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Entry version 138 (22 Apr 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Mitotic interactor and substrate of PLK1

Gene

MISP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processCell cycle, Cell division, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitotic interactor and substrate of PLK11 Publication
Alternative name(s):
Mitotic spindle positioning proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MISPImported
Synonyms:C19orf21Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27000 MISP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615289 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IVT2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi78S → A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-164; A-172; A-214; A-224; A-284; A-287; A-377 and A-575. 1 Publication1
Mutagenesisi164T → A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-172; A-214; A-224; A-284; A-287; A-377 and A-575. 1 Publication1
Mutagenesisi172T → A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-164; A-214; A-224; A-284; A-287; A-377 and A-575. 1 Publication1
Mutagenesisi214S → A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-164; A-172; A-224; A-284; A-287; A-377 and A-575. 1 Publication1
Mutagenesisi224T → A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-164; A-172; A-214; A-284; A-287; A-377 and A-575. 1 Publication1
Mutagenesisi284S → A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-164; A-172; A-214; A-224; A-287; A-377 and A-575. 1 Publication1
Mutagenesisi287T → A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-164; A-172; A-214; A-224; A-284; A-377 and A-575. 1 Publication1
Mutagenesisi377T → A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-164; A-172; A-214; A-224; A-284; A-287 and A-575. 1 Publication1
Mutagenesisi382S → A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-394; A-395; A-397; A-471; A-582 and A-586. 1 Publication1
Mutagenesisi394S → A: Drastic reduction in PLK1 phosphorylation in vitro, no effect on cortical localization; when associated with A-382; A-395; A-397; A-471; A-582 and A-586. 1 Publication1
Mutagenesisi394S → D: No effect on cortical localization; when associated with D-395; D-397; D-471; D-582 and D-586. 1 Publication1
Mutagenesisi395S → A: Drastic reduction in PLK1 phosphorylation in vitro, no effect on cortical localization; when associated with A-382; A-394; A-397; A-471; A-582 and A-586. 1 Publication1
Mutagenesisi395S → D: No effect on cortical localization; when associated with D-394; D-397; D-471; D-582 and D-586. 1 Publication1
Mutagenesisi397S → A: Drastic reduction in PLK1 phosphorylation in vitro, no effect on cortical localization; when associated with A-382; A-394; A-395; A-471; A-582 and A-586. 1 Publication1
Mutagenesisi397S → D: No effect on cortical localization; when associated with D-394; D-395; D-471; D-582 and D-586. 1 Publication1
Mutagenesisi471S → A: Drastic reduction in PLK1 phosphorylation in vitro, no effect on cortical localization; when associated with A-382; A-394; A-395; A-397; A-582 and A-586. 1 Publication1
Mutagenesisi471S → D: No effect on cortical localization; when associated with D-394; D-395; D-397; D-582 and D-586. 1 Publication1
Mutagenesisi575S → A: Almost complete loss of CDK1 phosphorylation in vitro, loss of PLK1-binding, no effect on cortical localization; when associated with A-78; A-164; A-172; A-214; A-224; A-284; A-287 and A-377. 1 Publication1
Mutagenesisi582S → A: Drastic reduction in PLK1 phosphorylation in vitro, no effect on cortical localization; when associated with A-382; A-394; A-395; A-397; A-471 and A-586. 1 Publication1
Mutagenesisi582S → D: No effect on cortical localization; when associated with D-394; D-395; D-397; D-471 and D-586. 1 Publication1
Mutagenesisi586S → A: Drastic reduction in PLK1 phosphorylation in vitro, no effect on cortical localization; when associated with A-382; A-394; A-395; A-397; A-471 and A-582. 1 Publication1
Mutagenesisi586S → D: No effect on cortical localization; when associated with D-394; D-395; D-397; D-471 and D-582. 1 Publication1

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000099812

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134861073

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IVT2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MISP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73620663

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000793811 – 679Mitotic interactor and substrate of PLK1Add BLAST679

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei78Phosphoserine; by CDK1; in vitroCombined sources1 Publication1
Modified residuei156PhosphoserineCombined sources1
Modified residuei164Phosphothreonine; by CDK1; in vitroCombined sources1 Publication1
Modified residuei172Phosphothreonine; by CDK1; in vitroCombined sources1 Publication1
Modified residuei179PhosphothreonineCombined sources1
Modified residuei214Phosphoserine; by CDK1; in vitroCombined sources1 Publication1
Modified residuei219PhosphothreonineCombined sources1
Modified residuei224Phosphothreonine; by CDK1; in vitroCombined sources1 Publication1
Modified residuei284Phosphoserine; by CDK1; in vitroCombined sources1 Publication1
Modified residuei287Phosphothreonine; by CDK1; in vitroCombined sources1 Publication1
Modified residuei348PhosphoserineCombined sources1
Modified residuei377Phosphothreonine; by CDK1; in vitroCombined sources1 Publication1
Modified residuei382Phosphoserine; by CDK1; in vitro1 Publication1
Modified residuei394Phosphoserine; by PLK1; in vitroCombined sources1 Publication1
Modified residuei395Phosphoserine; by PLK1; in vitroCombined sources1 Publication1
Modified residuei397Phosphoserine; by PLK1; in vitroCombined sources1 Publication1
Modified residuei400PhosphoserineCombined sources1
Modified residuei430PhosphoserineCombined sources1
Modified residuei471Phosphoserine; by PLK1; in vitroCombined sources1
Modified residuei541PhosphoserineCombined sources1
Modified residuei543PhosphoserineCombined sources1
Modified residuei575Phosphoserine; by CDK1; in vitroCombined sources1 Publication1
Modified residuei577PhosphothreonineCombined sources1
Modified residuei582Phosphoserine; by PLK1; in vitroCombined sources1 Publication1
Modified residuei586Phosphoserine; by PLK1; in vitro1 Publication1
Modified residuei675PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CDK1 and PLK1. CDK1 is the priming kinase for PLK1 phosphorylation. Phosphorylation by PLK1 is required for proper spindle orientation at metaphase.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8IVT2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IVT2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8IVT2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8IVT2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8IVT2

PeptideAtlas

More...
PeptideAtlasi
Q8IVT2

PRoteomics IDEntifications database

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PRIDEi
Q8IVT2

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
70765

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8IVT2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IVT2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Regulated in a cell-cycle dependent manner. Weakly expressed in G1 and S phases. Expression increases in G2/M phases and persisting until the end of mitosis (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000099812 Expressed in mucosa of transverse colon and 145 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IVT2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000099812 Group enriched (gallbladder, intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with F-actin.

Interacts with DCTN1; this interaction regulates DCTN1 distribution at the cell cortex.

Interacts with PTK2/FAK and MAPRE1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125982, 62 interactors

Protein interaction database and analysis system

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IntActi
Q8IVT2, 110 interactors

Molecular INTeraction database

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MINTi
Q8IVT2

STRING: functional protein association networks

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STRINGi
9606.ENSP00000215582

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IVT2 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili545 – 569Sequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MISP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IP6Q Eukaryota
ENOG41127B9 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154739

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_404873_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8IVT2

Identification of Orthologs from Complete Genome Data

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OMAi
WGQDEPQ

Database of Orthologous Groups

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OrthoDBi
481627at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8IVT2

TreeFam database of animal gene trees

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TreeFami
TF334067

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029304 AKAP2_C
IPR042779 MISP/MISP3

The PANTHER Classification System

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PANTHERi
PTHR18839 PTHR18839, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF15304 AKAP2_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IVT2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRVTRYPIL GIPQAHRGTG LVLDGDTSYT YHLVCMGPEA SGWGQDEPQT
60 70 80 90 100
WPTDHRAQQG VQRQGVSYSV HAYTGQPSPR GLHSENREDE GWQVYRLGAR
110 120 130 140 150
DAHQGRPTWA LRPEDGEDKE MKTYRLDAGD ADPRRLCDLE RERWAVIQGQ
160 170 180 190 200
AVRKSSTVAT LQGTPDHGDP RTPGPPRSTP LEENVVDREQ IDFLAARQQF
210 220 230 240 250
LSLEQANKGA PHSSPARGTP AGTTPGASQA PKAFNKPHLA NGHVVPIKPQ
260 270 280 290 300
VKGVVREENK VRAVPTWASV QVVDDPGSLA SVESPGTPKE TPIEREIRLA
310 320 330 340 350
QEREADLREQ RGLRQATDHQ ELVEIPTRPL LTKLSLITAP RRERGRPSLY
360 370 380 390 400
VQRDIVQETQ REEDHRREGL HVGRASTPDW VSEGPQPGLR RALSSDSILS
410 420 430 440 450
PAPDARAADP APEVRKVNRI PPDAYQPYLS PGTPQLEFSA FGAFGKPSSL
460 470 480 490 500
STAEAKAATS PKATMSPRHL SESSGKPLST KQEASKPPRG CPQANRGVVR
510 520 530 540 550
WEYFRLRPLR FRAPDEPQQA QVPHVWGWEV AGAPALRLQK SQSSDLLERE
560 570 580 590 600
RESVLRREQE VAEERRNALF PEVFSPTPDE NSDQNSRSSS QASGITGSYS
610 620 630 640 650
VSESPFFSPI HLHSNVAWTV EDPVDSAPPG QRKKEQWYAG INPSDGINSE
660 670
VLEAIRVTRH KNAMAERWES RIYASEEDD
Length:679
Mass (Da):75,357
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2881CF5087E61F8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06162999A → T. Corresponds to variant dbSNP:rs45477999Ensembl.1
Natural variantiVAR_033754156S → G. Corresponds to variant dbSNP:rs3746173Ensembl.1
Natural variantiVAR_033755232K → R. Corresponds to variant dbSNP:rs3746175Ensembl.1
Natural variantiVAR_050910269S → N. Corresponds to variant dbSNP:rs35384259Ensembl.1
Natural variantiVAR_033756653E → G. Corresponds to variant dbSNP:rs8107847Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BC042125 mRNA Translation: AAH42125.1
BC052236 mRNA Translation: AAH52236.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12042.1

Protein sequence database of the Protein Information Resource

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PIRi
T00636

NCBI Reference Sequences

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RefSeqi
NP_775752.1, NM_173481.3
XP_011525987.1, XM_011527685.2
XP_011525988.1, XM_011527686.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000215582; ENSP00000215582; ENSG00000099812

Database of genes from NCBI RefSeq genomes

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GeneIDi
126353

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:126353

UCSC genome browser

More...
UCSCi
uc002lpo.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC042125 mRNA Translation: AAH42125.1
BC052236 mRNA Translation: AAH52236.1
CCDSiCCDS12042.1
PIRiT00636
RefSeqiNP_775752.1, NM_173481.3
XP_011525987.1, XM_011527685.2
XP_011525988.1, XM_011527686.2

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi125982, 62 interactors
IntActiQ8IVT2, 110 interactors
MINTiQ8IVT2
STRINGi9606.ENSP00000215582

PTM databases

iPTMnetiQ8IVT2
PhosphoSitePlusiQ8IVT2

Polymorphism and mutation databases

BioMutaiMISP
DMDMi73620663

Proteomic databases

EPDiQ8IVT2
jPOSTiQ8IVT2
MassIVEiQ8IVT2
MaxQBiQ8IVT2
PaxDbiQ8IVT2
PeptideAtlasiQ8IVT2
PRIDEiQ8IVT2
ProteomicsDBi70765

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
22380 115 antibodies

Genome annotation databases

EnsembliENST00000215582; ENSP00000215582; ENSG00000099812
GeneIDi126353
KEGGihsa:126353
UCSCiuc002lpo.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
126353

GeneCards: human genes, protein and diseases

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GeneCardsi
MISP
HGNCiHGNC:27000 MISP
HPAiENSG00000099812 Group enriched (gallbladder, intestine)
MIMi615289 gene
neXtProtiNX_Q8IVT2
OpenTargetsiENSG00000099812
PharmGKBiPA134861073

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IP6Q Eukaryota
ENOG41127B9 LUCA
GeneTreeiENSGT00940000154739
HOGENOMiCLU_404873_0_0_1
InParanoidiQ8IVT2
OMAiWGQDEPQ
OrthoDBi481627at2759
PhylomeDBiQ8IVT2
TreeFamiTF334067

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MISP human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
126353
PharosiQ8IVT2 Tbio

Protein Ontology

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PROi
PR:Q8IVT2
RNActiQ8IVT2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000099812 Expressed in mucosa of transverse colon and 145 other tissues
GenevisibleiQ8IVT2 HS

Family and domain databases

InterProiView protein in InterPro
IPR029304 AKAP2_C
IPR042779 MISP/MISP3
PANTHERiPTHR18839 PTHR18839, 1 hit
PfamiView protein in Pfam
PF15304 AKAP2_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMISP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IVT2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: April 22, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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