360 1370 1380 1390 1400
ILSILSQHIN SNMPQSLKVG SFIIELASQR KSRGEKNPPV YSSRVKISMP
1410 1420 1430 1440 1450
SCQDQDDMAE KSGSETPDGP LSPGKMEDIS PVQTDALDSV RERLHGGKGL
1460 1470 1480 1490 1500
PFYAGLSPAG KLVAYKRKPS SSTSGLIQVA SNAKVAASRK PRTLLPSTSN
1510 1520 1530 1540 1550
SKMASSSGTA TNRPGKNLKA FVPAKRPIAA RPSPGGVFTQ FVMSKVGALQ
1560 1570 1580 1590 1600
QKIPGVSTPQ TLAGTQKFSI RPSPVMVVTP VVSSEPVQVC SPVTAAVTTT
1610 1620 1630 1640 1650
TPQVFLENTT AVTPMTAISD VETKETTYSS GATTTGVVEV SETNTSTSVT
1660 1670 1680 1690 1700
STQSTATVNL TKTTGITTPV ASVAFPKSLV ASPSTITLPV ASTASTSLVV
1710 1720 1730 1740 1750
VTAAASSSMV TTPTSSLGSV PIILSGINGS PPVSQRPENA AQIPVATPQV
1760 1770 1780 1790 1800
SPNTVKRAGP RLLLIPVQQG SPTLRPVSNT QLQGHRMVLQ PVRSPSGMNL
1810 1820 1830 1840 1850
FRHPNGQIVQ LLPLHQLRGS NTQPNLQPVM FRNPGSVMGI RLPAPSKPSE
1860 1870 1880 1890 1900
TPPSSTSSSA FSVMNPVIQA VGSSSAVNVI TQAPSLLSSG ASFVSQAGTL
1910 1920 1930 1940 1950
TLRISPPEPQ SFASKTGSET KITYSSGGQP VGTASLIPLQ SGSFALLQLP
1960 1970 1980 1990 2000
GQKPVPSSIL QHVASLQMKR ESQNPDQKDE TNSIKREQET KKVLQSEGEA
2010 2020 2030 2040 2050
VDPEANVIKQ NSGAATSEET LNDSLEDRGD HLDEECLPEE GCATVKPSEH
2060 2070 2080 2090 2100
SCITGSHTDQ DYKDVNEEYG ARNRKSSKEK VAVLEVRTIS EKASNKTVQN
2110 2120 2130 2140 2150
LSKVQHQKLG DVKVEQQKGF DNPEENSSEF PVTFKEESKF ELSGSKVMEQ
2160 2170 2180 2190 2200
QSNLQPEAKE KECGDSLEKD RERWRKHLKG PLTRKCVGAS QECKKEADEQ
2210 2220 2230 2240 2250
LIKETKTCQE NSDVFQQEQG ISDLLGKSGI TEDARVLKTE CDSWSRISNP
2260 2270 2280 2290 2300
SAFSIVPRRA AKSSRGNGHF QGHLLLPGEQ IQPKQEKKGG RSSADFTVLD
2310 2320 2330 2340 2350
LEEDDEDDNE KTDDSIDEIV DVVSDYQSEE VDDVEKNNCV EYIEDDEEHV
2360 2370 2380 2390 2400
DIETVEELSE EINVAHLKTT AAHTQSFKQP SCTHISADEK AAERSRKAPP
2410 2420 2430 2440 2450
IPLKLKPDYW SDKLQKEAEA FAYYRRTHTA NERRRRGEMR DLFEKLKITL
2460 2470 2480 2490 2500
GLLHSSKVSK SLILTRAFSE IQGLTDQADK LIGQKNLLTR KRNILIRKVS
2510 2520 2530 2540 2550
SLSGKTEEVV LKKLEYIYAK QQALEAQKRK KKMGSDEFDI SPRISKQQEG
2560 2570 2580 2590 2600
SSASSVDLGQ MFINNRRGKP LILSRKKDQA TENTSPLNTP HTSANLVMTP
2610 2620 2630 2640 2650
QGQLLTLKGP LFSGPVVAVS PDLLESDLKP QVAGSAVALP ENDDLFMMPR
2660 2670 2680 2690 2700
IVNVTSLATE GGLVDMGGSK YPHEVPDSKP SDHLKDTVRN EDNSLEDKGR
2710 2720 2730 2740 2750
ISSRGNRDGR VTLGPTQVFL ANKDSGYPQI VDVSNMQKAQ EFLPKKISGD
2760 2770 2780 2790 2800
MRGIQYKWKE SESRGERVKS KDSSFHKLKM KDLKDSSIEM ELRKVTSAIE
2810 2820 2830 2840 2850
EAALDSSELL TNMEDEDDTD ETLTSLLNEI AFLNQQLNDD SVGLAELPSS
2860 2870 2880 2890 2900
MDTEFPGDAR RAFISKVPPG SRATFQVEHL GTGLKELPDV QGESDSISPL
2910 2920 2930 2940 2950
LLHLEDDDFS ENEKQLAEPA SEPDVLKIVI DSEIKDSLLS NKKAIDGGKN
2960 2970 2980 2990 3000
TSGLPAEPES VSSPPTLHMK TGLENSNSTD TLWRPMPKLA PLGLKVANPS
3010 3020 3030 3040 3050
SDADGQSLKV MPCLAPIAAK VGSVGHKMNL TGNDQEGRES KVMPTLAPVV
3060
AKLGNSGASP SSAGK
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BP52 | H3BP52_HUMAN | MAX gene-associated protein | MGA | 1,086 | Annotation score: | ||
H3BTF4 | H3BTF4_HUMAN | MAX gene-associated protein | MGA | 1,138 | Annotation score: | ||
H3BU53 | H3BU53_HUMAN | MAX gene-associated protein | MGA | 1,174 | Annotation score: | ||
H3BTN2 | H3BTN2_HUMAN | MAX gene-associated protein | MGA | 83 | Annotation score: | ||
A0A087X194 | A0A087X194_HUMAN | MAX gene-associated protein | MGA | 61 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 266 | K → N in BAB14186 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 742 | S → R in BAB14186 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1383 | R → P in AAI36660 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 2230 | Missing in BAB14543 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 2365 | A → T in BAB14543 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 2744 | P → L in AAI36660 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_044341 | 338 | T → A. Corresponds to variant dbSNP:rs3803348EnsemblClinVar. | 1 | |
Natural variantiVAR_044342 | 716 | T → S. Corresponds to variant dbSNP:rs2178004Ensembl. | 1 | |
Natural variantiVAR_044343 | 1270 | C → R. Corresponds to variant dbSNP:rs17677811Ensembl. | 1 | |
Natural variantiVAR_057268 | 1523 | P → A. Corresponds to variant dbSNP:rs17677991Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060177 | 1529 – 1737 | Missing in isoform 2. Add BLAST | 209 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC016134 Genomic DNA No translation available. AC073657 Genomic DNA No translation available. BC136659 mRNA Translation: AAI36660.1 AK022696 mRNA Translation: BAB14186.1 Different initiation. AK023360 mRNA Translation: BAB14543.1 Different initiation. AB011090 mRNA Translation: BAA25444.1 AL050181 mRNA Translation: CAB43310.1 |
CCDSi | CCDS55959.1 [Q8IWI9-4] CCDS55960.1 [Q8IWI9-3] |
PIRi | T00081 |
RefSeqi | NP_001074010.2, NM_001080541.2 [Q8IWI9-3] NP_001157745.1, NM_001164273.1 [Q8IWI9-4] |
Genome annotation databases
Ensembli | ENST00000219905; ENSP00000219905; ENSG00000174197 [Q8IWI9-4] ENST00000545763; ENSP00000442467; ENSG00000174197 [Q8IWI9-3] ENST00000566586; ENSP00000456141; ENSG00000174197 [Q8IWI9-3] ENST00000570161; ENSP00000457035; ENSG00000174197 [Q8IWI9-4] |
GeneIDi | 23269 |
KEGGi | hsa:23269 |
UCSCi | uc010ucy.2, human [Q8IWI9-4] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC016134 Genomic DNA No translation available. AC073657 Genomic DNA No translation available. BC136659 mRNA Translation: AAI36660.1 AK022696 mRNA Translation: BAB14186.1 Different initiation. AK023360 mRNA Translation: BAB14543.1 Different initiation. AB011090 mRNA Translation: BAA25444.1 AL050181 mRNA Translation: CAB43310.1 |
CCDSi | CCDS55959.1 [Q8IWI9-4] CCDS55960.1 [Q8IWI9-3] |
PIRi | T00081 |
RefSeqi | NP_001074010.2, NM_001080541.2 [Q8IWI9-3] NP_001157745.1, NM_001164273.1 [Q8IWI9-4] |
3D structure databases
SMRi | Q8IWI9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116870, 85 interactors |
CORUMi | Q8IWI9 |
DIPi | DIP-57615N |
ELMi | Q8IWI9 |
IntActi | Q8IWI9, 66 interactors |
MINTi | Q8IWI9 |
STRINGi | 9606.ENSP00000219905 |
PTM databases
CarbonylDBi | Q8IWI9 |
GlyConnecti | 2859, 1 O-Linked glycan (1 site) |
iPTMneti | Q8IWI9 |
PhosphoSitePlusi | Q8IWI9 |
Polymorphism and mutation databases
BioMutai | MGA |
DMDMi | 527504082 |
Proteomic databases
EPDi | Q8IWI9 |
jPOSTi | Q8IWI9 |
MassIVEi | Q8IWI9 |
MaxQBi | Q8IWI9 |
PaxDbi | Q8IWI9 |
PeptideAtlasi | Q8IWI9 |
PRIDEi | Q8IWI9 |
ProteomicsDBi | 17160 27509 |
Protocols and materials databases
Antibodypediai | 6067, 61 antibodies |
Genome annotation databases
Ensembli | ENST00000219905; ENSP00000219905; ENSG00000174197 [Q8IWI9-4] ENST00000545763; ENSP00000442467; ENSG00000174197 [Q8IWI9-3] ENST00000566586; ENSP00000456141; ENSG00000174197 [Q8IWI9-3] ENST00000570161; ENSP00000457035; ENSG00000174197 [Q8IWI9-4] |
GeneIDi | 23269 |
KEGGi | hsa:23269 |
UCSCi | uc010ucy.2, human [Q8IWI9-4] |
Organism-specific databases
CTDi | 23269 |
DisGeNETi | 23269 |
EuPathDBi | HostDB:ENSG00000174197.16 |
GeneCardsi | MGA |
HGNCi | HGNC:14010, MGA |
HPAi | ENSG00000174197, Low tissue specificity |
MIMi | 616061, gene |
neXtProti | NX_Q8IWI9 |
OpenTargetsi | ENSG00000174197 |
PharmGKBi | PA134976336 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3585, Eukaryota |
GeneTreei | ENSGT00940000156269 |
HOGENOMi | CLU_000469_1_0_1 |
InParanoidi | Q8IWI9 |
OMAi | KERWRKH |
OrthoDBi | 1201455at2759 |
TreeFami | TF106341 |
Enzyme and pathway databases
PathwayCommonsi | Q8IWI9 |
Reactomei | R-HSA-8953750, Transcriptional Regulation by E2F6 |
SIGNORi | Q8IWI9 |
Miscellaneous databases
BioGRID-ORCSi | 23269, 29 hits in 864 CRISPR screens |
ChiTaRSi | MGA, human |
GenomeRNAii | 23269 |
Pharosi | Q8IWI9, Tbio |
PROi | PR:Q8IWI9 |
RNActi | Q8IWI9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000174197, Expressed in corpus callosum and 240 other tissues |
ExpressionAtlasi | Q8IWI9, baseline and differential |
Genevisiblei | Q8IWI9, HS |
Family and domain databases
CDDi | cd00083, HLH, 1 hit cd00182, TBOX, 1 hit |
Gene3Di | 2.60.40.820, 1 hit 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR032060, DUF4801 IPR036638, HLH_DNA-bd_sf IPR037935, MAX_gene-associated_protein IPR008967, p53-like_TF_DNA-bd IPR036960, T-box_sf IPR001699, TF_T-box IPR018186, TF_T-box_CS |
PANTHERi | PTHR11267, PTHR11267, 2 hits PTHR11267:SF32, PTHR11267:SF32, 2 hits |
Pfami | View protein in Pfam PF16059, DUF4801, 1 hit PF00010, HLH, 1 hit PF00907, T-box, 1 hit |
PRINTSi | PR00937, TBOX |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00425, TBOX, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS01264, TBOX_2, 1 hit PS50252, TBOX_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MGAP_HUMAN | |
Accessioni | Q8IWI9Primary (citable) accession number: Q8IWI9 Secondary accession number(s): B9EGR5 Q9Y4E9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 2008 |
Last sequence update: | June 5, 2019 | |
Last modified: | December 2, 2020 | |
This is version 155 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations