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Entry version 144 (12 Aug 2020)
Sequence version 2 (18 May 2010)
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Protein

Immunoglobulin superfamily DCC subclass member 3

Gene

IGDCC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IVU1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin superfamily DCC subclass member 3
Alternative name(s):
Putative neuronal cell adhesion molecule
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGDCC3
Synonyms:PUNC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000174498.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9700, IGDCC3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604184, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IVU1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini36 – 640ExtracellularSequence analysisAdd BLAST605
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei641 – 661HelicalSequence analysisAdd BLAST21
Topological domaini662 – 814CytoplasmicSequence analysisAdd BLAST153

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9543

Open Targets

More...
OpenTargetsi
ENSG00000174498

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164720881

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IVU1, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IGDCC3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434537

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001492036 – 814Immunoglobulin superfamily DCC subclass member 3Add BLAST779

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi63 ↔ 117PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 209PROSITE-ProRule annotation
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi259 ↔ 307PROSITE-ProRule annotation
Disulfide bondi351 ↔ 400PROSITE-ProRule annotation
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi580N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi604N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi634N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IVU1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IVU1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IVU1

PeptideAtlas

More...
PeptideAtlasi
Q8IVU1

PRoteomics IDEntifications database

More...
PRIDEi
Q8IVU1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70769

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8IVU1, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IVU1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IVU1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000174498, Expressed in oocyte and 155 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IVU1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IVU1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000174498, Tissue enhanced (brain, parathyroid gland, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114918, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000332773

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IVU1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IVU1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 139Ig-like C2-type 1Add BLAST104
Domaini140 – 220Ig-like C2-type 2Add BLAST81
Domaini238 – 321Ig-like C2-type 3Add BLAST84
Domaini329 – 416Ig-like C2-type 4Add BLAST88
Domaini426 – 520Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST95
Domaini523 – 618Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi783 – 786Poly-Pro4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. DCC family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4221, Eukaryota
KOG4222, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156969

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018612_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IVU1

KEGG Orthology (KO)

More...
KOi
K22654

Identification of Orthologs from Complete Genome Data

More...
OMAi
CGLMEGK

Database of Orthologous Groups

More...
OrthoDBi
1010015at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IVU1

TreeFam database of animal gene trees

More...
TreeFami
TF321506

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041, fn3, 2 hits
PF07679, I-set, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 2 hits
SM00409, IG, 4 hits
SM00408, IGc2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 4 hits
SSF49265, SSF49265, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 2 hits
PS50835, IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8IVU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVQRAASPR RPPAPLWPRL LLPLLLLLLP APSEGLGHSA ELAFAVEPSD
60 70 80 90 100
DVAVPGQPIV LDCRVEGTPP VRITWRKNGV ELPESTHSTL LANGSLMIRH
110 120 130 140 150
FRLEPGGSPS DEGDYECVAQ NRFGLVVSRK ARIQAATMSD FHVHPQATVG
160 170 180 190 200
EEGGVARFQC QIHGLPKPLI TWEKNRVPID TDNERYTLLP KGVLQITGLR
210 220 230 240 250
AEDGGIFHCV ASNIASIRIS HGARLTVSGS GSGAYKEPAI LVGPENLTLT
260 270 280 290 300
VHQTAVLECV ATGNPRPIVS WSRLDGRPIG VEGIQVLGTG NLIISDVTVQ
310 320 330 340 350
HSGVYVCAAN RPGTRVRRTA QGRLVVQAPA EFVQHPQSIS RPAGTTAMFT
360 370 380 390 400
CQAQGEPPPH VTWLKNGQVL GPGGHVRLKN NNSTLTISGI GPEDEAIYQC
410 420 430 440 450
VAENSAGSSQ ASARLTVLWA EGLPGPPRNV RAVSVSSTEV RVSWSEPLAN
460 470 480 490 500
TKEIIGYVLH IRKAADPPEL EYQEAVSKST FQHLVSDLEP STAYSFYIKA
510 520 530 540 550
YTPRGASSAS VPTLASTLGE APAPPPLSVR VLGSSSLQLL WEPWPRLAQH
560 570 580 590 600
EGGFKLFYRP ASKTSFTGPI LLPGTVSSYN LSQLDPTAVY EVKLLAYNQH
610 620 630 640 650
GDGNATVRFV SLRGASERTA LSPPCDCRKE EAANQTSTTG IVIGIHIGVT
660 670 680 690 700
CIIFCVLFLL FGQRGRVLLC KDVENQLSPP QGPRSQRDPG ILALNGARRG
710 720 730 740 750
QRGQLGRDEK RVDMKELEQL FPPASAAGQP DPRPTQDPAA PAPCEETQLS
760 770 780 790 800
VLPLQGCGLM EGKTTEAKTT EATAPCAGLA AAPPPPDGGP GLLSEGQASR
810
PAAARVTQPA HSEQ
Length:814
Mass (Da):86,724
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7081B88569F77C68
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YNQ1H0YNQ1_HUMAN
Immunoglobulin superfamily DCC subc...
IGDCC3
535Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKK1H0YKK1_HUMAN
Immunoglobulin superfamily DCC subc...
IGDCC3
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti598N → S in AAD13399 (PubMed:9922388).Curated1
Sequence conflicti650T → A in AAD13399 (PubMed:9922388).Curated1
Sequence conflicti654F → L in AAD13399 (PubMed:9922388).Curated1
Sequence conflicti729Q → R in AAD13399 (PubMed:9922388).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060356751V → L2 PublicationsCorresponds to variant dbSNP:rs12907128Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC105129 Genomic DNA No translation available.
BC042054 mRNA Translation: AAH42054.1
BC067107 mRNA Translation: AAH67107.1
AF063936 mRNA Translation: AAD13399.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10205.1

NCBI Reference Sequences

More...
RefSeqi
NP_004875.2, NM_004884.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000327987; ENSP00000332773; ENSG00000174498

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9543

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9543

UCSC genome browser

More...
UCSCi
uc002aos.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105129 Genomic DNA No translation available.
BC042054 mRNA Translation: AAH42054.1
BC067107 mRNA Translation: AAH67107.1
AF063936 mRNA Translation: AAD13399.1
CCDSiCCDS10205.1
RefSeqiNP_004875.2, NM_004884.3

3D structure databases

SMRiQ8IVU1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114918, 2 interactors
STRINGi9606.ENSP00000332773

PTM databases

GlyGeniQ8IVU1, 7 sites
iPTMnetiQ8IVU1
PhosphoSitePlusiQ8IVU1

Polymorphism and mutation databases

BioMutaiIGDCC3
DMDMi296434537

Proteomic databases

EPDiQ8IVU1
MassIVEiQ8IVU1
PaxDbiQ8IVU1
PeptideAtlasiQ8IVU1
PRIDEiQ8IVU1
ProteomicsDBi70769

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2652, 42 antibodies

Genome annotation databases

EnsembliENST00000327987; ENSP00000332773; ENSG00000174498
GeneIDi9543
KEGGihsa:9543
UCSCiuc002aos.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9543
DisGeNETi9543
EuPathDBiHostDB:ENSG00000174498.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IGDCC3
HGNCiHGNC:9700, IGDCC3
HPAiENSG00000174498, Tissue enhanced (brain, parathyroid gland, placenta)
MIMi604184, gene
neXtProtiNX_Q8IVU1
OpenTargetsiENSG00000174498
PharmGKBiPA164720881

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4221, Eukaryota
KOG4222, Eukaryota
GeneTreeiENSGT00940000156969
HOGENOMiCLU_018612_2_0_1
InParanoidiQ8IVU1
KOiK22654
OMAiCGLMEGK
OrthoDBi1010015at2759
PhylomeDBiQ8IVU1
TreeFamiTF321506

Enzyme and pathway databases

PathwayCommonsiQ8IVU1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
9543, 3 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IGDCC3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9543
PharosiQ8IVU1, Tdark

Protein Ontology

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PROi
PR:Q8IVU1
RNActiQ8IVU1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000174498, Expressed in oocyte and 155 other tissues
ExpressionAtlasiQ8IVU1, baseline and differential
GenevisibleiQ8IVU1, HS

Family and domain databases

CDDicd00063, FN3, 2 hits
Gene3Di2.60.40.10, 6 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
PfamiView protein in Pfam
PF00041, fn3, 2 hits
PF07679, I-set, 2 hits
SMARTiView protein in SMART
SM00060, FN3, 2 hits
SM00409, IG, 4 hits
SM00408, IGc2, 4 hits
SUPFAMiSSF48726, SSF48726, 4 hits
SSF49265, SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853, FN3, 2 hits
PS50835, IG_LIKE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGDC3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IVU1
Secondary accession number(s): O95215
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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