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UniProtKB - Q8IVW4 (CDKL3_HUMAN)
Protein
Cyclin-dependent kinase-like 3
Gene
CDKL3
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 33 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 125 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 18 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- protein kinase activity Source: ProtInc
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine kinase activity Source: RHEA
GO - Biological processi
- cellular protein modification process Source: ProtInc
- dendrite extension Source: GO_Central
- negative regulation of axon extension Source: GO_Central
- positive regulation of dendrite morphogenesis Source: GO_Central
- protein phosphorylation Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8IVW4 |
SignaLinki | Q8IVW4 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinase-like 3Curated (EC:2.7.11.22)Alternative name(s): Serine/threonine-protein kinase NKIAMRE |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15483, CDKL3 |
MIMi | 608459, gene |
neXtProti | NX_Q8IVW4 |
VEuPathDBi | HostDB:ENSG00000006837 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 51265 |
OpenTargetsi | ENSG00000006837 |
PharmGKBi | PA26319 |
Miscellaneous databases
Pharosi | Q8IVW4, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1163117 |
DrugCentrali | Q8IVW4 |
Genetic variation databases
BioMutai | CDKL3 |
DMDMi | 74762479 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085820 | 1 – 592 | Cyclin-dependent kinase-like 3Add BLAST | 592 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 158 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 160 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q8IVW4 |
MassIVEi | Q8IVW4 |
MaxQBi | Q8IVW4 |
PaxDbi | Q8IVW4 |
PeptideAtlasi | Q8IVW4 |
PRIDEi | Q8IVW4 |
ProteomicsDBi | 70783 [Q8IVW4-1] 70784 [Q8IVW4-2] |
PTM databases
iPTMneti | Q8IVW4 |
PhosphoSitePlusi | Q8IVW4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000006837, Expressed in testis and 122 other tissues |
ExpressionAtlasi | Q8IVW4, baseline and differential |
Genevisiblei | Q8IVW4, HS |
Organism-specific databases
HPAi | ENSG00000006837, Tissue enhanced (testis) |
Interactioni
Binary interactionsi
Q8IVW4
Protein-protein interaction databases
BioGRIDi | 119419, 36 interactors |
IntActi | Q8IVW4, 34 interactors |
STRINGi | 9606.ENSP00000265334 |
Chemistry databases
BindingDBi | Q8IVW4 |
Miscellaneous databases
RNActi | Q8IVW4, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8IVW4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 286 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 283 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 368 – 390 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 459 – 485 | DisorderedSequence analysisAdd BLAST | 27 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 44 – 50 | [NKR]KIAxRE | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 368 – 382 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 466 – 484 | Polar residuesSequence analysisAdd BLAST | 19 |
Domaini
The [NKR]KIAxRE motif seems to be a cyclin-binding region.
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0593, Eukaryota |
GeneTreei | ENSGT00940000161317 |
HOGENOMi | CLU_000288_136_1_1 |
InParanoidi | Q8IVW4 |
OMAi | PFTIQSK |
OrthoDBi | 398098at2759 |
PhylomeDBi | Q8IVW4 |
TreeFami | TF101031 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IVW4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEMYETLGKV GEGSYGTVMK CKHKNTGQIV AIKIFYERPE QSVNKIAMRE
60 70 80 90 100
IKFLKQFHHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK
110 120 130 140 150
RLRKYLFQIL RAIDYLHSNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL
160 170 180 190 200
AAPGDIYTDY VATRWYRAPE LVLKDTSYGK PVDIWALGCM IIEMATGNPY
210 220 230 240 250
LPSSSDLDLL HKIVLKVGNL SPHLQNIFSK SPIFAGVVLP QVQHPKNARK
260 270 280 290 300
KYPKLNGLLA DIVHACLQID PADRISSSDL LHHEYFTRDG FIEKFMPELK
310 320 330 340 350
AKLLQEAKVN SLIKPKESSK ENELRKDERK TVYTNTLLSS SVLGKEIEKE
360 370 380 390 400
KKPKEIKVRV IKVKGGRGDI SEPKKKEYEG GLGQQDANEN VHPMSPDTKL
410 420 430 440 450
VTIEPPNPIN PSTNCNGLKE NPHCGGSVTM PPINLTNSNL MAANLSSNLF
460 470 480 490 500
HPSVRLTERA KKRRTSSQSI GQVMPNSRQE DPGPIQSQME KGIFNERTGH
510 520 530 540 550
SDQMANENKR KLNFSRSDRK EFHFPELPVT IQSKDTKGME VKQIKMLKRE
560 570 580 590
SKKTESSKIP TLLNVDQNQE KQEGGDGHCE GKNLKRNRFF FW
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ET86 | E7ET86_HUMAN | Cyclin-dependent kinase-like 3 | CDKL3 | 590 | Annotation score: | ||
B4DX41 | B4DX41_HUMAN | Cyclin-dependent kinase-like 3 | CDKL3 | 401 | Annotation score: | ||
E5RGK4 | E5RGK4_HUMAN | Cyclin-dependent kinase-like 3 | CDKL3 | 106 | Annotation score: | ||
H0YAP8 | H0YAP8_HUMAN | Cyclin-dependent kinase-like 3 | CDKL3 | 73 | Annotation score: | ||
E5RFT9 | E5RFT9_HUMAN | Cyclin-dependent kinase-like 3 | CDKL3 | 44 | Annotation score: | ||
E5RI54 | E5RI54_HUMAN | Cyclin-dependent kinase-like 3 | CDKL3 | 82 | Annotation score: | ||
H0YB17 | H0YB17_HUMAN | Cyclin-dependent kinase-like 3 | CDKL3 | 18 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 345 | K → E in AAF36509 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041991 | 394 | M → T1 PublicationCorresponds to variant dbSNP:rs35687772Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016148 | 456 – 592 | Missing in isoform 2. 1 PublicationAdd BLAST | 137 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF130372 mRNA Translation: AAF36509.1 CH471062 Genomic DNA Translation: EAW62263.1 CH471062 Genomic DNA Translation: EAW62264.1 CH471062 Genomic DNA Translation: EAW62265.1 CH471062 Genomic DNA Translation: EAW62266.1 BC041799 mRNA Translation: AAH41799.1 |
CCDSi | CCDS47264.1 [Q8IVW4-1] CCDS47265.1 [Q8IVW4-2] |
RefSeqi | NP_001107047.1, NM_001113575.1 [Q8IVW4-1] NP_001287782.1, NM_001300853.1 NP_057592.2, NM_016508.3 [Q8IVW4-2] XP_016865024.1, XM_017009535.1 |
Genome annotation databases
Ensembli | ENST00000265334; ENSP00000265334; ENSG00000006837 ENST00000523832; ENSP00000430496; ENSG00000006837 [Q8IVW4-2] |
GeneIDi | 51265 |
KEGGi | hsa:51265 |
MANE-Selecti | ENST00000265334.9; ENSP00000265334.4; NM_001113575.2; NP_001107047.1 |
UCSCi | uc003kzf.5, human [Q8IVW4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF130372 mRNA Translation: AAF36509.1 CH471062 Genomic DNA Translation: EAW62263.1 CH471062 Genomic DNA Translation: EAW62264.1 CH471062 Genomic DNA Translation: EAW62265.1 CH471062 Genomic DNA Translation: EAW62266.1 BC041799 mRNA Translation: AAH41799.1 |
CCDSi | CCDS47264.1 [Q8IVW4-1] CCDS47265.1 [Q8IVW4-2] |
RefSeqi | NP_001107047.1, NM_001113575.1 [Q8IVW4-1] NP_001287782.1, NM_001300853.1 NP_057592.2, NM_016508.3 [Q8IVW4-2] XP_016865024.1, XM_017009535.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3ZDU | X-ray | 2.20 | A | 1-324 | [»] | |
SMRi | Q8IVW4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119419, 36 interactors |
IntActi | Q8IVW4, 34 interactors |
STRINGi | 9606.ENSP00000265334 |
Chemistry databases
BindingDBi | Q8IVW4 |
ChEMBLi | CHEMBL1163117 |
DrugCentrali | Q8IVW4 |
PTM databases
iPTMneti | Q8IVW4 |
PhosphoSitePlusi | Q8IVW4 |
Genetic variation databases
BioMutai | CDKL3 |
DMDMi | 74762479 |
Proteomic databases
jPOSTi | Q8IVW4 |
MassIVEi | Q8IVW4 |
MaxQBi | Q8IVW4 |
PaxDbi | Q8IVW4 |
PeptideAtlasi | Q8IVW4 |
PRIDEi | Q8IVW4 |
ProteomicsDBi | 70783 [Q8IVW4-1] 70784 [Q8IVW4-2] |
Protocols and materials databases
Antibodypediai | 2061, 199 antibodies from 28 providers |
DNASUi | 51265 |
Genome annotation databases
Ensembli | ENST00000265334; ENSP00000265334; ENSG00000006837 ENST00000523832; ENSP00000430496; ENSG00000006837 [Q8IVW4-2] |
GeneIDi | 51265 |
KEGGi | hsa:51265 |
MANE-Selecti | ENST00000265334.9; ENSP00000265334.4; NM_001113575.2; NP_001107047.1 |
UCSCi | uc003kzf.5, human [Q8IVW4-1] |
Organism-specific databases
CTDi | 51265 |
DisGeNETi | 51265 |
GeneCardsi | CDKL3 |
HGNCi | HGNC:15483, CDKL3 |
HPAi | ENSG00000006837, Tissue enhanced (testis) |
MIMi | 608459, gene |
neXtProti | NX_Q8IVW4 |
OpenTargetsi | ENSG00000006837 |
PharmGKBi | PA26319 |
VEuPathDBi | HostDB:ENSG00000006837 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0593, Eukaryota |
GeneTreei | ENSGT00940000161317 |
HOGENOMi | CLU_000288_136_1_1 |
InParanoidi | Q8IVW4 |
OMAi | PFTIQSK |
OrthoDBi | 398098at2759 |
PhylomeDBi | Q8IVW4 |
TreeFami | TF101031 |
Enzyme and pathway databases
PathwayCommonsi | Q8IVW4 |
SignaLinki | Q8IVW4 |
Miscellaneous databases
BioGRID-ORCSi | 51265, 7 hits in 1067 CRISPR screens |
ChiTaRSi | CDKL3, human |
GenomeRNAii | 51265 |
Pharosi | Q8IVW4, Tchem |
PROi | PR:Q8IVW4 |
RNActi | Q8IVW4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000006837, Expressed in testis and 122 other tissues |
ExpressionAtlasi | Q8IVW4, baseline and differential |
Genevisiblei | Q8IVW4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDKL3_HUMAN | |
Accessioni | Q8IVW4Primary (citable) accession number: Q8IVW4 Secondary accession number(s): D3DQA0, D3DQA1, Q9P114 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families