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Protein

Zinc finger protein 695

Gene

ZNF695

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri156 – 178C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 695
Alternative name(s):
Zinc finger protein SBZF3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF695
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197472.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30954 ZNF695

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616348 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IW36

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57116

Open Targets

More...
OpenTargetsi
ENSG00000197472

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670493

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF695

Domain mapping of disease mutations (DMDM)

More...
DMDMi
284018174

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002332821 – 515Zinc finger protein 695Add BLAST515

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IW36

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IW36

PeptideAtlas

More...
PeptideAtlasi
Q8IW36

PRoteomics IDEntifications database

More...
PRIDEi
Q8IW36

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70800
70801 [Q8IW36-1]
70802 [Q8IW36-2]
70803 [Q8IW36-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IW36

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IW36

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197472 Expressed in 71 organ(s), highest expression level in lung

CleanEx database of gene expression profiles

More...
CleanExi
HS_ZNF695

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IW36 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IW36 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024743

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2P502223EBI-10261951,EBI-748397

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121380, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IW36, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000341236

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IW36

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IW36

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 87KRABPROSITE-ProRule annotationAdd BLAST84

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri156 – 178C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154251

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231475

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG067759

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IW36

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCMSLIT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02KC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IW36

TreeFam database of animal gene trees

More...
TreeFami
TF342117

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q8IW36-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLLAFRDVA LEFSPEEWEC LDPAQRSLYR DVMLENYRNL ISLGEDSFNM
60 70 80 90 100
QFLFHSLAMS KPELIICLEA RKEPWNVNTE KTARHSVLSS YLTEDILPEQ
110 120 130 140 150
GLQVSFQKVM LRRYERCCLE KLRLRNDWEI VGEWKGQKAS YNGLDLCSAT
160 170 180 190 200
THSKNFQCNK CVKGFSKFAN LNKCKISHTG EKPFKCKECG NVSCMSLIMT
210 220 230 240 250
QQQRIHIGEN PYQCKKCGKA FNECSCFTDC KRIHVGEKHC KCEECNNIFK
260 270 280 290 300
SCSSLAVVEK NHTEKKTYRC EECGKAFNLC SVLTKHKKIH TGEKPYKCEE
310 320 330 340 350
CGKSFKLFPY LTQHKRIHSR EKPYKCEECG KVFKLLSYLT QHRRIHTGEK
360 370 380 390 400
TFRCEECGKA FNQSSHLTEH RRIHTGEKPY KCEECGKAFT WFSYLIQHKR
410 420 430 440 450
IHTGQKPYKC EECGKAFTWF SYLTQHKRIH TGEKPYKCDE CGKAFNWFSY
460 470 480 490 500
LTNHKRIHTG EKPYKCEECG KAFGQSSHLS KHKTIHTREK PYKCEECGKA
510
FNHSAQLAVH EKTHT
Length:515
Mass (Da):60,149
Last modified:January 19, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB37EA43D0B16E8B5
GO
Isoform 1 (identifier: Q8IW36-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-172: VGEWKGQKAS...KGFSKFANLN → PCEDVLASPL...PVQSSTIELL
     173-515: Missing.

Show »
Length:172
Mass (Da):20,056
Checksum:iCB9E86EC6447A085
GO
Isoform 2 (identifier: Q8IW36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-133: GE → AM
     134-515: Missing.

Show »
Length:133
Mass (Da):15,749
Checksum:i0312791F4F4DF485
GO
Isoform 3 (identifier: Q8IW36-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-88: L → M
     89-515: Missing.

Show »
Length:88
Mass (Da):10,324
Checksum:i08B9ED6E13BD857B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z3A3F2Z3A3_HUMAN
Zinc finger protein 695
ZNF695
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6W2C3F6W2C3_HUMAN
Zinc finger protein 695
ZNF695
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05744684R → K1 PublicationCorresponds to variant dbSNP:rs2642973Ensembl.1
Natural variantiVAR_05744787V → A1 PublicationCorresponds to variant dbSNP:rs2642992Ensembl.1
Natural variantiVAR_061963110M → I. Corresponds to variant dbSNP:rs55762230Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01810688L → M in isoform 3. 1 Publication1
Alternative sequenceiVSP_01810789 – 515Missing in isoform 3. 1 PublicationAdd BLAST427
Alternative sequenceiVSP_038548131 – 172VGEWK…FANLN → PCEDVLASPLPSAMILSFLR PPQKQKHVKPTEPVQSSTIE LL in isoform 1. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_018108132 – 133GE → AM in isoform 2. 1 Publication2
Alternative sequenceiVSP_018109134 – 515Missing in isoform 2. 1 PublicationAdd BLAST382
Alternative sequenceiVSP_038549173 – 515Missing in isoform 1. 1 PublicationAdd BLAST343

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC113174 Genomic DNA No translation available.
AL512637 Genomic DNA No translation available.
BC023527 mRNA No translation available.
BC041082 mRNA Translation: AAH41082.2
BC055096 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44344.1 [Q8IW36-4]
CCDS55694.1 [Q8IW36-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001191150.1, NM_001204221.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.669893

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339986; ENSP00000341236; ENSG00000197472 [Q8IW36-4]
ENST00000366504; ENSP00000355460; ENSG00000197472 [Q8IW36-2]
ENST00000487338; ENSP00000429736; ENSG00000197472 [Q8IW36-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57116

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57116

UCSC genome browser

More...
UCSCi
uc001ibx.4 human [Q8IW36-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113174 Genomic DNA No translation available.
AL512637 Genomic DNA No translation available.
BC023527 mRNA No translation available.
BC041082 mRNA Translation: AAH41082.2
BC055096 mRNA No translation available.
CCDSiCCDS44344.1 [Q8IW36-4]
CCDS55694.1 [Q8IW36-1]
RefSeqiNP_001191150.1, NM_001204221.1
UniGeneiHs.669893

3D structure databases

ProteinModelPortaliQ8IW36
SMRiQ8IW36
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121380, 14 interactors
IntActiQ8IW36, 2 interactors
STRINGi9606.ENSP00000341236

PTM databases

iPTMnetiQ8IW36
PhosphoSitePlusiQ8IW36

Polymorphism and mutation databases

BioMutaiZNF695
DMDMi284018174

Proteomic databases

EPDiQ8IW36
PaxDbiQ8IW36
PeptideAtlasiQ8IW36
PRIDEiQ8IW36
ProteomicsDBi70800
70801 [Q8IW36-1]
70802 [Q8IW36-2]
70803 [Q8IW36-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57116
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339986; ENSP00000341236; ENSG00000197472 [Q8IW36-4]
ENST00000366504; ENSP00000355460; ENSG00000197472 [Q8IW36-2]
ENST00000487338; ENSP00000429736; ENSG00000197472 [Q8IW36-1]
GeneIDi57116
KEGGihsa:57116
UCSCiuc001ibx.4 human [Q8IW36-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57116
DisGeNETi57116
EuPathDBiHostDB:ENSG00000197472.14

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF695
HGNCiHGNC:30954 ZNF695
HPAiHPA024743
MIMi616348 gene
neXtProtiNX_Q8IW36
OpenTargetsiENSG00000197472
PharmGKBiPA142670493

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000154251
HOGENOMiHOG000231475
HOVERGENiHBG067759
InParanoidiQ8IW36
OMAiSCMSLIT
OrthoDBiEOG091G02KC
PhylomeDBiQ8IW36
TreeFamiTF342117

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF695 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57116

Protein Ontology

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PROi
PR:Q8IW36

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000197472 Expressed in 71 organ(s), highest expression level in lung
CleanExiHS_ZNF695
ExpressionAtlasiQ8IW36 baseline and differential
GenevisibleiQ8IW36 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN695_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IW36
Secondary accession number(s): Q5T0N9
, Q5T0P1, Q5T0P3, Q7Z2W8, Q7Z648
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: January 19, 2010
Last modified: December 5, 2018
This is version 130 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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