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1 to 22 of 22  Show
  1. 1
    "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2134 other entries.

  2. 2
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Category: Sequences.
    Tissue: Brain.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 50448 other entries.

  3. 3
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Category: PTM / Processing, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 8769 other entries.

  4. 4
    "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Category: PTM / Processing, Sequences.
    Tissue: Leukemic T-cell.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 5570 other entries.

  5. 5
    "Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells."
    Liu L., Feng D., Chen G., Chen M., Zheng Q., Song P., Ma Q., Zhu C., Wang R., Qi W., Huang L., Xue P., Li B., Wang X., Jin H., Wang J., Yang F., Liu P.
    Chen Q.
    Nat. Cell Biol. 14:177-185(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, TISSUE SPECIFICITY, PHOSPHORYLATION AT TYR-18, INTERACTION WITH MAP1LC3A; MAP1LC3B AND GABARAP, MUTAGENESIS OF TYR-18; LEU-21 AND 31-TRP-TRP-32.
    Category: Function, Subcellular Location, Pathology & Biotech, PTM / Processing, Expression, Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 4 other entries.

  6. 6
    "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Category: Sequences.
    Tissue: Erythroleukemia.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 13410 other entries.

  7. 7
    "A novel EBP c.224T>A mutation supports the existence of a male-specific disorder independent of CDPX2."
    Barboza-Cerda M.C., Wong L.J., Martinez-de-Villarreal L.E., Zhang V.W., Dector M.A.
    Am. J. Med. Genet. A 164A:1642-1647(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT VAL-56.
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 other entries.

  8. 8
    Category: Pathology & Biotech.
    Annotation: Associated with PSYCH: personality dimensions.
    Source: GAD:597681.

    This publication is mapped to 60 other entries.

  9. 9
    "Network organization of the human autophagy system."
    Behrends C., Sowa M.E., Gygi S.P., Harper J.W.
    Nature 466:68-76(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Source: IntAct:Q8IVP5.

    This publication is cited by 6 and mapped to 1203 other entries.

  10. 10
    "Autophagosome formation and molecular mechanism of autophagy."
    Tanida I.
    Antioxid. Redox Signal. 14:2201-2214(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-8948140.

    This publication is mapped to 9 other entries.

  11. 11
    Category: Interaction.
    Source: IntAct:Q8IVP5.

    This publication is mapped to 112 other entries.

  12. 12
    "ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy."
    Wu W., Tian W., Hu Z., Chen G., Huang L., Li W., Zhang X., Xue P., Zhou C., Liu L., Zhu Y., Zhang X., Li L., Zhang L., Sui S., Zhao B., Feng D.
    EMBO Rep. 15:566-575(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Function, PTM / Processing, Interaction.
    Annotation: FUNDC1 regulates ULK1 recruitment to damaged mitochondria where FUNDC1 phosphorylation by ULK1 is crucial for mitophagy. [GeneRIF:139341]. Pathway. [Reactome:R-HSA-8948140, Reactome:R-HSA-8934922].
    Source: Reactome:R-HSA-8948140, IntAct:Q8IVP5, Reactome:R-HSA-8934922, GeneRIF:139341.

    This publication is mapped to 16 other entries.

  13. 13
    "A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy."
    Chen G., Han Z., Feng D., Chen Y., Chen L., Wu H., Huang L., Zhou C., Cai X., Fu C., Duan L., Wang X., Liu L., Liu X., Shen Y., Zhu Y., Chen Q.
    Mol. Cell 54:362-377(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-8934910, Reactome:R-HSA-8934915, Reactome:R-HSA-8934922.

    This publication is mapped to 5 other entries.

  14. 14
    "The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy."
    Wu H., Xue D., Chen G., Han Z., Huang L., Zhu C., Wang X., Jin H., Wang J., Zhu Y., Liu L., Chen Q.
    Autophagy 10:1712-1725(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Function, PTM / Processing, Interaction.
    Annotation: The BCL2L1-PGAM5-FUNDC1 axis is critical for receptor-mediated mitophagy.
    Source: GeneRIF:139341.

    This publication is mapped to 5 other entries.

  15. 15
    Category: Interaction.
    Source: IntAct:Q8IVP5.

    This publication is mapped to 4105 other entries.

  16. 16
    "Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy."
    Chen M., Chen Z., Wang Y., Tan Z., Zhu C., Li Y., Han Z., Chen L., Gao R., Liu L., Chen Q.
    Autophagy 12:689-702(2016) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: FUNDC1 regulates both mitochondrial fission or fusion and mitophagy.
    Source: GeneRIF:139341.
  17. 17
    "FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions."
    Wu W., Lin C., Wu K., Jiang L., Wang X., Li W., Zhuang H., Zhang X., Chen H., Li S., Yang Y., Lu Y., Wang J., Zhu R., Zhang L., Sui S., Tan N., Zhao B.
    Feng D.
    EMBO J. 35:1368-1384(2016) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: FUNDC1 integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 and calnexin under hypoxic conditions in mammalian cells.
    Source: GeneRIF:139341.

    This publication is mapped to 11 other entries.

  18. 18
    "Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy."
    Kuang Y., Ma K., Zhou C., Ding P., Zhu Y., Chen Q., Xia B.
    Autophagy 12:2363-2373(2016) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing, Structure.
    Annotation: phosphorylation of Tyr18 of FUNDC1 serves as a molecular switch for mitophagy. [GeneRIF:139341]. Phosphorylation. [iPTMnet:Q8IVP5].
    Source: iPTMnet:Q8IVP5, GeneRIF:139341, PDB:2N9X.

    This publication is mapped to 1 other entry.

  19. 19
    "Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy."
    Lv M., Wang C., Li F., Peng J., Wen B., Gong Q., Shi Y., Tang Y.
    Protein Cell 8:25-38(2017) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing, Structure.
    Annotation: structural and biochemical results reveal a working model for the specific recognition of FUNDC1 by LC3B and imply that the reversible phosphorylation modification of mitophagy receptors may be a switch for selective mitophagy. [GeneRIF:139341]. Phosphorylation. [iPTMnet:Q8IVP5].
    Source: iPTMnet:Q8IVP5, GeneRIF:139341, PDB:5GMV.

    This publication is mapped to 5 other entries.

  20. 20
    "Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy."
    Chen Z., Liu L., Cheng Q., Li Y., Wu H., Zhang W., Wang Y., Sehgal S.A., Siraj S., Wang X., Wang J., Zhu Y., Chen Q.
    EMBO Rep. 18:495-509(2017) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Annotation: MARCH5 directly interacts with FUNDC1 to mediate its ubiquitylation at lysine 119 for subsequent degradation.
    Source: GeneRIF:139341.

    This publication is mapped to 2 other entries.

  21. 21
    "High expression of FUNDC1 predicts poor prognostic outcomes and is a promising target to improve chemoradiotherapy effects in patients with cervical cancer."
    Hou H., Er P., Cheng J., Chen X., Ding X., Wang Y., Chen X., Yuan Z., Pang Q., Wang P., Qian D.
    Cancer Med 6:1871-1881(2017) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: Our data suggested that FUNDC1 can be used as a prognostic biomarker in patients with cervical cancer and may be a new therapeutic target to improve the antitumor effects of chemoradiotherapy.
    Source: GeneRIF:139341.
  22. 22
    "FUN14 domain-containing 1 promotes breast cancer proliferation and migration by activating calcium-NFATC1-BMI1 axis."
    Wu L., Zhang D., Zhou L., Pei Y., Zhuang Y., Cui W., Chen J.
    EBioMedicine 41:384-394(2019) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Subcellular Location.
    Annotation: Elevated FUNDC1 levelcould stimulate human breast cancer proliferation and migration via Ca2+influxas well as NFATC1 activation and translocation into the nucleus whichfurther binds and activates BMI1 transcription. The positive relationshipbetween FUNDC1 and BMI1 expression further predicts worse progres-sion of breast cancer.
    Source: GeneRIF:139341.
1 to 22 of 22  Show
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