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Protein

Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

Gene

MCAT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria.1 Publication

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].1 Publication

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei153By similarity1
Active sitei270By similarity1

GO - Molecular functioni

  • [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB
  • fatty acid synthase activity Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • fatty acid beta-oxidation Source: Reactome
  • fatty acid biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS02028-MONOMER
ReactomeiR-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation
SIGNORiQ8IVS2
UniPathwayiUPA00094

Chemistry databases

SwissLipidsiSLP:000001251

Names & Taxonomyi

Protein namesi
Recommended name:
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (EC:2.3.1.39)
Short name:
MCT
Alternative name(s):
Mitochondrial malonyl CoA:ACP acyltransferase
Mitochondrial malonyltransferase
[Acyl-carrier-protein] malonyltransferase
Gene namesi
Name:MCAT
Synonyms:MT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100294.12
HGNCiHGNC:29622 MCAT
MIMi614479 gene
neXtProtiNX_Q8IVS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi27349
OpenTargetsiENSG00000100294
PharmGKBiPA162395058

Polymorphism and mutation databases

BioMutaiMCAT
DMDMi48428076

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21MitochondrionSequence analysisAdd BLAST21
ChainiPRO_000000058922 – 390Malonyl-CoA-acyl carrier protein transacylase, mitochondrialAdd BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei314N6-succinyllysineBy similarity1

Proteomic databases

EPDiQ8IVS2
MaxQBiQ8IVS2
PaxDbiQ8IVS2
PeptideAtlasiQ8IVS2
PRIDEiQ8IVS2
ProteomicsDBi70755
70756 [Q8IVS2-2]

PTM databases

iPTMnetiQ8IVS2
PhosphoSitePlusiQ8IVS2

Expressioni

Gene expression databases

BgeeiENSG00000100294
CleanExiHS_MCAT
ExpressionAtlasiQ8IVS2 baseline and differential
GenevisibleiQ8IVS2 HS

Organism-specific databases

HPAiHPA003122
HPA035471

Interactioni

Protein-protein interaction databases

BioGridi118161, 53 interactors
IntActiQ8IVS2, 5 interactors
MINTiQ8IVS2
STRINGi9606.ENSP00000290429

Structurei

Secondary structure

1390
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi63 – 67Combined sources5
Turni75 – 83Combined sources9
Helixi87 – 98Combined sources12
Helixi102 – 108Combined sources7
Helixi111 – 115Combined sources5
Helixi117 – 138Combined sources22
Helixi140 – 144Combined sources5
Beta strandi146 – 151Combined sources6
Helixi155 – 162Combined sources8
Helixi168 – 187Combined sources20
Beta strandi191 – 197Combined sources7
Helixi204 – 217Combined sources14
Beta strandi225 – 232Combined sources8
Beta strandi235 – 241Combined sources7
Helixi242 – 250Combined sources9
Helixi252 – 255Combined sources4
Beta strandi259 – 262Combined sources4
Helixi272 – 274Combined sources3
Helixi275 – 286Combined sources12
Beta strandi294 – 298Combined sources5
Turni300 – 302Combined sources3
Beta strandi303 – 305Combined sources3
Helixi309 – 311Combined sources3
Helixi312 – 319Combined sources8
Helixi326 – 333Combined sources8
Beta strandi344 – 352Combined sources9
Helixi353 – 361Combined sources9
Helixi363 – 366Combined sources4
Beta strandi369 – 372Combined sources4

3D structure databases

ProteinModelPortaliQ8IVS2
SMRiQ8IVS2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IVS2

Family & Domainsi

Sequence similaritiesi

Belongs to the type II malonyltransferase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2926 Eukaryota
COG0331 LUCA
GeneTreeiENSGT00390000013715
HOGENOMiHOG000038000
HOVERGENiHBG051540
InParanoidiQ8IVS2
KOiK00645
OMAiAANYNCP
OrthoDBiEOG091G09QO
PhylomeDBiQ8IVS2
TreeFamiTF313401

Family and domain databases

Gene3Di3.40.366.10, 2 hits
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR016036 Malonyl_transacylase_ACP-bd
IPR020801 PKS_acyl_transferase
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SUPFAMiSSF52151 SSF52151, 2 hits
SSF55048 SSF55048, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IVS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVRVARVAW VRGLGASYRR GASSFPVPPP GAQGVAELLR DATGAEEEAP
60 70 80 90 100
WAATERRMPG QCSVLLFPGQ GSQVVGMGRG LLNYPRVREL YAAARRVLGY
110 120 130 140 150
DLLELSLHGP QETLDRTVHC QPAIFVASLA AVEKLHHLQP SVIENCVAAA
160 170 180 190 200
GFSVGEFAAL VFAGAMEFAE GLYAVKIRAE AMQEASEAVP SGMLSVLGQP
210 220 230 240 250
QSKFNFACLE AREHCKSLGI ENPVCEVSNY LFPDCRVISG HQEALRFLQK
260 270 280 290 300
NSSKFHFRRT RMLPVSGAFH TRLMEPAVEP LTQALKAVDI KKPLVSVYSN
310 320 330 340 350
VHAHRYRHPG HIHKLLAQQL VSPVKWEQTM HAIYERKKGR GFPQTFEVGP
360 370 380 390
GRQLGAILKS CNMQAWKSYS AVDVLQTLEH VDLDPQEPPR
Length:390
Mass (Da):42,962
Last modified:June 7, 2004 - v2
Checksum:i5CAF7AE9DFF36A21
GO
Isoform 2 (identifier: Q8IVS2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     172-180: LYAVKIRAE → STVSPEEFL
     181-390: Missing.

Show »
Length:180
Mass (Da):19,176
Checksum:i8DA3FDA905D219C7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048183303A → G1 PublicationCorresponds to variant dbSNP:rs13815Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010517172 – 180LYAVKIRAE → STVSPEEFL in isoform 2. 3 Publications9
Alternative sequenceiVSP_010518181 – 390Missing in isoform 2. 3 PublicationsAdd BLAST210

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL359401 mRNA Translation: CAB94789.1
AL359403 mRNA Translation: CAB94790.1
AK314059 mRNA Translation: BAG36765.1
AL022237 Genomic DNA Translation: CAQ07851.1
AL022237 Genomic DNA Translation: CAA18261.1
CH471138 Genomic DNA Translation: EAW73286.1
BC030985 mRNA Translation: AAH30985.1
BC042195 mRNA Translation: AAH42195.2
CCDSiCCDS14045.1 [Q8IVS2-2]
CCDS33660.1 [Q8IVS2-1]
RefSeqiNP_055322.1, NM_014507.3 [Q8IVS2-2]
NP_775738.3, NM_173467.4 [Q8IVS2-1]
UniGeneiHs.349111

Genome annotation databases

EnsembliENST00000290429; ENSP00000290429; ENSG00000100294 [Q8IVS2-1]
ENST00000327555; ENSP00000331306; ENSG00000100294 [Q8IVS2-2]
GeneIDi27349
KEGGihsa:27349
UCSCiuc003bdl.2 human [Q8IVS2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFABD_HUMAN
AccessioniPrimary (citable) accession number: Q8IVS2
Secondary accession number(s): B0QY72, O95510, O95511
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: June 20, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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