MAPKAPK5

Functionⁱ

Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.5 Publications

Caution

The role of p38 MAPK kinases is unclear in phosphorylation and activation of MAPKAPK5. According to some reports, it interacts and is phosphorylated by p38-alpha/MAPK14 and p38-beta/MAPK11 (PubMed:9628874 and PubMed:12808055). According to other reports, it is not activated by p38-alpha/MAPK14 and p38-beta/MAPK11. An explanation for these discrepancies, might be that the interaction with p38 MAPK kinases is weak and occurs only under specific conditions.Curated

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Activity regulationⁱ

Activated following phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11, ERK2/MAPK1, ERK3/MAPK6, and ERK4/MAPK4. Activated by stress-related extracellular stimuli; such as H₂O₂, arsenite, anisomycin TNF alpha and also PMA and the calcium ionophore A23187; but to a lesser extent. In vitro, activated by SQSTM1. Inhibited by diterpenoid alkaloid noroxoaconitine.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	51	ATPPROSITE-ProRule annotation		1
Active siteⁱ	148	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	28 – 36	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
calcium-dependent protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
calmodulin-dependent protein kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
MAP kinase kinase activity
Source: ProtInc
Traceable author statementⁱ
- 9628874
mitogen-activated protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
p53 binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17254968
protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17254968
- 21329882

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

intracellular signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of TOR signaling Source: UniProtKB
peptidyl-serine phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of telomerase activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21531765
positive regulation of telomere capping
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21531765
positive regulation of telomere maintenance via telomerase
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21531765
protein autophosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 21329882
Ras protein signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 17254968
regulation of signal transduction by p53 class mediator Source: Reactome
regulation of translation
Source: UniProtKB
Inferred from direct assayⁱ
- 21329882
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 9628874
stress-induced premature senescence
Source: UniProtKB
Inferred from direct assayⁱ
- 17254968

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-5687128 MAPK6/MAPK4 signaling R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
SignaLinkⁱ	Q8IW41
SIGNORⁱ	Q8IW41

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: MAP kinase-activated protein kinase 5 (EC:2.7.11.1) Short name: MAPK-activated protein kinase 5 Short name: MAPKAP kinase 5 Short name: MAPKAP-K5 Short name: MAPKAPK-5 Short name: MK-5 Short name: MK5 Alternative name(s): p38-regulated/activated protein kinase Short name: PRAK
Gene namesⁱ	Name:MAPKAPK5 Synonyms:PRAK
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000089022.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6889 MAPKAPK5
MIMⁱ	606723 gene
neXtProtⁱ	NX_Q8IW41

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	51	K → M: Kinase defective mutant, abolishes activity. 1 Publication	1
Mutagenesisⁱ	182	T → A: No p38-beta/MAPK11-induced activation. 3 Publications	1
Mutagenesisⁱ	182	T → D: Mimicks phosphorylation state and induces constitutive protein kinase activity. 3 Publications	1
Mutagenesisⁱ	212	S → D: Mimicks phosphorylation state and displays a slightly higher protein kinase activity. 1 Publication	1
Mutagenesisⁱ	337	L → G: Induces constitutive protein kinase activity. 1 Publication	1

Keywords - Diseaseⁱ

Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8550
Open Targets More...OpenTargetsⁱ	ENSG00000089022
PharmGKBⁱ	PA30633

Chemistry databases

ChEMBLⁱ	CHEMBL3094
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2096

Polymorphism and mutation databases

DMDMⁱ	52000829

DMDMⁱ

52000829

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086296	1 – 473	MAP kinase-activated protein kinase 5Add BLAST		473

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	115	Phosphoserine; by PKABy similarity	1
Modified residueⁱ	182	Phosphothreonine; by MAPK11, MAPK14, MAPK4, MAPK6 and PKACombined sources1 Publication	1
Modified residueⁱ	212	Phosphoserine1 Publication	1
Modified residueⁱ	354	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated on Thr-182 ERK3/MAPK6 or ERK4/MAPK4; which is the regulatory phosphorylation site and is located on the T-loop/loop 12, leading to activation. Phosphorylation at Thr-182 by p38-alpha/MAPK14, p38-beta/MAPK11 is subject to debate. Phosphorylated at Ser-115 by PKA/PRKACA, leading to localization to the cytoplasm. Autophosphorylated (By similarity).By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8IW41
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IW41
PaxDbⁱ	Q8IW41
PeptideAtlas More...PeptideAtlasⁱ	Q8IW41
PRIDEⁱ	Q8IW41
ProteomicsDBⁱ	70805 70806 [Q8IW41-2]

PTM databases

iPTMnetⁱ	Q8IW41
PhosphoSitePlusⁱ	Q8IW41

Expressionⁱ

Tissue specificityⁱ

Expressed ubiquitously.1 Publication

Inductionⁱ

Directly regulated by MYC: expression is activated by MYC, suggesting the existence of a feedback regulatory loop.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000089022 Expressed in 209 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_MAPKAPK5
ExpressionAtlasⁱ	Q8IW41 baseline and differential
Genevisibleⁱ	Q8IW41 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004546 HPA015515

HPAⁱ

CAB004546
HPA015515

Interactionⁱ

Subunit structureⁱ

Interacts with ERK3/MAPK6 and ERK4/MAPK4 (via FRIEDE motif); the interaction is direct (By similarity). Interacts with YWHAE; the interaction prevents phosphorylation of HSP27/HSPB1 leading to disrupt F-actin polymerization. Interacts with SQSTM1.By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
HSPB1	P04792	2	EBI-1201460,EBI-352682
MAPK6	Q16659	7	EBI-1201460,EBI-1384105
TP53	P04637	2	EBI-1201460,EBI-366083

GO - Molecular functionⁱ

mitogen-activated protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
p53 binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17254968

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114120, 22 interactors
IntActⁱ	Q8IW41, 19 interactors
Molecular INTeraction database More...MINTⁱ	Q8IW41
STRINGⁱ	9606.ENSP00000202788

Chemistry databases

BindingDBⁱ

Q8IW41

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IW41
SMRⁱ	Q8IW41
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	22 – 304	Protein kinasePROSITE-ProRule annotationAdd BLAST		283

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	409 – 440	Sequence analysisAdd BLAST		32

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0604 Eukaryota ENOG410XP8F LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150819
HOGENOMⁱ	HOG000233031
HOVERGENⁱ	HBG106948
InParanoidⁱ	Q8IW41
KEGG Orthology (KO) More...KOⁱ	K04442
OMAⁱ	IHDRENG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G14PL
PhylomeDBⁱ	Q8IW41
TreeFamⁱ	TF312891

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8IW41-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEESDMDKA IKETSILEEY SINWTQKLGA GISGPVRVCV KKSTQERFAL 
        60         70         80         90        100
KILLDRPKAR NEVRLHMMCA THPNIVQIIE VFANSVQFPH ESSPRARLLI 
       110        120        130        140        150
VMEMMEGGEL FHRISQHRHF TEKQASQVTK QIALALRHCH LLNIAHRDLK 
       160        170        180        190        200
PENLLFKDNS LDAPVKLCDF GFAKIDQGDL MTPQFTPYYV APQVLEAQRR 
       210        220        230        240        250
HQKEKSGIIP TSPTPYTYNK SCDLWSLGVI IYVMLCGYPP FYSKHHSRTI 
       260        270        280        290        300
PKDMRRKIMT GSFEFPEEEW SQISEMAKDV VRKLLKVKPE ERLTIEGVLD 
       310        320        330        340        350
HPWLNSTEAL DNVLPSAQLM MDKAVVAGIQ QAHAEQLANM RIQDLKVSLK 
       360        370        380        390        400
PLHSVNNPIL RKRKLLGTKP KDSVYIHDHE NGAEDSNVAL EKLRDVIAQC 
       410        420        430        440        450
ILPQAGKGEN EDEKLNEVMQ EAWKYNRECK LLRDTLQSFS WNGRGFTDKV 
       460        470 
DRLKLAEIVK QVIEEQTTSH ESQ

Note: No experimental confirmation available.

Length:473

Mass (Da):54,220

Last modified:September 13, 2004 - v2

Checksum:ⁱF3D9DDC83CC0C49D

GO

Isoform 2 (identifier: Q8IW41-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
407-408: Missing.

« Hide

        10         20         30         40         50
MSEESDMDKA IKETSILEEY SINWTQKLGA GISGPVRVCV KKSTQERFAL 
        60         70         80         90        100
KILLDRPKAR NEVRLHMMCA THPNIVQIIE VFANSVQFPH ESSPRARLLI 
       110        120        130        140        150
VMEMMEGGEL FHRISQHRHF TEKQASQVTK QIALALRHCH LLNIAHRDLK 
       160        170        180        190        200
PENLLFKDNS LDAPVKLCDF GFAKIDQGDL MTPQFTPYYV APQVLEAQRR 
       210        220        230        240        250
HQKEKSGIIP TSPTPYTYNK SCDLWSLGVI IYVMLCGYPP FYSKHHSRTI 
       260        270        280        290        300
PKDMRRKIMT GSFEFPEEEW SQISEMAKDV VRKLLKVKPE ERLTIEGVLD 
       310        320        330        340        350
HPWLNSTEAL DNVLPSAQLM MDKAVVAGIQ QAHAEQLANM RIQDLKVSLK 
       360        370        380        390        400
PLHSVNNPIL RKRKLLGTKP KDSVYIHDHE NGAEDSNVAL EKLRDVIAQC 
       410        420        430        440        450
ILPQAGENED EKLNEVMQEA WKYNRECKLL RDTLQSFSWN GRGFTDKVDR 
       460        470 
LKLAEIVKQV IEEQTTSHES Q

Show »

Length:471

Mass (Da):54,035

Checksum:ⁱ176FA041A7F28570

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

R4GN33	R4GN33_HUMAN	MAP kinase-activated protein kinase... MAP kinase-activated protein kinase 5	MAPKAPK5	324	Annotation score:
F8VRP2	F8VRP2_HUMAN	MAP kinase-activated protein kinase... MAP kinase-activated protein kinase 5	MAPKAPK5	74	Annotation score:
R4GN93	R4GN93_HUMAN	MAP kinase-activated protein kinase... MAP kinase-activated protein kinase 5	MAPKAPK5	51	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	273	I → T in CAB53747 (PubMed:17974005).Curated		1
Sequence conflictⁱ	291	E → R in AAC39863 (PubMed:9628874).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_040758	67	M → I1 PublicationCorresponds to variant dbSNP:rs34132040Ensembl.		1
Natural variantⁱVAR_040759	282	R → K1 PublicationCorresponds to variant dbSNP:rs34843470Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_011597	407 – 408	Missing in isoform 2. 3 Publications		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF032437 Genomic DNA Translation: AAC39863.1 AK122767 mRNA Translation: BAG53717.1 CH471054 Genomic DNA Translation: EAW97981.1 BC000833 mRNA Translation: AAH00833.1 BC041049 mRNA Translation: AAH41049.1 BC047284 mRNA Translation: AAH47284.2 AL110301 mRNA Translation: CAB53747.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44975.1 [Q8IW41-1] CCDS44976.1 [Q8IW41-2]
PIRⁱ	T34519
NCBI Reference Sequences More...RefSeqⁱ	NP_003659.2, NM_003668.3 [Q8IW41-2] NP_620777.1, NM_139078.2 [Q8IW41-1]
UniGeneⁱ	Hs.333120 Hs.413901

Genome annotation databases

Ensemblⁱ	ENST00000550735; ENSP00000449667; ENSG00000089022 [Q8IW41-2] ENST00000551404; ENSP00000449381; ENSG00000089022 [Q8IW41-1]
GeneIDⁱ	8550
KEGGⁱ	hsa:8550
UCSC genome browser More...UCSCⁱ	uc001tta.5 human [Q8IW41-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IW41	MAPKAPK5 isoform 3		PANTR		473	UniRef100_Q8IW41
Q8IW41-2	MAPKAPK5 isoform 1		PANTR		471	UniRef100_K7ANM9
Uncharacterized protein		PANPA		471
UPI0007DC5550		HUMAN		291
UPI0007DC760E		HUMAN		238
UPI0007DC78AA		HUMAN		405

Protein	Similar proteins		Species	Score	Length	Source
Q8IW41	MAP kinase-activated protein kinase 5		MOUSE		473	UniRef90_O54992
Mitogen-activated protein kinase-activated protein kinase 5		GORGO		490
Uncharacterized protein		PANPA		490
Putative map kinase-activated protein kinase 5 (Fragment)		DESRO		490
MAP kinase-activated protein kinase 5		MYOBR		488
+287

Protein	Similar proteins		Species	Score	Length	Source
Q8IW41	MAP kinase-activated protein kinase 5		MOUSE		473	UniRef50_O54992
Putative map kinase-activated protein kinase 5 (Fragment)		DESRO		490
Mitogen-activated protein kinase-activated protein kinase 5		GORGO		490
Uncharacterized protein		PANPA		490
MAP kinase-activated protein kinase 5		MYOBR		488
+298

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF032437 Genomic DNA Translation: AAC39863.1 AK122767 mRNA Translation: BAG53717.1 CH471054 Genomic DNA Translation: EAW97981.1 BC000833 mRNA Translation: AAH00833.1 BC041049 mRNA Translation: AAH41049.1 BC047284 mRNA Translation: AAH47284.2 AL110301 mRNA Translation: CAB53747.1
CCDSⁱ	CCDS44975.1 [Q8IW41-1] CCDS44976.1 [Q8IW41-2]
PIRⁱ	T34519
RefSeqⁱ	NP_003659.2, NM_003668.3 [Q8IW41-2] NP_620777.1, NM_139078.2 [Q8IW41-1]
UniGeneⁱ	Hs.333120 Hs.413901

3D structure databases

ProteinModelPortalⁱ	Q8IW41
SMRⁱ	Q8IW41
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114120, 22 interactors
IntActⁱ	Q8IW41, 19 interactors
MINTⁱ	Q8IW41
STRINGⁱ	9606.ENSP00000202788

Chemistry databases

BindingDBⁱ	Q8IW41
ChEMBLⁱ	CHEMBL3094
GuidetoPHARMACOLOGYⁱ	2096

PTM databases

iPTMnetⁱ	Q8IW41
PhosphoSitePlusⁱ	Q8IW41

Polymorphism and mutation databases

DMDMⁱ	52000829

DMDMⁱ

52000829

Proteomic databases

EPDⁱ	Q8IW41
MaxQBⁱ	Q8IW41
PaxDbⁱ	Q8IW41
PeptideAtlasⁱ	Q8IW41
PRIDEⁱ	Q8IW41
ProteomicsDBⁱ	70805 70806 [Q8IW41-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8550
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000550735; ENSP00000449667; ENSG00000089022 [Q8IW41-2] ENST00000551404; ENSP00000449381; ENSG00000089022 [Q8IW41-1]
GeneIDⁱ	8550
KEGGⁱ	hsa:8550
UCSCⁱ	uc001tta.5 human [Q8IW41-1]

Organism-specific databases

CTDⁱ	8550
DisGeNETⁱ	8550
EuPathDBⁱ	HostDB:ENSG00000089022.13
GeneCardsⁱ	MAPKAPK5
HGNCⁱ	HGNC:6889 MAPKAPK5
HPAⁱ	CAB004546 HPA015515
MIMⁱ	606723 gene
neXtProtⁱ	NX_Q8IW41
OpenTargetsⁱ	ENSG00000089022
PharmGKBⁱ	PA30633
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0604 Eukaryota ENOG410XP8F LUCA
GeneTreeⁱ	ENSGT00930000150819
HOGENOMⁱ	HOG000233031
HOVERGENⁱ	HBG106948
InParanoidⁱ	Q8IW41
KOⁱ	K04442
OMAⁱ	IHDRENG
OrthoDBⁱ	EOG091G14PL
PhylomeDBⁱ	Q8IW41
TreeFamⁱ	TF312891

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-5687128 MAPK6/MAPK4 signaling R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
SignaLinkⁱ	Q8IW41
SIGNORⁱ	Q8IW41

Miscellaneous databases

ChiTaRSⁱ	MAPKAPK5 human
GeneWikiⁱ	MAPKAPK5
GenomeRNAiⁱ	8550
Protein Ontology More...PROⁱ	PR:Q8IW41
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000089022 Expressed in 209 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_MAPKAPK5
ExpressionAtlasⁱ	Q8IW41 baseline and differential
Genevisibleⁱ	Q8IW41 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MAPK5_HUMAN
Accessionⁱ	Q8IW41Primary (citable) accession number: Q8IW41 Secondary accession number(s): B3KVA5 , O60491, Q86X46, Q9BVX9, Q9UG86
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 13, 2004
	Last sequence update:	September 13, 2004
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q8IW41 (MAPK5_HUMAN)

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MAP kinase-activated protein kinase 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ