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Entry version 117 (11 Dec 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Protein DENND6A

Gene

DENND6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes.1 Publication

Caution

Identified as having similarity to the core DENN family and referred to as DENN6A (PubMed:21330364). Prediction methods do not indicate a DENN domain for this sequence and, the exact role of the DENN or the DENN-like domain in GEF activity needs to be clarified.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein DENND6A
Alternative name(s):
DENN domain-containing protein 6A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DENND6A
Synonyms:FAM116A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000174839.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26635 DENND6A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IWF6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000174839

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596431

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IWF6 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DENND6A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728180

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002891161 – 608Protein DENND6AAdd BLAST608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei127PhosphoserineCombined sources1
Modified residuei510N6-methyllysineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IWF6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IWF6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IWF6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IWF6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IWF6

PeptideAtlas

More...
PeptideAtlasi
Q8IWF6

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWF6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70853

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IWF6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IWF6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000174839 Expressed in 214 organ(s), highest expression level in germinal epithelium of ovary

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IWF6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IWF6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA062618
HPA069725
HPA071711

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128398, 27 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IWF6, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000311401

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IWF6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IWF6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 247uDENNPROSITE-ProRule annotationAdd BLAST185
Domaini273 – 393cDENNPROSITE-ProRule annotationAdd BLAST121
Domaini395 – 528dDENNPROSITE-ProRule annotationAdd BLAST134

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DENND6 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2432 Eukaryota
ENOG410XP3F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005529

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000000674

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IWF6

Identification of Orthologs from Complete Genome Data

More...
OMAi
WYEARHR

Database of Orthologous Groups

More...
OrthoDBi
252077at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IWF6

TreeFam database of animal gene trees

More...
TreeFami
TF320228

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018307 ABL9/DENND6_dom
IPR024224 DENND6
IPR037516 Tripartite_DENN

The PANTHER Classification System

More...
PANTHERi
PTHR13677 PTHR13677, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09794 Avl9, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211 DENN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8IWF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRGPAGLG PGSRRPLDEA VAGAEGREAP ALVAAGGAPE DDEEDDGRGR
60 70 80 90 100
GLLRWDSFSA WLHCVCVVGF DLELGQAVEV IYPQHSKLTD REKTNICYLS
110 120 130 140 150
FPDSNSGCLG DTQFCFRFRQ SSGRRVSLHC LLDQFDKDLP VYLKKDPAYF
160 170 180 190 200
YGYVYFRQVR DKTLKRGYFQ KSLVLISKLP YIHFFHTVLK QIAPEYFEKN
210 220 230 240 250
EPYLEAACND VDRWPAPVPG KTLHLPIMGV VMKVRIPTCH DKPGTTQIVQ
260 270 280 290 300
LTQQVDTNIS VILPTVHEVD IFRCFCPVFL HSQMLWELVL LGEPLVVMAP
310 320 330 340 350
SPSESSETVL ALVNCISPLK YFSDFRPYFT IHDSEFKEYT TRTQAPPSVI
360 370 380 390 400
LGVTNPFFAK TLQHWPHIIR IGDLKPTGEI PKQVKVKKLK NLKTLDSKPG
410 420 430 440 450
VYTSYKPYLN RDEEIIKQLQ KGVQQKRPSE AQSVILRRYF LELTQSFIIP
460 470 480 490 500
LERYVASLMP LQKSISPWKS PPQLRQFLPE EFMKTLEKTG PQLTSRIKGD
510 520 530 540 550
WIGLYRHFLK SPNFDGWFKT RRKEMTQKLE ALHLEALCEE DLLLWIQKHT
560 570 580 590 600
EVETVDLVLK LKNKLLQADR EHLPVKPDTM EKLRTHIDAI ILALPEDLQG

ILLKTGMT
Length:608
Mass (Da):69,575
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA0DFC75B7E4796BF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C598H7C598_HUMAN
Protein DENND6A
DENND6A
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5D0H7C5D0_HUMAN
Protein DENND6A
DENND6A
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB84982 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC03852 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti229G → A in BAB84982 (PubMed:12693554).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK074156 mRNA Translation: BAB84982.1 Different initiation.
AC114480 Genomic DNA No translation available.
BC040291 mRNA Translation: AAH40291.1
BC054343 mRNA Translation: AAH54343.1
AK092288 mRNA Translation: BAC03852.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33773.1

NCBI Reference Sequences

More...
RefSeqi
NP_689891.1, NM_152678.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311128; ENSP00000311401; ENSG00000174839

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
201627

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:201627

UCSC genome browser

More...
UCSCi
uc003dja.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074156 mRNA Translation: BAB84982.1 Different initiation.
AC114480 Genomic DNA No translation available.
BC040291 mRNA Translation: AAH40291.1
BC054343 mRNA Translation: AAH54343.1
AK092288 mRNA Translation: BAC03852.1 Different initiation.
CCDSiCCDS33773.1
RefSeqiNP_689891.1, NM_152678.2

3D structure databases

SMRiQ8IWF6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128398, 27 interactors
IntActiQ8IWF6, 15 interactors
STRINGi9606.ENSP00000311401

PTM databases

iPTMnetiQ8IWF6
PhosphoSitePlusiQ8IWF6

Polymorphism and mutation databases

BioMutaiDENND6A
DMDMi74728180

Proteomic databases

EPDiQ8IWF6
jPOSTiQ8IWF6
MassIVEiQ8IWF6
MaxQBiQ8IWF6
PaxDbiQ8IWF6
PeptideAtlasiQ8IWF6
PRIDEiQ8IWF6
ProteomicsDBi70853

Genome annotation databases

EnsembliENST00000311128; ENSP00000311401; ENSG00000174839
GeneIDi201627
KEGGihsa:201627
UCSCiuc003dja.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
201627
EuPathDBiHostDB:ENSG00000174839.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DENND6A
HGNCiHGNC:26635 DENND6A
HPAiHPA062618
HPA069725
HPA071711
neXtProtiNX_Q8IWF6
OpenTargetsiENSG00000174839
PharmGKBiPA144596431

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2432 Eukaryota
ENOG410XP3F LUCA
GeneTreeiENSGT00390000005529
HOGENOMiHOG000000674
InParanoidiQ8IWF6
OMAiWYEARHR
OrthoDBi252077at2759
PhylomeDBiQ8IWF6
TreeFamiTF320228

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DENND6A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
201627
PharosiQ8IWF6 Tbio

Protein Ontology

More...
PROi
PR:Q8IWF6
RNActiQ8IWF6 protein

Gene expression databases

BgeeiENSG00000174839 Expressed in 214 organ(s), highest expression level in germinal epithelium of ovary
ExpressionAtlasiQ8IWF6 baseline and differential
GenevisibleiQ8IWF6 HS

Family and domain databases

InterProiView protein in InterPro
IPR018307 ABL9/DENND6_dom
IPR024224 DENND6
IPR037516 Tripartite_DENN
PANTHERiPTHR13677 PTHR13677, 1 hit
PfamiView protein in Pfam
PF09794 Avl9, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEN6A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWF6
Secondary accession number(s): Q7Z5T4, Q8N235, Q8TEG8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2003
Last modified: December 11, 2019
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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