UniProtKB - Q8IVW4 (CDKL3_HUMAN)

BLAST

>sp|Q8IVW4|CDKL3_HUMAN Cyclin-dependent kinase-like 3 OS=Homo sapiens OX=9606 GN=CDKL3 PE=1 SV=1
MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE
NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNN
IIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGK
PVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLP
QVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELK
AKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVRV
IKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKE
NPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVRLTERAKKRRTSSQSIGQVMPNSRQE
DPGPIQSQMEKGIFNERTGHSDQMANENKRKLNFSRSDRKEFHFPELPVTIQSKDTKGME
VKQIKMLKRESKKTESSKIPTLLNVDQNQEKQEGGDGHCEGKNLKRNRFFFW

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History
Entry version 151 (07 Nov 2018)
Sequence version 1 (01 Mar 2003)
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Protein

Cyclin-dependent kinase-like 3

Gene

CDKL3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	33	ATPPROSITE-ProRule annotation		1
Active siteⁱ	125	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	10 – 18	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
cyclin-dependent protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein kinase activity
Source: ProtInc
Traceable author statementⁱ
- 10463609

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein modification process
Source: ProtInc
Traceable author statementⁱ
- 10463609
dendrite extension
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of axon extension
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of dendrite morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q8IVW4

SignaLinkⁱ

Q8IVW4

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-dependent kinase-like 3Curated (EC:2.7.11.22) Alternative name(s): Serine/threonine-protein kinase NKIAMRE
Gene namesⁱ	Name:CDKL3Imported Synonyms:NKIAMRE1 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000006837.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15483 CDKL3
MIMⁱ	608459 gene
neXtProtⁱ	NX_Q8IVW4

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51265
Open Targets More...OpenTargetsⁱ	ENSG00000006837
PharmGKBⁱ	PA26319

Chemistry databases

ChEMBLⁱ	CHEMBL1163117

ChEMBLⁱ

CHEMBL1163117

Polymorphism and mutation databases

BioMutaⁱ	CDKL3
DMDMⁱ	74762479

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000085820	1 – 592	Cyclin-dependent kinase-like 3Add BLAST		592

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	158	PhosphothreonineBy similarity		1
Modified residueⁱ	160	PhosphotyrosineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IVW4
PaxDbⁱ	Q8IVW4
PeptideAtlas More...PeptideAtlasⁱ	Q8IVW4
PRIDEⁱ	Q8IVW4
ProteomicsDBⁱ	70783 70784 [Q8IVW4-2]

PTM databases

iPTMnetⁱ	Q8IVW4
PhosphoSitePlusⁱ	Q8IVW4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000006837 Expressed in 99 organ(s), highest expression level in right testis
ExpressionAtlasⁱ	Q8IVW4 baseline and differential
Genevisibleⁱ	Q8IVW4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027751

HPAⁱ

HPA027751

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ATG4A	Q8WYN0	3	EBI-3919850,EBI-3044060
CCDC155	Q8N6L0	3	EBI-3919850,EBI-749265
FXR2	P51116	5	EBI-3919850,EBI-740459
GOLGA2	Q08379	3	EBI-3919850,EBI-618309
KRTAP10-9	P60411	3	EBI-3919850,EBI-10172052
LZTS2	Q9BRK4	3	EBI-3919850,EBI-741037
MDFI	Q99750	3	EBI-3919850,EBI-724076
MTUS2	Q5JR59	3	EBI-3919850,EBI-742948
PIH1D3	Q9NQM4	3	EBI-3919850,EBI-10239299
TRIM27	P14373	5	EBI-3919850,EBI-719493
ZBTB14	O43829	3	EBI-3919850,EBI-10176632
ZBTB8A	Q96BR9	5	EBI-3919850,EBI-742740

Protein-protein interaction databases

BioGridⁱ	119419, 21 interactors
IntActⁱ	Q8IVW4, 31 interactors
STRINGⁱ	9606.ENSP00000265334

Chemistry databases

BindingDBⁱ

Q8IVW4

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	4 – 13	Combined sources	10
Beta strandⁱ	16 – 23	Combined sources	8
Turnⁱ	24 – 26	Combined sources	3
Beta strandⁱ	29 – 34	Combined sources	6
Helixⁱ	45 – 56	Combined sources	12
Beta strandⁱ	65 – 69	Combined sources	5
Beta strandⁱ	72 – 74	Combined sources	3
Beta strandⁱ	76 – 80	Combined sources	5
Beta strandⁱ	83 – 85	Combined sources	3
Helixⁱ	86 – 92	Combined sources	7
Helixⁱ	99 – 118	Combined sources	20
Helixⁱ	128 – 130	Combined sources	3
Beta strandⁱ	131 – 133	Combined sources	3
Beta strandⁱ	139 – 141	Combined sources	3
Helixⁱ	161 – 164	Combined sources	4
Helixⁱ	169 – 172	Combined sources	4
Helixⁱ	181 – 196	Combined sources	16
Helixⁱ	206 – 216	Combined sources	11
Helixⁱ	222 – 230	Combined sources	9
Helixⁱ	232 – 234	Combined sources	3
Helixⁱ	248 – 251	Combined sources	4
Helixⁱ	257 – 266	Combined sources	10
Helixⁱ	271 – 273	Combined sources	3
Helixⁱ	277 – 281	Combined sources	5
Helixⁱ	284 – 287	Combined sources	4
Helixⁱ	291 – 308	Combined sources	18

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8IVW4
SMRⁱ	Q8IVW4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 286	Protein kinasePROSITE-ProRule annotationAdd BLAST		283

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	44 – 50	[NKR]KIAxRE		7

Domainⁱ

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0593 Eukaryota ENOG410XNSW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00830000128262
HOGENOMⁱ	HOG000233024
HOVERGENⁱ	HBG080204
InParanoidⁱ	Q8IVW4
KEGG Orthology (KO) More...KOⁱ	K08824
OMAⁱ	MTMPPIN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BZP
PhylomeDBⁱ	Q8IVW4
TreeFamⁱ	TF101031

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8IVW4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMYETLGKV GEGSYGTVMK CKHKNTGQIV AIKIFYERPE QSVNKIAMRE 
        60         70         80         90        100
IKFLKQFHHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK 
       110        120        130        140        150
RLRKYLFQIL RAIDYLHSNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL 
       160        170        180        190        200
AAPGDIYTDY VATRWYRAPE LVLKDTSYGK PVDIWALGCM IIEMATGNPY 
       210        220        230        240        250
LPSSSDLDLL HKIVLKVGNL SPHLQNIFSK SPIFAGVVLP QVQHPKNARK 
       260        270        280        290        300
KYPKLNGLLA DIVHACLQID PADRISSSDL LHHEYFTRDG FIEKFMPELK 
       310        320        330        340        350
AKLLQEAKVN SLIKPKESSK ENELRKDERK TVYTNTLLSS SVLGKEIEKE 
       360        370        380        390        400
KKPKEIKVRV IKVKGGRGDI SEPKKKEYEG GLGQQDANEN VHPMSPDTKL 
       410        420        430        440        450
VTIEPPNPIN PSTNCNGLKE NPHCGGSVTM PPINLTNSNL MAANLSSNLF 
       460        470        480        490        500
HPSVRLTERA KKRRTSSQSI GQVMPNSRQE DPGPIQSQME KGIFNERTGH 
       510        520        530        540        550
SDQMANENKR KLNFSRSDRK EFHFPELPVT IQSKDTKGME VKQIKMLKRE 
       560        570        580        590 
SKKTESSKIP TLLNVDQNQE KQEGGDGHCE GKNLKRNRFF FW

Length:592

Mass (Da):67,514

Last modified:March 1, 2003 - v1

Checksum:ⁱ2B1AF08906EB7697

Isoform 2 (identifier: Q8IVW4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
456-592: Missing.

« Hide

        10         20         30         40         50
MEMYETLGKV GEGSYGTVMK CKHKNTGQIV AIKIFYERPE QSVNKIAMRE 
        60         70         80         90        100
IKFLKQFHHE NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK 
       110        120        130        140        150
RLRKYLFQIL RAIDYLHSNN IIHRDIKPEN ILVSQSGITK LCDFGFARTL 
       160        170        180        190        200
AAPGDIYTDY VATRWYRAPE LVLKDTSYGK PVDIWALGCM IIEMATGNPY 
       210        220        230        240        250
LPSSSDLDLL HKIVLKVGNL SPHLQNIFSK SPIFAGVVLP QVQHPKNARK 
       260        270        280        290        300
KYPKLNGLLA DIVHACLQID PADRISSSDL LHHEYFTRDG FIEKFMPELK 
       310        320        330        340        350
AKLLQEAKVN SLIKPKESSK ENELRKDERK TVYTNTLLSS SVLGKEIEKE 
       360        370        380        390        400
KKPKEIKVRV IKVKGGRGDI SEPKKKEYEG GLGQQDANEN VHPMSPDTKL 
       410        420        430        440        450
VTIEPPNPIN PSTNCNGLKE NPHCGGSVTM PPINLTNSNL MAANLSSNLF 

HPSVR

Note: No experimental confirmation available.

Show »

Length:455

Mass (Da):51,566

Checksum:ⁱB2046F84A9C95AC0

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E7ET86	E7ET86_HUMAN	Cyclin-dependent kinase-like 3 Cyclin-dependent kinase-like 3	CDKL3	590	Annotation score:
B4DX41	B4DX41_HUMAN	Cyclin-dependent kinase-like 3 Cyclin-dependent kinase-like 3 (cDNA FLJ50724, highly similar to Cyclin-dependent kinase-like 3)	CDKL3	401	Annotation score:
E5RGK4	E5RGK4_HUMAN	Cyclin-dependent kinase-like 3 Cyclin-dependent kinase-like 3	CDKL3	106	Annotation score:
H0YAP8	H0YAP8_HUMAN	Cyclin-dependent kinase-like 3 Cyclin-dependent kinase-like 3	CDKL3	73	Annotation score:
E5RFT9	E5RFT9_HUMAN	Cyclin-dependent kinase-like 3 Cyclin-dependent kinase-like 3	CDKL3	44	Annotation score:
E5RI54	E5RI54_HUMAN	Cyclin-dependent kinase-like 3 Cyclin-dependent kinase-like 3	CDKL3	82	Annotation score:
H0YB17	H0YB17_HUMAN	Cyclin-dependent kinase-like 3 Cyclin-dependent kinase-like 3	CDKL3	18	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	345	K → E in AAF36509 (Ref. 1) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_041991	394	M → T1 PublicationCorresponds to variant dbSNP:rs35687772Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_016148	456 – 592	Missing in isoform 2. 1 PublicationAdd BLAST		137

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF130372 mRNA Translation: AAF36509.1 CH471062 Genomic DNA Translation: EAW62263.1 CH471062 Genomic DNA Translation: EAW62264.1 CH471062 Genomic DNA Translation: EAW62265.1 CH471062 Genomic DNA Translation: EAW62266.1 BC041799 mRNA Translation: AAH41799.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47264.1 [Q8IVW4-1] CCDS47265.1 [Q8IVW4-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001107047.1, NM_001113575.1 [Q8IVW4-1] NP_001287782.1, NM_001300853.1 NP_057592.2, NM_016508.3 [Q8IVW4-2] XP_016865024.1, XM_017009535.1
UniGeneⁱ	Hs.719926

Genome annotation databases

Ensemblⁱ	ENST00000265334; ENSP00000265334; ENSG00000006837 [Q8IVW4-1] ENST00000523832; ENSP00000430496; ENSG00000006837 [Q8IVW4-2]
GeneIDⁱ	51265
KEGGⁱ	hsa:51265
UCSC genome browser More...UCSCⁱ	uc003kzf.5 human [Q8IVW4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IVW4	Cyclin-dependent kinase-like 3		MACFA		590	UniRef90_Q8IVW4
Uncharacterized protein		PAPAN		598
Uncharacterized protein		CHLSB		593
Uncharacterized protein		MANLE		592
Uncharacterized protein		MACNE		592
+92

Protein	Similar proteins		Species	Score	Length	Source
Q8IVW4	Cyclin-dependent kinase-like 3		MACFA		590	UniRef50_Q8IVW4
Cyclin-dependent kinase-like 3		MOUSE		595
Cyclin-dependent kinase-like 3		RAT		593
Uncharacterized protein		PAPAN		598
Uncharacterized protein		CHLSB		593
+377

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF130372 mRNA Translation: AAF36509.1 CH471062 Genomic DNA Translation: EAW62263.1 CH471062 Genomic DNA Translation: EAW62264.1 CH471062 Genomic DNA Translation: EAW62265.1 CH471062 Genomic DNA Translation: EAW62266.1 BC041799 mRNA Translation: AAH41799.1
CCDSⁱ	CCDS47264.1 [Q8IVW4-1] CCDS47265.1 [Q8IVW4-2]
RefSeqⁱ	NP_001107047.1, NM_001113575.1 [Q8IVW4-1] NP_001287782.1, NM_001300853.1 NP_057592.2, NM_016508.3 [Q8IVW4-2] XP_016865024.1, XM_017009535.1
UniGeneⁱ	Hs.719926

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3ZDU	X-ray	2.20	A	1-324	[»]
ProteinModelPortalⁱ	Q8IVW4
SMRⁱ	Q8IVW4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119419, 21 interactors
IntActⁱ	Q8IVW4, 31 interactors
STRINGⁱ	9606.ENSP00000265334

Chemistry databases

BindingDBⁱ	Q8IVW4
ChEMBLⁱ	CHEMBL1163117

PTM databases

iPTMnetⁱ	Q8IVW4
PhosphoSitePlusⁱ	Q8IVW4

Polymorphism and mutation databases

BioMutaⁱ	CDKL3
DMDMⁱ	74762479

Proteomic databases

MaxQBⁱ	Q8IVW4
PaxDbⁱ	Q8IVW4
PeptideAtlasⁱ	Q8IVW4
PRIDEⁱ	Q8IVW4
ProteomicsDBⁱ	70783 70784 [Q8IVW4-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51265
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000265334; ENSP00000265334; ENSG00000006837 [Q8IVW4-1] ENST00000523832; ENSP00000430496; ENSG00000006837 [Q8IVW4-2]
GeneIDⁱ	51265
KEGGⁱ	hsa:51265
UCSCⁱ	uc003kzf.5 human [Q8IVW4-1]

Organism-specific databases

CTDⁱ	51265
DisGeNETⁱ	51265
EuPathDBⁱ	HostDB:ENSG00000006837.11
GeneCardsⁱ	CDKL3
HGNCⁱ	HGNC:15483 CDKL3
HPAⁱ	HPA027751
MIMⁱ	608459 gene
neXtProtⁱ	NX_Q8IVW4
OpenTargetsⁱ	ENSG00000006837
PharmGKBⁱ	PA26319
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0593 Eukaryota ENOG410XNSW LUCA
GeneTreeⁱ	ENSGT00830000128262
HOGENOMⁱ	HOG000233024
HOVERGENⁱ	HBG080204
InParanoidⁱ	Q8IVW4
KOⁱ	K08824
OMAⁱ	MTMPPIN
OrthoDBⁱ	EOG091G0BZP
PhylomeDBⁱ	Q8IVW4
TreeFamⁱ	TF101031

Enzyme and pathway databases

SignaLinkⁱ	Q8IVW4

SignaLinkⁱ

Q8IVW4

Miscellaneous databases

ChiTaRSⁱ	CDKL3 human
GenomeRNAiⁱ	51265
Protein Ontology More...PROⁱ	PR:Q8IVW4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000006837 Expressed in 99 organ(s), highest expression level in right testis
ExpressionAtlasⁱ	Q8IVW4 baseline and differential
Genevisibleⁱ	Q8IVW4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CDKL3_HUMAN
Accessionⁱ	Q8IVW4Primary (citable) accession number: Q8IVW4 Secondary accession number(s): D3DQA0, D3DQA1, Q9P114
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q8IVW4 (CDKL3_HUMAN)

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Cyclin-dependent kinase-like 3

CDKL3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ