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Entry version 106 (02 Dec 2020)
Sequence version 2 (26 Feb 2008)
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Protein

Major facilitator superfamily domain-containing protein 6-like

Gene

MFSD6L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IWD5

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.65.10, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 6-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MFSD6L
ORF Names:FP7072
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000185156.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26656, MFSD6L

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IWD5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Transmembranei433 – 455HelicalSequence analysisAdd BLAST23
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Transmembranei499 – 519HelicalSequence analysisAdd BLAST21
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164722299

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IWD5, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MFSD6L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
190360169

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003219441 – 586Major facilitator superfamily domain-containing protein 6-likeAdd BLAST586

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IWD5

PeptideAtlas

More...
PeptideAtlasi
Q8IWD5

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWD5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70847

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8IWD5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IWD5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IWD5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185156, Expressed in testis and 73 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IWD5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000185156, Tissue enhanced (pancreas, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000330051

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IWD5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3762, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063599

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013133_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IWD5

Identification of Orthologs from Complete Genome Data

More...
OMAi
GQLDCFL

Database of Orthologous Groups

More...
OrthoDBi
453672at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IWD5

TreeFam database of animal gene trees

More...
TreeFami
TF314366

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024989, MFS_assoc_dom
IPR036259, MFS_trans_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12832, MFS_1_like, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IWD5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSANPRWDIS RALGVAKLFH LVCGVREACV TPFLTLYLRQ LGLAAPWVGT
60 70 80 90 100
LMGTKHLIAA FWAPVCAFLA KSYRKRRALL IGSLLGSVGA SLLMVLVPPV
110 120 130 140 150
DKNRVHFPCN GSSGLTSTDA LPGVTLPVNI TSAQESASSH PAKRTAEVEM
160 170 180 190 200
PGFRNPPGES DRETFRDLHV YLAPSVEGAR TTSQALLHPV TSGLKDHPWE
210 220 230 240 250
VTFEVVKTAL PLLPGGKGPG NPANLSGTKG KAWAFDLSLE ALRRTFILSL
260 270 280 290 300
GSVAFWELLT APLEQVADDS LYEFLDFVDA TDRYRSLWVW RLLGMSAGVC
310 320 330 340 350
GITALVGQLD CFLMTSGPRG VVHFYGYSVV STLALLVSIA FPIPICQQWE
360 370 380 390 400
PSYKRVKALS IVGGDPHLIL LASTTVLVGA IVSTVQNFLF WHMKDHGSGE
410 420 430 440 450
LVMGFSVALS LLGEILLHPF KATLLRKLSR TGLVGLGLSC LAGQLLYYSF
460 470 480 490 500
LWSWWSVLPI QILSAISNRA LWWAVGASVE DLATPRMERA LSALFRGHFY
510 520 530 540 550
GSGCSLGSFV GGFVVMRFSL AVLYQACCVA LLLWLALLLS IQRRLPRERK
560 570 580
IKYSKLLSME VSDTSDSEQG TEQDWLVKAM REEHSD
Length:586
Mass (Da):64,005
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF1607041015758D
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM98769 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti214P → T in AAH40487 (PubMed:15489334).Curated1
Sequence conflicti277F → S in BAC04050 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039389486R → H. Corresponds to variant dbSNP:rs2242373Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY129026 mRNA Translation: AAM98769.1 Frameshift.
AK093092 mRNA Translation: BAC04050.1
BC040487 mRNA Translation: AAH40487.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11146.1

NCBI Reference Sequences

More...
RefSeqi
NP_689812.3, NM_152599.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329805; ENSP00000330051; ENSG00000185156

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
162387

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:162387

UCSC genome browser

More...
UCSCi
uc002glp.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129026 mRNA Translation: AAM98769.1 Frameshift.
AK093092 mRNA Translation: BAC04050.1
BC040487 mRNA Translation: AAH40487.1
CCDSiCCDS11146.1
RefSeqiNP_689812.3, NM_152599.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000330051

Protein family/group databases

TCDBi2.A.1.65.10, the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ8IWD5
PhosphoSitePlusiQ8IWD5

Polymorphism and mutation databases

BioMutaiMFSD6L
DMDMi190360169

Proteomic databases

PaxDbiQ8IWD5
PeptideAtlasiQ8IWD5
PRIDEiQ8IWD5
ProteomicsDBi70847
TopDownProteomicsiQ8IWD5

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
12633, 15 antibodies

The DNASU plasmid repository

More...
DNASUi
162387

Genome annotation databases

EnsembliENST00000329805; ENSP00000330051; ENSG00000185156
GeneIDi162387
KEGGihsa:162387
UCSCiuc002glp.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
162387
EuPathDBiHostDB:ENSG00000185156.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MFSD6L
HGNCiHGNC:26656, MFSD6L
HPAiENSG00000185156, Tissue enhanced (pancreas, testis)
neXtProtiNX_Q8IWD5
PharmGKBiPA164722299

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3762, Eukaryota
GeneTreeiENSGT00530000063599
HOGENOMiCLU_013133_4_0_1
InParanoidiQ8IWD5
OMAiGQLDCFL
OrthoDBi453672at2759
PhylomeDBiQ8IWD5
TreeFamiTF314366

Enzyme and pathway databases

PathwayCommonsiQ8IWD5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
162387, 2 hits in 840 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MFSD6L, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
162387
PharosiQ8IWD5, Tdark

Protein Ontology

More...
PROi
PR:Q8IWD5
RNActiQ8IWD5, protein

Gene expression databases

BgeeiENSG00000185156, Expressed in testis and 73 other tissues
GenevisibleiQ8IWD5, HS

Family and domain databases

InterProiView protein in InterPro
IPR024989, MFS_assoc_dom
IPR036259, MFS_trans_sf
PfamiView protein in Pfam
PF12832, MFS_1_like, 1 hit
SUPFAMiSSF103473, SSF103473, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMFS6L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWD5
Secondary accession number(s): Q6YL34, Q8NA76
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: December 2, 2020
This is version 106 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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