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UniProtKB - Q8IWD4 (CC117_HUMAN)

Entry version 132 (07 Apr 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Coiled-coil domain-containing protein 117

Gene

CCDC117

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IWD4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 117
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC117
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26599, CCDC117

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IWD4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000159873.9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000159873

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA145149315

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IWD4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCDC117

Domain mapping of disease mutations (DMDM)

More...DMDMi		74759628

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002541381 – 279Coiled-coil domain-containing protein 117Add BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei48Omega-N-methylarginineBy similarity1
Modified residuei53PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IWD4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IWD4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IWD4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IWD4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IWD4

PeptideAtlas

More...PeptideAtlasi		Q8IWD4

PRoteomics IDEntifications database

More...PRIDEi		Q8IWD4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		6467
6927
70845 [Q8IWD4-1]
70846 [Q8IWD4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IWD4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IWD4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000159873, Expressed in female gonad and 218 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IWD4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IWD4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000159873, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127277, 14 interactors

Protein interaction database and analysis system

More...IntActi		Q8IWD4, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000249064

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IWD4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IWD4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili141 – 168Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S42Q, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005772

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_083045_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IWD4

Identification of Orthologs from Complete Genome Data

More...OMAi		CLRKHRR

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IWD4

TreeFam database of animal gene trees

More...TreeFami		TF335674

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031630, CCDC117

The PANTHER Classification System

More...PANTHERi		PTHR36128, PTHR36128, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15810, CCDC117, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IWD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALGRPFSG LPLSGGSDFL QPPQPAFPGR AFPPGADGAE LAPRPGPRAV 
        60         70         80         90        100
PSSPAGSAAR GRVSVHCKKK HKREEEEDDD CPVRKKRITE AELCAGPNDW 
       110        120        130        140        150
ILCAHQDVEG HGVNPSVSGL SIPGILDVIC EEMDQTTGEP QCEVARRKLQ 
       160        170        180        190        200
EIEDRIIDED EEVEADRNVN HLPSLVLSDT MKTGLKREFD EVFTKKMIES 
       210        220        230        240        250
MSRPSMELVL WKPLPELLSD KPKPSSNTKN YTGESQAKHV AAGTAFPQRT 
       260        270 
ELFSEPRPTG MSLYNSLETA TSTEEEMEL
Length:279
Mass (Da):30,541
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97D5FBB76AE5ABFE
GO
Isoform 2 (identifier: Q8IWD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-120: Missing.

Show »
Length:170
Mass (Da):19,092
Checksum:i796444A611D98774
GO
Isoform 3 (identifier: Q8IWD4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-80: Missing.

Show »
Length:261
Mass (Da):28,348
Checksum:i3724420956B356F5
GO
Isoform 4 (identifier: Q8IWD4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-155: DCPVRKKRIT...RRKLQEIEDR → E

Show »
Length:204
Mass (Da):22,288
Checksum:iF3C86513751C6696
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYH3B0QYH3_HUMAN
Coiled-coil domain-containing prote...
CCDC117
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QYH1B0QYH1_HUMAN
Coiled-coil domain-containing prote...
CCDC117
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBN8F8WBN8_HUMAN
Coiled-coil domain-containing prote...
CCDC117
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti102L → P in BAC03592 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028823147R → S. Corresponds to variant dbSNP:rs13057011Ensembl.1
Natural variantiVAR_028824272S → N. Corresponds to variant dbSNP:rs9613680Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02118512 – 120Missing in isoform 2. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_05491263 – 80Missing in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_05491380 – 155DCPVR…EIEDR → E in isoform 4. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CR456461 mRNA Translation: CAG30347.1
AK091133 mRNA Translation: BAC03592.1
AK289516 mRNA Translation: BAF82205.1
AK295140 mRNA Translation: BAH11987.1
AK302925 mRNA Translation: BAH13846.1
AL023494 Genomic DNA No translation available.
Z93930 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59761.1
BC040488 mRNA Translation: AAH40488.1
BC053874 mRNA Translation: AAH53874.1
BC065549 mRNA Translation: AAH65549.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13846.1 [Q8IWD4-1]
CCDS63435.1 [Q8IWD4-4]
CCDS63436.1 [Q8IWD4-3]

NCBI Reference Sequences

More...RefSeqi		NP_001271192.1, NM_001284263.1 [Q8IWD4-3]
NP_001271193.1, NM_001284264.1 [Q8IWD4-4]
NP_001271194.1, NM_001284265.1
NP_775781.1, NM_173510.3 [Q8IWD4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000249064; ENSP00000249064; ENSG00000159873 [Q8IWD4-1]
ENST00000421503; ENSP00000387827; ENSG00000159873 [Q8IWD4-4]
ENST00000448492; ENSP00000389478; ENSG00000159873 [Q8IWD4-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		150275

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:150275

UCSC genome browser

More...UCSCi		uc003aeb.5, human [Q8IWD4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456461 mRNA Translation: CAG30347.1
AK091133 mRNA Translation: BAC03592.1
AK289516 mRNA Translation: BAF82205.1
AK295140 mRNA Translation: BAH11987.1
AK302925 mRNA Translation: BAH13846.1
AL023494 Genomic DNA No translation available.
Z93930 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59761.1
BC040488 mRNA Translation: AAH40488.1
BC053874 mRNA Translation: AAH53874.1
BC065549 mRNA Translation: AAH65549.1
CCDSiCCDS13846.1 [Q8IWD4-1]
CCDS63435.1 [Q8IWD4-4]
CCDS63436.1 [Q8IWD4-3]
RefSeqiNP_001271192.1, NM_001284263.1 [Q8IWD4-3]
NP_001271193.1, NM_001284264.1 [Q8IWD4-4]
NP_001271194.1, NM_001284265.1
NP_775781.1, NM_173510.3 [Q8IWD4-1]

3D structure databases

SMRiQ8IWD4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127277, 14 interactors
IntActiQ8IWD4, 12 interactors
STRINGi9606.ENSP00000249064

PTM databases

iPTMnetiQ8IWD4
PhosphoSitePlusiQ8IWD4

Genetic variation databases

BioMutaiCCDC117
DMDMi74759628

Proteomic databases

EPDiQ8IWD4
jPOSTiQ8IWD4
MassIVEiQ8IWD4
MaxQBiQ8IWD4
PaxDbiQ8IWD4
PeptideAtlasiQ8IWD4
PRIDEiQ8IWD4
ProteomicsDBi6467
6927
70845 [Q8IWD4-1]
70846 [Q8IWD4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		226, 118 antibodies

The DNASU plasmid repository

More...DNASUi		150275

Genome annotation databases

EnsembliENST00000249064; ENSP00000249064; ENSG00000159873 [Q8IWD4-1]
ENST00000421503; ENSP00000387827; ENSG00000159873 [Q8IWD4-4]
ENST00000448492; ENSP00000389478; ENSG00000159873 [Q8IWD4-3]
GeneIDi150275
KEGGihsa:150275
UCSCiuc003aeb.5, human [Q8IWD4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		150275

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCDC117
HGNCiHGNC:26599, CCDC117
HPAiENSG00000159873, Low tissue specificity
neXtProtiNX_Q8IWD4
OpenTargetsiENSG00000159873
PharmGKBiPA145149315
VEuPathDBiHostDB:ENSG00000159873.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S42Q, Eukaryota
GeneTreeiENSGT00390000005772
HOGENOMiCLU_083045_0_0_1
InParanoidiQ8IWD4
OMAiCLRKHRR
PhylomeDBiQ8IWD4
TreeFamiTF335674

Enzyme and pathway databases

PathwayCommonsiQ8IWD4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		150275, 19 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCDC117, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		150275
PharosiQ8IWD4, Tdark

Protein Ontology

More...PROi		PR:Q8IWD4
RNActiQ8IWD4, protein

Gene expression databases

BgeeiENSG00000159873, Expressed in female gonad and 218 other tissues
ExpressionAtlasiQ8IWD4, baseline and differential
GenevisibleiQ8IWD4, HS

Family and domain databases

InterProiView protein in InterPro
IPR031630, CCDC117
PANTHERiPTHR36128, PTHR36128, 1 hit
PfamiView protein in Pfam
PF15810, CCDC117, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC117_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWD4
Secondary accession number(s): A8K0F1
, B7Z2V1, B7Z860, Q6ICA7, Q8N278
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2003
Last modified: April 7, 2021
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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