Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP-ribosylation factor-like protein 17

Gene

ARL17A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi125 – 128GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 17
Alternative name(s):
ADP-ribosylation factor 7 variant
Gene namesi
Name:ARL17A
Synonyms:ARL17P1
AND
Name:ARL17B
Synonyms:ARF1P2, ARL17A
ORF Names:PRO2667
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000185829.15
HostDB:ENSG00000228696.8
HGNCiHGNC:24096 ARL17A
HGNC:32387 ARL17B
neXtProtiNX_Q8IVW1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185829
ENSG00000228696
PharmGKBiPA165431478

Polymorphism and mutation databases

BioMutaiARL17A
DMDMi93141230

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074822 – 177ADP-ribosylation factor-like protein 17Add BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ8IVW1
PaxDbiQ8IVW1
PeptideAtlasiQ8IVW1
PRIDEiQ8IVW1
ProteomicsDBi70780
70781 [Q8IVW1-2]
70782 [Q8IVW1-4]

PTM databases

iPTMnetiQ8IVW1
PhosphoSitePlusiQ8IVW1

Expressioni

Gene expression databases

BgeeiENSG00000185829
CleanExiHS_ARL17
ExpressionAtlasiQ8IVW1 baseline and differential
GenevisibleiQ8IVW1 HS

Organism-specific databases

HPAiHPA046814

Interactioni

Protein-protein interaction databases

BioGridi119475, 3 interactors
STRINGi9606.ENSP00000337478

Structurei

3D structure databases

ProteinModelPortaliQ8IVW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000134110
HOVERGENiHBG002073
InParanoidiQ8IVW1
OMAiYYTNTET
OrthoDBiEOG091G0R1S
PhylomeDBiQ8IVW1
TreeFamiTF300808
TF341532

Family and domain databases

InterProiView protein in InterPro
IPR031687 ARL17_C
IPR027417 P-loop_NTPase
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PF15840 ARL17, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNIFEKLFK SLLGKKKMRI LILSLDTAGK TTILYKLKLG ETVPAVPTVG
60 70 80 90 100
FCVETVEYKN NTFAVWDVGS HFKIRPLWQH FFQNTKGARS PGSTHQGSLA
110 120 130 140 150
SGVLPIKCSH VEFGMWKGGR SHPFLPHSSR CAGSGGQLDS ILPHQSPAWG
160 170
PWGCKDLSSG FPSFLTSSIL WKSAVVK
Length:177
Mass (Da):19,388
Last modified:April 18, 2006 - v2
Checksum:iD9AE68B0C19ABBAE
GO
Isoform 2 (identifier: Q8IVW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-177: GARSPGSTHQ...SILWKSAVVK → ELSASQFAQF...TSYPSHLLDR

Show »
Length:125
Mass (Da):14,028
Checksum:iFFAC838B026D4045
GO
Isoform 4 (identifier: Q8IVW1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-177: VK → SYQLPSLHNSSRNYAGSPAQMMRHLLEA

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):22,302
Checksum:i322F3ABF9AB0B5D8
GO

Sequence cautioni

The sequence AAF64278 differs from that shown. Reason: Frameshift at position 114.Curated
The sequence AAF69643 differs from that shown. Reason: Frameshift at position 17.Curated
The sequence AAH30570 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92581 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75R → G in AAF64278 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017170170L → I1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00875387 – 177GARSP…SAVVK → ELSASQFAQFIKKLCGVTGT NDEASPGSLTSYPSHLLDR in isoform 2. 2 PublicationsAdd BLAST91
Alternative sequenceiVSP_008756176 – 177VK → SYQLPSLHNSSRNYAGSPAQ MMRHLLEA in isoform 4. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119889 mRNA Translation: AAF69643.1 Frameshift.
AF208864 mRNA Translation: AAF64278.1 Frameshift.
AF493886 mRNA Translation: AAM12600.1
AK315857 mRNA Translation: BAF98748.1
AB209344 mRNA Translation: BAD92581.1 Different initiation.
BC030570 mRNA Translation: AAH30570.1 Different initiation.
BC041803 mRNA Translation: AAH41803.1
CCDSiCCDS54137.1 [Q8IVW1-2]
CCDS58557.1 [Q8IVW1-1]
RefSeqiNP_001034172.3, NM_001039083.3 [Q8IVW1-1]
NP_001096624.1, NM_001103154.1 [Q8IVW1-2]
NP_001107210.1, NM_001113738.1 [Q8IVW1-1]
NP_001275741.1, NM_001288812.1 [Q8IVW1-2]
NP_057716.2, NM_016632.2 [Q8IVW1-2]
XP_005256975.1, XM_005256918.4
XP_005257496.1, XM_005257439.4 [Q8IVW1-2]
XP_006725347.1, XM_006725284.3 [Q8IVW1-2]
XP_011523177.1, XM_011524875.2 [Q8IVW1-4]
UniGeneiHs.559259
Hs.646568
Hs.655261
Hs.671696
Hs.720599
Hs.720602
Hs.733127

Genome annotation databases

EnsembliENST00000336125; ENSP00000337478; ENSG00000185829 [Q8IVW1-1]
ENST00000434041; ENSP00000391751; ENSG00000228696 [Q8IVW1-2]
ENST00000445552; ENSP00000416535; ENSG00000185829 [Q8IVW1-2]
ENST00000450673; ENSP00000404247; ENSG00000228696 [Q8IVW1-1]
ENST00000570618; ENSP00000459151; ENSG00000228696 [Q8IVW1-2]
ENST00000613440; ENSP00000482789; ENSG00000275748 [Q8IVW1-2]
ENST00000615623; ENSP00000482856; ENSG00000276276 [Q8IVW1-2]
ENST00000617818; ENSP00000479224; ENSG00000276276 [Q8IVW1-2]
ENST00000618729; ENSP00000483271; ENSG00000276276 [Q8IVW1-1]
ENST00000622165; ENSP00000481838; ENSG00000275748 [Q8IVW1-1]
ENST00000626328; ENSP00000487334; ENSG00000275748 [Q8IVW1-2]
ENST00000634170; ENSP00000487605; ENSG00000276276 [Q8IVW1-2]
GeneIDi100506084
100996709
51326
KEGGihsa:100506084
hsa:100996709
hsa:51326
UCSCiuc002ikk.4 human [Q8IVW1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARL17_HUMAN
AccessioniPrimary (citable) accession number: Q8IVW1
Secondary accession number(s): B0AZR6
, Q59FW5, Q8N6E2, Q8TD73, Q8WW54, Q9NZD5, Q9P158
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: April 18, 2006
Last modified: July 18, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health