Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

AT-rich interactive domain-containing protein 3B

Gene

ARID3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A.2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 3B
Short name:
ARID domain-containing protein 3B
Alternative name(s):
Bright and dead ringer protein
Bright-like protein
Gene namesi
Name:ARID3B
Synonyms:BDP, DRIL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000179361.17
HGNCiHGNC:14350 ARID3B
MIMi612457 gene
neXtProtiNX_Q8IVW6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi240P → H: Impairs binding to RB1. 1 Publication1
Mutagenesisi271W → S: Impairs binding to RB1. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi10620
OpenTargetsiENSG00000179361
PharmGKBiPA134896829

Polymorphism and mutation databases

BioMutaiARID3B
DMDMi152013359

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951621 – 561AT-rich interactive domain-containing protein 3BAdd BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei311PhosphoserineCombined sources1
Modified residuei361Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8IVW6
MaxQBiQ8IVW6
PaxDbiQ8IVW6
PeptideAtlasiQ8IVW6
PRIDEiQ8IVW6
ProteomicsDBi70785
70786 [Q8IVW6-3]
70787 [Q8IVW6-4]

PTM databases

iPTMnetiQ8IVW6
PhosphoSitePlusiQ8IVW6

Expressioni

Tissue specificityi

Expressed in placenta, testis and leukocytes. Expressed in neuroblastoma. Present in K-562 erythrocytic leukemia cell line (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000179361 Expressed in 183 organ(s), highest expression level in embryo
CleanExiHS_ARID3B
ExpressionAtlasiQ8IVW6 baseline and differential
GenevisibleiQ8IVW6 HS

Organism-specific databases

HPAiHPA050320

Interactioni

Subunit structurei

Heterodimer with ARID3A. Interacts with unphosphorylated RB1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TINF2Q9BSI42EBI-5458329,EBI-717399

Protein-protein interaction databases

BioGridi115865, 27 interactors
IntActiQ8IVW6, 11 interactors
MINTiQ8IVW6
STRINGi9606.ENSP00000343126

Structurei

3D structure databases

ProteinModelPortaliQ8IVW6
SMRiQ8IVW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini215 – 307ARIDPROSITE-ProRule annotationAdd BLAST93
Domaini419 – 517REKLESPROSITE-ProRule annotationAdd BLAST99

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni203 – 365Interaction with RB11 PublicationAdd BLAST163
Regioni490 – 513Interaction with ARID3A1 PublicationAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 49Gln-richAdd BLAST45
Compositional biasi341 – 353Poly-AlaAdd BLAST13
Compositional biasi523 – 560Ser-richAdd BLAST38

Phylogenomic databases

eggNOGiKOG2744 Eukaryota
ENOG410Y2AP LUCA
GeneTreeiENSGT00550000074575
HOGENOMiHOG000236281
HOVERGENiHBG103680
InParanoidiQ8IVW6
OMAiLQMDSRE
OrthoDBiEOG091G16XQ
PhylomeDBiQ8IVW6
TreeFamiTF320364

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR023334 REKLES_domain
PfamiView protein in Pfam
PF01388 ARID, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit
PS51486 REKLES, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IVW6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPLQQQQQQ QQQQQKQPHL APLQMDAREK QGQQMREAQF LYAQKLVTQP
60 70 80 90 100
TLLSATAGRP SGSTPLGPLA RVPPTAAVAQ VFERGNMNSE PEEEDGGLED
110 120 130 140 150
EDGDDEVAEV AEKETQAASK YFHVQKVARQ DPRVAPMSNL LPAPGLPPHG
160 170 180 190 200
QQAKEDHTKD ASKASPSVST AGQPNWNLDE QLKQNGGLAW SDDADGGRGR
210 220 230 240 250
EISRDFAKLY ELDGDPERKE FLDDLFVFMQ KRGTPINRIP IMAKQILDLY
260 270 280 290 300
MLYKLVTEKG GLVEIINKKI WREITKGLNL PTSITSAAFT LRTQYMKYLY
310 320 330 340 350
AYECEKKALS SPAELQAAID GNRREGRRPS YSSSLFGYSP AAATAAAAAG
360 370 380 390 400
APALLSPPKI RFPILGLGSS SGTNTSSPRI SPATTLRKGD GAPVTTVPVP
410 420 430 440 450
NRLAVPVTLA SQQAGTRTAA LEQLRERLES GEPAEKKASR LSEEEQRLVQ
460 470 480 490 500
QAFQRNFFSM ARQLPMKIRI NGRAEDRAEA SAAALNLTTS SIGSINMSVD
510 520 530 540 550
IDGTTYAGVL FAQKPVVHLI TGSAPQSLGS SASSSSSSHC SPSPTSSRGT
560
PSAEPSTSWS L
Length:561
Mass (Da):60,637
Last modified:July 10, 2007 - v2
Checksum:i5F0CFF83BAFC12D2
GO
Isoform 3 (identifier: Q8IVW6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-471: DGAPVTTVPV...RQLPMKIRIN → QQGSWGRRKK...PVPLQVMEPQ
     472-561: Missing.

Note: No experimental confirmation available.
Show »
Length:435
Mass (Da):47,661
Checksum:i10364C23137AFDB9
GO
Isoform 4 (identifier: Q8IVW6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     474-474: Missing.

Show »
Length:560
Mass (Da):60,566
Checksum:i93A741BF1B631B6A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQ92H3BQ92_HUMAN
AT-rich interactive domain-containi...
ARID3B
138Annotation score:

Sequence cautioni

The sequence BAD92067 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7Q → QQ in AAH41792 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026773390 – 471DGAPV…KIRIN → QQGSWGRRKKGRKGCQFPVF KTGVLGQEGQLWIGPAPVPL QVMEPQ in isoform 3. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_026774472 – 561Missing in isoform 3. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_039860474Missing in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116846 mRNA Translation: AAD09133.1
AB208830 mRNA Translation: BAD92067.1 Different initiation.
AC100835 Genomic DNA No translation available.
BC041792 mRNA Translation: AAH41792.1
CCDSiCCDS10264.1 [Q8IVW6-4]
CCDS76777.1 [Q8IVW6-1]
RefSeqiNP_001294868.1, NM_001307939.1 [Q8IVW6-1]
NP_006456.1, NM_006465.3 [Q8IVW6-4]
UniGeneiHs.647642
Hs.655532

Genome annotation databases

EnsembliENST00000346246; ENSP00000343126; ENSG00000179361 [Q8IVW6-4]
ENST00000622429; ENSP00000477878; ENSG00000179361 [Q8IVW6-1]
GeneIDi10620
KEGGihsa:10620
UCSCiuc002ayd.4 human [Q8IVW6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116846 mRNA Translation: AAD09133.1
AB208830 mRNA Translation: BAD92067.1 Different initiation.
AC100835 Genomic DNA No translation available.
BC041792 mRNA Translation: AAH41792.1
CCDSiCCDS10264.1 [Q8IVW6-4]
CCDS76777.1 [Q8IVW6-1]
RefSeqiNP_001294868.1, NM_001307939.1 [Q8IVW6-1]
NP_006456.1, NM_006465.3 [Q8IVW6-4]
UniGeneiHs.647642
Hs.655532

3D structure databases

ProteinModelPortaliQ8IVW6
SMRiQ8IVW6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115865, 27 interactors
IntActiQ8IVW6, 11 interactors
MINTiQ8IVW6
STRINGi9606.ENSP00000343126

PTM databases

iPTMnetiQ8IVW6
PhosphoSitePlusiQ8IVW6

Polymorphism and mutation databases

BioMutaiARID3B
DMDMi152013359

Proteomic databases

EPDiQ8IVW6
MaxQBiQ8IVW6
PaxDbiQ8IVW6
PeptideAtlasiQ8IVW6
PRIDEiQ8IVW6
ProteomicsDBi70785
70786 [Q8IVW6-3]
70787 [Q8IVW6-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346246; ENSP00000343126; ENSG00000179361 [Q8IVW6-4]
ENST00000622429; ENSP00000477878; ENSG00000179361 [Q8IVW6-1]
GeneIDi10620
KEGGihsa:10620
UCSCiuc002ayd.4 human [Q8IVW6-1]

Organism-specific databases

CTDi10620
DisGeNETi10620
EuPathDBiHostDB:ENSG00000179361.17
GeneCardsiARID3B
HGNCiHGNC:14350 ARID3B
HPAiHPA050320
MIMi612457 gene
neXtProtiNX_Q8IVW6
OpenTargetsiENSG00000179361
PharmGKBiPA134896829
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2744 Eukaryota
ENOG410Y2AP LUCA
GeneTreeiENSGT00550000074575
HOGENOMiHOG000236281
HOVERGENiHBG103680
InParanoidiQ8IVW6
OMAiLQMDSRE
OrthoDBiEOG091G16XQ
PhylomeDBiQ8IVW6
TreeFamiTF320364

Miscellaneous databases

ChiTaRSiARID3B human
GeneWikiiARID3B
GenomeRNAii10620
PROiPR:Q8IVW6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179361 Expressed in 183 organ(s), highest expression level in embryo
CleanExiHS_ARID3B
ExpressionAtlasiQ8IVW6 baseline and differential
GenevisibleiQ8IVW6 HS

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR023334 REKLES_domain
PfamiView protein in Pfam
PF01388 ARID, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit
PS51486 REKLES, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARI3B_HUMAN
AccessioniPrimary (citable) accession number: Q8IVW6
Secondary accession number(s): O95443, Q59HC9, Q6P9C9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again