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Protein

ADP-ribosylation factor-like protein 17

Gene

ARL17A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi125 – 128GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 17
Alternative name(s):
ADP-ribosylation factor 7 variant
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARL17A
Synonyms:ARL17P1
AND
Name:ARL17B
Synonyms:ARF1P2, ARL17A
ORF Names:PRO2667
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185829.15
HostDB:ENSG00000228696.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24096 ARL17A
HGNC:32387 ARL17B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IVW1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000185829
ENSG00000228696

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165431478

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARL17A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
93141230

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedSequence analysis
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002074822 – 177ADP-ribosylation factor-like protein 17Add BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IVW1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IVW1

PeptideAtlas

More...
PeptideAtlasi
Q8IVW1

PRoteomics IDEntifications database

More...
PRIDEi
Q8IVW1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70780
70781 [Q8IVW1-2]
70782 [Q8IVW1-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IVW1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IVW1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185829 Expressed in 187 organ(s), highest expression level in kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_ARL17

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IVW1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IVW1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046814

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119475, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337478

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IVW1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0070 Eukaryota
COG1100 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156188

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002073

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IVW1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VHRCIKE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0R1S

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IVW1

TreeFam database of animal gene trees

More...
TreeFami
TF300808
TF341532

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031687 ARL17_C
IPR027417 P-loop_NTPase
IPR006689 Small_GTPase_ARF/SAR

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00025 Arf, 1 hit
PF15840 ARL17, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00328 SAR1GTPBP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51417 ARF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IVW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNIFEKLFK SLLGKKKMRI LILSLDTAGK TTILYKLKLG ETVPAVPTVG
60 70 80 90 100
FCVETVEYKN NTFAVWDVGS HFKIRPLWQH FFQNTKGARS PGSTHQGSLA
110 120 130 140 150
SGVLPIKCSH VEFGMWKGGR SHPFLPHSSR CAGSGGQLDS ILPHQSPAWG
160 170
PWGCKDLSSG FPSFLTSSIL WKSAVVK
Length:177
Mass (Da):19,388
Last modified:April 18, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9AE68B0C19ABBAE
GO
Isoform 2 (identifier: Q8IVW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-177: GARSPGSTHQ...SILWKSAVVK → ELSASQFAQF...TSYPSHLLDR

Show »
Length:125
Mass (Da):14,028
Checksum:iFFAC838B026D4045
GO
Isoform 4 (identifier: Q8IVW1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-177: VK → SYQLPSLHNSSRNYAGSPAQMMRHLLEA

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):22,302
Checksum:i322F3ABF9AB0B5D8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1V5I3L1V5_HUMAN
ADP-ribosylation factor-like protei...
ARL17A ARL17B
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVX3A0A087WVX3_HUMAN
ADP-ribosylation factor-like protei...
ARL17A ARL17B
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WY76A0A087WY76_HUMAN
ADP-ribosylation factor-like protei...
ARL17A ARL17B
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2E4I3L2E4_HUMAN
ADP-ribosylation factor-like protei...
ARL17B ARL17A
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3L1I3L3L1_HUMAN
ADP-ribosylation factor-like protei...
ARL17B
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1A0I3L1A0_HUMAN
ADP-ribosylation factor-like protei...
ARL17B
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF64278 differs from that shown. Reason: Frameshift at position 114.Curated
The sequence AAF69643 differs from that shown. Reason: Frameshift at position 17.Curated
The sequence AAH30570 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92581 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti75R → G in AAF64278 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017170170L → I1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00875387 – 177GARSP…SAVVK → ELSASQFAQFIKKLCGVTGT NDEASPGSLTSYPSHLLDR in isoform 2. 2 PublicationsAdd BLAST91
Alternative sequenceiVSP_008756176 – 177VK → SYQLPSLHNSSRNYAGSPAQ MMRHLLEA in isoform 4. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF119889 mRNA Translation: AAF69643.1 Frameshift.
AF208864 mRNA Translation: AAF64278.1 Frameshift.
AF493886 mRNA Translation: AAM12600.1
AK315857 mRNA Translation: BAF98748.1
AB209344 mRNA Translation: BAD92581.1 Different initiation.
BC030570 mRNA Translation: AAH30570.1 Different initiation.
BC041803 mRNA Translation: AAH41803.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54137.1 [Q8IVW1-2]
CCDS58557.1 [Q8IVW1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001034172.3, NM_001039083.3 [Q8IVW1-1]
NP_001096624.1, NM_001103154.1 [Q8IVW1-2]
NP_001107210.1, NM_001113738.1 [Q8IVW1-1]
NP_001275741.1, NM_001288812.1 [Q8IVW1-2]
NP_057716.2, NM_016632.2 [Q8IVW1-2]
XP_005256975.1, XM_005256918.4
XP_005257496.1, XM_005257439.4 [Q8IVW1-2]
XP_006725347.1, XM_006725284.3 [Q8IVW1-2]
XP_011523177.1, XM_011524875.2 [Q8IVW1-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.559259
Hs.646568
Hs.655261
Hs.671696
Hs.720599
Hs.720602
Hs.733127

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336125; ENSP00000337478; ENSG00000185829 [Q8IVW1-1]
ENST00000434041; ENSP00000391751; ENSG00000228696 [Q8IVW1-2]
ENST00000445552; ENSP00000416535; ENSG00000185829 [Q8IVW1-2]
ENST00000450673; ENSP00000404247; ENSG00000228696 [Q8IVW1-1]
ENST00000570618; ENSP00000459151; ENSG00000228696 [Q8IVW1-2]
ENST00000613440; ENSP00000482789; ENSG00000275748 [Q8IVW1-2]
ENST00000615623; ENSP00000482856; ENSG00000276276 [Q8IVW1-2]
ENST00000617818; ENSP00000479224; ENSG00000276276 [Q8IVW1-2]
ENST00000618729; ENSP00000483271; ENSG00000276276 [Q8IVW1-1]
ENST00000622165; ENSP00000481838; ENSG00000275748 [Q8IVW1-1]
ENST00000626328; ENSP00000487334; ENSG00000275748 [Q8IVW1-2]
ENST00000634170; ENSP00000487605; ENSG00000276276 [Q8IVW1-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100506084
100996709
51326

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100506084
hsa:100996709
hsa:51326

UCSC genome browser

More...
UCSCi
uc002ikk.4 human [Q8IVW1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119889 mRNA Translation: AAF69643.1 Frameshift.
AF208864 mRNA Translation: AAF64278.1 Frameshift.
AF493886 mRNA Translation: AAM12600.1
AK315857 mRNA Translation: BAF98748.1
AB209344 mRNA Translation: BAD92581.1 Different initiation.
BC030570 mRNA Translation: AAH30570.1 Different initiation.
BC041803 mRNA Translation: AAH41803.1
CCDSiCCDS54137.1 [Q8IVW1-2]
CCDS58557.1 [Q8IVW1-1]
RefSeqiNP_001034172.3, NM_001039083.3 [Q8IVW1-1]
NP_001096624.1, NM_001103154.1 [Q8IVW1-2]
NP_001107210.1, NM_001113738.1 [Q8IVW1-1]
NP_001275741.1, NM_001288812.1 [Q8IVW1-2]
NP_057716.2, NM_016632.2 [Q8IVW1-2]
XP_005256975.1, XM_005256918.4
XP_005257496.1, XM_005257439.4 [Q8IVW1-2]
XP_006725347.1, XM_006725284.3 [Q8IVW1-2]
XP_011523177.1, XM_011524875.2 [Q8IVW1-4]
UniGeneiHs.559259
Hs.646568
Hs.655261
Hs.671696
Hs.720599
Hs.720602
Hs.733127

3D structure databases

ProteinModelPortaliQ8IVW1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119475, 3 interactors
STRINGi9606.ENSP00000337478

PTM databases

iPTMnetiQ8IVW1
PhosphoSitePlusiQ8IVW1

Polymorphism and mutation databases

BioMutaiARL17A
DMDMi93141230

Proteomic databases

MaxQBiQ8IVW1
PaxDbiQ8IVW1
PeptideAtlasiQ8IVW1
PRIDEiQ8IVW1
ProteomicsDBi70780
70781 [Q8IVW1-2]
70782 [Q8IVW1-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336125; ENSP00000337478; ENSG00000185829 [Q8IVW1-1]
ENST00000434041; ENSP00000391751; ENSG00000228696 [Q8IVW1-2]
ENST00000445552; ENSP00000416535; ENSG00000185829 [Q8IVW1-2]
ENST00000450673; ENSP00000404247; ENSG00000228696 [Q8IVW1-1]
ENST00000570618; ENSP00000459151; ENSG00000228696 [Q8IVW1-2]
ENST00000613440; ENSP00000482789; ENSG00000275748 [Q8IVW1-2]
ENST00000615623; ENSP00000482856; ENSG00000276276 [Q8IVW1-2]
ENST00000617818; ENSP00000479224; ENSG00000276276 [Q8IVW1-2]
ENST00000618729; ENSP00000483271; ENSG00000276276 [Q8IVW1-1]
ENST00000622165; ENSP00000481838; ENSG00000275748 [Q8IVW1-1]
ENST00000626328; ENSP00000487334; ENSG00000275748 [Q8IVW1-2]
ENST00000634170; ENSP00000487605; ENSG00000276276 [Q8IVW1-2]
GeneIDi100506084
100996709
51326
KEGGihsa:100506084
hsa:100996709
hsa:51326
UCSCiuc002ikk.4 human [Q8IVW1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100506084
51326
EuPathDBiHostDB:ENSG00000185829.15
HostDB:ENSG00000228696.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARL17A
ARL17B

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0174152
HGNCiHGNC:24096 ARL17A
HGNC:32387 ARL17B
HPAiHPA046814
neXtProtiNX_Q8IVW1
OpenTargetsiENSG00000185829
ENSG00000228696
PharmGKBiPA165431478

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00940000156188
HOVERGENiHBG002073
InParanoidiQ8IVW1
OMAiVHRCIKE
OrthoDBiEOG091G0R1S
PhylomeDBiQ8IVW1
TreeFamiTF300808
TF341532

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARL17A human
ARL17B human

Protein Ontology

More...
PROi
PR:Q8IVW1

Gene expression databases

BgeeiENSG00000185829 Expressed in 187 organ(s), highest expression level in kidney
CleanExiHS_ARL17
ExpressionAtlasiQ8IVW1 baseline and differential
GenevisibleiQ8IVW1 HS

Family and domain databases

InterProiView protein in InterPro
IPR031687 ARL17_C
IPR027417 P-loop_NTPase
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PF15840 ARL17, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARL17_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IVW1
Secondary accession number(s): B0AZR6
, Q59FW5, Q8N6E2, Q8TD73, Q8WW54, Q9NZD5, Q9P158
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: April 18, 2006
Last modified: December 5, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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