MFSD6L

Functionⁱ

Protein family/group databases

TCDBⁱ	2.A.1.65.10 the major facilitator superfamily (mfs)

TCDBⁱ

2.A.1.65.10 the major facilitator superfamily (mfs)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Major facilitator superfamily domain-containing protein 6-like
Gene namesⁱ	Name:MFSD6L ORF Names:FP7072
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000185156.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26656 MFSD6L
neXtProtⁱ	NX_Q8IWD5

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	50 – 70	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	78 – 98	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	246 – 266	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	287 – 307	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	326 – 346	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	361 – 381	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	400 – 420	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	433 – 455	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	456 – 476	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	499 – 519	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	521 – 541	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	162387
PharmGKBⁱ	PA164722299

Polymorphism and mutation databases

BioMutaⁱ	MFSD6L
DMDMⁱ	190360169

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000321944	1 – 586	Major facilitator superfamily domain-containing protein 6-likeAdd BLAST		586

Proteomic databases

PaxDbⁱ	Q8IWD5
PeptideAtlas More...PeptideAtlasⁱ	Q8IWD5
PRIDEⁱ	Q8IWD5
ProteomicsDBⁱ	70847
TopDownProteomicsⁱ	Q8IWD5

PTM databases

iPTMnetⁱ	Q8IWD5
PhosphoSitePlusⁱ	Q8IWD5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000185156 Expressed in 55 organ(s), highest expression level in testis
CleanExⁱ	HS_MFSD6L
Genevisibleⁱ	Q8IWD5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA023164

HPAⁱ

HPA023164

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000330051

STRINGⁱ

9606.ENSP00000330051

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IWD5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the major facilitator superfamily. MFSD6 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3762 Eukaryota ENOG410YMHR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063599
HOGENOMⁱ	HOG000049138
HOVERGENⁱ	HBG097504
InParanoidⁱ	Q8IWD5
OMAⁱ	YEYLDFV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0507
PhylomeDBⁱ	Q8IWD5
TreeFamⁱ	TF314366

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR024989 MFS_assoc_dom IPR020846 MFS_dom IPR036259 MFS_trans_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12832 MFS_1_like, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8IWD5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSANPRWDIS RALGVAKLFH LVCGVREACV TPFLTLYLRQ LGLAAPWVGT 
        60         70         80         90        100
LMGTKHLIAA FWAPVCAFLA KSYRKRRALL IGSLLGSVGA SLLMVLVPPV 
       110        120        130        140        150
DKNRVHFPCN GSSGLTSTDA LPGVTLPVNI TSAQESASSH PAKRTAEVEM 
       160        170        180        190        200
PGFRNPPGES DRETFRDLHV YLAPSVEGAR TTSQALLHPV TSGLKDHPWE 
       210        220        230        240        250
VTFEVVKTAL PLLPGGKGPG NPANLSGTKG KAWAFDLSLE ALRRTFILSL 
       260        270        280        290        300
GSVAFWELLT APLEQVADDS LYEFLDFVDA TDRYRSLWVW RLLGMSAGVC 
       310        320        330        340        350
GITALVGQLD CFLMTSGPRG VVHFYGYSVV STLALLVSIA FPIPICQQWE 
       360        370        380        390        400
PSYKRVKALS IVGGDPHLIL LASTTVLVGA IVSTVQNFLF WHMKDHGSGE 
       410        420        430        440        450
LVMGFSVALS LLGEILLHPF KATLLRKLSR TGLVGLGLSC LAGQLLYYSF 
       460        470        480        490        500
LWSWWSVLPI QILSAISNRA LWWAVGASVE DLATPRMERA LSALFRGHFY 
       510        520        530        540        550
GSGCSLGSFV GGFVVMRFSL AVLYQACCVA LLLWLALLLS IQRRLPRERK 
       560        570        580 
IKYSKLLSME VSDTSDSEQG TEQDWLVKAM REEHSD

Length:586

Mass (Da):64,005

Last modified:February 26, 2008 - v2

Checksum:ⁱAF1607041015758D

GO

Sequence cautionⁱ

The sequence AAM98769 differs from that shown. Reason: Frameshift at position 365.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	214	P → T in AAH40487 (PubMed:15489334).Curated		1
Sequence conflictⁱ	277	F → S in BAC04050 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_039389	486	R → H. Corresponds to variant dbSNP:rs2242373Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY129026 mRNA Translation: AAM98769.1 Frameshift. AK093092 mRNA Translation: BAC04050.1 BC040487 mRNA Translation: AAH40487.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11146.1
NCBI Reference Sequences More...RefSeqⁱ	NP_689812.3, NM_152599.3
UniGeneⁱ	Hs.213603

Genome annotation databases

Ensemblⁱ	ENST00000329805; ENSP00000330051; ENSG00000185156
GeneIDⁱ	162387
KEGGⁱ	hsa:162387
UCSC genome browser More...UCSCⁱ	uc002glp.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IWD5	MFSD6L isoform 1		PANTR		586	UniRef90_Q8IWD5
Uncharacterized protein		PANPA		586
MFSD6L isoform 1		PONAB		586
Major facilitator superfamily domain-containing protein 6-like protein		MACMU		586
Uncharacterized protein		RHIRO		586
+15

Protein	Similar proteins		Species	Score	Length	Source
Q8IWD5	Major facilitator superfamily domain-containing protein 6-like		MOUSE		586	UniRef50_Q8IWD5
Major facilitator superfamily domain-containing protein 6-like protein		MACMU		586
MFSD6L isoform 1		PONAB		586
Uncharacterized protein		MACNE		586
Uncharacterized protein		CHLSB		586
+117

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY129026 mRNA Translation: AAM98769.1 Frameshift. AK093092 mRNA Translation: BAC04050.1 BC040487 mRNA Translation: AAH40487.1
CCDSⁱ	CCDS11146.1
RefSeqⁱ	NP_689812.3, NM_152599.3
UniGeneⁱ	Hs.213603

3D structure databases

ProteinModelPortalⁱ	Q8IWD5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000330051

STRINGⁱ

9606.ENSP00000330051

Protein family/group databases

TCDBⁱ	2.A.1.65.10 the major facilitator superfamily (mfs)

TCDBⁱ

2.A.1.65.10 the major facilitator superfamily (mfs)

PTM databases

iPTMnetⁱ	Q8IWD5
PhosphoSitePlusⁱ	Q8IWD5

Polymorphism and mutation databases

BioMutaⁱ	MFSD6L
DMDMⁱ	190360169

Proteomic databases

PaxDbⁱ	Q8IWD5
PeptideAtlasⁱ	Q8IWD5
PRIDEⁱ	Q8IWD5
ProteomicsDBⁱ	70847
TopDownProteomicsⁱ	Q8IWD5

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	162387
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000329805; ENSP00000330051; ENSG00000185156
GeneIDⁱ	162387
KEGGⁱ	hsa:162387
UCSCⁱ	uc002glp.3 human

Organism-specific databases

CTDⁱ	162387
DisGeNETⁱ	162387
EuPathDBⁱ	HostDB:ENSG00000185156.5
GeneCardsⁱ	MFSD6L
H-InvDBⁱ	HIX0013527
HGNCⁱ	HGNC:26656 MFSD6L
HPAⁱ	HPA023164
neXtProtⁱ	NX_Q8IWD5
PharmGKBⁱ	PA164722299
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3762 Eukaryota ENOG410YMHR LUCA
GeneTreeⁱ	ENSGT00530000063599
HOGENOMⁱ	HOG000049138
HOVERGENⁱ	HBG097504
InParanoidⁱ	Q8IWD5
OMAⁱ	YEYLDFV
OrthoDBⁱ	EOG091G0507
PhylomeDBⁱ	Q8IWD5
TreeFamⁱ	TF314366

Miscellaneous databases

GenomeRNAiⁱ	162387
Protein Ontology More...PROⁱ	PR:Q8IWD5

Gene expression databases

Bgeeⁱ	ENSG00000185156 Expressed in 55 organ(s), highest expression level in testis
CleanExⁱ	HS_MFSD6L
Genevisibleⁱ	Q8IWD5 HS

Family and domain databases

CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR024989 MFS_assoc_dom IPR020846 MFS_dom IPR036259 MFS_trans_sf
Pfamⁱ	View protein in Pfam PF12832 MFS_1_like, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MFS6L_HUMAN
Accessionⁱ	Q8IWD5Primary (citable) accession number: Q8IWD5 Secondary accession number(s): Q6YL34, Q8NA76
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	February 26, 2008
	Last modified:	September 12, 2018
	This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8IWD5 (MFS6L_HUMAN)

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Major facilitator superfamily domain-containing protein 6-like

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ