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Protein

Seven in absentia homolog 3

Gene

SIAH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi107ZincBy similarity1
Metal bindingi114ZincBy similarity1
Metal bindingi126ZincBy similarity1
Metal bindingi131ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri61 – 132SIAH-type; degenerateAdd BLAST72

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ubiquitin conjugating enzyme binding Source: GO_Central
  • ubiquitin protein ligase activity Source: GO_Central

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Seven in absentia homolog 3
Short name:
Siah-3
Gene namesi
Name:SIAH3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000215475.4
HGNCiHGNC:30553 SIAH3
MIMi615609 gene
neXtProtiNX_Q8IW03

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi283514
OpenTargetsiENSG00000215475
PharmGKBiPA164725697

Polymorphism and mutation databases

BioMutaiSIAH3
DMDMi189046787

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347011 – 269Seven in absentia homolog 3Add BLAST269

Proteomic databases

PaxDbiQ8IW03
PeptideAtlasiQ8IW03
PRIDEiQ8IW03
ProteomicsDBi70794

Expressioni

Gene expression databases

BgeeiENSG00000215475 Expressed in 59 organ(s), highest expression level in peritoneum
GenevisibleiQ8IW03 HS

Organism-specific databases

HPAiHPA060576

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8IW03, 1 interactor
STRINGi9606.ENSP00000383256

Structurei

3D structure databases

ProteinModelPortaliQ8IW03
SMRiQ8IW03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi64 – 98His-richAdd BLAST35

Sequence similaritiesi

Belongs to the SINA (Seven in absentia) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri61 – 132SIAH-type; degenerateAdd BLAST72

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3002 Eukaryota
ENOG410XVP0 LUCA
GeneTreeiENSGT00390000005434
HOGENOMiHOG000154320
InParanoidiQ8IW03
KOiK22256
OMAiTHRVDIL
OrthoDBiEOG091G0JY1
PhylomeDBiQ8IW03
TreeFamiTF312976

Family and domain databases

Gene3Di2.60.210.10, 1 hit
InterProiView protein in InterPro
IPR018121 7-in-absentia-prot_TRAF-dom
IPR004162 SINA-like
IPR008974 TRAF-like
PANTHERiPTHR10315 PTHR10315, 1 hit
PfamiView protein in Pfam
PF03145 Sina, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IW03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFFTQCFGA VLDLIHLRFQ HYKAKRVFSA AGQLVCVVNP THNLKYVSSR
60 70 80 90 100
RAVTQSAPEQ GSFHPHHLSH HHCHHRHHHH LRHHAHPHHL HHQEAGLHAN
110 120 130 140 150
PVTPCLCMCP LFSCQWEGRL EVVVPHLRQI HRVDILQGAE IVFLATDMHL
160 170 180 190 200
PAPADWIIMH SCLGHHFLLV LRKQERHEGH PQFFATMMLI GTPTQADCFT
210 220 230 240 250
YRLELNRNHR RLKWEATPRS VLECVDSVIT DGDCLVLNTS LAQLFSDNGS
260
LAIGIAITAT EVLPSEAEM
Length:269
Mass (Da):30,660
Last modified:May 20, 2008 - v3
Checksum:i7006A263D374F973
GO

Sequence cautioni

The sequence AAH41372 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC04809 differs from that shown. Chimeric cDNA. A chimeric cDNA originating from chromosomes 13 and 19.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157819 Genomic DNA No translation available.
BC041372 mRNA Translation: AAH41372.2 Different initiation.
AK096522 mRNA Translation: BAC04809.1 Sequence problems.
CCDSiCCDS41883.1
RefSeqiNP_942146.2, NM_198849.2
UniGeneiHs.368483

Genome annotation databases

EnsembliENST00000400405; ENSP00000383256; ENSG00000215475
GeneIDi283514
KEGGihsa:283514
UCSCiuc001vap.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157819 Genomic DNA No translation available.
BC041372 mRNA Translation: AAH41372.2 Different initiation.
AK096522 mRNA Translation: BAC04809.1 Sequence problems.
CCDSiCCDS41883.1
RefSeqiNP_942146.2, NM_198849.2
UniGeneiHs.368483

3D structure databases

ProteinModelPortaliQ8IW03
SMRiQ8IW03
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8IW03, 1 interactor
STRINGi9606.ENSP00000383256

Polymorphism and mutation databases

BioMutaiSIAH3
DMDMi189046787

Proteomic databases

PaxDbiQ8IW03
PeptideAtlasiQ8IW03
PRIDEiQ8IW03
ProteomicsDBi70794

Protocols and materials databases

DNASUi283514
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400405; ENSP00000383256; ENSG00000215475
GeneIDi283514
KEGGihsa:283514
UCSCiuc001vap.4 human

Organism-specific databases

CTDi283514
DisGeNETi283514
EuPathDBiHostDB:ENSG00000215475.4
GeneCardsiSIAH3
HGNCiHGNC:30553 SIAH3
HPAiHPA060576
MIMi615609 gene
neXtProtiNX_Q8IW03
OpenTargetsiENSG00000215475
PharmGKBiPA164725697
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3002 Eukaryota
ENOG410XVP0 LUCA
GeneTreeiENSGT00390000005434
HOGENOMiHOG000154320
InParanoidiQ8IW03
KOiK22256
OMAiTHRVDIL
OrthoDBiEOG091G0JY1
PhylomeDBiQ8IW03
TreeFamiTF312976

Miscellaneous databases

ChiTaRSiSIAH3 human
GenomeRNAii283514
PROiPR:Q8IW03
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000215475 Expressed in 59 organ(s), highest expression level in peritoneum
GenevisibleiQ8IW03 HS

Family and domain databases

Gene3Di2.60.210.10, 1 hit
InterProiView protein in InterPro
IPR018121 7-in-absentia-prot_TRAF-dom
IPR004162 SINA-like
IPR008974 TRAF-like
PANTHERiPTHR10315 PTHR10315, 1 hit
PfamiView protein in Pfam
PF03145 Sina, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIAH3_HUMAN
AccessioniPrimary (citable) accession number: Q8IW03
Secondary accession number(s): B7ZBP0, Q8N8M6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 7, 2018
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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