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Protein

FAD-dependent oxidoreductase domain-containing protein 2

Gene

FOXRED2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.1 Publication

Cofactori

FAD1 Publication

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: UniProtKB
  • oxidoreductase activity Source: UniProtKB-KW

GO - Biological processi

  • ubiquitin-dependent ERAD pathway Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
FAD-dependent oxidoreductase domain-containing protein 2
Alternative name(s):
Endoplasmic reticulum flavoprotein associated with degradation
Gene namesi
Name:FOXRED2Imported
Synonyms:ERFAD1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100350.14
HGNCiHGNC:26264 FOXRED2
MIMi613777 gene
neXtProtiNX_Q8IWF2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100350
PharmGKBiPA145148808

Polymorphism and mutation databases

BioMutaiFOXRED2
DMDMi74759632

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000033769227 – 684FAD-dependent oxidoreductase domain-containing protein 2Add BLAST658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi143N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8IWF2
MaxQBiQ8IWF2
PaxDbiQ8IWF2
PeptideAtlasiQ8IWF2
PRIDEiQ8IWF2
ProteomicsDBi70851
70852 [Q8IWF2-2]

PTM databases

iPTMnetiQ8IWF2
PhosphoSitePlusiQ8IWF2

Expressioni

Gene expression databases

BgeeiENSG00000100350 Expressed in 178 organ(s), highest expression level in amniotic fluid
CleanExiHS_FOXRED2
ExpressionAtlasiQ8IWF2 baseline and differential
GenevisibleiQ8IWF2 HS

Organism-specific databases

HPAiHPA031611
HPA031612

Interactioni

Subunit structurei

Interacts with SEL1L. May interact with OS9 and DNAJC10. Interacts with TXNDC16 (PubMed:21359175).2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi123074, 40 interactors
DIPiDIP-48946N
IntActiQ8IWF2, 10 interactors
MINTiQ8IWF2
STRINGi9606.ENSP00000216187

Structurei

3D structure databases

ProteinModelPortaliQ8IWF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi681 – 684Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the FOXRED2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1399 Eukaryota
COG2072 LUCA
GeneTreeiENSGT00640000091519
HOGENOMiHOG000031485
HOVERGENiHBG100868
InParanoidiQ8IWF2
OMAiQAWNGHY
OrthoDBiEOG091G08UJ
PhylomeDBiQ8IWF2
TreeFamiTF324712

Family and domain databases

Gene3Di3.50.50.60, 4 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
SUPFAMiSSF51905 SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q8IWF2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLSAAAPLW GPPGLLLAIA LHPALSVPPR RDYCVLGAGP AGLQMAYFLQ
60 70 80 90 100
RAGRDYAVFE RAPRPGSFFT RYPRHRKLIS INKRYTGKAN AEFNLRHDWN
110 120 130 140 150
SLLSHDPRLL FRHYSRAYFP DARDMVRYLG DFADTLGLRV QYNTTIAHVT
160 170 180 190 200
LDKDRQAWNG HYFILTDQKG QVHQCSVLFV ATGLSVPNQV DFPGSEYAEG
210 220 230 240 250
YESVSVDPED FVGQNVLILG RGNSAFETAE NILGVTNFIH MLSRSRVRLS
260 270 280 290 300
WATHYVGDLR AINNGLLDTY QLKSLDGLLE SDLTDLAILK DSKGKFHVTP
310 320 330 340 350
KFFLEEANTN QSADSITLPQ DDNDNFAMRV PYDRVIRCLG WNFDFSIFNK
360 370 380 390 400
SLRLNSGNAF GKKYPLIRAS YESKGSRGLF ILGTASHSVD YRKSAGGFIH
410 420 430 440 450
GFRYTVRAVH RLLEHRHHSV TWPATELPIT QLTSSIVRRV NEASGLYQMF
460 470 480 490 500
GVLADVILLK ENSTAFEYLE EFPIQMLAQL ETLTGRKAKH GLFVINMEYG
510 520 530 540 550
RNFSGPDKDV FFDDRSVGHT EDAWQSNFLH PVIYYYRYLP TEQEVRFRPA
560 570 580 590 600
HWPLPRPTAI HHIVEDFLTD WTAPIGHILP LRRFLENCLD TDLRSFYAES
610 620 630 640 650
CFLFALTRQK LPPFCQQGYL RMQGLVSTES LWQHRVESRL LRDYAPTGRR
660 670 680
LEDSSQQLGD QEPLGSPLAP GPLAQSVDSN KEEL
Length:684
Mass (Da):77,791
Last modified:March 1, 2003 - v1
Checksum:i8209FFAF6289DDAF
GO
Isoform 2 (identifier: Q8IWF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-327: Missing.

Note: No experimental confirmation available.
Show »
Length:357
Mass (Da):41,157
Checksum:i14C82B1E14D54A0A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYA2B0QYA2_HUMAN
FAD-dependent oxidoreductase domain...
FOXRED2
86Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti345F → S in BAB15610 (PubMed:14702039).Curated1
Sequence conflicti607T → A in BAB15227 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06224771R → C. Corresponds to variant dbSNP:rs56767103Ensembl.1
Natural variantiVAR_043704179F → L2 PublicationsCorresponds to variant dbSNP:rs760718Ensembl.1
Natural variantiVAR_043705308N → S3 PublicationsCorresponds to variant dbSNP:rs2277841Ensembl.1
Natural variantiVAR_043706374K → R. Corresponds to variant dbSNP:rs35813894Ensembl.1
Natural variantiVAR_043707637E → D. Corresponds to variant dbSNP:rs35748020Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0339971 – 327Missing in isoform 2. 1 PublicationAdd BLAST327

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456444 mRNA Translation: CAG30330.1
AK025714 mRNA Translation: BAB15227.1
AK026975 mRNA Translation: BAB15610.1
AK315555 mRNA Translation: BAG37931.1
AL022313 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60106.1
BC015726 mRNA Translation: AAH15726.1
BC027716 mRNA Translation: AAH27716.1
BC040351 mRNA Translation: AAH40351.1
CCDSiCCDS13929.1 [Q8IWF2-1]
RefSeqiNP_001095841.1, NM_001102371.1 [Q8IWF2-1]
NP_079231.4, NM_024955.5 [Q8IWF2-1]
UniGeneiHs.387601

Genome annotation databases

EnsembliENST00000216187; ENSP00000216187; ENSG00000100350 [Q8IWF2-1]
ENST00000397223; ENSP00000380400; ENSG00000100350 [Q8IWF2-1]
ENST00000397224; ENSP00000380401; ENSG00000100350 [Q8IWF2-1]
GeneIDi80020
KEGGihsa:80020
UCSCiuc003apn.5 human [Q8IWF2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFXRD2_HUMAN
AccessioniPrimary (citable) accession number: Q8IWF2
Secondary accession number(s): B2RDI4
, Q8N378, Q96BD1, Q9H5L5, Q9H6M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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