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Entry version 72 (12 Aug 2020)
Sequence version 1 (01 Mar 2003)
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Protein
Submitted name:

SYCP2 protein

Gene

SYCP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SYCP2 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYCP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

ChromosomeARBA annotation, NucleusARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36272

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q8IWA1

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IWA1, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 184SYCP2_ARLDInterPro annotationAdd BLAST175
Domaini278 – 389SYCP2_SLDInterPro annotationAdd BLAST112

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni439 – 480DisorderedSequence analysisAdd BLAST42
Regioni496 – 555DisorderedSequence analysisAdd BLAST60
Regioni653 – 676DisorderedSequence analysisAdd BLAST24
Regioni693 – 717DisorderedSequence analysisAdd BLAST25
Regioni755 – 795DisorderedSequence analysisAdd BLAST41
Regioni962 – 1024DisorderedSequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi439 – 456PolyampholyteSequence analysisAdd BLAST18
Compositional biasi457 – 471PolarSequence analysisAdd BLAST15
Compositional biasi517 – 540PolarSequence analysisAdd BLAST24
Compositional biasi541 – 555PolyampholyteSequence analysisAdd BLAST15
Compositional biasi696 – 717PolarSequence analysisAdd BLAST22
Compositional biasi765 – 795PolyampholyteSequence analysisAdd BLAST31
Compositional biasi983 – 997PolarSequence analysisAdd BLAST15
Compositional biasi998 – 1014PolyampholyteSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SYCP2 family.ARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
285929at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024835, SYCP1/2
IPR024832, SYCP2
IPR041322, SYCP2_ARLD
IPR040560, SYCP2_SLD

The PANTHER Classification System

More...
PANTHERi
PTHR15607, PTHR15607, 1 hit
PTHR15607:SF12, PTHR15607:SF12, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18581, SYCP2_ARLD, 1 hit
PF18584, SYCP2_SLD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q8IWA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIRPDLQQL EKCIDDALRK NDFKPLKTLL QIDICEDVKI KCSKQFFHKV
60 70 80 90 100
DNLICRELNK EDIHNVSAIL VSVGRCGKNI SVLGQAGLLT MIKQGLIQKM
110 120 130 140 150
VAWFEKSKDI IQSQGNSKDE AVLNMIEDLV DLLLVIHDVS DEGKKQVVES
160 170 180 190 200
FVPRICSLVI DSRVNICIQQ EIIKKMNAML DKMPQDARKI LSNQEMLILM
210 220 230 240 250
SSMGERILDA GDYDLQVGIV EALCRMTTEK QRQELAHQWF SMDFIAKAFK
260 270 280 290 300
RIKDSEFETD CRIFLNLVNG MLGDKRRVFT FPCLSAFLDK YELQIPSDEK
310 320 330 340 350
LEEFWIDFNL GSQTLSFYIA GDNDDHQWEA VTVPEEKVQI YSIEVRESKK
360 370 380 390 400
LLTIILKNTV KISKREGKEL LLYFDASLEI TNVTQKIFGA TKHRESIRKQ
410 420 430 440 450
GISVAKTSLH ILFDASGSQI LVPESQISPV GEELVSLKEK SKSPKEFAKP
460 470 480 490 500
SKYIKNSDKG NRNNSQLEKT TPSKRKMSEA SMIVSGADRY TMRSPVLFSN
510 520 530 540 550
TSIPPRRRRI KPPLQMTSSA EKPSVSQTSE NRVDNAASLK SRSSEGRHRR
560 570 580 590 600
DNIDKHIKTA KCVENTENKN VEFPNQNFSE LQDVIPDSQA AEKRDHTILP
610 620 630 640 650
GVLDNICGNK IHSKWACWTP VTNIELCNNQ RASTSSGDTL NQDIVINKKL
660 670 680 690 700
TKQKSSSSIS DHNSEGTGKV KYKKEQTDHI KIDKAEVEVC KKHNQQQNHP
710 720 730 740 750
KYSGQKNTEN AKQSDWPVES ETTFKSVLLN KTIEESLIYR KKYILSKDVN
760 770 780 790 800
TATCDKNPSA SKNVQSHRKA EKELTSELNS WDSKQKKMRE KSKGKEFTNV
810 820 830 840 850
AESLISQINK RYKTKDDIKS TRKLKESLIN SGFSNKPVVQ LSKEKVQKKS
860 870 880 890 900
YRKLKTTFVN VTSECPVNDV YNFNLNGADD PIIKLGIQEF QATAKEACAD
910 920 930 940 950
RSIRLVGPRN HDELKSSVKT KDKKIITNHQ KKNLFSDTET EYRCDDSKTD
960 970 980 990 1000
ISWLREPKSK PQLIDYSRNK NVKNHKSGKS RSSLEKGQPS SKMTPSKNIT
1010 1020
KKMDKTIPEG RIRLPRKATK KKKK
Length:1,024
Mass (Da):116,690
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2911138692A09910
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1024Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC040566 mRNA Translation: AAH40566.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC040566 mRNA Translation: AAH40566.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ8IWA1
PRIDEiQ8IWA1

Organism-specific databases

PharmGKBiPA36272

Phylogenomic databases

OrthoDBi285929at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SYCP2, human

Gene expression databases

GenevisibleiQ8IWA1, HS

Family and domain databases

InterProiView protein in InterPro
IPR024835, SYCP1/2
IPR024832, SYCP2
IPR041322, SYCP2_ARLD
IPR040560, SYCP2_SLD
PANTHERiPTHR15607, PTHR15607, 1 hit
PTHR15607:SF12, PTHR15607:SF12, 1 hit
PfamiView protein in Pfam
PF18581, SYCP2_ARLD, 1 hit
PF18584, SYCP2_SLD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8IWA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWA1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: August 12, 2020
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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