Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q8IWA6 (CCD60_HUMAN)

Entry version 107 (17 Jun 2020)
Sequence version 2 (18 May 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Coiled-coil domain-containing protein 60

Gene

CCDC60

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 60
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC60
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000183273.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:28610 CCDC60

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IWA6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000183273

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485413

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IWA6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCDC60

Domain mapping of disease mutations (DMDM)

More...DMDMi		296434427

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002396651 – 550Coiled-coil domain-containing protein 60Add BLAST550

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IWA6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IWA6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IWA6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IWA6

PeptideAtlas

More...PeptideAtlasi		Q8IWA6

PRoteomics IDEntifications database

More...PRIDEi		Q8IWA6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70832

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IWA6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IWA6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183273 Expressed in right uterine tube and 110 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IWA6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IWA6 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000183273 Tissue enhanced (brain, fallopian tube, smooth muscle, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127766, 10 interactors

Protein interaction database and analysis system

More...IntActi		Q8IWA6, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000333374

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IWA6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IWA6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili71 – 98Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IJXB Eukaryota
ENOG4111UXH LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015428

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_036722_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IWA6

Identification of Orthologs from Complete Genome Data

More...OMAi		MQRKAPS

Database of Orthologous Groups

More...OrthoDBi		1215093at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IWA6

TreeFam database of animal gene trees

More...TreeFami		TF336372

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031526 DUF4698

The PANTHER Classification System

More...PANTHERi		PTHR34754 PTHR34754, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15769 DUF4698, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8IWA6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKVPATKKL QSSPNSGAVR PFYASENLRQ VPDKPMKSIK YMDKEIINLK 
        60         70         80         90        100
KDLIRSRFLI QSVKIGRGYF AILREETAKK KKQQQLQKLK EEERNKFQPA 
       110        120        130        140        150
EKISEIHYGD TLLSTYDDEK LKTLGARVTR RPFTPIHSCI ISPSLTEAHV 
       160        170        180        190        200
EPLFRQLCAL HWLLEALTID HTHHTMKPVI TCWNPKDPGG SKSTIKKINK 
       210        220        230        240        250
DKSMGQKWEH FITAPKTKKF KIPTMRVTNR KPSRRGSTLS LSRASGGSSP 
       260        270        280        290        300
QSSMISVNPG SDEPPSVNTQ VTSSKDIEDN ESSSTKPDEE PLYMNLQKLL 
       310        320        330        340        350
EMVREDARRT VTIENGMQRK APSILSVLKQ NKSNSAYKEM QTTLKSSERS 
       360        370        380        390        400
SSTSAESHIQ PVQKKSKNRT NCDINIHYKS GVCNTMRAKF YSVAQEAGFC 
       410        420        430        440        450
LQDKMEILMK RQEERGIQKF RAFVLVSNFQ KDIAKMRHHI SVVKGDAEEI 
       460        470        480        490        500
ADHWYFDLLS KLPEDLKNFR PAKKILVKLQ KFGENLDLRI RPHVLLKVLQ 
       510        520        530        540        550
DLRIWELCSP DIAVAIEFVR EHIIHMPQED YISWLQSRIN IPIGPYSALR
Length:550
Mass (Da):63,091
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD48DC84933C3C61
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H2N8F5H2N8_HUMAN
Coiled-coil domain-containing prote...
CCDC60
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H5H4F5H5H4_HUMAN
Coiled-coil domain-containing prote...
CCDC60
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti219K → E in AAH40553 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03366746I → V. Corresponds to variant dbSNP:rs1064319Ensembl.1
Natural variantiVAR_033668115T → A. Corresponds to variant dbSNP:rs2519540Ensembl.1
Natural variantiVAR_033669393V → I. Corresponds to variant dbSNP:rs16949292Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC002070 Genomic DNA No translation available.
AC084881 Genomic DNA No translation available.
BC040553 mRNA Translation: AAH40553.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9190.1

NCBI Reference Sequences

More...RefSeqi		NP_848594.2, NM_178499.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000327554; ENSP00000333374; ENSG00000183273

Database of genes from NCBI RefSeq genomes

More...GeneIDi		160777

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:160777

UCSC genome browser

More...UCSCi		uc001txe.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002070 Genomic DNA No translation available.
AC084881 Genomic DNA No translation available.
BC040553 mRNA Translation: AAH40553.1
CCDSiCCDS9190.1
RefSeqiNP_848594.2, NM_178499.4

3D structure databases

SMRiQ8IWA6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127766, 10 interactors
IntActiQ8IWA6, 7 interactors
STRINGi9606.ENSP00000333374

PTM databases

iPTMnetiQ8IWA6
PhosphoSitePlusiQ8IWA6

Polymorphism and mutation databases

BioMutaiCCDC60
DMDMi296434427

Proteomic databases

jPOSTiQ8IWA6
MassIVEiQ8IWA6
MaxQBiQ8IWA6
PaxDbiQ8IWA6
PeptideAtlasiQ8IWA6
PRIDEiQ8IWA6
ProteomicsDBi70832

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31402 95 antibodies

The DNASU plasmid repository

More...DNASUi		160777

Genome annotation databases

EnsembliENST00000327554; ENSP00000333374; ENSG00000183273
GeneIDi160777
KEGGihsa:160777
UCSCiuc001txe.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		160777
EuPathDBiHostDB:ENSG00000183273.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCDC60
HGNCiHGNC:28610 CCDC60
HPAiENSG00000183273 Tissue enhanced (brain, fallopian tube, smooth muscle, testis)
neXtProtiNX_Q8IWA6
OpenTargetsiENSG00000183273
PharmGKBiPA143485413

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IJXB Eukaryota
ENOG4111UXH LUCA
GeneTreeiENSGT00390000015428
HOGENOMiCLU_036722_0_0_1
InParanoidiQ8IWA6
OMAiMQRKAPS
OrthoDBi1215093at2759
PhylomeDBiQ8IWA6
TreeFamiTF336372

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		160777 0 hits in 784 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCDC60 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		160777
PharosiQ8IWA6 Tdark

Protein Ontology

More...PROi		PR:Q8IWA6
RNActiQ8IWA6 protein

Gene expression databases

BgeeiENSG00000183273 Expressed in right uterine tube and 110 other tissues
ExpressionAtlasiQ8IWA6 baseline and differential
GenevisibleiQ8IWA6 HS

Family and domain databases

InterProiView protein in InterPro
IPR031526 DUF4698
PANTHERiPTHR34754 PTHR34754, 1 hit
PfamiView protein in Pfam
PF15769 DUF4698, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD60_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWA6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: May 18, 2010
Last modified: June 17, 2020
This is version 107 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again