UniProtKB - Q8IVU3 (HERC6_HUMAN)
Protein
Probable E3 ubiquitin-protein ligase HERC6
Gene
HERC6
Organism
Homo sapiens (Human)
Status
Functioni
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 985 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ubiquitin-protein transferase activity Source: InterPro
GO - Biological processi
- hematopoietic progenitor cell differentiation Source: Ensembl
- protein polyubiquitination Source: Reactome
- response to bacterium Source: Ensembl
Keywordsi
Molecular function | Transferase |
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q8IVU3 |
Reactomei | R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable E3 ubiquitin-protein ligase HERC6 (EC:2.3.2.26)Alternative name(s): HECT domain and RCC1-like domain-containing protein 6 HECT-type E3 ubiquitin transferase HERC6 |
Gene namesi | Name:HERC6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138642.14 |
HGNCi | HGNC:26072, HERC6 |
MIMi | 609249, gene |
neXtProti | NX_Q8IVU3 |
Subcellular locationi
Cytosol
- cytosol 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 55008 |
OpenTargetsi | ENSG00000138642 |
PharmGKBi | PA134894313 |
Miscellaneous databases
Pharosi | Q8IVU3, Tdark |
Polymorphism and mutation databases
BioMutai | HERC6 |
DMDMi | 74750679 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000278219 | 1 – 1022 | Probable E3 ubiquitin-protein ligase HERC6Add BLAST | 1022 |
Proteomic databases
EPDi | Q8IVU3 |
jPOSTi | Q8IVU3 |
MassIVEi | Q8IVU3 |
MaxQBi | Q8IVU3 |
PaxDbi | Q8IVU3 |
PeptideAtlasi | Q8IVU3 |
PRIDEi | Q8IVU3 |
ProteomicsDBi | 70770 [Q8IVU3-1] 70771 [Q8IVU3-2] 70772 [Q8IVU3-3] |
PTM databases
iPTMneti | Q8IVU3 |
PhosphoSitePlusi | Q8IVU3 |
Expressioni
Tissue specificityi
Detected in brain, heart, placenta and testis.1 Publication
Developmental stagei
Expressed in fetal brain.1 Publication
Gene expression databases
Bgeei | ENSG00000138642, Expressed in epithelium of bronchus and 214 other tissues |
ExpressionAtlasi | Q8IVU3, baseline and differential |
Genevisiblei | Q8IVU3, HS |
Organism-specific databases
HPAi | ENSG00000138642, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120340, 11 interactors |
IntActi | Q8IVU3, 2 interactors |
STRINGi | 9606.ENSP00000264346 |
Miscellaneous databases
RNActi | Q8IVU3, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8IVU3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 41 – 92 | RCC1 1Add BLAST | 52 | |
Repeati | 93 – 145 | RCC1 2Add BLAST | 53 | |
Repeati | 147 – 198 | RCC1 3Add BLAST | 52 | |
Repeati | 200 – 253 | RCC1 4Add BLAST | 54 | |
Repeati | 254 – 304 | RCC1 5Add BLAST | 51 | |
Domaini | 693 – 1017 | HECTPROSITE-ProRule annotationAdd BLAST | 325 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0941, Eukaryota |
GeneTreei | ENSGT00940000162279 |
HOGENOMi | CLU_002173_5_3_1 |
InParanoidi | Q8IVU3 |
OMAi | NFVTTYQ |
OrthoDBi | 1062377at2759 |
PhylomeDBi | Q8IVU3 |
TreeFami | TF315189 |
Family and domain databases
CDDi | cd00078, HECTc, 1 hit |
Gene3Di | 2.130.10.30, 2 hits |
InterProi | View protein in InterPro IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR009091, RCC1/BLIP-II IPR000408, Reg_chr_condens |
Pfami | View protein in Pfam PF00632, HECT, 1 hit PF00415, RCC1, 5 hits |
PRINTSi | PR00633, RCCNDNSATION |
SMARTi | View protein in SMART SM00119, HECTc, 1 hit |
SUPFAMi | SSF50985, SSF50985, 1 hit SSF56204, SSF56204, 1 hit |
PROSITEi | View protein in PROSITE PS50237, HECT, 1 hit PS00626, RCC1_2, 3 hits PS50012, RCC1_3, 5 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IVU3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYFCWGADSR ELQRRRTAGS PGAELLQAAS GERHSLLLLT NHRVLSCGDN
60 70 80 90 100
SRGQLGRRGA QRGELPEPIQ ALETLIVDLV SCGKEHSLAV CHKGRVFAWG
110 120 130 140 150
AGSEGQLGIG EFKEISFTPK KIMTLNDIKI IQVSCGHYHS LALSKDSQVF
160 170 180 190 200
SWGKNSHGQL GLGKEFPSQA SPQRVRSLEG IPLAQVAAGG AHSFALSLCG
210 220 230 240 250
TSFGWGSNSA GQLALSGRNV PVQSNKPLSV GALKNLGVVY ISCGDAHTAV
260 270 280 290 300
LTQDGKVFTF GDNRSGQLGY SPTPEKRGPQ LVERIDGLVS QIDCGSYHTL
310 320 330 340 350
AYVHTTGQVV SFGHGPSDTS KPTHPEALTE NFDISCLISA EDFVDVQVKH
360 370 380 390 400
IFAGTYANFV TTHQDTSSTR APGKTLPEIS RISQSMAEKW IAVKRRSTEH
410 420 430 440 450
EMAKSEIRMI FSSPACLTAS FLKKRGTGET TSIDVDLEMA RDTFKKLTKK
460 470 480 490 500
EWISSMITTC LEDDLLRALP CHSPHQEALS VFLLLPECPV MHDSKNWKNL
510 520 530 540 550
VVPFAKAVCE MSKQSLQVLK KCWAFLQESS LNPLIQMLKA AIISQLLHQT
560 570 580 590 600
KTEQDHCNVK ALLGMMKELH KVNKANCRLP ENTFNINELS NLLNFYIDRG
610 620 630 640 650
RQLFRDNHLI PAETPSPVIF SDFPFIFNSL SKIKLLQADS HIKMQMSEKK
660 670 680 690 700
AYMLMHETIL QKKDEFPPSP RFILRVRRSR LVKDALRQLS QAEATDFCKV
710 720 730 740 750
LVVEFINEIC PESGGVSSEF FHCMFEEMTK PEYGMFMYPE MGSCMWFPAK
760 770 780 790 800
PKPEKKRYFL FGMLCGLSLF NLNVANLPFP LALYKKLLDQ KPSLEDLKEL
810 820 830 840 850
SPRLGKSLQE VLDDAADDIG DALCIRFSIH WDQNDVDLIP NGISIPVDQT
860 870 880 890 900
NKRDYVSKYI DYIFNVSVKA VYEEFQRGFY RVCEKEILRH FYPEELMTAI
910 920 930 940 950
IGNTDYDWKQ FEQNSKYEQG YQKSHPTIQL FWKAFHKLTL DEKKKFLFFL
960 970 980 990 1000
TGRDRLHARG IQKMEIVFRC PETFSERDHP TSITCHNILS LPKYSTMERM
1010 1020
EEALQVAINN NRGFVSPMLT QS
Note: Major transcript.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y9U0 | H0Y9U0_HUMAN | Probable E3 ubiquitin-protein ligas... | HERC6 | 186 | Annotation score: | ||
A0A0B4J1R3 | A0A0B4J1R3_HUMAN | Probable E3 ubiquitin-protein ligas... | HERC6 | 322 | Annotation score: | ||
D6RCT4 | D6RCT4_HUMAN | Probable E3 ubiquitin-protein ligas... | HERC6 | 73 | Annotation score: |
Sequence cautioni
The sequence BAA91303 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03879 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI46056 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI46151 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 742 | G → C in BAA91303 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051725 | 123 | M → T. Corresponds to variant dbSNP:rs7677237Ensembl. | 1 | |
Natural variantiVAR_051726 | 199 | C → R. Corresponds to variant dbSNP:rs12510688Ensembl. | 1 | |
Natural variantiVAR_051727 | 343 | F → L. Corresponds to variant dbSNP:rs17014118Ensembl. | 1 | |
Natural variantiVAR_051728 | 614 | T → I. Corresponds to variant dbSNP:rs6532068EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023183 | 296 – 306 | SYHTLAYVHTT → RNSKHGFMTFF in isoform 3. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_023184 | 307 – 1022 | Missing in isoform 3. 1 PublicationAdd BLAST | 716 | |
Alternative sequenceiVSP_023185 | 610 – 645 | Missing in isoform 2. 1 PublicationAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF336798 mRNA Translation: AAQ14893.1 AY653201 mRNA Translation: AAV66895.1 AK000644 mRNA Translation: BAA91303.1 Different initiation. AK092403 mRNA Translation: BAC03879.1 Different initiation. AK295832 mRNA Translation: BAG58647.1 BC035775 mRNA Translation: AAH35775.2 BC042047 mRNA Translation: AAH42047.2 AL833664 mRNA Translation: CAI46151.1 Different initiation. BX647121 mRNA Translation: CAI46056.1 Different initiation. |
CCDSi | CCDS47098.1 [Q8IVU3-1] CCDS54777.1 [Q8IVU3-2] |
RefSeqi | NP_001158608.1, NM_001165136.1 [Q8IVU3-2] NP_060382.3, NM_017912.3 [Q8IVU3-1] |
Genome annotation databases
Ensembli | ENST00000264346; ENSP00000264346; ENSG00000138642 [Q8IVU3-1] ENST00000380265; ENSP00000369617; ENSG00000138642 [Q8IVU3-2] |
GeneIDi | 55008 |
KEGGi | hsa:55008 |
UCSCi | uc011cdi.3, human [Q8IVU3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF336798 mRNA Translation: AAQ14893.1 AY653201 mRNA Translation: AAV66895.1 AK000644 mRNA Translation: BAA91303.1 Different initiation. AK092403 mRNA Translation: BAC03879.1 Different initiation. AK295832 mRNA Translation: BAG58647.1 BC035775 mRNA Translation: AAH35775.2 BC042047 mRNA Translation: AAH42047.2 AL833664 mRNA Translation: CAI46151.1 Different initiation. BX647121 mRNA Translation: CAI46056.1 Different initiation. |
CCDSi | CCDS47098.1 [Q8IVU3-1] CCDS54777.1 [Q8IVU3-2] |
RefSeqi | NP_001158608.1, NM_001165136.1 [Q8IVU3-2] NP_060382.3, NM_017912.3 [Q8IVU3-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5W87 | X-ray | 2.20 | A/B | 902-1022 | [»] | |
SMRi | Q8IVU3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120340, 11 interactors |
IntActi | Q8IVU3, 2 interactors |
STRINGi | 9606.ENSP00000264346 |
PTM databases
iPTMneti | Q8IVU3 |
PhosphoSitePlusi | Q8IVU3 |
Polymorphism and mutation databases
BioMutai | HERC6 |
DMDMi | 74750679 |
Proteomic databases
EPDi | Q8IVU3 |
jPOSTi | Q8IVU3 |
MassIVEi | Q8IVU3 |
MaxQBi | Q8IVU3 |
PaxDbi | Q8IVU3 |
PeptideAtlasi | Q8IVU3 |
PRIDEi | Q8IVU3 |
ProteomicsDBi | 70770 [Q8IVU3-1] 70771 [Q8IVU3-2] 70772 [Q8IVU3-3] |
Protocols and materials databases
Antibodypediai | 25568, 63 antibodies |
Genome annotation databases
Ensembli | ENST00000264346; ENSP00000264346; ENSG00000138642 [Q8IVU3-1] ENST00000380265; ENSP00000369617; ENSG00000138642 [Q8IVU3-2] |
GeneIDi | 55008 |
KEGGi | hsa:55008 |
UCSCi | uc011cdi.3, human [Q8IVU3-1] |
Organism-specific databases
CTDi | 55008 |
DisGeNETi | 55008 |
EuPathDBi | HostDB:ENSG00000138642.14 |
GeneCardsi | HERC6 |
HGNCi | HGNC:26072, HERC6 |
HPAi | ENSG00000138642, Low tissue specificity |
MIMi | 609249, gene |
neXtProti | NX_Q8IVU3 |
OpenTargetsi | ENSG00000138642 |
PharmGKBi | PA134894313 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0941, Eukaryota |
GeneTreei | ENSGT00940000162279 |
HOGENOMi | CLU_002173_5_3_1 |
InParanoidi | Q8IVU3 |
OMAi | NFVTTYQ |
OrthoDBi | 1062377at2759 |
PhylomeDBi | Q8IVU3 |
TreeFami | TF315189 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q8IVU3 |
Reactomei | R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 55008, 4 hits in 849 CRISPR screens |
ChiTaRSi | HERC6, human |
GenomeRNAii | 55008 |
Pharosi | Q8IVU3, Tdark |
PROi | PR:Q8IVU3 |
RNActi | Q8IVU3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138642, Expressed in epithelium of bronchus and 214 other tissues |
ExpressionAtlasi | Q8IVU3, baseline and differential |
Genevisiblei | Q8IVU3, HS |
Family and domain databases
CDDi | cd00078, HECTc, 1 hit |
Gene3Di | 2.130.10.30, 2 hits |
InterProi | View protein in InterPro IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR009091, RCC1/BLIP-II IPR000408, Reg_chr_condens |
Pfami | View protein in Pfam PF00632, HECT, 1 hit PF00415, RCC1, 5 hits |
PRINTSi | PR00633, RCCNDNSATION |
SMARTi | View protein in SMART SM00119, HECTc, 1 hit |
SUPFAMi | SSF50985, SSF50985, 1 hit SSF56204, SSF56204, 1 hit |
PROSITEi | View protein in PROSITE PS50237, HECT, 1 hit PS00626, RCC1_2, 3 hits PS50012, RCC1_3, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HERC6_HUMAN | |
Accessioni | Q8IVU3Primary (citable) accession number: Q8IVU3 Secondary accession number(s): B4DIY5 Q9NWS4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | July 5, 2005 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations