UniProtKB - Q8IW50 (F219A_HUMAN)
Protein
Protein FAM219A
Gene
FAM219A
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM219A |
Gene namesi | Name:FAM219A Synonyms:C9orf25 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19920, FAM219A |
neXtProti | NX_Q8IW50 |
VEuPathDBi | HostDB:ENSG00000164970.14 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 203259 |
OpenTargetsi | ENSG00000164970 |
PharmGKBi | PA134916501 |
Miscellaneous databases
Pharosi | Q8IW50, Tdark |
Genetic variation databases
BioMutai | FAM219A |
DMDMi | 209572756 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089676 | 1 – 185 | Protein FAM219AAdd BLAST | 185 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 47 | PhosphoserineCombined sources | 1 | |
Modified residuei | 72 | PhosphoserineBy similarity | 1 | |
Modified residuei | 102 | PhosphoserineCombined sources | 1 | |
Modified residuei | 113 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 115 | PhosphoserineCombined sources | 1 | |
Modified residuei | 122 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8IW50 |
jPOSTi | Q8IW50 |
MassIVEi | Q8IW50 |
MaxQBi | Q8IW50 |
PaxDbi | Q8IW50 |
PeptideAtlasi | Q8IW50 |
PRIDEi | Q8IW50 |
ProteomicsDBi | 70811 [Q8IW50-1] 70812 [Q8IW50-2] 70813 [Q8IW50-3] 70814 [Q8IW50-4] 70815 [Q8IW50-5] 70816 [Q8IW50-6] 70817 [Q8IW50-7] |
PTM databases
iPTMneti | Q8IW50 |
PhosphoSitePlusi | Q8IW50 |
SwissPalmi | Q8IW50 |
Expressioni
Gene expression databases
Bgeei | ENSG00000164970, Expressed in ventricular zone and 212 other tissues |
ExpressionAtlasi | Q8IW50, baseline and differential |
Genevisiblei | Q8IW50, HS |
Organism-specific databases
HPAi | ENSG00000164970, Tissue enhanced (brain) |
Interactioni
Binary interactionsi
Isoform 3 [Q8IW50-3]
With | #Exp. | IntAct |
---|---|---|
LIMS4 [P0CW20] | 3 | EBI-13358054,EBI-10196832 |
Protein-protein interaction databases
BioGRIDi | 128461, 38 interactors |
IntActi | Q8IW50, 29 interactors |
MINTi | Q8IW50 |
STRINGi | 9606.ENSP00000392452 |
Miscellaneous databases
RNActi | Q8IW50, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the FAM219 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QS86, Eukaryota |
GeneTreei | ENSGT00390000000860 |
InParanoidi | Q8IW50 |
OMAi | EMQDPAS |
OrthoDBi | 1299495at2759 |
PhylomeDBi | Q8IW50 |
TreeFami | TF331928 |
Family and domain databases
InterProi | View protein in InterPro IPR029339, FAM219 |
PANTHERi | PTHR31281, PTHR31281, 1 hit |
Pfami | View protein in Pfam PF15260, FAM219A, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IW50-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMEEIDRFQV PTAHSEMQPL DPAAASISDG DCDAREGESV AMNYKPSPLQ
60 70 80 90 100
VKLEKQRELA RKGSLKNGSM GSPVNQQPKK NNVMARTRLV VPNKGYSSLD
110 120 130 140 150
QSPDEKPLVA LDTDSDDDFD MSRYSSSGYS SAEQINQDLN IQLLKDGYRL
160 170 180
DEIPDDEDLD LIPPKSVNPT CMCCQATSST ACHIQ
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T586 | Q5T586_HUMAN | Protein FAM219A | FAM219A | 164 | Annotation score: | ||
A0A0A0MRV9 | A0A0A0MRV9_HUMAN | Protein FAM219A | FAM219A | 156 | Annotation score: | ||
A0A0A0MRW1 | A0A0A0MRW1_HUMAN | Protein FAM219A | FAM219A | 156 | Annotation score: | ||
Q5T593 | Q5T593_HUMAN | Protein FAM219A | FAM219A | 168 | Annotation score: | ||
A0A0A0MRW0 | A0A0A0MRW0_HUMAN | Protein FAM219A | FAM219A | 172 | Annotation score: | ||
A0A0A0MRW2 | A0A0A0MRW2_HUMAN | Protein FAM219A | FAM219A | 166 | Annotation score: | ||
A0A0A0MRW3 | A0A0A0MRW3_HUMAN | Protein FAM219A | FAM219A | 183 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 123 | R → G in AK123887 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035492 | 10 – 20 | Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 11 | |
Alternative sequenceiVSP_035493 | 37 – 53 | Missing in isoform 2, isoform 3, isoform 5 and isoform 6. 2 PublicationsAdd BLAST | 17 | |
Alternative sequenceiVSP_035494 | 115 – 169 | SDDDF…KSVNP → RCVWGLGGSWAAQRNLYSTS GLYRPHLLYCQNWDILQPES LQG in isoform 7. 1 PublicationAdd BLAST | 55 | |
Alternative sequenceiVSP_035496 | 134 | Missing in isoform 3, isoform 4 and isoform 5. 2 Publications | 1 | |
Alternative sequenceiVSP_035495 | 170 – 185 | Missing in isoform 7. 1 PublicationAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AI953059 mRNA No translation available. AK096350 mRNA Translation: BAG53270.1 AK123887 mRNA No translation available. AK294054 mRNA Translation: BAG57402.1 AK299882 mRNA Translation: BAG61730.1 AL160270 Genomic DNA No translation available. AL356494 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58454.1 BC025348 mRNA Translation: AAH25348.1 BC041009 mRNA Translation: AAH41009.1 |
CCDSi | CCDS55304.1 [Q8IW50-1] CCDS6556.1 [Q8IW50-6] |
RefSeqi | NP_001171869.1, NM_001184940.1 [Q8IW50-1] NP_001171870.1, NM_001184941.1 NP_001171871.1, NM_001184942.1 [Q8IW50-4] NP_001171872.1, NM_001184943.1 [Q8IW50-5] NP_001171874.1, NM_001184945.1 [Q8IW50-3] NP_671735.1, NM_147202.1 [Q8IW50-6] XP_011516100.1, XM_011517798.2 |
Genome annotation databases
Ensembli | ENST00000297620; ENSP00000297620; ENSG00000164970 [Q8IW50-6] ENST00000445726; ENSP00000392452; ENSG00000164970 [Q8IW50-1] ENST00000651358; ENSP00000499069; ENSG00000164970 [Q8IW50-1] |
GeneIDi | 203259 |
KEGGi | hsa:203259 |
UCSCi | uc003zuj.4, human [Q8IW50-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AI953059 mRNA No translation available. AK096350 mRNA Translation: BAG53270.1 AK123887 mRNA No translation available. AK294054 mRNA Translation: BAG57402.1 AK299882 mRNA Translation: BAG61730.1 AL160270 Genomic DNA No translation available. AL356494 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58454.1 BC025348 mRNA Translation: AAH25348.1 BC041009 mRNA Translation: AAH41009.1 |
CCDSi | CCDS55304.1 [Q8IW50-1] CCDS6556.1 [Q8IW50-6] |
RefSeqi | NP_001171869.1, NM_001184940.1 [Q8IW50-1] NP_001171870.1, NM_001184941.1 NP_001171871.1, NM_001184942.1 [Q8IW50-4] NP_001171872.1, NM_001184943.1 [Q8IW50-5] NP_001171874.1, NM_001184945.1 [Q8IW50-3] NP_671735.1, NM_147202.1 [Q8IW50-6] XP_011516100.1, XM_011517798.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 128461, 38 interactors |
IntActi | Q8IW50, 29 interactors |
MINTi | Q8IW50 |
STRINGi | 9606.ENSP00000392452 |
PTM databases
iPTMneti | Q8IW50 |
PhosphoSitePlusi | Q8IW50 |
SwissPalmi | Q8IW50 |
Genetic variation databases
BioMutai | FAM219A |
DMDMi | 209572756 |
Proteomic databases
EPDi | Q8IW50 |
jPOSTi | Q8IW50 |
MassIVEi | Q8IW50 |
MaxQBi | Q8IW50 |
PaxDbi | Q8IW50 |
PeptideAtlasi | Q8IW50 |
PRIDEi | Q8IW50 |
ProteomicsDBi | 70811 [Q8IW50-1] 70812 [Q8IW50-2] 70813 [Q8IW50-3] 70814 [Q8IW50-4] 70815 [Q8IW50-5] 70816 [Q8IW50-6] 70817 [Q8IW50-7] |
Protocols and materials databases
Antibodypediai | 11236, 78 antibodies |
Genome annotation databases
Ensembli | ENST00000297620; ENSP00000297620; ENSG00000164970 [Q8IW50-6] ENST00000445726; ENSP00000392452; ENSG00000164970 [Q8IW50-1] ENST00000651358; ENSP00000499069; ENSG00000164970 [Q8IW50-1] |
GeneIDi | 203259 |
KEGGi | hsa:203259 |
UCSCi | uc003zuj.4, human [Q8IW50-1] |
Organism-specific databases
CTDi | 203259 |
DisGeNETi | 203259 |
GeneCardsi | FAM219A |
HGNCi | HGNC:19920, FAM219A |
HPAi | ENSG00000164970, Tissue enhanced (brain) |
neXtProti | NX_Q8IW50 |
OpenTargetsi | ENSG00000164970 |
PharmGKBi | PA134916501 |
VEuPathDBi | HostDB:ENSG00000164970.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QS86, Eukaryota |
GeneTreei | ENSGT00390000000860 |
InParanoidi | Q8IW50 |
OMAi | EMQDPAS |
OrthoDBi | 1299495at2759 |
PhylomeDBi | Q8IW50 |
TreeFami | TF331928 |
Enzyme and pathway databases
PathwayCommonsi | Q8IW50 |
Miscellaneous databases
BioGRID-ORCSi | 203259, 31 hits in 877 CRISPR screens |
ChiTaRSi | FAM219A, human |
GenomeRNAii | 203259 |
Pharosi | Q8IW50, Tdark |
PROi | PR:Q8IW50 |
RNActi | Q8IW50, protein |
Gene expression databases
Bgeei | ENSG00000164970, Expressed in ventricular zone and 212 other tissues |
ExpressionAtlasi | Q8IW50, baseline and differential |
Genevisiblei | Q8IW50, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029339, FAM219 |
PANTHERi | PTHR31281, PTHR31281, 1 hit |
Pfami | View protein in Pfam PF15260, FAM219A, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F219A_HUMAN | |
Accessioni | Q8IW50Primary (citable) accession number: Q8IW50 Secondary accession number(s): A2A364 Q8TAZ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | October 14, 2008 | |
Last modified: | February 10, 2021 | |
This is version 129 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families