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Entry version 149 (23 Feb 2022)
Sequence version 1 (01 Mar 2003)
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Protein

Glycerate kinase

Gene

GLYCTK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.1 mM for D-glycerate1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.1.31, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q8IVS8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-70350, Fructose catabolism

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
Q8IVS8

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8IVS8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycerate kinase (EC:2.7.1.312 Publications)
Alternative name(s):
HBeAg-binding protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GLYCTK
Synonyms:HBEBP4
ORF Names:LP5910
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24247, GLYCTK

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610516, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8IVS8

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000168237

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

D-glyceric aciduria (D-GA)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare metabolic disease characterized by chronic metabolic acidosis and a highly variable clinical phenotype. Clinical features range from an encephalopathic presentation with seizures, microcephaly, severe mental retardation and early death, to milder manifestations with only speech delay or even normal development.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_065909493F → C in D-GA; the mutant protein is not expressed and has no enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs121909448EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...
DisGeNETi
132158

MalaCards human disease database

More...
MalaCardsi
GLYCTK
MIMi220120, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000168237

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
941, D-glyceric aciduria

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162389865

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IVS8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GLYCTK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728080

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002871921 – 523Glycerate kinaseAdd BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IVS8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IVS8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IVS8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IVS8

PeptideAtlas

More...
PeptideAtlasi
Q8IVS8

PRoteomics IDEntifications database

More...
PRIDEi
Q8IVS8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70758 [Q8IVS8-1]
70759 [Q8IVS8-2]
70760 [Q8IVS8-3]
70761 [Q8IVS8-4]
70762 [Q8IVS8-5]
70763 [Q8IVS8-6]
70764 [Q8IVS8-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IVS8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IVS8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168237, Expressed in right lobe of liver and 139 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IVS8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IVS8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000168237, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8IVS8
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-748515,EBI-10173507
ANKRD53 - isoform 2 [Q8N9V6-2]3EBI-748515,EBI-13345447
ARMC5 [Q96C12]3EBI-748515,EBI-6425121
ATP23 [Q9Y6H3]3EBI-748515,EBI-12811889
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-748515,EBI-11976299
CALCOCO2 [Q13137]3EBI-748515,EBI-739580
CEP70 [Q8NHQ1]3EBI-748515,EBI-739624
DTX2 [Q86UW9]6EBI-748515,EBI-740376
EFHC2 [Q5JST6]3EBI-748515,EBI-2349927
GMPPB [Q9Y5P6]5EBI-748515,EBI-750945
GOLGA2 [Q08379]6EBI-748515,EBI-618309
IHO1 [Q8IYA8]3EBI-748515,EBI-8638439
KLHL12 [Q53G59]3EBI-748515,EBI-740929
KRT13 [P13646]3EBI-748515,EBI-1223876
KRT15 [P19012]3EBI-748515,EBI-739566
KRT19 [P08727]3EBI-748515,EBI-742756
KRT34 [O76011]3EBI-748515,EBI-1047093
KRT75 [O95678]3EBI-748515,EBI-2949715
KRTAP19-5 [Q3LI72]3EBI-748515,EBI-1048945
KRTAP6-2 [Q3LI66]5EBI-748515,EBI-11962084
LZTS2 [Q9BRK4]3EBI-748515,EBI-741037
MAGED1 [Q9Y5V3]3EBI-748515,EBI-716006
METTL15 - isoform 4 [A6NJ78-4]3EBI-748515,EBI-10174029
METTL27 [Q8N6F8]3EBI-748515,EBI-8487781
MIS18A [Q9NYP9]4EBI-748515,EBI-1104552
MORN3 [Q6PF18]3EBI-748515,EBI-9675802
NFKBID [Q8NI38]3EBI-748515,EBI-10271199
NOTO [A8MTQ0]3EBI-748515,EBI-17490746
NT5C2 [P49902]3EBI-748515,EBI-742084
PFDN5 [Q99471]3EBI-748515,EBI-357275
PICK1 [Q9NRD5]3EBI-748515,EBI-79165
PLAGL2 [Q9UPG8]3EBI-748515,EBI-2876622
POMC [P01189]3EBI-748515,EBI-12219503
PRDM14 [Q9GZV8]3EBI-748515,EBI-3957793
PUDP [Q08623]3EBI-748515,EBI-12807240
RBCK1 [Q9BYM8]3EBI-748515,EBI-2340624
RBPMS [Q93062]3EBI-748515,EBI-740322
REL [Q04864]3EBI-748515,EBI-307352
REL - isoform 2 [Q04864-2]3EBI-748515,EBI-10829018
SAXO1 [Q8IYX7]3EBI-748515,EBI-3957636
SERTAD1 [Q9UHV2]3EBI-748515,EBI-748601
SMUG1 - isoform 2 [Q53HV7-2]3EBI-748515,EBI-12275818
SNF8 [Q96H20]5EBI-748515,EBI-747719
SPAG8 - isoform 2 [Q99932-2]3EBI-748515,EBI-11959123
SPRED1 [Q7Z699]3EBI-748515,EBI-5235340
TRIM27 [P14373]3EBI-748515,EBI-719493
TRIM42 [Q8IWZ5]3EBI-748515,EBI-5235829
TRIP13 [Q15645]9EBI-748515,EBI-358993
TUBGCP4 [Q9UGJ1]3EBI-748515,EBI-1052544
UFSP1 [Q6NVU6]3EBI-748515,EBI-12068150
ZFP90 [Q8TF47]3EBI-748515,EBI-11419867
ZG16 [O60844]3EBI-748515,EBI-746479
ZIM2 [Q9NZV7]3EBI-748515,EBI-11962760
ZNF620 [Q6ZNG0]3EBI-748515,EBI-4395669
ZNF688 [P0C7X2]3EBI-748515,EBI-4395732

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126307, 60 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IVS8, 58 interactors

Molecular INTeraction database

More...
MINTi
Q8IVS8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000389175

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IVS8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IVS8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycerate kinase type-2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3935, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014365

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_112512_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IVS8

Identification of Orthologs from Complete Genome Data

More...
OMAi
ICGGEPV

Database of Orthologous Groups

More...
OrthoDBi
1371490at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IVS8

TreeFam database of animal gene trees

More...
TreeFami
TF313770

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1480.10, 1 hit
3.40.50.10180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037035, GK-like_C_sf
IPR038614, GK_N_sf
IPR007835, MOFRL
IPR025286, MOFRL_assoc_dom
IPR039760, MOFRL_protein

The PANTHER Classification System

More...
PANTHERi
PTHR12227, PTHR12227, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13660, DUF4147, 1 hit
PF05161, MOFRL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IVS8-1) [UniParc]FASTAAdd to basket
Also known as: Glycerate kinase 11 Publication, GLYCTK11 Publication

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAALQVLPR LARAPLHPLL WRGSVARLAS SMALAEQARQ LFESAVGAVL
60 70 80 90 100
PGPMLHRALS LDPGGRQLKV RDRNFQLRQN LYLVGFGKAV LGMAAAAEEL
110 120 130 140 150
LGQHLVQGVI SVPKGIRAAM ERAGKQEMLL KPHSRVQVFE GAEDNLPDRD
160 170 180 190 200
ALRAALAIQQ LAEGLTADDL LLVLISGGGS ALLPAPIPPV TLEEKQTLTR
210 220 230 240 250
LLAARGATIQ ELNTIRKALS QLKGGGLAQA AYPAQVVSLI LSDVVGDPVE
260 270 280 290 300
VIASGPTVAS SHNVQDCLHI LNRYGLRAAL PRSVKTVLSR ADSDPHGPHT
310 320 330 340 350
CGHVLNVIIG SNVLALAEAQ RQAEALGYQA VVLSAAMQGD VKSMAQFYGL
360 370 380 390 400
LAHVARTRLT PSMAGASVEE DAQLHELAAE LQIPDLQLEE ALETMAWGRG
410 420 430 440 450
PVCLLAGGEP TVQLQGSGRG GRNQELALRV GAELRRWPLG PIDVLFLSGG
460 470 480 490 500
TDGQDGPTEA AGAWVTPELA SQAAAEGLDI ATFLAHNDSH TFFCCLQGGA
510 520
HLLHTGMTGT NVMDTHLLFL RPR
Length:523
Mass (Da):55,253
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCCBEC88E8850FC11
GO
Isoform 2 (identifier: Q8IVS8-2) [UniParc]FASTAAdd to basket
Also known as: Glycerate kinase 21 Publication, GLYCTK21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     179-234: GSALLPAPIP...GGLAQAAYPA → EPHPVRCGGG...CEDCAVSGRL
     235-523: Missing.

Show »
Length:234
Mass (Da):25,037
Checksum:iFC94283B39472157
GO
Isoform 3 (identifier: Q8IVS8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-184: Missing.

Show »
Length:457
Mass (Da):48,276
Checksum:iF14D0F0F05086422
GO
Isoform 4 (identifier: Q8IVS8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-367: DVKSMAQFYGLLAHVARTRLTPSMAGAS → WGTPAAHRDDRYQCHGHPPLVPAASVMA
     368-523: Missing.

Show »
Length:367
Mass (Da):38,743
Checksum:iBD1676AC40F6A128
GO
Isoform 5 (identifier: Q8IVS8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.
     340-367: DVKSMAQFYGLLAHVARTRLTPSMAGAS → WGTPAAHRDDRYQCHGHPPIVPAASVMA
     368-523: Missing.

Show »
Length:240
Mass (Da):25,138
Checksum:i2D3CC412413553BF
GO
Isoform 6 (identifier: Q8IVS8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-336: Missing.

Show »
Length:187
Mass (Da):19,867
Checksum:iA0D08595835AABD5
GO
Isoform 7 (identifier: Q8IVS8-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-205: GGSALLPAPIPPVTLEEKQTLTRLLAAR → WGTPAAHRDDRYQCHGHPPLVPAASVMA
     206-523: Missing.

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Length:205
Mass (Da):22,027
Checksum:i44BEE76722C8F7A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JA32C9JA32_HUMAN
CG9886-like, isoform CRA_f
GLYCTK hCG_42582
240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3N5C9J3N5_HUMAN
CG9886-like, isoform CRA_a
GLYCTK hCG_42582
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGA0A0A0C4DGA0_HUMAN
CG9886-like, isoform CRA_d
GLYCTK hCG_42582
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH36862 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti144D → Y in AAP51132 (PubMed:16753811).Curated1
Sequence conflicti245V → E in BAB85018 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06120527R → C. Corresponds to variant dbSNP:rs34502608EnsemblClinVar.1
Natural variantiVAR_032285170L → V. Corresponds to variant dbSNP:rs35130772Ensembl.1
Natural variantiVAR_032286394T → I. Corresponds to variant dbSNP:rs9813489EnsemblClinVar.1
Natural variantiVAR_065909493F → C in D-GA; the mutant protein is not expressed and has no enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs121909448EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0253561 – 336Missing in isoform 6. 2 PublicationsAdd BLAST336
Alternative sequenceiVSP_0253571 – 127Missing in isoform 5. 1 PublicationAdd BLAST127
Alternative sequenceiVSP_025358119 – 184Missing in isoform 3. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_025359178 – 205GGSAL…LLAAR → WGTPAAHRDDRYQCHGHPPL VPAASVMA in isoform 7. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_025360179 – 234GSALL…AAYPA → EPHPVRCGGGPCGGDCQWPH RGQFPQCARLPAYPQSLRPP CSPATFCEDCAVSGRL in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_025361206 – 523Missing in isoform 7. 1 PublicationAdd BLAST318
Alternative sequenceiVSP_025362235 – 523Missing in isoform 2. 1 PublicationAdd BLAST289
Alternative sequenceiVSP_025363340 – 367DVKSM…MAGAS → WGTPAAHRDDRYQCHGHPPL VPAASVMA in isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_025364340 – 367DVKSM…MAGAS → WGTPAAHRDDRYQCHGHPPI VPAASVMA in isoform 5. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_025365368 – 523Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST156

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY295075 mRNA Translation: AAP51132.1
AF448855 mRNA Translation: AAP41923.1
AY172690 mRNA Translation: AAO17719.1
AY189286 mRNA Translation: AAO86730.1
AK074215 mRNA Translation: BAB85018.1
AY134474 mRNA Translation: AAM95456.1
DQ352863 mRNA Translation: ABD22985.1
BC021896 mRNA Translation: AAH21896.1
BC036862 mRNA Translation: AAH36862.1 Frameshift.
BC042151 mRNA Translation: AAH42151.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2852.1 [Q8IVS8-1]
CCDS46841.1 [Q8IVS8-2]

NCBI Reference Sequences

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RefSeqi
NP_001138423.1, NM_001144951.1 [Q8IVS8-2]
NP_660305.2, NM_145262.3 [Q8IVS8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000305690; ENSP00000301965; ENSG00000168237 [Q8IVS8-2]
ENST00000436784; ENSP00000389175; ENSG00000168237
ENST00000473032; ENSP00000418951; ENSG00000168237 [Q8IVS8-7]
ENST00000477382; ENSP00000419008; ENSG00000168237 [Q8IVS8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
132158

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:132158

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

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MANE-Selecti
ENST00000436784.7; ENSP00000389175.2; NM_145262.4; NP_660305.2

UCSC genome browser

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UCSCi
uc003ddo.4, human [Q8IVS8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY295075 mRNA Translation: AAP51132.1
AF448855 mRNA Translation: AAP41923.1
AY172690 mRNA Translation: AAO17719.1
AY189286 mRNA Translation: AAO86730.1
AK074215 mRNA Translation: BAB85018.1
AY134474 mRNA Translation: AAM95456.1
DQ352863 mRNA Translation: ABD22985.1
BC021896 mRNA Translation: AAH21896.1
BC036862 mRNA Translation: AAH36862.1 Frameshift.
BC042151 mRNA Translation: AAH42151.1
CCDSiCCDS2852.1 [Q8IVS8-1]
CCDS46841.1 [Q8IVS8-2]
RefSeqiNP_001138423.1, NM_001144951.1 [Q8IVS8-2]
NP_660305.2, NM_145262.3 [Q8IVS8-1]

3D structure databases

SMRiQ8IVS8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126307, 60 interactors
IntActiQ8IVS8, 58 interactors
MINTiQ8IVS8
STRINGi9606.ENSP00000389175

PTM databases

iPTMnetiQ8IVS8
PhosphoSitePlusiQ8IVS8

Genetic variation databases

BioMutaiGLYCTK
DMDMi74728080

Proteomic databases

jPOSTiQ8IVS8
MassIVEiQ8IVS8
MaxQBiQ8IVS8
PaxDbiQ8IVS8
PeptideAtlasiQ8IVS8
PRIDEiQ8IVS8
ProteomicsDBi70758 [Q8IVS8-1]
70759 [Q8IVS8-2]
70760 [Q8IVS8-3]
70761 [Q8IVS8-4]
70762 [Q8IVS8-5]
70763 [Q8IVS8-6]
70764 [Q8IVS8-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1847, 273 antibodies from 30 providers

The DNASU plasmid repository

More...
DNASUi
132158

Genome annotation databases

EnsembliENST00000305690; ENSP00000301965; ENSG00000168237 [Q8IVS8-2]
ENST00000436784; ENSP00000389175; ENSG00000168237
ENST00000473032; ENSP00000418951; ENSG00000168237 [Q8IVS8-7]
ENST00000477382; ENSP00000419008; ENSG00000168237 [Q8IVS8-2]
GeneIDi132158
KEGGihsa:132158
MANE-SelectiENST00000436784.7; ENSP00000389175.2; NM_145262.4; NP_660305.2
UCSCiuc003ddo.4, human [Q8IVS8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
132158
DisGeNETi132158

GeneCards: human genes, protein and diseases

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GeneCardsi
GLYCTK
HGNCiHGNC:24247, GLYCTK
HPAiENSG00000168237, Tissue enriched (liver)
MalaCardsiGLYCTK
MIMi220120, phenotype
610516, gene
neXtProtiNX_Q8IVS8
OpenTargetsiENSG00000168237
Orphaneti941, D-glyceric aciduria
PharmGKBiPA162389865
VEuPathDBiHostDB:ENSG00000168237

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3935, Eukaryota
GeneTreeiENSGT00390000014365
HOGENOMiCLU_112512_0_0_1
InParanoidiQ8IVS8
OMAiICGGEPV
OrthoDBi1371490at2759
PhylomeDBiQ8IVS8
TreeFamiTF313770

Enzyme and pathway databases

BRENDAi2.7.1.31, 2681
PathwayCommonsiQ8IVS8
ReactomeiR-HSA-70350, Fructose catabolism
SABIO-RKiQ8IVS8
SignaLinkiQ8IVS8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
132158, 7 hits in 1042 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GLYCTK, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
132158
PharosiQ8IVS8, Tbio

Protein Ontology

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PROi
PR:Q8IVS8
RNActiQ8IVS8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168237, Expressed in right lobe of liver and 139 other tissues
ExpressionAtlasiQ8IVS8, baseline and differential
GenevisibleiQ8IVS8, HS

Family and domain databases

Gene3Di3.40.1480.10, 1 hit
3.40.50.10180, 1 hit
InterProiView protein in InterPro
IPR037035, GK-like_C_sf
IPR038614, GK_N_sf
IPR007835, MOFRL
IPR025286, MOFRL_assoc_dom
IPR039760, MOFRL_protein
PANTHERiPTHR12227, PTHR12227, 1 hit
PfamiView protein in Pfam
PF13660, DUF4147, 1 hit
PF05161, MOFRL, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLCTK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IVS8
Secondary accession number(s): Q0P630
, Q2EZ43, Q6Y2K6, Q7Z6G5, Q86YR8, Q8TED2, Q8WTY2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: February 23, 2022
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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