UniProtKB - Q8IWD5 (MFS6L_HUMAN)
Protein
Major facilitator superfamily domain-containing protein 6-like
Gene
MFSD6L
Organism
Homo sapiens (Human)
Status
Functioni
Enzyme and pathway databases
PathwayCommonsi | Q8IWD5 |
Protein family/group databases
TCDBi | 2.A.1.65.10, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Major facilitator superfamily domain-containing protein 6-like |
Gene namesi | Name:MFSD6L ORF Names:FP7072 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000185156.5 |
HGNCi | HGNC:26656, MFSD6L |
neXtProti | NX_Q8IWD5 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 50 – 70 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 78 – 98 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 246 – 266 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 287 – 307 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 326 – 346 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 361 – 381 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 400 – 420 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 433 – 455 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 456 – 476 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 499 – 519 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 521 – 541 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA164722299 |
Miscellaneous databases
Pharosi | Q8IWD5, Tdark |
Polymorphism and mutation databases
BioMutai | MFSD6L |
DMDMi | 190360169 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000321944 | 1 – 586 | Major facilitator superfamily domain-containing protein 6-likeAdd BLAST | 586 |
Proteomic databases
PaxDbi | Q8IWD5 |
PeptideAtlasi | Q8IWD5 |
PRIDEi | Q8IWD5 |
ProteomicsDBi | 70847 |
TopDownProteomicsi | Q8IWD5 |
PTM databases
iPTMneti | Q8IWD5 |
PhosphoSitePlusi | Q8IWD5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000185156, Expressed in testis and 73 other tissues |
Genevisiblei | Q8IWD5, HS |
Organism-specific databases
HPAi | ENSG00000185156, Tissue enhanced (pancreas, testis) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000330051 |
Miscellaneous databases
RNActi | Q8IWD5, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3762, Eukaryota |
GeneTreei | ENSGT00530000063599 |
HOGENOMi | CLU_013133_4_0_1 |
InParanoidi | Q8IWD5 |
OMAi | GQLDCFL |
OrthoDBi | 453672at2759 |
PhylomeDBi | Q8IWD5 |
TreeFami | TF314366 |
Family and domain databases
InterProi | View protein in InterPro IPR024989, MFS_assoc_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF12832, MFS_1_like, 1 hit |
SUPFAMi | SSF103473, SSF103473, 2 hits |
i Sequence
Sequence statusi: Complete.
Q8IWD5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSANPRWDIS RALGVAKLFH LVCGVREACV TPFLTLYLRQ LGLAAPWVGT
60 70 80 90 100
LMGTKHLIAA FWAPVCAFLA KSYRKRRALL IGSLLGSVGA SLLMVLVPPV
110 120 130 140 150
DKNRVHFPCN GSSGLTSTDA LPGVTLPVNI TSAQESASSH PAKRTAEVEM
160 170 180 190 200
PGFRNPPGES DRETFRDLHV YLAPSVEGAR TTSQALLHPV TSGLKDHPWE
210 220 230 240 250
VTFEVVKTAL PLLPGGKGPG NPANLSGTKG KAWAFDLSLE ALRRTFILSL
260 270 280 290 300
GSVAFWELLT APLEQVADDS LYEFLDFVDA TDRYRSLWVW RLLGMSAGVC
310 320 330 340 350
GITALVGQLD CFLMTSGPRG VVHFYGYSVV STLALLVSIA FPIPICQQWE
360 370 380 390 400
PSYKRVKALS IVGGDPHLIL LASTTVLVGA IVSTVQNFLF WHMKDHGSGE
410 420 430 440 450
LVMGFSVALS LLGEILLHPF KATLLRKLSR TGLVGLGLSC LAGQLLYYSF
460 470 480 490 500
LWSWWSVLPI QILSAISNRA LWWAVGASVE DLATPRMERA LSALFRGHFY
510 520 530 540 550
GSGCSLGSFV GGFVVMRFSL AVLYQACCVA LLLWLALLLS IQRRLPRERK
560 570 580
IKYSKLLSME VSDTSDSEQG TEQDWLVKAM REEHSD
Sequence cautioni
The sequence AAM98769 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 214 | P → T in AAH40487 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 277 | F → S in BAC04050 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039389 | 486 | R → H. Corresponds to variant dbSNP:rs2242373Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY129026 mRNA Translation: AAM98769.1 Frameshift. AK093092 mRNA Translation: BAC04050.1 BC040487 mRNA Translation: AAH40487.1 |
CCDSi | CCDS11146.1 |
RefSeqi | NP_689812.3, NM_152599.3 |
Genome annotation databases
Ensembli | ENST00000329805; ENSP00000330051; ENSG00000185156 |
GeneIDi | 162387 |
KEGGi | hsa:162387 |
UCSCi | uc002glp.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY129026 mRNA Translation: AAM98769.1 Frameshift. AK093092 mRNA Translation: BAC04050.1 BC040487 mRNA Translation: AAH40487.1 |
CCDSi | CCDS11146.1 |
RefSeqi | NP_689812.3, NM_152599.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000330051 |
Protein family/group databases
TCDBi | 2.A.1.65.10, the major facilitator superfamily (mfs) |
PTM databases
iPTMneti | Q8IWD5 |
PhosphoSitePlusi | Q8IWD5 |
Polymorphism and mutation databases
BioMutai | MFSD6L |
DMDMi | 190360169 |
Proteomic databases
PaxDbi | Q8IWD5 |
PeptideAtlasi | Q8IWD5 |
PRIDEi | Q8IWD5 |
ProteomicsDBi | 70847 |
TopDownProteomicsi | Q8IWD5 |
Protocols and materials databases
Antibodypediai | 12633, 15 antibodies |
DNASUi | 162387 |
Genome annotation databases
Ensembli | ENST00000329805; ENSP00000330051; ENSG00000185156 |
GeneIDi | 162387 |
KEGGi | hsa:162387 |
UCSCi | uc002glp.3, human |
Organism-specific databases
CTDi | 162387 |
EuPathDBi | HostDB:ENSG00000185156.5 |
GeneCardsi | MFSD6L |
HGNCi | HGNC:26656, MFSD6L |
HPAi | ENSG00000185156, Tissue enhanced (pancreas, testis) |
neXtProti | NX_Q8IWD5 |
PharmGKBi | PA164722299 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3762, Eukaryota |
GeneTreei | ENSGT00530000063599 |
HOGENOMi | CLU_013133_4_0_1 |
InParanoidi | Q8IWD5 |
OMAi | GQLDCFL |
OrthoDBi | 453672at2759 |
PhylomeDBi | Q8IWD5 |
TreeFami | TF314366 |
Enzyme and pathway databases
PathwayCommonsi | Q8IWD5 |
Miscellaneous databases
BioGRID-ORCSi | 162387, 2 hits in 840 CRISPR screens |
ChiTaRSi | MFSD6L, human |
GenomeRNAii | 162387 |
Pharosi | Q8IWD5, Tdark |
PROi | PR:Q8IWD5 |
RNActi | Q8IWD5, protein |
Gene expression databases
Bgeei | ENSG00000185156, Expressed in testis and 73 other tissues |
Genevisiblei | Q8IWD5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR024989, MFS_assoc_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF12832, MFS_1_like, 1 hit |
SUPFAMi | SSF103473, SSF103473, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MFS6L_HUMAN | |
Accessioni | Q8IWD5Primary (citable) accession number: Q8IWD5 Secondary accession number(s): Q6YL34, Q8NA76 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | December 2, 2020 | |
This is version 106 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations