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UniProtKB - Q8IVU3 (HERC6_HUMAN)

Entry version 146 (12 Aug 2020)
Sequence version 2 (05 Jul 2005)
Previous versions | rss
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Protein

Probable E3 ubiquitin-protein ligase HERC6

Gene

HERC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei985Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IVU3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase HERC6 (EC:2.3.2.26)
Alternative name(s):
HECT domain and RCC1-like domain-containing protein 6
HECT-type E3 ubiquitin transferase HERC6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HERC6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000138642.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:26072, HERC6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609249, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IVU3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55008

Open Targets

More...OpenTargetsi		ENSG00000138642

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134894313

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IVU3, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HERC6

Domain mapping of disease mutations (DMDM)

More...DMDMi		74750679

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002782191 – 1022Probable E3 ubiquitin-protein ligase HERC6Add BLAST1022

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IVU3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IVU3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IVU3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IVU3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IVU3

PeptideAtlas

More...PeptideAtlasi		Q8IVU3

PRoteomics IDEntifications database

More...PRIDEi		Q8IVU3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70770 [Q8IVU3-1]
70771 [Q8IVU3-2]
70772 [Q8IVU3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IVU3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IVU3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain, heart, placenta and testis.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000138642, Expressed in epithelium of bronchus and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IVU3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IVU3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000138642, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120340, 11 interactors

Protein interaction database and analysis system

More...IntActi		Q8IVU3, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000264346

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IVU3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11022
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IVU3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati41 – 92RCC1 1Add BLAST52
Repeati93 – 145RCC1 2Add BLAST53
Repeati147 – 198RCC1 3Add BLAST52
Repeati200 – 253RCC1 4Add BLAST54
Repeati254 – 304RCC1 5Add BLAST51
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini693 – 1017HECTPROSITE-ProRule annotationAdd BLAST325

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0941, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162279

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002173_5_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IVU3

KEGG Orthology (KO)

More...KOi		K22372

Identification of Orthologs from Complete Genome Data

More...OMAi		NFVTTYQ

Database of Orthologous Groups

More...OrthoDBi		1062377at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IVU3

TreeFam database of animal gene trees

More...TreeFami		TF315189

Family and domain databases

Conserved Domains Database

More...CDDi		cd00078, HECTc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00632, HECT, 1 hit
PF00415, RCC1, 5 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00633, RCCNDNSATION

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00119, HECTc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50985, SSF50985, 1 hit
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50237, HECT, 1 hit
PS00626, RCC1_2, 3 hits
PS50012, RCC1_3, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IVU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYFCWGADSR ELQRRRTAGS PGAELLQAAS GERHSLLLLT NHRVLSCGDN 
        60         70         80         90        100
SRGQLGRRGA QRGELPEPIQ ALETLIVDLV SCGKEHSLAV CHKGRVFAWG 
       110        120        130        140        150
AGSEGQLGIG EFKEISFTPK KIMTLNDIKI IQVSCGHYHS LALSKDSQVF 
       160        170        180        190        200
SWGKNSHGQL GLGKEFPSQA SPQRVRSLEG IPLAQVAAGG AHSFALSLCG 
       210        220        230        240        250
TSFGWGSNSA GQLALSGRNV PVQSNKPLSV GALKNLGVVY ISCGDAHTAV 
       260        270        280        290        300
LTQDGKVFTF GDNRSGQLGY SPTPEKRGPQ LVERIDGLVS QIDCGSYHTL 
       310        320        330        340        350
AYVHTTGQVV SFGHGPSDTS KPTHPEALTE NFDISCLISA EDFVDVQVKH 
       360        370        380        390        400
IFAGTYANFV TTHQDTSSTR APGKTLPEIS RISQSMAEKW IAVKRRSTEH 
       410        420        430        440        450
EMAKSEIRMI FSSPACLTAS FLKKRGTGET TSIDVDLEMA RDTFKKLTKK 
       460        470        480        490        500
EWISSMITTC LEDDLLRALP CHSPHQEALS VFLLLPECPV MHDSKNWKNL 
       510        520        530        540        550
VVPFAKAVCE MSKQSLQVLK KCWAFLQESS LNPLIQMLKA AIISQLLHQT 
       560        570        580        590        600
KTEQDHCNVK ALLGMMKELH KVNKANCRLP ENTFNINELS NLLNFYIDRG 
       610        620        630        640        650
RQLFRDNHLI PAETPSPVIF SDFPFIFNSL SKIKLLQADS HIKMQMSEKK 
       660        670        680        690        700
AYMLMHETIL QKKDEFPPSP RFILRVRRSR LVKDALRQLS QAEATDFCKV 
       710        720        730        740        750
LVVEFINEIC PESGGVSSEF FHCMFEEMTK PEYGMFMYPE MGSCMWFPAK 
       760        770        780        790        800
PKPEKKRYFL FGMLCGLSLF NLNVANLPFP LALYKKLLDQ KPSLEDLKEL 
       810        820        830        840        850
SPRLGKSLQE VLDDAADDIG DALCIRFSIH WDQNDVDLIP NGISIPVDQT 
       860        870        880        890        900
NKRDYVSKYI DYIFNVSVKA VYEEFQRGFY RVCEKEILRH FYPEELMTAI 
       910        920        930        940        950
IGNTDYDWKQ FEQNSKYEQG YQKSHPTIQL FWKAFHKLTL DEKKKFLFFL 
       960        970        980        990       1000
TGRDRLHARG IQKMEIVFRC PETFSERDHP TSITCHNILS LPKYSTMERM 
      1010       1020 
EEALQVAINN NRGFVSPMLT QS
Note: Major transcript.
Length:1,022
Mass (Da):115,126
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i713646243F269AD9
GO
Isoform 2 (identifier: Q8IVU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     610-645: Missing.

Note: Minor transcript.Curated
Show »
Length:986
Mass (Da):111,084
Checksum:iE0E3B207DBBEE50C
GO
Isoform 3 (identifier: Q8IVU3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-306: SYHTLAYVHTT → RNSKHGFMTFF
     307-1022: Missing.

Note: Minor transcript.Curated
Show »
Length:306
Mass (Da):32,717
Checksum:i9E8044CA333B16F5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9U0H0Y9U0_HUMAN
Probable E3 ubiquitin-protein ligas...
HERC6
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J1R3A0A0B4J1R3_HUMAN
Probable E3 ubiquitin-protein ligas...
HERC6
322Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCT4D6RCT4_HUMAN
Probable E3 ubiquitin-protein ligas...
HERC6
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91303 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03879 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI46056 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI46151 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti742G → C in BAA91303 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051725123M → T. Corresponds to variant dbSNP:rs7677237Ensembl.1
Natural variantiVAR_051726199C → R. Corresponds to variant dbSNP:rs12510688Ensembl.1
Natural variantiVAR_051727343F → L. Corresponds to variant dbSNP:rs17014118Ensembl.1
Natural variantiVAR_051728614T → I. Corresponds to variant dbSNP:rs6532068EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023183296 – 306SYHTLAYVHTT → RNSKHGFMTFF in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_023184307 – 1022Missing in isoform 3. 1 PublicationAdd BLAST716
Alternative sequenceiVSP_023185610 – 645Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF336798 mRNA Translation: AAQ14893.1
AY653201 mRNA Translation: AAV66895.1
AK000644 mRNA Translation: BAA91303.1 Different initiation.
AK092403 mRNA Translation: BAC03879.1 Different initiation.
AK295832 mRNA Translation: BAG58647.1
BC035775 mRNA Translation: AAH35775.2
BC042047 mRNA Translation: AAH42047.2
AL833664 mRNA Translation: CAI46151.1 Different initiation.
BX647121 mRNA Translation: CAI46056.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47098.1 [Q8IVU3-1]
CCDS54777.1 [Q8IVU3-2]

NCBI Reference Sequences

More...RefSeqi		NP_001158608.1, NM_001165136.1 [Q8IVU3-2]
NP_060382.3, NM_017912.3 [Q8IVU3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264346; ENSP00000264346; ENSG00000138642 [Q8IVU3-1]
ENST00000380265; ENSP00000369617; ENSG00000138642 [Q8IVU3-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55008

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55008

UCSC genome browser

More...UCSCi		uc011cdi.3, human [Q8IVU3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336798 mRNA Translation: AAQ14893.1
AY653201 mRNA Translation: AAV66895.1
AK000644 mRNA Translation: BAA91303.1 Different initiation.
AK092403 mRNA Translation: BAC03879.1 Different initiation.
AK295832 mRNA Translation: BAG58647.1
BC035775 mRNA Translation: AAH35775.2
BC042047 mRNA Translation: AAH42047.2
AL833664 mRNA Translation: CAI46151.1 Different initiation.
BX647121 mRNA Translation: CAI46056.1 Different initiation.
CCDSiCCDS47098.1 [Q8IVU3-1]
CCDS54777.1 [Q8IVU3-2]
RefSeqiNP_001158608.1, NM_001165136.1 [Q8IVU3-2]
NP_060382.3, NM_017912.3 [Q8IVU3-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5W87X-ray2.20A/B902-1022[»]
SMRiQ8IVU3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120340, 11 interactors
IntActiQ8IVU3, 2 interactors
STRINGi9606.ENSP00000264346

PTM databases

iPTMnetiQ8IVU3
PhosphoSitePlusiQ8IVU3

Polymorphism and mutation databases

BioMutaiHERC6
DMDMi74750679

Proteomic databases

EPDiQ8IVU3
jPOSTiQ8IVU3
MassIVEiQ8IVU3
MaxQBiQ8IVU3
PaxDbiQ8IVU3
PeptideAtlasiQ8IVU3
PRIDEiQ8IVU3
ProteomicsDBi70770 [Q8IVU3-1]
70771 [Q8IVU3-2]
70772 [Q8IVU3-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25568, 63 antibodies

Genome annotation databases

EnsembliENST00000264346; ENSP00000264346; ENSG00000138642 [Q8IVU3-1]
ENST00000380265; ENSP00000369617; ENSG00000138642 [Q8IVU3-2]
GeneIDi55008
KEGGihsa:55008
UCSCiuc011cdi.3, human [Q8IVU3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55008
DisGeNETi55008
EuPathDBiHostDB:ENSG00000138642.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		HERC6
HGNCiHGNC:26072, HERC6
HPAiENSG00000138642, Low tissue specificity
MIMi609249, gene
neXtProtiNX_Q8IVU3
OpenTargetsiENSG00000138642
PharmGKBiPA134894313

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0941, Eukaryota
GeneTreeiENSGT00940000162279
HOGENOMiCLU_002173_5_3_1
InParanoidiQ8IVU3
KOiK22372
OMAiNFVTTYQ
OrthoDBi1062377at2759
PhylomeDBiQ8IVU3
TreeFamiTF315189

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ8IVU3
ReactomeiR-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55008, 3 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HERC6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55008
PharosiQ8IVU3, Tdark

Protein Ontology

More...PROi		PR:Q8IVU3
RNActiQ8IVU3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000138642, Expressed in epithelium of bronchus and 214 other tissues
ExpressionAtlasiQ8IVU3, baseline and differential
GenevisibleiQ8IVU3, HS

Family and domain databases

CDDicd00078, HECTc, 1 hit
Gene3Di2.130.10.30, 2 hits
InterProiView protein in InterPro
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens
PfamiView protein in Pfam
PF00632, HECT, 1 hit
PF00415, RCC1, 5 hits
PRINTSiPR00633, RCCNDNSATION
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SUPFAMiSSF50985, SSF50985, 1 hit
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit
PS00626, RCC1_2, 3 hits
PS50012, RCC1_3, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHERC6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IVU3
Secondary accession number(s): B4DIY5
, Q5GC90, Q5GRH3, Q5HYM6, Q5JPB6, Q6PIF4, Q8NAN3, Q9NWS4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2005
Last modified: August 12, 2020
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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