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UniProtKB - Q8IVS8 (GLCTK_HUMAN)

Entry version 133 (13 Feb 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Glycerate kinase

Gene

GLYCTK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.1 mM for D-glycerate1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • ATP binding Source: UniProtKB-KW
    • glycerate kinase activity Source: UniProtKB
    View the complete GO annotation on QuickGO ...

    GO - Biological processi

    View the complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		2.7.1.31 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-70350 Fructose catabolism

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		Q8IVS8

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Glycerate kinase (EC:2.7.1.312 Publications)
    Alternative name(s):
    HBeAg-binding protein 4
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:GLYCTK
    Synonyms:HBEBP4
    ORF Names:LP5910
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000168237.17

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:24247 GLYCTK

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		610516 gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q8IVS8

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    D-glyceric aciduria (D-GA)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA rare metabolic disease characterized by chronic metabolic acidosis and a highly variable clinical phenotype. Clinical features range from an encephalopathic presentation with seizures, microcephaly, severe mental retardation and early death, to milder manifestations with only speech delay or even normal development.
    See also OMIM:220120
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_065909493F → C in D-GA; the mutant protein is not expressed and has no enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs121909448EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		132158

    MalaCards human disease database

    More...    MalaCardsi    		GLYCTK
    MIMi220120 phenotype

    Open Targets

    More...    OpenTargetsi    		ENSG00000168237

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...    Orphaneti    		941 D-glyceric aciduria

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA162389865

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		GLYCTK

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		74728080

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002871921 – 523Glycerate kinaseAdd BLAST523

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q8IVS8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q8IVS8

    PeptideAtlas

    More...    PeptideAtlasi    		Q8IVS8

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q8IVS8

    ProteomicsDB human proteome resource

    More...    ProteomicsDBi    		70758
    70759 [Q8IVS8-2]
    70760 [Q8IVS8-3]
    70761 [Q8IVS8-4]
    70762 [Q8IVS8-5]
    70763 [Q8IVS8-6]
    70764 [Q8IVS8-7]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q8IVS8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q8IVS8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000168237 Expressed in 116 organ(s), highest expression level in right lobe of liver

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q8IVS8 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q8IVS8 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		HPA006913

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...    BioGridi    		126307, 14 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q8IVS8, 63 interactors

    Molecular INTeraction database

    More...    MINTi    		Q8IVS8

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000389175

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...    ProteinModelPortali    		Q8IVS8

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q8IVS8

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi94 – 97Poly-Ala4

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycerate kinase type-2 family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG3935 Eukaryota
    COG2379 LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00390000014365

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...    HOVERGENi    		HBG098351

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q8IVS8

    KEGG Orthology (KO)

    More...    KOi    		K11529

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		ICGGEPV

    Database of Orthologous Groups

    More...    OrthoDBi    		1083437at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q8IVS8

    TreeFam database of animal gene trees

    More...    TreeFami    		TF313770

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		3.40.50.10180, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR038614 GK_N_sf
    IPR007835 MOFRL
    IPR025286 MOFRL_assoc_dom
    IPR039760 MOFRL_protein

    The PANTHER Classification System

    More...    PANTHERi    		PTHR12227 PTHR12227, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF13660 DUF4147, 1 hit
    PF05161 MOFRL, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8IVS8-1) [UniParc]FASTAAdd to basket
    Also known as: Glycerate kinase 11 Publication, GLYCTK11 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAAALQVLPR LARAPLHPLL WRGSVARLAS SMALAEQARQ LFESAVGAVL 
            60         70         80         90        100
    PGPMLHRALS LDPGGRQLKV RDRNFQLRQN LYLVGFGKAV LGMAAAAEEL 
           110        120        130        140        150
    LGQHLVQGVI SVPKGIRAAM ERAGKQEMLL KPHSRVQVFE GAEDNLPDRD 
           160        170        180        190        200
    ALRAALAIQQ LAEGLTADDL LLVLISGGGS ALLPAPIPPV TLEEKQTLTR 
           210        220        230        240        250
    LLAARGATIQ ELNTIRKALS QLKGGGLAQA AYPAQVVSLI LSDVVGDPVE 
           260        270        280        290        300
    VIASGPTVAS SHNVQDCLHI LNRYGLRAAL PRSVKTVLSR ADSDPHGPHT 
           310        320        330        340        350
    CGHVLNVIIG SNVLALAEAQ RQAEALGYQA VVLSAAMQGD VKSMAQFYGL 
           360        370        380        390        400
    LAHVARTRLT PSMAGASVEE DAQLHELAAE LQIPDLQLEE ALETMAWGRG 
           410        420        430        440        450
    PVCLLAGGEP TVQLQGSGRG GRNQELALRV GAELRRWPLG PIDVLFLSGG 
           460        470        480        490        500
    TDGQDGPTEA AGAWVTPELA SQAAAEGLDI ATFLAHNDSH TFFCCLQGGA 
           510        520 
    HLLHTGMTGT NVMDTHLLFL RPR
    Length:523
    Mass (Da):55,253
    Last modified:March 1, 2003 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCCBEC88E8850FC11
    GO
    Isoform 2 (identifier: Q8IVS8-2) [UniParc]FASTAAdd to basket
    Also known as: Glycerate kinase 21 Publication, GLYCTK21 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         179-234: GSALLPAPIP...GGLAQAAYPA → EPHPVRCGGG...CEDCAVSGRL
         235-523: Missing.

    Show »
    Length:234
    Mass (Da):25,037
    Checksum:iFC94283B39472157
    GO
    Isoform 3 (identifier: Q8IVS8-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         119-184: Missing.

    Show »
    Length:457
    Mass (Da):48,276
    Checksum:iF14D0F0F05086422
    GO
    Isoform 4 (identifier: Q8IVS8-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         340-367: DVKSMAQFYGLLAHVARTRLTPSMAGAS → WGTPAAHRDDRYQCHGHPPLVPAASVMA
         368-523: Missing.

    Show »
    Length:367
    Mass (Da):38,743
    Checksum:iBD1676AC40F6A128
    GO
    Isoform 5 (identifier: Q8IVS8-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-127: Missing.
         340-367: DVKSMAQFYGLLAHVARTRLTPSMAGAS → WGTPAAHRDDRYQCHGHPPIVPAASVMA
         368-523: Missing.

    Show »
    Length:240
    Mass (Da):25,138
    Checksum:i2D3CC412413553BF
    GO
    Isoform 6 (identifier: Q8IVS8-6) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-336: Missing.

    Show »
    Length:187
    Mass (Da):19,867
    Checksum:iA0D08595835AABD5
    GO
    Isoform 7 (identifier: Q8IVS8-7) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         178-205: GGSALLPAPIPPVTLEEKQTLTRLLAAR → WGTPAAHRDDRYQCHGHPPLVPAASVMA
         206-523: Missing.

    Show »
    Length:205
    Mass (Da):22,027
    Checksum:i44BEE76722C8F7A8
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    C9JA32C9JA32_HUMAN
    CG9886-like, isoform CRA_f
    GLYCTK hCG_42582
    		240Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9J3N5C9J3N5_HUMAN
    CG9886-like, isoform CRA_a
    GLYCTK hCG_42582
    		283Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0C4DGA0A0A0C4DGA0_HUMAN
    CG9886-like, isoform CRA_d
    GLYCTK hCG_42582
    		212Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH36862 differs from that shown. Reason: Frameshift at position 177.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti144D → Y in AAP51132 (PubMed:16753811).Curated1
    Sequence conflicti245V → E in BAB85018 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_06120527R → C. Corresponds to variant dbSNP:rs34502608Ensembl.1
    Natural variantiVAR_032285170L → V. Corresponds to variant dbSNP:rs35130772Ensembl.1
    Natural variantiVAR_032286394T → I. Corresponds to variant dbSNP:rs9813489EnsemblClinVar.1
    Natural variantiVAR_065909493F → C in D-GA; the mutant protein is not expressed and has no enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs121909448EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0253561 – 336Missing in isoform 6. 2 PublicationsAdd BLAST336
    Alternative sequenceiVSP_0253571 – 127Missing in isoform 5. 1 PublicationAdd BLAST127
    Alternative sequenceiVSP_025358119 – 184Missing in isoform 3. 1 PublicationAdd BLAST66
    Alternative sequenceiVSP_025359178 – 205GGSAL…LLAAR → WGTPAAHRDDRYQCHGHPPL VPAASVMA in isoform 7. 1 PublicationAdd BLAST28
    Alternative sequenceiVSP_025360179 – 234GSALL…AAYPA → EPHPVRCGGGPCGGDCQWPH RGQFPQCARLPAYPQSLRPP CSPATFCEDCAVSGRL in isoform 2. 1 PublicationAdd BLAST56
    Alternative sequenceiVSP_025361206 – 523Missing in isoform 7. 1 PublicationAdd BLAST318
    Alternative sequenceiVSP_025362235 – 523Missing in isoform 2. 1 PublicationAdd BLAST289
    Alternative sequenceiVSP_025363340 – 367DVKSM…MAGAS → WGTPAAHRDDRYQCHGHPPL VPAASVMA in isoform 4. 1 PublicationAdd BLAST28
    Alternative sequenceiVSP_025364340 – 367DVKSM…MAGAS → WGTPAAHRDDRYQCHGHPPI VPAASVMA in isoform 5. 1 PublicationAdd BLAST28
    Alternative sequenceiVSP_025365368 – 523Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST156

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AY295075 mRNA Translation: AAP51132.1
    AF448855 mRNA Translation: AAP41923.1
    AY172690 mRNA Translation: AAO17719.1
    AY189286 mRNA Translation: AAO86730.1
    AK074215 mRNA Translation: BAB85018.1
    AY134474 mRNA Translation: AAM95456.1
    DQ352863 mRNA Translation: ABD22985.1
    BC021896 mRNA Translation: AAH21896.1
    BC036862 mRNA Translation: AAH36862.1 Frameshift.
    BC042151 mRNA Translation: AAH42151.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS2852.1 [Q8IVS8-1]
    CCDS46841.1 [Q8IVS8-2]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001138423.1, NM_001144951.1 [Q8IVS8-2]
    NP_660305.2, NM_145262.3 [Q8IVS8-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...    UniGenei    		Hs.415312

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000305690; ENSP00000301965; ENSG00000168237 [Q8IVS8-2]
    ENST00000436784; ENSP00000389175; ENSG00000168237 [Q8IVS8-1]
    ENST00000473032; ENSP00000418951; ENSG00000168237 [Q8IVS8-7]
    ENST00000477382; ENSP00000419008; ENSG00000168237 [Q8IVS8-2]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		132158

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:132158

    UCSC genome browser

    More...    UCSCi    		uc003ddo.4 human [Q8IVS8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AY295075 mRNA Translation: AAP51132.1
    AF448855 mRNA Translation: AAP41923.1
    AY172690 mRNA Translation: AAO17719.1
    AY189286 mRNA Translation: AAO86730.1
    AK074215 mRNA Translation: BAB85018.1
    AY134474 mRNA Translation: AAM95456.1
    DQ352863 mRNA Translation: ABD22985.1
    BC021896 mRNA Translation: AAH21896.1
    BC036862 mRNA Translation: AAH36862.1 Frameshift.
    BC042151 mRNA Translation: AAH42151.1
    CCDSiCCDS2852.1 [Q8IVS8-1]
    CCDS46841.1 [Q8IVS8-2]
    RefSeqiNP_001138423.1, NM_001144951.1 [Q8IVS8-2]
    NP_660305.2, NM_145262.3 [Q8IVS8-1]
    UniGeneiHs.415312

    3D structure databases

    ProteinModelPortaliQ8IVS8
    SMRiQ8IVS8
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi126307, 14 interactors
    IntActiQ8IVS8, 63 interactors
    MINTiQ8IVS8
    STRINGi9606.ENSP00000389175

    PTM databases

    iPTMnetiQ8IVS8
    PhosphoSitePlusiQ8IVS8

    Polymorphism and mutation databases

    BioMutaiGLYCTK
    DMDMi74728080

    Proteomic databases

    MaxQBiQ8IVS8
    PaxDbiQ8IVS8
    PeptideAtlasiQ8IVS8
    PRIDEiQ8IVS8
    ProteomicsDBi70758
    70759 [Q8IVS8-2]
    70760 [Q8IVS8-3]
    70761 [Q8IVS8-4]
    70762 [Q8IVS8-5]
    70763 [Q8IVS8-6]
    70764 [Q8IVS8-7]

    Protocols and materials databases

    The DNASU plasmid repository

    More...    DNASUi    		132158
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000305690; ENSP00000301965; ENSG00000168237 [Q8IVS8-2]
    ENST00000436784; ENSP00000389175; ENSG00000168237 [Q8IVS8-1]
    ENST00000473032; ENSP00000418951; ENSG00000168237 [Q8IVS8-7]
    ENST00000477382; ENSP00000419008; ENSG00000168237 [Q8IVS8-2]
    GeneIDi132158
    KEGGihsa:132158
    UCSCiuc003ddo.4 human [Q8IVS8-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		132158
    DisGeNETi132158
    EuPathDBiHostDB:ENSG00000168237.17

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		GLYCTK
    HGNCiHGNC:24247 GLYCTK
    HPAiHPA006913
    MalaCardsiGLYCTK
    MIMi220120 phenotype
    610516 gene
    neXtProtiNX_Q8IVS8
    OpenTargetsiENSG00000168237
    Orphaneti941 D-glyceric aciduria
    PharmGKBiPA162389865

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG3935 Eukaryota
    COG2379 LUCA
    GeneTreeiENSGT00390000014365
    HOVERGENiHBG098351
    InParanoidiQ8IVS8
    KOiK11529
    OMAiICGGEPV
    OrthoDBi1083437at2759
    PhylomeDBiQ8IVS8
    TreeFamiTF313770

    Enzyme and pathway databases

    BRENDAi2.7.1.31 2681
    ReactomeiR-HSA-70350 Fructose catabolism
    SABIO-RKiQ8IVS8

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		GLYCTK human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		132158

    Protein Ontology

    More...    PROi    		PR:Q8IVS8

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000168237 Expressed in 116 organ(s), highest expression level in right lobe of liver
    ExpressionAtlasiQ8IVS8 baseline and differential
    GenevisibleiQ8IVS8 HS

    Family and domain databases

    Gene3Di3.40.50.10180, 1 hit
    InterProiView protein in InterPro
    IPR038614 GK_N_sf
    IPR007835 MOFRL
    IPR025286 MOFRL_assoc_dom
    IPR039760 MOFRL_protein
    PANTHERiPTHR12227 PTHR12227, 1 hit
    PfamiView protein in Pfam
    PF13660 DUF4147, 1 hit
    PF05161 MOFRL, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLCTK_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IVS8
    Secondary accession number(s): Q0P630
    , Q2EZ43, Q6Y2K6, Q7Z6G5, Q86YR8, Q8TED2, Q8WTY2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: March 1, 2003
    Last modified: February 13, 2019
    This is version 133 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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