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Protein

WD repeat and FYVE domain-containing protein 1

Gene

WDFY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 352FYVE-typePROSITE-ProRule annotationAdd BLAST72

GO - Molecular functioni

  • 1-phosphatidylinositol binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ8IWB7

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and FYVE domain-containing protein 1
Alternative name(s):
FENS-1
Phosphoinositide-binding protein 1
WD40- and FYVE domain-containing protein 1
Zinc finger FYVE domain-containing protein 17
Gene namesi
Name:WDFY1
Synonyms:KIAA1435, WDF1, ZFYVE17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000085449.14
HGNCiHGNC:20451 WDFY1
neXtProtiNX_Q8IWB7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000085449
PharmGKBiPA134929936

Polymorphism and mutation databases

BioMutaiWDFY1
DMDMi51316866

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513351 – 410WD repeat and FYVE domain-containing protein 1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei408PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IWB7
MaxQBiQ8IWB7
PaxDbiQ8IWB7
PeptideAtlasiQ8IWB7
PRIDEiQ8IWB7
ProteomicsDBi70838

PTM databases

iPTMnetiQ8IWB7
PhosphoSitePlusiQ8IWB7

Expressioni

Gene expression databases

BgeeiENSG00000085449 Expressed in 203 organ(s), highest expression level in secondary oocyte
CleanExiHS_WDFY1
ExpressionAtlasiQ8IWB7 baseline and differential
GenevisibleiQ8IWB7 HS

Organism-specific databases

HPAiHPA050603

Interactioni

Subunit structurei

Binds PtdIns3P in vitro with high specificity over other phosphoinositides. Interacts (via WD repeat 2) with tyrosine-phosphorylated TLR3 (via TIR domain) in response to poly(I:C) (PubMed:25736436). Interacts with TICAM1 in response to poly(I:C) (By similarity). Interacts with TLR4 in response to LPS (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi121641, 34 interactors
IntActiQ8IWB7, 1 interactor
STRINGi9606.ENSP00000233055

Structurei

3D structure databases

ProteinModelPortaliQ8IWB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 61WD 1Add BLAST40
Repeati66 – 105WD 2Add BLAST40
Repeati112 – 150WD 3Add BLAST39
Repeati153 – 192WD 4Add BLAST40
Repeati197 – 236WD 5Add BLAST40
Repeati240 – 279WD 6Add BLAST40
Repeati364 – 403WD 7Add BLAST40

Domaini

The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns3P-enriched membranes is substantially increased in acidic conditions. The FYVE domain is required for its function in regulating TLR3 signaling (PubMed:25736436).2 Publications

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 352FYVE-typePROSITE-ProRule annotationAdd BLAST72

Keywords - Domaini

Repeat, WD repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1409 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00670000098022
HOGENOMiHOG000007835
HOVERGENiHBG054128
InParanoidiQ8IWB7
OMAiMLGRHYF
OrthoDBiEOG091G0ANN
PhylomeDBiQ8IWB7
TreeFamiTF314470

Family and domain databases

Gene3Di2.130.10.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 2 hits
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q8IWB7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEIHSRPQ SSRPVLLSKI EGHQDAVTAA LLIPKEDGVI TASEDRTIRV
60 70 80 90 100
WLKRDSGQYW PSIYHTMASP CSAMAYHHDS RRIFVGQDNG AVMEFHVSED
110 120 130 140 150
FNKMNFIKTY PAHQNRVSAI IFSLATEWVI STGHDKCVSW MCTRSGNMLG
160 170 180 190 200
RHFFTSWASC LQYDFDTQYA FVGDYSGQIT LLKLEQNTCS VITTLKGHEG
210 220 230 240 250
SVACLWWDPI QRLLFSGASD NSIIMWDIGG RKGRTLLLQG HHDKVQSLCY
260 270 280 290 300
LQLTRQLVSC SSDGGIAVWN MDVSREEAPQ WLESDSCQKC EQPFFWNIKQ
310 320 330 340 350
MWDTKTLGLR QHHCRKCGQA VCGKCSSKRS SYPVMGFEFQ VRVCDSCYDS
360 370 380 390 400
IKDEDRTSLA TFHEGKHNIS HMSMDIARGL MVTCGTDRIV KIWDMTPVVG
410
CSLATGFSPH
Length:410
Mass (Da):46,324
Last modified:March 1, 2003 - v1
Checksum:i25D981799D918BE3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JJ54C9JJ54_HUMAN
WD repeat and FYVE domain-containin...
WDFY1
215Annotation score:

Sequence cautioni

The sequence BAA92673 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310568 mRNA Translation: CAC83947.1
AF411977 mRNA Translation: AAL04161.1
AB037856 mRNA Translation: BAA92673.1 Different initiation.
AK022888 mRNA Translation: BAB14294.1
AC073641 Genomic DNA Translation: AAY14924.1
CH471063 Genomic DNA Translation: EAW70817.1
BC040525 mRNA Translation: AAH40525.1
BC065934 mRNA Translation: AAH65934.1
CCDSiCCDS33387.1
RefSeqiNP_065881.1, NM_020830.4
UniGeneiHs.368359

Genome annotation databases

EnsembliENST00000233055; ENSP00000233055; ENSG00000085449
GeneIDi57590
KEGGihsa:57590
UCSCiuc002vnq.4 human

Similar proteinsi

Entry informationi

Entry nameiWDFY1_HUMAN
AccessioniPrimary (citable) accession number: Q8IWB7
Secondary accession number(s): Q53S17, Q9H9D5, Q9P2B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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