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Protein

Somatomedin-B and thrombospondin type-1 domain-containing protein

Gene

SBSPON

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Somatomedin-B and thrombospondin type-1 domain-containing protein
Alternative name(s):
RPE-spondin
Gene namesi
Name:SBSPON
Synonyms:C8orf84, RPESP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000164764.10
HGNCiHGNC:30362 SBSPON
neXtProtiNX_Q8IVN8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164764
PharmGKBiPA164717487

Polymorphism and mutation databases

BioMutaiSBSPON
DMDMi187611420

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000033215821 – 264Somatomedin-B and thrombospondin type-1 domain-containing proteinAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 52AlternatePROSITE-ProRule annotation
Disulfide bondi28 ↔ 36AlternatePROSITE-ProRule annotation
Disulfide bondi36 ↔ 70AlternatePROSITE-ProRule annotation
Disulfide bondi50 ↔ 63AlternatePROSITE-ProRule annotation
Disulfide bondi50 ↔ 52AlternatePROSITE-ProRule annotation
Disulfide bondi56 ↔ 62By similarity
Disulfide bondi63 ↔ 70AlternatePROSITE-ProRule annotation
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IVN8
PeptideAtlasiQ8IVN8
PRIDEiQ8IVN8
ProteomicsDBi70748

PTM databases

GlyConnecti1764
iPTMnetiQ8IVN8
PhosphoSitePlusiQ8IVN8

Expressioni

Tissue specificityi

Detected in aorta extracellular matrix (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000164764 Expressed in 180 organ(s), highest expression level in metanephric glomerulus
GenevisibleiQ8IVN8 HS

Organism-specific databases

HPAiCAB034214
CAB034332
HPA029595

Interactioni

Protein-protein interaction databases

BioGridi127630, 4 interactors
STRINGi9606.ENSP00000297354

Structurei

3D structure databases

ProteinModelPortaliQ8IVN8
SMRiQ8IVN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 75SMBPROSITE-ProRule annotationAdd BLAST52
Domaini74 – 127TSP type-1PROSITE-ProRule annotationAdd BLAST54

Sequence similaritiesi

Belongs to the thrombospondin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGXF Eukaryota
ENOG41118V9 LUCA
GeneTreeiENSGT00390000008325
HOGENOMiHOG000006768
HOVERGENiHBG108417
InParanoidiQ8IVN8
OMAiCFDYARA
OrthoDBiEOG091G06PW
PhylomeDBiQ8IVN8
TreeFamiTF315634

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR039942 SBSPON
IPR036024 Somatomedin_B-like_dom_sf
IPR001212 Somatomedin_B_dom
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PANTHERiPTHR20920 PTHR20920, 1 hit
PfamiView protein in Pfam
PF00090 TSP_1, 1 hit
SMARTiView protein in SMART
SM00209 TSP1, 1 hit
SUPFAMiSSF82895 SSF82895, 1 hit
SSF90188 SSF90188, 1 hit
PROSITEiView protein in PROSITE
PS00524 SMB_1, 1 hit
PS50958 SMB_2, 1 hit
PS50092 TSP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IVN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTLWMALCA LSRLWPGAQA GCAEAGRCCP GRDPACFARG WRLDRVYGTC
60 70 80 90 100
FCDQACRFTG DCCFDYDRAC PARPCFVGEW SPWSGCADQC KPTTRVRRRS
110 120 130 140 150
VQQEPQNGGA PCPPLEERAG CLEYSTPQGQ DCGHTYVPAF ITTSAFNKER
160 170 180 190 200
TRQATSPHWS THTEDAGYCM EFKTESLTPH CALENWPLTR WMQYLREGYT
210 220 230 240 250
VCVDCQPPAM NSVSLRCSGD GLDSDGNQTL HWQAIGNPRC QGTWKKVRRV
260
DQCSCPAVHS FIFI
Length:264
Mass (Da):29,610
Last modified:April 29, 2008 - v2
Checksum:i1A8406EC6BDC8A41
GO

Sequence cautioni

The sequence AAH42877 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK83466 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAF85659 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06191458F → L1 PublicationCorresponds to variant dbSNP:rs59331088Ensembl.1
Natural variantiVAR_042961186W → R2 PublicationsCorresponds to variant dbSNP:rs2291219Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040546 mRNA Translation: AAK83466.1 Different initiation.
AK292970 mRNA Translation: BAF85659.1 Different initiation.
AC022893 Genomic DNA No translation available.
AC100823 Genomic DNA No translation available.
BC042877 mRNA Translation: AAH42877.1 Different initiation.
CCDSiCCDS43747.2
RefSeqiNP_694957.3, NM_153225.3
UniGeneiHs.439040

Genome annotation databases

EnsembliENST00000297354; ENSP00000297354; ENSG00000164764
GeneIDi157869
KEGGihsa:157869
UCSCiuc003xzf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY040546 mRNA Translation: AAK83466.1 Different initiation.
AK292970 mRNA Translation: BAF85659.1 Different initiation.
AC022893 Genomic DNA No translation available.
AC100823 Genomic DNA No translation available.
BC042877 mRNA Translation: AAH42877.1 Different initiation.
CCDSiCCDS43747.2
RefSeqiNP_694957.3, NM_153225.3
UniGeneiHs.439040

3D structure databases

ProteinModelPortaliQ8IVN8
SMRiQ8IVN8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127630, 4 interactors
STRINGi9606.ENSP00000297354

PTM databases

GlyConnecti1764
iPTMnetiQ8IVN8
PhosphoSitePlusiQ8IVN8

Polymorphism and mutation databases

BioMutaiSBSPON
DMDMi187611420

Proteomic databases

PaxDbiQ8IVN8
PeptideAtlasiQ8IVN8
PRIDEiQ8IVN8
ProteomicsDBi70748

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297354; ENSP00000297354; ENSG00000164764
GeneIDi157869
KEGGihsa:157869
UCSCiuc003xzf.4 human

Organism-specific databases

CTDi157869
EuPathDBiHostDB:ENSG00000164764.10
GeneCardsiSBSPON
H-InvDBiHIX0020800
HGNCiHGNC:30362 SBSPON
HPAiCAB034214
CAB034332
HPA029595
neXtProtiNX_Q8IVN8
OpenTargetsiENSG00000164764
PharmGKBiPA164717487
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGXF Eukaryota
ENOG41118V9 LUCA
GeneTreeiENSGT00390000008325
HOGENOMiHOG000006768
HOVERGENiHBG108417
InParanoidiQ8IVN8
OMAiCFDYARA
OrthoDBiEOG091G06PW
PhylomeDBiQ8IVN8
TreeFamiTF315634

Enzyme and pathway databases

ReactomeiR-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

GenomeRNAii157869
PROiPR:Q8IVN8

Gene expression databases

BgeeiENSG00000164764 Expressed in 180 organ(s), highest expression level in metanephric glomerulus
GenevisibleiQ8IVN8 HS

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR039942 SBSPON
IPR036024 Somatomedin_B-like_dom_sf
IPR001212 Somatomedin_B_dom
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PANTHERiPTHR20920 PTHR20920, 1 hit
PfamiView protein in Pfam
PF00090 TSP_1, 1 hit
SMARTiView protein in SMART
SM00209 TSP1, 1 hit
SUPFAMiSSF82895 SSF82895, 1 hit
SSF90188 SSF90188, 1 hit
PROSITEiView protein in PROSITE
PS00524 SMB_1, 1 hit
PS50958 SMB_2, 1 hit
PS50092 TSP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSBSPO_HUMAN
AccessioniPrimary (citable) accession number: Q8IVN8
Secondary accession number(s): A8KAA5, Q96J64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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