Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q8IW50 (F219A_HUMAN)

Entry version 129 (10 Feb 2021)
Sequence version 3 (14 Oct 2008)
Previous versions | rss
Add a publicationFeedback
Protein

Protein FAM219A

Gene

FAM219A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IW50

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM219A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM219A
Synonyms:C9orf25
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19920, FAM219A

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IW50

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000164970.14

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		203259

Open Targets

More...OpenTargetsi		ENSG00000164970

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134916501

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IW50, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FAM219A

Domain mapping of disease mutations (DMDM)

More...DMDMi		209572756

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000896761 – 185Protein FAM219AAdd BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei72PhosphoserineBy similarity1
Modified residuei102PhosphoserineCombined sources1
Modified residuei113PhosphothreonineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IW50

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IW50

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IW50

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IW50

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IW50

PeptideAtlas

More...PeptideAtlasi		Q8IW50

PRoteomics IDEntifications database

More...PRIDEi		Q8IW50

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70811 [Q8IW50-1]
70812 [Q8IW50-2]
70813 [Q8IW50-3]
70814 [Q8IW50-4]
70815 [Q8IW50-5]
70816 [Q8IW50-6]
70817 [Q8IW50-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IW50

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IW50

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8IW50

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164970, Expressed in ventricular zone and 212 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IW50, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IW50, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000164970, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		128461, 38 interactors

Protein interaction database and analysis system

More...IntActi		Q8IW50, 29 interactors

Molecular INTeraction database

More...MINTi		Q8IW50

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000392452

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IW50, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM219 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QS86, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000860

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IW50

Identification of Orthologs from Complete Genome Data

More...OMAi		EMQDPAS

Database of Orthologous Groups

More...OrthoDBi		1299495at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IW50

TreeFam database of animal gene trees

More...TreeFami		TF331928

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029339, FAM219

The PANTHER Classification System

More...PANTHERi		PTHR31281, PTHR31281, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15260, FAM219A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IW50-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMEEIDRFQV PTAHSEMQPL DPAAASISDG DCDAREGESV AMNYKPSPLQ 
        60         70         80         90        100
VKLEKQRELA RKGSLKNGSM GSPVNQQPKK NNVMARTRLV VPNKGYSSLD 
       110        120        130        140        150
QSPDEKPLVA LDTDSDDDFD MSRYSSSGYS SAEQINQDLN IQLLKDGYRL 
       160        170        180 
DEIPDDEDLD LIPPKSVNPT CMCCQATSST ACHIQ
Length:185
Mass (Da):20,400
Last modified:October 14, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i114C59F2A3307D1E
GO
Isoform 2 (identifier: Q8IW50-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-20: Missing.
     37-53: Missing.

Show »
Length:157
Mass (Da):17,365
Checksum:i577A4FA4A6B7DC74
GO
Isoform 3 (identifier: Q8IW50-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-20: Missing.
     37-53: Missing.
     134-134: Missing.

Show »
Length:156
Mass (Da):17,237
Checksum:i23C408A7E30506A4
GO
Isoform 4 (identifier: Q8IW50-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-20: Missing.
     134-134: Missing.

Show »
Length:173
Mass (Da):19,080
Checksum:i1AC61D0AE876C0EC
GO
Isoform 5 (identifier: Q8IW50-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-53: Missing.
     134-134: Missing.

Show »
Length:167
Mass (Da):18,428
Checksum:iDF0BBC7B85EE99C1
GO
Isoform 6 (identifier: Q8IW50-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-53: Missing.

Show »
Length:168
Mass (Da):18,557
Checksum:i0AF680107AD137EB
GO
Isoform 7 (identifier: Q8IW50-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-169: SDDDFDMSRY...DLIPPKSVNP → RCVWGLGGSW...DILQPESLQG
     170-185: Missing.

Show »
Length:157
Mass (Da):17,433
Checksum:i389E604116E36355
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T586Q5T586_HUMAN
Protein FAM219A
FAM219A
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRV9A0A0A0MRV9_HUMAN
Protein FAM219A
FAM219A
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRW1A0A0A0MRW1_HUMAN
Protein FAM219A
FAM219A
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T593Q5T593_HUMAN
Protein FAM219A
FAM219A
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRW0A0A0A0MRW0_HUMAN
Protein FAM219A
FAM219A
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRW2A0A0A0MRW2_HUMAN
Protein FAM219A
FAM219A
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRW3A0A0A0MRW3_HUMAN
Protein FAM219A
FAM219A
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti123R → G in AK123887 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03549210 – 20Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_03549337 – 53Missing in isoform 2, isoform 3, isoform 5 and isoform 6. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_035494115 – 169SDDDF…KSVNP → RCVWGLGGSWAAQRNLYSTS GLYRPHLLYCQNWDILQPES LQG in isoform 7. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_035496134Missing in isoform 3, isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_035495170 – 185Missing in isoform 7. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AI953059 mRNA No translation available.
AK096350 mRNA Translation: BAG53270.1
AK123887 mRNA No translation available.
AK294054 mRNA Translation: BAG57402.1
AK299882 mRNA Translation: BAG61730.1
AL160270 Genomic DNA No translation available.
AL356494 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58454.1
BC025348 mRNA Translation: AAH25348.1
BC041009 mRNA Translation: AAH41009.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55304.1 [Q8IW50-1]
CCDS6556.1 [Q8IW50-6]

NCBI Reference Sequences

More...RefSeqi		NP_001171869.1, NM_001184940.1 [Q8IW50-1]
NP_001171870.1, NM_001184941.1
NP_001171871.1, NM_001184942.1 [Q8IW50-4]
NP_001171872.1, NM_001184943.1 [Q8IW50-5]
NP_001171874.1, NM_001184945.1 [Q8IW50-3]
NP_671735.1, NM_147202.1 [Q8IW50-6]
XP_011516100.1, XM_011517798.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000297620; ENSP00000297620; ENSG00000164970 [Q8IW50-6]
ENST00000445726; ENSP00000392452; ENSG00000164970 [Q8IW50-1]
ENST00000651358; ENSP00000499069; ENSG00000164970 [Q8IW50-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		203259

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:203259

UCSC genome browser

More...UCSCi		uc003zuj.4, human [Q8IW50-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AI953059 mRNA No translation available.
AK096350 mRNA Translation: BAG53270.1
AK123887 mRNA No translation available.
AK294054 mRNA Translation: BAG57402.1
AK299882 mRNA Translation: BAG61730.1
AL160270 Genomic DNA No translation available.
AL356494 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58454.1
BC025348 mRNA Translation: AAH25348.1
BC041009 mRNA Translation: AAH41009.1
CCDSiCCDS55304.1 [Q8IW50-1]
CCDS6556.1 [Q8IW50-6]
RefSeqiNP_001171869.1, NM_001184940.1 [Q8IW50-1]
NP_001171870.1, NM_001184941.1
NP_001171871.1, NM_001184942.1 [Q8IW50-4]
NP_001171872.1, NM_001184943.1 [Q8IW50-5]
NP_001171874.1, NM_001184945.1 [Q8IW50-3]
NP_671735.1, NM_147202.1 [Q8IW50-6]
XP_011516100.1, XM_011517798.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi128461, 38 interactors
IntActiQ8IW50, 29 interactors
MINTiQ8IW50
STRINGi9606.ENSP00000392452

PTM databases

iPTMnetiQ8IW50
PhosphoSitePlusiQ8IW50
SwissPalmiQ8IW50

Genetic variation databases

BioMutaiFAM219A
DMDMi209572756

Proteomic databases

EPDiQ8IW50
jPOSTiQ8IW50
MassIVEiQ8IW50
MaxQBiQ8IW50
PaxDbiQ8IW50
PeptideAtlasiQ8IW50
PRIDEiQ8IW50
ProteomicsDBi70811 [Q8IW50-1]
70812 [Q8IW50-2]
70813 [Q8IW50-3]
70814 [Q8IW50-4]
70815 [Q8IW50-5]
70816 [Q8IW50-6]
70817 [Q8IW50-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11236, 78 antibodies

Genome annotation databases

EnsembliENST00000297620; ENSP00000297620; ENSG00000164970 [Q8IW50-6]
ENST00000445726; ENSP00000392452; ENSG00000164970 [Q8IW50-1]
ENST00000651358; ENSP00000499069; ENSG00000164970 [Q8IW50-1]
GeneIDi203259
KEGGihsa:203259
UCSCiuc003zuj.4, human [Q8IW50-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		203259
DisGeNETi203259

GeneCards: human genes, protein and diseases

More...GeneCardsi		FAM219A
HGNCiHGNC:19920, FAM219A
HPAiENSG00000164970, Tissue enhanced (brain)
neXtProtiNX_Q8IW50
OpenTargetsiENSG00000164970
PharmGKBiPA134916501
VEuPathDBiHostDB:ENSG00000164970.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QS86, Eukaryota
GeneTreeiENSGT00390000000860
InParanoidiQ8IW50
OMAiEMQDPAS
OrthoDBi1299495at2759
PhylomeDBiQ8IW50
TreeFamiTF331928

Enzyme and pathway databases

PathwayCommonsiQ8IW50

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		203259, 31 hits in 877 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FAM219A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		203259
PharosiQ8IW50, Tdark

Protein Ontology

More...PROi		PR:Q8IW50
RNActiQ8IW50, protein

Gene expression databases

BgeeiENSG00000164970, Expressed in ventricular zone and 212 other tissues
ExpressionAtlasiQ8IW50, baseline and differential
GenevisibleiQ8IW50, HS

Family and domain databases

InterProiView protein in InterPro
IPR029339, FAM219
PANTHERiPTHR31281, PTHR31281, 1 hit
PfamiView protein in Pfam
PF15260, FAM219A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF219A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IW50
Secondary accession number(s): A2A364
, B4DFE1, B4DSR8, Q5T590, Q5T591, Q5T592, Q5T594, Q5T595, Q8TAZ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 14, 2008
Last modified: February 10, 2021
This is version 129 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again