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Protein

Protein DENND6A

Gene

DENND6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes.1 Publication

Caution

Identified as having similarity to the core DENN family and referred to as DENN6A (PubMed:21330364). Prediction methods do not indicate a DENN domain for this sequence and, the exact role of the DENN or the DENN-like domain in GEF activity needs to be clarified.1 Publication

GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DENND6A
Alternative name(s):
DENN domain-containing protein 6A
Gene namesi
Name:DENND6A
Synonyms:FAM116A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000174839.12
HGNCiHGNC:26635 DENND6A
neXtProtiNX_Q8IWF6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174839
PharmGKBiPA144596431

Polymorphism and mutation databases

BioMutaiDENND6A
DMDMi74728180

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002891161 – 608Protein DENND6AAdd BLAST608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127PhosphoserineCombined sources1
Modified residuei510N6-methyllysineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8IWF6
MaxQBiQ8IWF6
PaxDbiQ8IWF6
PeptideAtlasiQ8IWF6
PRIDEiQ8IWF6
ProteomicsDBi70853

PTM databases

iPTMnetiQ8IWF6
PhosphoSitePlusiQ8IWF6

Expressioni

Gene expression databases

BgeeiENSG00000174839 Expressed in 214 organ(s), highest expression level in germinal epithelium of ovary
CleanExiHS_FAM116A
ExpressionAtlasiQ8IWF6 baseline and differential
GenevisibleiQ8IWF6 HS

Organism-specific databases

HPAiHPA062618
HPA069725
HPA071711

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128398, 24 interactors
IntActiQ8IWF6, 3 interactors
STRINGi9606.ENSP00000311401

Structurei

3D structure databases

ProteinModelPortaliQ8IWF6
SMRiQ8IWF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 247uDENNPROSITE-ProRule annotationAdd BLAST185
Domaini273 – 393cDENNPROSITE-ProRule annotationAdd BLAST121
Domaini395 – 528dDENNPROSITE-ProRule annotationAdd BLAST134

Sequence similaritiesi

Belongs to the DENND6 family.Curated

Phylogenomic databases

eggNOGiKOG2432 Eukaryota
ENOG410XP3F LUCA
GeneTreeiENSGT00390000005529
HOGENOMiHOG000000674
HOVERGENiHBG055587
InParanoidiQ8IWF6
OMAiEANLEHW
OrthoDBiEOG091G04NT
PhylomeDBiQ8IWF6
TreeFamiTF320228

Family and domain databases

InterProiView protein in InterPro
IPR018307 ABL9/DENND6_dom
IPR024224 DENND6
IPR037516 Tripartite_DENN
PANTHERiPTHR13677 PTHR13677, 1 hit
PfamiView protein in Pfam
PF09794 Avl9, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8IWF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRGPAGLG PGSRRPLDEA VAGAEGREAP ALVAAGGAPE DDEEDDGRGR
60 70 80 90 100
GLLRWDSFSA WLHCVCVVGF DLELGQAVEV IYPQHSKLTD REKTNICYLS
110 120 130 140 150
FPDSNSGCLG DTQFCFRFRQ SSGRRVSLHC LLDQFDKDLP VYLKKDPAYF
160 170 180 190 200
YGYVYFRQVR DKTLKRGYFQ KSLVLISKLP YIHFFHTVLK QIAPEYFEKN
210 220 230 240 250
EPYLEAACND VDRWPAPVPG KTLHLPIMGV VMKVRIPTCH DKPGTTQIVQ
260 270 280 290 300
LTQQVDTNIS VILPTVHEVD IFRCFCPVFL HSQMLWELVL LGEPLVVMAP
310 320 330 340 350
SPSESSETVL ALVNCISPLK YFSDFRPYFT IHDSEFKEYT TRTQAPPSVI
360 370 380 390 400
LGVTNPFFAK TLQHWPHIIR IGDLKPTGEI PKQVKVKKLK NLKTLDSKPG
410 420 430 440 450
VYTSYKPYLN RDEEIIKQLQ KGVQQKRPSE AQSVILRRYF LELTQSFIIP
460 470 480 490 500
LERYVASLMP LQKSISPWKS PPQLRQFLPE EFMKTLEKTG PQLTSRIKGD
510 520 530 540 550
WIGLYRHFLK SPNFDGWFKT RRKEMTQKLE ALHLEALCEE DLLLWIQKHT
560 570 580 590 600
EVETVDLVLK LKNKLLQADR EHLPVKPDTM EKLRTHIDAI ILALPEDLQG

ILLKTGMT
Length:608
Mass (Da):69,575
Last modified:March 1, 2003 - v1
Checksum:iA0DFC75B7E4796BF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C5D0H7C5D0_HUMAN
Protein DENND6A
DENND6A
125Annotation score:
H7C598H7C598_HUMAN
Protein DENND6A
DENND6A
168Annotation score:

Sequence cautioni

The sequence BAB84982 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC03852 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229G → A in BAB84982 (PubMed:12693554).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074156 mRNA Translation: BAB84982.1 Different initiation.
AC114480 Genomic DNA No translation available.
BC040291 mRNA Translation: AAH40291.1
BC054343 mRNA Translation: AAH54343.1
AK092288 mRNA Translation: BAC03852.1 Different initiation.
CCDSiCCDS33773.1
RefSeqiNP_689891.1, NM_152678.2
UniGeneiHs.91085

Genome annotation databases

EnsembliENST00000311128; ENSP00000311401; ENSG00000174839
GeneIDi201627
KEGGihsa:201627
UCSCiuc003dja.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074156 mRNA Translation: BAB84982.1 Different initiation.
AC114480 Genomic DNA No translation available.
BC040291 mRNA Translation: AAH40291.1
BC054343 mRNA Translation: AAH54343.1
AK092288 mRNA Translation: BAC03852.1 Different initiation.
CCDSiCCDS33773.1
RefSeqiNP_689891.1, NM_152678.2
UniGeneiHs.91085

3D structure databases

ProteinModelPortaliQ8IWF6
SMRiQ8IWF6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128398, 24 interactors
IntActiQ8IWF6, 3 interactors
STRINGi9606.ENSP00000311401

PTM databases

iPTMnetiQ8IWF6
PhosphoSitePlusiQ8IWF6

Polymorphism and mutation databases

BioMutaiDENND6A
DMDMi74728180

Proteomic databases

EPDiQ8IWF6
MaxQBiQ8IWF6
PaxDbiQ8IWF6
PeptideAtlasiQ8IWF6
PRIDEiQ8IWF6
ProteomicsDBi70853

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311128; ENSP00000311401; ENSG00000174839
GeneIDi201627
KEGGihsa:201627
UCSCiuc003dja.4 human

Organism-specific databases

CTDi201627
EuPathDBiHostDB:ENSG00000174839.12
GeneCardsiDENND6A
H-InvDBiHIX0003395
HIX0023340
HGNCiHGNC:26635 DENND6A
HPAiHPA062618
HPA069725
HPA071711
neXtProtiNX_Q8IWF6
OpenTargetsiENSG00000174839
PharmGKBiPA144596431
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2432 Eukaryota
ENOG410XP3F LUCA
GeneTreeiENSGT00390000005529
HOGENOMiHOG000000674
HOVERGENiHBG055587
InParanoidiQ8IWF6
OMAiEANLEHW
OrthoDBiEOG091G04NT
PhylomeDBiQ8IWF6
TreeFamiTF320228

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiDENND6A human
GenomeRNAii201627
PROiPR:Q8IWF6

Gene expression databases

BgeeiENSG00000174839 Expressed in 214 organ(s), highest expression level in germinal epithelium of ovary
CleanExiHS_FAM116A
ExpressionAtlasiQ8IWF6 baseline and differential
GenevisibleiQ8IWF6 HS

Family and domain databases

InterProiView protein in InterPro
IPR018307 ABL9/DENND6_dom
IPR024224 DENND6
IPR037516 Tripartite_DENN
PANTHERiPTHR13677 PTHR13677, 1 hit
PfamiView protein in Pfam
PF09794 Avl9, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDEN6A_HUMAN
AccessioniPrimary (citable) accession number: Q8IWF6
Secondary accession number(s): Q7Z5T4, Q8N235, Q8TEG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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