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Entry version 165 (12 Aug 2020)
Sequence version 2 (18 Apr 2006)
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Protein

ADP-ribosylation factor-like protein 17

Gene

ARL17A

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Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi125 – 128GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTP binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IVW1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 17
Alternative name(s):
ADP-ribosylation factor 7 variant
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARL17A
Synonyms:ARL17P1
AND
Name:ARL17B
Synonyms:ARF1P2, ARL17A
ORF Names:PRO2667
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185829.15
HostDB:ENSG00000228696.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24096, ARL17A
HGNC:32387, ARL17B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IVW1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
100506084
51326

Open Targets

More...
OpenTargetsi
ENSG00000185829
ENSG00000228696

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165431478

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IVW1, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARL17A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
93141230

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedSequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002074822 – 177ADP-ribosylation factor-like protein 17Add BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IVW1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IVW1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IVW1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IVW1

PeptideAtlas

More...
PeptideAtlasi
Q8IVW1

PRoteomics IDEntifications database

More...
PRIDEi
Q8IVW1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70780 [Q8IVW1-1]
70781 [Q8IVW1-2]
70782 [Q8IVW1-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IVW1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IVW1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185829, Expressed in kidney and 200 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IVW1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IVW1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000185829, Low tissue specificity
ENSG00000228696, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119475, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IVW1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000404247

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IVW1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0070, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183080

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_040729_15_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IVW1

Database of Orthologous Groups

More...
OrthoDBi
1362554at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IVW1

TreeFam database of animal gene trees

More...
TreeFami
TF300808
TF341532

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031687, ARL17_C
IPR027417, P-loop_NTPase
IPR006689, Small_GTPase_ARF/SAR

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00025, Arf, 1 hit
PF15840, ARL17, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00328, SAR1GTPBP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51417, ARF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IVW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNIFEKLFK SLLGKKKMRI LILSLDTAGK TTILYKLKLG ETVPAVPTVG
60 70 80 90 100
FCVETVEYKN NTFAVWDVGS HFKIRPLWQH FFQNTKGARS PGSTHQGSLA
110 120 130 140 150
SGVLPIKCSH VEFGMWKGGR SHPFLPHSSR CAGSGGQLDS ILPHQSPAWG
160 170
PWGCKDLSSG FPSFLTSSIL WKSAVVK
Length:177
Mass (Da):19,388
Last modified:April 18, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9AE68B0C19ABBAE
GO
Isoform 2 (identifier: Q8IVW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-177: GARSPGSTHQ...SILWKSAVVK → ELSASQFAQF...TSYPSHLLDR

Show »
Length:125
Mass (Da):14,028
Checksum:iFFAC838B026D4045
GO
Isoform 4 (identifier: Q8IVW1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-177: VK → SYQLPSLHNSSRNYAGSPAQMMRHLLEA

Show »
Length:203
Mass (Da):22,302
Checksum:i322F3ABF9AB0B5D8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1V5I3L1V5_HUMAN
ADP-ribosylation factor-like protei...
ARL17A ARL17B
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WY76A0A087WY76_HUMAN
ADP-ribosylation factor-like protei...
ARL17A ARL17B
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVX3A0A087WVX3_HUMAN
ADP-ribosylation factor-like protei...
ARL17A ARL17B
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2E4I3L2E4_HUMAN
ADP-ribosylation factor-like protei...
ARL17B ARL17A
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3L1I3L3L1_HUMAN
ADP-ribosylation factor-like protei...
ARL17B
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1A0I3L1A0_HUMAN
ADP-ribosylation factor-like protei...
ARL17B
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF64278 differs from that shown. Reason: Frameshift.Curated
The sequence AAF69643 differs from that shown. Reason: Frameshift.Curated
The sequence AAH30570 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92581 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti75R → G in AAF64278 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017170170L → I1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00875387 – 177GARSP…SAVVK → ELSASQFAQFIKKLCGVTGT NDEASPGSLTSYPSHLLDR in isoform 2. 2 PublicationsAdd BLAST91
Alternative sequenceiVSP_008756176 – 177VK → SYQLPSLHNSSRNYAGSPAQ MMRHLLEA in isoform 4. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF119889 mRNA Translation: AAF69643.1 Frameshift.
AF208864 mRNA Translation: AAF64278.1 Frameshift.
AF493886 mRNA Translation: AAM12600.1
AK315857 mRNA Translation: BAF98748.1
AB209344 mRNA Translation: BAD92581.1 Different initiation.
BC030570 mRNA Translation: AAH30570.1 Different initiation.
BC041803 mRNA Translation: AAH41803.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54137.1 [Q8IVW1-2]
CCDS58557.1 [Q8IVW1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001034172.3, NM_001039083.3 [Q8IVW1-1]
NP_001096624.1, NM_001103154.1 [Q8IVW1-2]
NP_001107210.1, NM_001113738.1 [Q8IVW1-1]
NP_001275741.1, NM_001288812.1 [Q8IVW1-2]
NP_057716.2, NM_016632.2 [Q8IVW1-2]
XP_005256975.1, XM_005256918.4
XP_005257496.1, XM_005257439.4 [Q8IVW1-2]
XP_006725347.1, XM_006725284.3 [Q8IVW1-2]
XP_011523177.1, XM_011524875.2 [Q8IVW1-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336125; ENSP00000337478; ENSG00000185829 [Q8IVW1-1]
ENST00000434041; ENSP00000391751; ENSG00000228696 [Q8IVW1-2]
ENST00000445552; ENSP00000416535; ENSG00000185829 [Q8IVW1-2]
ENST00000450673; ENSP00000404247; ENSG00000228696 [Q8IVW1-1]
ENST00000570618; ENSP00000459151; ENSG00000228696 [Q8IVW1-2]
ENST00000613440; ENSP00000482789; ENSG00000275748 [Q8IVW1-2]
ENST00000615623; ENSP00000482856; ENSG00000276276 [Q8IVW1-2]
ENST00000617818; ENSP00000479224; ENSG00000276276 [Q8IVW1-2]
ENST00000618729; ENSP00000483271; ENSG00000276276 [Q8IVW1-1]
ENST00000622165; ENSP00000481838; ENSG00000275748 [Q8IVW1-1]
ENST00000626328; ENSP00000487334; ENSG00000275748 [Q8IVW1-2]
ENST00000634170; ENSP00000487605; ENSG00000276276 [Q8IVW1-2]
ENST00000656849; ENSP00000499587; ENSG00000228696 [Q8IVW1-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100506084
100996709
51326

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100506084
hsa:100996709
hsa:51326

UCSC genome browser

More...
UCSCi
uc002ikk.4, human [Q8IVW1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119889 mRNA Translation: AAF69643.1 Frameshift.
AF208864 mRNA Translation: AAF64278.1 Frameshift.
AF493886 mRNA Translation: AAM12600.1
AK315857 mRNA Translation: BAF98748.1
AB209344 mRNA Translation: BAD92581.1 Different initiation.
BC030570 mRNA Translation: AAH30570.1 Different initiation.
BC041803 mRNA Translation: AAH41803.1
CCDSiCCDS54137.1 [Q8IVW1-2]
CCDS58557.1 [Q8IVW1-1]
RefSeqiNP_001034172.3, NM_001039083.3 [Q8IVW1-1]
NP_001096624.1, NM_001103154.1 [Q8IVW1-2]
NP_001107210.1, NM_001113738.1 [Q8IVW1-1]
NP_001275741.1, NM_001288812.1 [Q8IVW1-2]
NP_057716.2, NM_016632.2 [Q8IVW1-2]
XP_005256975.1, XM_005256918.4
XP_005257496.1, XM_005257439.4 [Q8IVW1-2]
XP_006725347.1, XM_006725284.3 [Q8IVW1-2]
XP_011523177.1, XM_011524875.2 [Q8IVW1-4]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119475, 3 interactors
IntActiQ8IVW1, 1 interactor
STRINGi9606.ENSP00000404247

PTM databases

iPTMnetiQ8IVW1
PhosphoSitePlusiQ8IVW1

Polymorphism and mutation databases

BioMutaiARL17A
DMDMi93141230

Proteomic databases

jPOSTiQ8IVW1
MassIVEiQ8IVW1
MaxQBiQ8IVW1
PaxDbiQ8IVW1
PeptideAtlasiQ8IVW1
PRIDEiQ8IVW1
ProteomicsDBi70780 [Q8IVW1-1]
70781 [Q8IVW1-2]
70782 [Q8IVW1-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
45114, 33 antibodies
73103, 38 antibodies

Genome annotation databases

EnsembliENST00000336125; ENSP00000337478; ENSG00000185829 [Q8IVW1-1]
ENST00000434041; ENSP00000391751; ENSG00000228696 [Q8IVW1-2]
ENST00000445552; ENSP00000416535; ENSG00000185829 [Q8IVW1-2]
ENST00000450673; ENSP00000404247; ENSG00000228696 [Q8IVW1-1]
ENST00000570618; ENSP00000459151; ENSG00000228696 [Q8IVW1-2]
ENST00000613440; ENSP00000482789; ENSG00000275748 [Q8IVW1-2]
ENST00000615623; ENSP00000482856; ENSG00000276276 [Q8IVW1-2]
ENST00000617818; ENSP00000479224; ENSG00000276276 [Q8IVW1-2]
ENST00000618729; ENSP00000483271; ENSG00000276276 [Q8IVW1-1]
ENST00000622165; ENSP00000481838; ENSG00000275748 [Q8IVW1-1]
ENST00000626328; ENSP00000487334; ENSG00000275748 [Q8IVW1-2]
ENST00000634170; ENSP00000487605; ENSG00000276276 [Q8IVW1-2]
ENST00000656849; ENSP00000499587; ENSG00000228696 [Q8IVW1-2]
GeneIDi100506084
100996709
51326
KEGGihsa:100506084
hsa:100996709
hsa:51326
UCSCiuc002ikk.4, human [Q8IVW1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100506084
51326
DisGeNETi100506084
51326
EuPathDBiHostDB:ENSG00000185829.15
HostDB:ENSG00000228696.8

GeneCards: human genes, protein and diseases

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GeneCardsi
ARL17A
ARL17B
HGNCiHGNC:24096, ARL17A
HGNC:32387, ARL17B
HPAiENSG00000185829, Low tissue specificity
ENSG00000228696, Low tissue specificity
neXtProtiNX_Q8IVW1
OpenTargetsiENSG00000185829
ENSG00000228696
PharmGKBiPA165431478

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0070, Eukaryota
GeneTreeiENSGT00950000183080
HOGENOMiCLU_040729_15_1_1
InParanoidiQ8IVW1
OrthoDBi1362554at2759
PhylomeDBiQ8IVW1
TreeFamiTF300808
TF341532

Enzyme and pathway databases

PathwayCommonsiQ8IVW1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
100506084, 8 hits in 153 CRISPR screens
51326, 10 hits in 509 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARL17A, human
ARL17B, human
PharosiQ8IVW1, Tdark

Protein Ontology

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PROi
PR:Q8IVW1
RNActiQ8IVW1, protein

Gene expression databases

BgeeiENSG00000185829, Expressed in kidney and 200 other tissues
ExpressionAtlasiQ8IVW1, baseline and differential
GenevisibleiQ8IVW1, HS

Family and domain databases

InterProiView protein in InterPro
IPR031687, ARL17_C
IPR027417, P-loop_NTPase
IPR006689, Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025, Arf, 1 hit
PF15840, ARL17, 1 hit
PRINTSiPR00328, SAR1GTPBP
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51417, ARF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARL17_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IVW1
Secondary accession number(s): B0AZR6
, Q59FW5, Q8N6E2, Q8TD73, Q8WW54, Q9NZD5, Q9P158
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: April 18, 2006
Last modified: August 12, 2020
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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