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Protein

WD repeat-containing protein 75

Gene

WDR75

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.1 Publication

GO - Molecular functioni

GO - Biological processi

  • positive regulation of rRNA processing Source: UniProtKB
  • positive regulation of transcription by RNA polymerase I Source: UniProtKB
  • rRNA processing Source: Reactome

Keywordsi

Biological processRibosome biogenesis, rRNA processing, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiQ8IWA0

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 75
Alternative name(s):
U3 small nucleolar RNA-associated protein 17 homolog
Gene namesi
Name:WDR75
Synonyms:UTP17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115368.9
HGNCiHGNC:25725 WDR75
neXtProtiNX_Q8IWA0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000115368
PharmGKBiPA142670579

Polymorphism and mutation databases

BioMutaiWDR75
DMDMi73622083

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514301 – 830WD repeat-containing protein 75Add BLAST830

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki123Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki427Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei466N6-acetyllysineCombined sources1
Modified residuei664PhosphoserineCombined sources1
Modified residuei672PhosphoserineCombined sources1
Cross-linki676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei779PhosphoserineCombined sources1
Modified residuei782PhosphoserineCombined sources1
Modified residuei796PhosphoserineCombined sources1
Modified residuei811PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IWA0
MaxQBiQ8IWA0
PaxDbiQ8IWA0
PeptideAtlasiQ8IWA0
PRIDEiQ8IWA0
ProteomicsDBi70825

2D gel databases

SWISS-2DPAGEiQ8IWA0

PTM databases

iPTMnetiQ8IWA0
PhosphoSitePlusiQ8IWA0
SwissPalmiQ8IWA0

Expressioni

Gene expression databases

BgeeiENSG00000115368 Expressed in 200 organ(s), highest expression level in lung
CleanExiHS_WDR75
ExpressionAtlasiQ8IWA0 baseline and differential
GenevisibleiQ8IWA0 HS

Organism-specific databases

HPAiHPA038199

Interactioni

Subunit structurei

May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75 (PubMed:17699751, PubMed:22916032).2 Publications

Protein-protein interaction databases

BioGridi123901, 29 interactors
IntActiQ8IWA0, 14 interactors
STRINGi9606.ENSP00000314193

Structurei

3D structure databases

ProteinModelPortaliQ8IWA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 43WD 1Add BLAST40
Repeati47 – 86WD 2Add BLAST40
Repeati90 – 131WD 3Add BLAST42
Repeati145 – 184WD 4Add BLAST40
Repeati193 – 231WD 5Add BLAST39
Repeati237 – 276WD 6Add BLAST40
Repeati279 – 318WD 7Add BLAST40
Repeati324 – 362WD 8Add BLAST39
Repeati376 – 423WD 9Add BLAST48
Repeati430 – 474WD 10Add BLAST45
Repeati487 – 525WD 11Add BLAST39
Repeati529 – 569WD 12Add BLAST41
Repeati574 – 611WD 13Add BLAST38

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1963 Eukaryota
ENOG410YY9G LUCA
GeneTreeiENSGT00390000006303
HOGENOMiHOG000043113
HOVERGENiHBG061237
InParanoidiQ8IWA0
KOiK14552
OMAiCIAFGNE
OrthoDBiEOG091G02TD
PhylomeDBiQ8IWA0
TreeFamiTF323469

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 8 hits
SUPFAMiSSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8IWA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEEENIRVV RCGGSELNFR RAVFSADSKY IFCVSGDFVK VYSTVTEECV
60 70 80 90 100
HILHGHRNLV TGIQLNPNNH LQLYSCSLDG TIKLWDYIDG ILIKTFIVGC
110 120 130 140 150
KLHALFTLAQ AEDSVFVIVN KEKPDIFQLV SVKLPKSSSQ EVEAKELSFV
160 170 180 190 200
LDYINQSPKC IAFGNEGVYV AAVREFYLSV YFFKKKTTSR FTLSSSRNKK
210 220 230 240 250
HAKNNFTCVA CHPTEDCIAS GHMDGKIRLW RNFYDDKKYT YTCLHWHHDM
260 270 280 290 300
VMDLAFSVTG TSLLSGGRES VLVEWRDATE KNKEFLPRLG ATIEHISVSP
310 320 330 340 350
AGDLFCTSHS DNKIIIIHRN LEASAVIQGL VKDRSIFTGL MIDPRTKALV
360 370 380 390 400
LNGKPGHLQF YSLQSDKQLY NLDIIQQEYI NDYGLIQIEL TKAAFGCFGN
410 420 430 440 450
WLATVEQRQE KETELELQMK LWMYNKKTQG FILNTKINMP HEDCITALCF
460 470 480 490 500
CNAEKSEQPT LVTASKDGYF KVWILTDDSD IYKKAVGWTC DFVGSYHKYQ
510 520 530 540 550
ATNCCFSEDG SLLAVSFEEI VTIWDSVTWE LKCTFCQRAG KIRHLCFGRL
560 570 580 590 600
TCSKYLLGAT ENGILCCWNL LSCALEWNAK LNVRVMEPDP NSENIAAISQ
610 620 630 640 650
SSVGSDLFVF KPSEPRPLYI QKGISREKVQ WGVFVPRDVP ESFTSEAYQW
660 670 680 690 700
LNRSQFYFLT KSQSLLTFST KSPEEKLTPT SKQLLAEESL PTTPFYFILG
710 720 730 740 750
KHRQQQDEKL NETLENELVQ LPLTENIPAI SELLHTPAHV LPSAAFLCSM
760 770 780 790 800
FVNSLLLSKE TKSAKEIPED VDMEEEKESE DSDEENDFTE KVQDTSNTGL
810 820 830
GEDIIHQLSK SEEKELRKFR KIDYSWIAAL
Length:830
Mass (Da):94,499
Last modified:March 1, 2003 - v1
Checksum:iAE2A3C2C156C0939
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WC81F8WC81_HUMAN
WD repeat-containing protein 75
WDR75
97Annotation score:
F8WE20F8WE20_HUMAN
WD repeat-containing protein 75
WDR75
89Annotation score:

Sequence cautioni

The sequence BAB14503 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116F → L in BAB14503 (PubMed:14702039).Curated1
Sequence conflicti125D → N in BAB14111 (PubMed:14702039).Curated1
Sequence conflicti250M → T in BAB14111 (PubMed:14702039).Curated1
Sequence conflicti279T → I in BAB14503 (PubMed:14702039).Curated1
Sequence conflicti393A → T in BAB14111 (PubMed:14702039).Curated1
Sequence conflicti479S → T in BAB14126 (PubMed:14702039).Curated1
Sequence conflicti733L → H in BAB14126 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122097 mRNA Translation: CAB59265.1
CR749440 mRNA Translation: CAH18278.1
AC013439 Genomic DNA Translation: AAX93081.1
BC040567 mRNA Translation: AAH40567.1
BC006816 mRNA Translation: AAH06816.1
AK022581 mRNA Translation: BAB14111.1
AK022607 mRNA Translation: BAB14126.1
AK023276 mRNA Translation: BAB14503.1 Different initiation.
CCDSiCCDS2298.1
PIRiT34531
RefSeqiNP_001290025.1, NM_001303096.1
NP_115544.1, NM_032168.2
UniGeneiHs.399984

Genome annotation databases

EnsembliENST00000314761; ENSP00000314193; ENSG00000115368
GeneIDi84128
KEGGihsa:84128
UCSCiuc002uql.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122097 mRNA Translation: CAB59265.1
CR749440 mRNA Translation: CAH18278.1
AC013439 Genomic DNA Translation: AAX93081.1
BC040567 mRNA Translation: AAH40567.1
BC006816 mRNA Translation: AAH06816.1
AK022581 mRNA Translation: BAB14111.1
AK022607 mRNA Translation: BAB14126.1
AK023276 mRNA Translation: BAB14503.1 Different initiation.
CCDSiCCDS2298.1
PIRiT34531
RefSeqiNP_001290025.1, NM_001303096.1
NP_115544.1, NM_032168.2
UniGeneiHs.399984

3D structure databases

ProteinModelPortaliQ8IWA0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123901, 29 interactors
IntActiQ8IWA0, 14 interactors
STRINGi9606.ENSP00000314193

PTM databases

iPTMnetiQ8IWA0
PhosphoSitePlusiQ8IWA0
SwissPalmiQ8IWA0

Polymorphism and mutation databases

BioMutaiWDR75
DMDMi73622083

2D gel databases

SWISS-2DPAGEiQ8IWA0

Proteomic databases

EPDiQ8IWA0
MaxQBiQ8IWA0
PaxDbiQ8IWA0
PeptideAtlasiQ8IWA0
PRIDEiQ8IWA0
ProteomicsDBi70825

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314761; ENSP00000314193; ENSG00000115368
GeneIDi84128
KEGGihsa:84128
UCSCiuc002uql.2 human

Organism-specific databases

CTDi84128
EuPathDBiHostDB:ENSG00000115368.9
GeneCardsiWDR75
HGNCiHGNC:25725 WDR75
HPAiHPA038199
neXtProtiNX_Q8IWA0
OpenTargetsiENSG00000115368
PharmGKBiPA142670579
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1963 Eukaryota
ENOG410YY9G LUCA
GeneTreeiENSGT00390000006303
HOGENOMiHOG000043113
HOVERGENiHBG061237
InParanoidiQ8IWA0
KOiK14552
OMAiCIAFGNE
OrthoDBiEOG091G02TD
PhylomeDBiQ8IWA0
TreeFamiTF323469

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
SignaLinkiQ8IWA0

Miscellaneous databases

ChiTaRSiWDR75 human
GenomeRNAii84128
PROiPR:Q8IWA0

Gene expression databases

BgeeiENSG00000115368 Expressed in 200 organ(s), highest expression level in lung
CleanExiHS_WDR75
ExpressionAtlasiQ8IWA0 baseline and differential
GenevisibleiQ8IWA0 HS

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 8 hits
SUPFAMiSSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiWDR75_HUMAN
AccessioniPrimary (citable) accession number: Q8IWA0
Secondary accession number(s): Q96J10
, Q9H8U8, Q9H9U5, Q9H9V8, Q9UIX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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