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Entry version 111 (13 Feb 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Coiled-coil domain-containing protein 103

Gene

CCDC103

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dynein-attachment factor required for cilia motility.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  • axonemal dynein complex assembly Source: BHF-UCL
  • cilium movement Source: BHF-UCL
  • determination of digestive tract left/right asymmetry Source: BHF-UCL
  • epithelial cilium movement involved in determination of left/right asymmetry Source: BHF-UCL
  • heart looping Source: BHF-UCL
  • inner dynein arm assembly Source: BHF-UCL
  • outer dynein arm assembly Source: BHF-UCL

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 103
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC103
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000167131.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32700 CCDC103

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614677 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IW40

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Flagellum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ciliary dyskinesia, primary, 17 (CILD17)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
See also OMIM:614679
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_068449154H → P in CILD17; unknown pathological significance; hypomorphic variant; reduced cilia beat amplitude in homozygous nasal respiratory cells; does not fully rescue abnormal phenotype in a zebrafish animal model. 1 PublicationCorresponds to variant dbSNP:rs145457535EnsemblClinVar.1

Keywords - Diseasei

Ciliopathy, Disease mutation, Kartagener syndrome, Primary ciliary dyskinesia

Organism-specific databases

DisGeNET

More...
DisGeNETi
388389

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
CCDC103

MalaCards human disease database

More...
MalaCardsi
CCDC103
MIMi614679 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000167131

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
244 Primary ciliary dyskinesia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145008596

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC103

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728126

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002636361 – 242Coiled-coil domain-containing protein 103Add BLAST242

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IW40

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IW40

PeptideAtlas

More...
PeptideAtlasi
Q8IW40

PRoteomics IDEntifications database

More...
PRIDEi
Q8IW40

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70804

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IW40

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IW40

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167131 Expressed in 82 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IW40 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IW40 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043131

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
132670, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IW40, 19 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000387252

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IW40

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IW40

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili8 – 32Sequence analysisAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCDC103/PR46b family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INY9 Eukaryota
ENOG4111QAN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004038

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000090000

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080287

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IW40

Identification of Orthologs from Complete Genome Data

More...
OMAi
AERESCK

Database of Orthologous Groups

More...
OrthoDBi
1451158at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IW40

TreeFam database of animal gene trees

More...
TreeFami
TF324467

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031733 Dynein_attach_N
IPR025986 RPAP3-like_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15867 Dynein_attach_N, 1 hit
PF13877 RPAP3_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IW40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERNDIINFK ALEKELQAAL TADEKYKREN AAKLRAVEQR VASYEEFRGI
60 70 80 90 100
VLASHLKPLE RKDKMGGKRT VPWNCHTIQG RTFQDVATEI SPEKAPLQPE
110 120 130 140 150
TSADFYRDWR RHLPSGPERY QALLQLGGPR LGCLFQTDVG FGLLGELLVA
160 170 180 190 200
LADHVGPADR AAVLGILCSL ASTGRFTLNL SLLSRAERES CKGLFQKLQA
210 220 230 240
MGNPRSVKEG LSWEEQGLEE QSGGLQEEER LLQELLELYQ VD
Length:242
Mass (Da):27,163
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82738F07296FEDC9
GO
Isoform 2 (identifier: Q8IW40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-98: EKAPLQ → NSWKSS
     99-242: Missing.

Note: No experimental confirmation available.
Show »
Length:98
Mass (Da):11,276
Checksum:i2D3B7C6788474100
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W6J8F8W6J8_HUMAN
Coiled-coil domain-containing prote...
CCDC103
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSE5J3KSE5_HUMAN
Coiled-coil domain-containing prote...
CCDC103
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti62K → E in BAF82449 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068449154H → P in CILD17; unknown pathological significance; hypomorphic variant; reduced cilia beat amplitude in homozygous nasal respiratory cells; does not fully rescue abnormal phenotype in a zebrafish animal model. 1 PublicationCorresponds to variant dbSNP:rs145457535EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04603793 – 98EKAPLQ → NSWKSS in isoform 2. 1 Publication6
Alternative sequenceiVSP_04603899 – 242Missing in isoform 2. 1 PublicationAdd BLAST144

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK289760 mRNA Translation: BAF82449.1
DA749894 mRNA No translation available.
AC015936 Genomic DNA No translation available.
BC041060 mRNA Translation: AAH41060.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11490.1 [Q8IW40-1]
CCDS58554.1 [Q8IW40-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001245324.1, NM_001258395.1 [Q8IW40-1]
NP_001245325.1, NM_001258396.1 [Q8IW40-1]
NP_001245326.1, NM_001258397.1 [Q8IW40-2]
NP_998772.1, NM_213607.2 [Q8IW40-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.743398

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000410006; ENSP00000387252; ENSG00000167131 [Q8IW40-1]
ENST00000410027; ENSP00000386640; ENSG00000167131 [Q8IW40-2]
ENST00000417826; ENSP00000391692; ENSG00000167131 [Q8IW40-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
388389

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:388389

UCSC genome browser

More...
UCSCi
uc002iho.4 human [Q8IW40-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289760 mRNA Translation: BAF82449.1
DA749894 mRNA No translation available.
AC015936 Genomic DNA No translation available.
BC041060 mRNA Translation: AAH41060.1
CCDSiCCDS11490.1 [Q8IW40-1]
CCDS58554.1 [Q8IW40-2]
RefSeqiNP_001245324.1, NM_001258395.1 [Q8IW40-1]
NP_001245325.1, NM_001258396.1 [Q8IW40-1]
NP_001245326.1, NM_001258397.1 [Q8IW40-2]
NP_998772.1, NM_213607.2 [Q8IW40-1]
UniGeneiHs.743398

3D structure databases

ProteinModelPortaliQ8IW40
SMRiQ8IW40
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132670, 22 interactors
IntActiQ8IW40, 19 interactors
STRINGi9606.ENSP00000387252

PTM databases

iPTMnetiQ8IW40
PhosphoSitePlusiQ8IW40

Polymorphism and mutation databases

BioMutaiCCDC103
DMDMi74728126

Proteomic databases

MaxQBiQ8IW40
PaxDbiQ8IW40
PeptideAtlasiQ8IW40
PRIDEiQ8IW40
ProteomicsDBi70804

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
388389
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000410006; ENSP00000387252; ENSG00000167131 [Q8IW40-1]
ENST00000410027; ENSP00000386640; ENSG00000167131 [Q8IW40-2]
ENST00000417826; ENSP00000391692; ENSG00000167131 [Q8IW40-1]
GeneIDi388389
KEGGihsa:388389
UCSCiuc002iho.4 human [Q8IW40-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
388389
DisGeNETi388389
EuPathDBiHostDB:ENSG00000167131.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC103
GeneReviewsiCCDC103
HGNCiHGNC:32700 CCDC103
HPAiHPA043131
MalaCardsiCCDC103
MIMi614677 gene
614679 phenotype
neXtProtiNX_Q8IW40
OpenTargetsiENSG00000167131
Orphaneti244 Primary ciliary dyskinesia
PharmGKBiPA145008596

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410INY9 Eukaryota
ENOG4111QAN LUCA
GeneTreeiENSGT00390000004038
HOGENOMiHOG000090000
HOVERGENiHBG080287
InParanoidiQ8IW40
OMAiAERESCK
OrthoDBi1451158at2759
PhylomeDBiQ8IW40
TreeFamiTF324467

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC103 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
388389

Protein Ontology

More...
PROi
PR:Q8IW40

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167131 Expressed in 82 organ(s), highest expression level in testis
ExpressionAtlasiQ8IW40 baseline and differential
GenevisibleiQ8IW40 HS

Family and domain databases

InterProiView protein in InterPro
IPR031733 Dynein_attach_N
IPR025986 RPAP3-like_C
PfamiView protein in Pfam
PF15867 Dynein_attach_N, 1 hit
PF13877 RPAP3_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC103_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IW40
Secondary accession number(s): A8K145, B8ZZU0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2003
Last modified: February 13, 2019
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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