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UniProtKB - Q8IWA6 (CCD60_HUMAN)
Protein
Coiled-coil domain-containing protein 60
Gene
CCDC60
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 60 |
Gene namesi | Name:CCDC60 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28610, CCDC60 |
neXtProti | NX_Q8IWA6 |
VEuPathDBi | HostDB:ENSG00000183273 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 160777 |
OpenTargetsi | ENSG00000183273 |
PharmGKBi | PA143485413 |
Miscellaneous databases
Pharosi | Q8IWA6, Tdark |
Genetic variation databases
BioMutai | CCDC60 |
DMDMi | 296434427 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000239665 | 1 – 550 | Coiled-coil domain-containing protein 60Add BLAST | 550 |
Proteomic databases
MassIVEi | Q8IWA6 |
MaxQBi | Q8IWA6 |
PaxDbi | Q8IWA6 |
PeptideAtlasi | Q8IWA6 |
PRIDEi | Q8IWA6 |
ProteomicsDBi | 70832 |
PTM databases
iPTMneti | Q8IWA6 |
PhosphoSitePlusi | Q8IWA6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000183273, Expressed in right uterine tube and 127 other tissues |
ExpressionAtlasi | Q8IWA6, baseline and differential |
Genevisiblei | Q8IWA6, HS |
Organism-specific databases
HPAi | ENSG00000183273, Tissue enhanced (choroid plexus, fallopian tube, testis) |
Interactioni
Binary interactionsi
Q8IWA6
With | #Exp. | IntAct |
---|---|---|
MTUS2 [Q5JR59] | 4 | EBI-10262147,EBI-742948 |
Protein-protein interaction databases
BioGRIDi | 127766, 11 interactors |
IntActi | Q8IWA6, 8 interactors |
STRINGi | 9606.ENSP00000333374 |
Miscellaneous databases
RNActi | Q8IWA6, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 219 – 293 | DisorderedSequence analysisAdd BLAST | 75 | |
Regioni | 336 – 367 | DisorderedSequence analysisAdd BLAST | 32 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 71 – 98 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 20 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 230 – 278 | Polar residuesSequence analysisAdd BLAST | 49 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QVFX, Eukaryota |
GeneTreei | ENSGT00390000015428 |
HOGENOMi | CLU_036722_0_0_1 |
InParanoidi | Q8IWA6 |
OMAi | MQRKAPS |
OrthoDBi | 1215093at2759 |
PhylomeDBi | Q8IWA6 |
TreeFami | TF336372 |
Family and domain databases
InterProi | View protein in InterPro IPR031526, DUF4698 |
PANTHERi | PTHR34754, PTHR34754, 1 hit |
Pfami | View protein in Pfam PF15769, DUF4698, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8IWA6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKVPATKKL QSSPNSGAVR PFYASENLRQ VPDKPMKSIK YMDKEIINLK
60 70 80 90 100
KDLIRSRFLI QSVKIGRGYF AILREETAKK KKQQQLQKLK EEERNKFQPA
110 120 130 140 150
EKISEIHYGD TLLSTYDDEK LKTLGARVTR RPFTPIHSCI ISPSLTEAHV
160 170 180 190 200
EPLFRQLCAL HWLLEALTID HTHHTMKPVI TCWNPKDPGG SKSTIKKINK
210 220 230 240 250
DKSMGQKWEH FITAPKTKKF KIPTMRVTNR KPSRRGSTLS LSRASGGSSP
260 270 280 290 300
QSSMISVNPG SDEPPSVNTQ VTSSKDIEDN ESSSTKPDEE PLYMNLQKLL
310 320 330 340 350
EMVREDARRT VTIENGMQRK APSILSVLKQ NKSNSAYKEM QTTLKSSERS
360 370 380 390 400
SSTSAESHIQ PVQKKSKNRT NCDINIHYKS GVCNTMRAKF YSVAQEAGFC
410 420 430 440 450
LQDKMEILMK RQEERGIQKF RAFVLVSNFQ KDIAKMRHHI SVVKGDAEEI
460 470 480 490 500
ADHWYFDLLS KLPEDLKNFR PAKKILVKLQ KFGENLDLRI RPHVLLKVLQ
510 520 530 540 550
DLRIWELCSP DIAVAIEFVR EHIIHMPQED YISWLQSRIN IPIGPYSALR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H2N8 | F5H2N8_HUMAN | Coiled-coil domain-containing prote... | CCDC60 | 133 | Annotation score: | ||
F5H5H4 | F5H5H4_HUMAN | Coiled-coil domain-containing prote... | CCDC60 | 57 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 219 | K → E in AAH40553 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033667 | 46 | I → V. Corresponds to variant dbSNP:rs1064319Ensembl. | 1 | |
Natural variantiVAR_033668 | 115 | T → A. Corresponds to variant dbSNP:rs2519540Ensembl. | 1 | |
Natural variantiVAR_033669 | 393 | V → I. Corresponds to variant dbSNP:rs16949292Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC002070 Genomic DNA No translation available. AC084881 Genomic DNA No translation available. BC040553 mRNA Translation: AAH40553.1 |
CCDSi | CCDS9190.1 |
RefSeqi | NP_848594.2, NM_178499.4 |
Genome annotation databases
Ensembli | ENST00000327554; ENSP00000333374; ENSG00000183273 |
GeneIDi | 160777 |
KEGGi | hsa:160777 |
MANE-Selecti | ENST00000327554.3; ENSP00000333374.2; NM_178499.5; NP_848594.2 |
UCSCi | uc001txe.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC002070 Genomic DNA No translation available. AC084881 Genomic DNA No translation available. BC040553 mRNA Translation: AAH40553.1 |
CCDSi | CCDS9190.1 |
RefSeqi | NP_848594.2, NM_178499.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127766, 11 interactors |
IntActi | Q8IWA6, 8 interactors |
STRINGi | 9606.ENSP00000333374 |
PTM databases
iPTMneti | Q8IWA6 |
PhosphoSitePlusi | Q8IWA6 |
Genetic variation databases
BioMutai | CCDC60 |
DMDMi | 296434427 |
Proteomic databases
MassIVEi | Q8IWA6 |
MaxQBi | Q8IWA6 |
PaxDbi | Q8IWA6 |
PeptideAtlasi | Q8IWA6 |
PRIDEi | Q8IWA6 |
ProteomicsDBi | 70832 |
Protocols and materials databases
Antibodypediai | 31402, 94 antibodies from 14 providers |
DNASUi | 160777 |
Genome annotation databases
Ensembli | ENST00000327554; ENSP00000333374; ENSG00000183273 |
GeneIDi | 160777 |
KEGGi | hsa:160777 |
MANE-Selecti | ENST00000327554.3; ENSP00000333374.2; NM_178499.5; NP_848594.2 |
UCSCi | uc001txe.3, human |
Organism-specific databases
CTDi | 160777 |
DisGeNETi | 160777 |
GeneCardsi | CCDC60 |
HGNCi | HGNC:28610, CCDC60 |
HPAi | ENSG00000183273, Tissue enhanced (choroid plexus, fallopian tube, testis) |
neXtProti | NX_Q8IWA6 |
OpenTargetsi | ENSG00000183273 |
PharmGKBi | PA143485413 |
VEuPathDBi | HostDB:ENSG00000183273 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVFX, Eukaryota |
GeneTreei | ENSGT00390000015428 |
HOGENOMi | CLU_036722_0_0_1 |
InParanoidi | Q8IWA6 |
OMAi | MQRKAPS |
OrthoDBi | 1215093at2759 |
PhylomeDBi | Q8IWA6 |
TreeFami | TF336372 |
Enzyme and pathway databases
PathwayCommonsi | Q8IWA6 |
SignaLinki | Q8IWA6 |
Miscellaneous databases
BioGRID-ORCSi | 160777, 3 hits in 1033 CRISPR screens |
ChiTaRSi | CCDC60, human |
GenomeRNAii | 160777 |
Pharosi | Q8IWA6, Tdark |
PROi | PR:Q8IWA6 |
RNActi | Q8IWA6, protein |
Gene expression databases
Bgeei | ENSG00000183273, Expressed in right uterine tube and 127 other tissues |
ExpressionAtlasi | Q8IWA6, baseline and differential |
Genevisiblei | Q8IWA6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031526, DUF4698 |
PANTHERi | PTHR34754, PTHR34754, 1 hit |
Pfami | View protein in Pfam PF15769, DUF4698, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCD60_HUMAN | |
Accessioni | Q8IWA6Primary (citable) accession number: Q8IWA6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 13, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 23, 2022 | |
This is version 114 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports