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Entry version 166 (13 Nov 2019)
Sequence version 1 (01 Mar 2003)
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Protein

WD repeat-containing protein 75

Gene

WDR75

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis, rRNA processing, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8IWA0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 75
Alternative name(s):
U3 small nucleolar RNA-associated protein 17 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR75
Synonyms:UTP17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25725 WDR75

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IWA0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000115368

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670579

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IWA0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR75

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73622083

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000514301 – 830WD repeat-containing protein 75Add BLAST830

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki123Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki427Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei466N6-acetyllysineCombined sources1
Modified residuei664PhosphoserineCombined sources1
Modified residuei672PhosphoserineCombined sources1
Cross-linki676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei779PhosphoserineCombined sources1
Modified residuei782PhosphoserineCombined sources1
Modified residuei796PhosphoserineCombined sources1
Modified residuei811PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8IWA0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IWA0

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8IWA0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IWA0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IWA0

PeptideAtlas

More...
PeptideAtlasi
Q8IWA0

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWA0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70825

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
Q8IWA0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IWA0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IWA0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8IWA0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115368 Expressed in 200 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IWA0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IWA0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038199

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75 (PubMed:17699751, PubMed:22916032).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123901, 36 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IWA0, 26 interactors

Molecular INTeraction database

More...
MINTi
Q8IWA0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000314193

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati4 – 43WD 1Add BLAST40
Repeati47 – 86WD 2Add BLAST40
Repeati90 – 131WD 3Add BLAST42
Repeati145 – 184WD 4Add BLAST40
Repeati193 – 231WD 5Add BLAST39
Repeati237 – 276WD 6Add BLAST40
Repeati279 – 318WD 7Add BLAST40
Repeati324 – 362WD 8Add BLAST39
Repeati376 – 423WD 9Add BLAST48
Repeati430 – 474WD 10Add BLAST45
Repeati487 – 525WD 11Add BLAST39
Repeati529 – 569WD 12Add BLAST41
Repeati574 – 611WD 13Add BLAST38

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1963 Eukaryota
ENOG410YY9G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006303

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000043113

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IWA0

KEGG Orthology (KO)

More...
KOi
K14552

Identification of Orthologs from Complete Genome Data

More...
OMAi
CIATGHE

Database of Orthologous Groups

More...
OrthoDBi
1437651at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IWA0

TreeFam database of animal gene trees

More...
TreeFami
TF323469

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50998 SSF50998, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8IWA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEEENIRVV RCGGSELNFR RAVFSADSKY IFCVSGDFVK VYSTVTEECV
60 70 80 90 100
HILHGHRNLV TGIQLNPNNH LQLYSCSLDG TIKLWDYIDG ILIKTFIVGC
110 120 130 140 150
KLHALFTLAQ AEDSVFVIVN KEKPDIFQLV SVKLPKSSSQ EVEAKELSFV
160 170 180 190 200
LDYINQSPKC IAFGNEGVYV AAVREFYLSV YFFKKKTTSR FTLSSSRNKK
210 220 230 240 250
HAKNNFTCVA CHPTEDCIAS GHMDGKIRLW RNFYDDKKYT YTCLHWHHDM
260 270 280 290 300
VMDLAFSVTG TSLLSGGRES VLVEWRDATE KNKEFLPRLG ATIEHISVSP
310 320 330 340 350
AGDLFCTSHS DNKIIIIHRN LEASAVIQGL VKDRSIFTGL MIDPRTKALV
360 370 380 390 400
LNGKPGHLQF YSLQSDKQLY NLDIIQQEYI NDYGLIQIEL TKAAFGCFGN
410 420 430 440 450
WLATVEQRQE KETELELQMK LWMYNKKTQG FILNTKINMP HEDCITALCF
460 470 480 490 500
CNAEKSEQPT LVTASKDGYF KVWILTDDSD IYKKAVGWTC DFVGSYHKYQ
510 520 530 540 550
ATNCCFSEDG SLLAVSFEEI VTIWDSVTWE LKCTFCQRAG KIRHLCFGRL
560 570 580 590 600
TCSKYLLGAT ENGILCCWNL LSCALEWNAK LNVRVMEPDP NSENIAAISQ
610 620 630 640 650
SSVGSDLFVF KPSEPRPLYI QKGISREKVQ WGVFVPRDVP ESFTSEAYQW
660 670 680 690 700
LNRSQFYFLT KSQSLLTFST KSPEEKLTPT SKQLLAEESL PTTPFYFILG
710 720 730 740 750
KHRQQQDEKL NETLENELVQ LPLTENIPAI SELLHTPAHV LPSAAFLCSM
760 770 780 790 800
FVNSLLLSKE TKSAKEIPED VDMEEEKESE DSDEENDFTE KVQDTSNTGL
810 820 830
GEDIIHQLSK SEEKELRKFR KIDYSWIAAL
Length:830
Mass (Da):94,499
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE2A3C2C156C0939
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WC81F8WC81_HUMAN
WD repeat-containing protein 75
WDR75
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE20F8WE20_HUMAN
WD repeat-containing protein 75
WDR75
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14503 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti116F → L in BAB14503 (PubMed:14702039).Curated1
Sequence conflicti125D → N in BAB14111 (PubMed:14702039).Curated1
Sequence conflicti250M → T in BAB14111 (PubMed:14702039).Curated1
Sequence conflicti279T → I in BAB14503 (PubMed:14702039).Curated1
Sequence conflicti393A → T in BAB14111 (PubMed:14702039).Curated1
Sequence conflicti479S → T in BAB14126 (PubMed:14702039).Curated1
Sequence conflicti733L → H in BAB14126 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL122097 mRNA Translation: CAB59265.1
CR749440 mRNA Translation: CAH18278.1
AC013439 Genomic DNA Translation: AAX93081.1
BC040567 mRNA Translation: AAH40567.1
BC006816 mRNA Translation: AAH06816.1
AK022581 mRNA Translation: BAB14111.1
AK022607 mRNA Translation: BAB14126.1
AK023276 mRNA Translation: BAB14503.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS2298.1

Protein sequence database of the Protein Information Resource

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PIRi
T34531

NCBI Reference Sequences

More...
RefSeqi
NP_001290025.1, NM_001303096.1
NP_115544.1, NM_032168.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314761; ENSP00000314193; ENSG00000115368

Database of genes from NCBI RefSeq genomes

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GeneIDi
84128

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84128

UCSC genome browser

More...
UCSCi
uc002uql.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122097 mRNA Translation: CAB59265.1
CR749440 mRNA Translation: CAH18278.1
AC013439 Genomic DNA Translation: AAX93081.1
BC040567 mRNA Translation: AAH40567.1
BC006816 mRNA Translation: AAH06816.1
AK022581 mRNA Translation: BAB14111.1
AK022607 mRNA Translation: BAB14126.1
AK023276 mRNA Translation: BAB14503.1 Different initiation.
CCDSiCCDS2298.1
PIRiT34531
RefSeqiNP_001290025.1, NM_001303096.1
NP_115544.1, NM_032168.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123901, 36 interactors
IntActiQ8IWA0, 26 interactors
MINTiQ8IWA0
STRINGi9606.ENSP00000314193

PTM databases

iPTMnetiQ8IWA0
PhosphoSitePlusiQ8IWA0
SwissPalmiQ8IWA0

Polymorphism and mutation databases

BioMutaiWDR75
DMDMi73622083

2D gel databases

SWISS-2DPAGEiQ8IWA0

Proteomic databases

EPDiQ8IWA0
jPOSTiQ8IWA0
MassIVEiQ8IWA0
MaxQBiQ8IWA0
PaxDbiQ8IWA0
PeptideAtlasiQ8IWA0
PRIDEiQ8IWA0
ProteomicsDBi70825

Genome annotation databases

EnsembliENST00000314761; ENSP00000314193; ENSG00000115368
GeneIDi84128
KEGGihsa:84128
UCSCiuc002uql.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84128

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WDR75
HGNCiHGNC:25725 WDR75
HPAiHPA038199
neXtProtiNX_Q8IWA0
OpenTargetsiENSG00000115368
PharmGKBiPA142670579

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1963 Eukaryota
ENOG410YY9G LUCA
GeneTreeiENSGT00390000006303
HOGENOMiHOG000043113
InParanoidiQ8IWA0
KOiK14552
OMAiCIATGHE
OrthoDBi1437651at2759
PhylomeDBiQ8IWA0
TreeFamiTF323469

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiQ8IWA0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WDR75 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84128
PharosiQ8IWA0

Protein Ontology

More...
PROi
PR:Q8IWA0

Gene expression databases

BgeeiENSG00000115368 Expressed in 200 organ(s), highest expression level in lung
ExpressionAtlasiQ8IWA0 baseline and differential
GenevisibleiQ8IWA0 HS

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 8 hits
SUPFAMiSSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR75_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWA0
Secondary accession number(s): Q96J10
, Q9H8U8, Q9H9U5, Q9H9V8, Q9UIX2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: November 13, 2019
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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