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Entry version 146 (12 Aug 2020)
Sequence version 3 (05 Oct 2010)
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Protein

Neuron navigator 2

Gene

NAV2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.2 Publications

Caution

PubMed:15158073 experiments have been carried out in mouse.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi2157 – 2164ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IVL1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuron navigator 2 (EC:3.6.4.12)
Alternative name(s):
Helicase APC down-regulated 1
Pore membrane and/or filament-interacting-like protein 2
Retinoic acid inducible in neuroblastoma 1
Steerin-2
Unc-53 homolog 2
Short name:
unc53H2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NAV2
Synonyms:HELAD1, KIAA1419, POMFIL2, RAINB1, STEERIN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166833.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15997, NAV2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607026, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IVL1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
89797

Open Targets

More...
OpenTargetsi
ENSG00000166833

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31452

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IVL1, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NAV2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153582

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002671981 – 2488Neuron navigator 2Add BLAST2488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1480PhosphoserineCombined sources1
Modified residuei1484PhosphoserineCombined sources1
Modified residuei1488PhosphoserineCombined sources1
Modified residuei1977PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IVL1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IVL1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IVL1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IVL1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IVL1

PeptideAtlas

More...
PeptideAtlasi
Q8IVL1

PRoteomics IDEntifications database

More...
PRIDEi
Q8IVL1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70724 [Q8IVL1-1]
70725 [Q8IVL1-10]
70726 [Q8IVL1-11]
70727 [Q8IVL1-12]
70728 [Q8IVL1-13]
70729 [Q8IVL1-2]
70730 [Q8IVL1-3]
70731 [Q8IVL1-4]
70732 [Q8IVL1-5]
70733 [Q8IVL1-6]
70734 [Q8IVL1-7]
70735 [Q8IVL1-8]
70736 [Q8IVL1-9]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q8IVL1

GlyConnect protein glycosylation platform

More...
GlyConnecti
1961, 13 N-Linked glycans (7 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8IVL1, 6 sites, 2 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IVL1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IVL1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers.4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in the nervous system of developing embryos. Also expressed in fetal heart, liver and kidney.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By all-trans retinoic acid (ATRA). Up-regulated in colorectal carcinomas.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166833, Expressed in epithelium of mammary gland and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IVL1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IVL1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166833, Tissue enhanced (heart)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124606, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IVL1, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379396

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IVL1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12488
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IVL1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8IVL1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini85 – 192Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili498 – 531Sequence analysisAdd BLAST34
Coiled coili743 – 771Sequence analysisAdd BLAST29
Coiled coili1686 – 1773Sequence analysisAdd BLAST88
Coiled coili1897 – 1964Sequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi192 – 255Gln-richAdd BLAST64
Compositional biasi324 – 328Poly-Pro5
Compositional biasi633 – 638Poly-Ser6
Compositional biasi1363 – 1683Ser-richAdd BLAST321
Compositional biasi1824 – 1829Poly-Lys6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Nav/unc-53 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPT3, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155663

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001002_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IVL1

KEGG Orthology (KO)

More...
KOi
K19483

Database of Orthologous Groups

More...
OrthoDBi
21830at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IVL1

TreeFam database of animal gene trees

More...
TreeFami
TF329881

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR039041, Nav/unc-53
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR12784, PTHR12784, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 1 hit
SM00033, CH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021, CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (13+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 13 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms may exist.

This entry has 13 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IVL1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAILVASKM KSGLPKPVHS AAPILHVPPA RAGPQPCYLK LGSKVEVSKT
60 70 80 90 100
TYPSQIPLKS QVLQGLQEPA GEGLPLRKSG SVENGFDTQI YTDWANHYLA
110 120 130 140 150
KSGHKRLIRD LQQDVTDGVL LAQIIQVVAN EKIEDINGCP KNRSQMIENI
160 170 180 190 200
DACLNFLAAK GINIQGLSAE EIRNGNLKAI LGLFFSLSRY KQQQQQPQKQ
210 220 230 240 250
HLSSPLPPAV SQVAGAPSQC QAGTPQQQVP VTPQAPCQPH QPAPHQQSKA
260 270 280 290 300
QAEMQSSASS KDSSQSKIIR FTLGQKKISR LPGPTARVSA AGSEAKTRGG
310 320 330 340 350
STTANNRRSQ SFNNYDKSKP VTSPPPPPSS HEKEPLASSA SSHPGMSDNA
360 370 380 390 400
PASLESGSSS TPTNCSTSSA IPQPGAATKP WRSKSLSVKH SATVSMLSVK
410 420 430 440 450
PPGPEAPRPT PEAMKPAPNN QKSMLEKLKL FNSKGGSKAG EGPGSRDTSC
460 470 480 490 500
ERLETLPSFE ESEELEAASR MLTTVGPASS SPKIALKGIA QRTFSRALTN
510 520 530 540 550
KKSSLKGNEK EKEKQQREKD KEKSKDLAKR ASVTERLDLK EEPKEDPSGA
560 570 580 590 600
AVPEMPKKSS KIASFIPKGG KLNSAKKEPM APSHSGIPKP GMKSMPGKSP
610 620 630 640 650
SAPAPSKEGE RSRSGKLSSG LPQQKPQLDG RHSSSSSSLA SSEGKGPGGT
660 670 680 690 700
TLNHSISSQT VSGSVGTTQT TGSNTVSVQL PQPQQQYNHP NTATVAPFLY
710 720 730 740 750
RSQTDTEGNV TAESSSTGVS VEPSHFTKTG QPALEELTGE DPEARRLRTV
760 770 780 790 800
KNIADLRQNL EETMSSLRGT QVTHSTLETT FDTNVTTEMS GRSILSLTGR
810 820 830 840 850
PTPLSWRLGQ SSPRLQAGDA PSMGNGYPPR ANASRFINTE SGRYVYSAPL
860 870 880 890 900
RRQLASRGSS VCHVDVSDKA GDEMDLEGIS MDAPGYMSDG DVLSKNIRTD
910 920 930 940 950
DITSGYMTDG GLGLYTRRLN RLPDGMAVVR ETLQRNTSLG LGDADSWDDS
960 970 980 990 1000
SSVSSGISDT IDNLSTDDIN TSSSISSYAN TPASSRKNLD VQTDAEKHSQ
1010 1020 1030 1040 1050
VERNSLWSGD DVKKSDGGSD SGIKMEPGSK WRRNPSDVSD ESDKSTSGKK
1060 1070 1080 1090 1100
NPVISQTGSW RRGMTAQVGI TMPRTKPSAP AGALKTPGTG KTDDAKVSEK
1110 1120 1130 1140 1150
GRLSPKASQV KRSPSDAGRS SGDESKKPLP SSSRTPTANA NSFGFKKQSG
1160 1170 1180 1190 1200
SAAGLAMITA SGVTVTSRSA TLGKIPKSSA LVSRSAGRKS SMDGAQNQDD
1210 1220 1230 1240 1250
GYLALSSRTN LQYRSLPRPS KSNSRNGAGN RSSTSSIDSN ISSKSAGLPV
1260 1270 1280 1290 1300
PKLREPSKTA LGSSLPGLVN QTDKEKGISS DNESVASCNS VKVNPAAQPV
1310 1320 1330 1340 1350
SSPAQTSLQP GAKYPDVASP TLRRLFGGKP TKQVPIATAE NMKNSVVISN
1360 1370 1380 1390 1400
PHATMTQQGN LDSPSGSGVL SSGSSSPLYS KNVDLNQSPL ASSPSSAHSA
1410 1420 1430 1440 1450
PSNSLTWGTN ASSSSAVSKD GLGFQSVSSL HTSCESIDIS LSSGGVPSHN
1460 1470 1480 1490 1500
SSTGLIASSK DDSLTPFVRT NSVKTTLSES PLSSPAASPK FCRSTLPRKQ
1510 1520 1530 1540 1550
DSDPHLDRNT LPKKGLRYTP TSQLRTQEDA KEWLRSHSAG GLQDTAANSP
1560 1570 1580 1590 1600
FSSGSSVTSP SGTRFNFSQL ASPTTVTQMS LSNPTMLRTH SLSNADGQYD
1610 1620 1630 1640 1650
PYTDSRFRNS SMSLDEKSRT MSRSGSFRDG FEEESWEKSS VDNFVSRLHS
1660 1670 1680 1690 1700
SLHFSLPLFH HARYELVHGS SLSLVSSTSS VYSTPEEKCQ SEIRKLRREL
1710 1720 1730 1740 1750
DASQEKVSAL TTQLTANAHL VAAFEQSLGN MTIRLQSLTM TAEQKDSELN
1760 1770 1780 1790 1800
ELRKTIELLK KQNAAAQAAI NGVINTPELN CKGNGTAQSA DLRIRRQHSS
1810 1820 1830 1840 1850
DSVSSINSAT SHSSVGSNIE SDSKKKKRKN WVNELRSSFK QAFGKKKSPK
1860 1870 1880 1890 1900
SASSHSDIEE MTDSSLPSSP KLPHNGSTGS TPLLRNSHSN SLISECMDSE
1910 1920 1930 1940 1950
AETVMQLRNE LRDKEMKLTD IRLEALSSAH QLDQLREAMN RMQSEIEKLK
1960 1970 1980 1990 2000
AENDRLKSES QGSGCSRAPS QVSISASPRQ SMGLSQHSLN LTESTSLDML
2010 2020 2030 2040 2050
LDDTGECSAR KEGGRHVKIV VSFQEEMKWK EDSRPHLFLI GCIGVSGKTK
2060 2070 2080 2090 2100
WDVLDGVVRR LFKEYIIHVD PVSQLGLNSD SVLGYSIGEI KRSNTSETPE
2110 2120 2130 2140 2150
LLPCGYLVGE NTTISVTVKG LAENSLDSLV FESLIPKPIL QRYVSLLIEH
2160 2170 2180 2190 2200
RRIILSGPSG TGKTYLANRL SEYIVLREGR ELTDGVIATF NVDHKSSKEL
2210 2220 2230 2240 2250
RQYLSNLADQ CNSENNAVDM PLVIILDNLH HVSSLGEIFN GLLNCKYHKC
2260 2270 2280 2290 2300
PYIIGTMNQA TSSTPNLQLH HNFRWVLCAN HTEPVKGFLG RFLRRKLMET
2310 2320 2330 2340 2350
EISGRVRNME LVKIIDWIPK VWHHLNRFLE AHSSSDVTIG PRLFLSCPID
2360 2370 2380 2390 2400
VDGSRVWFTD LWNYSIIPYL LEAVREGLQL YGRRAPWEDP AKWVMDTYPW
2410 2420 2430 2440 2450
AASPQQHEWP PLLQLRPEDV GFDGYSMPRE GSTSKQMPPS DAEGDPLMNM
2460 2470 2480
LMRLQEAANY SSPQSYDSDS NSNSHHDDIL DSSLESTL
Length:2,488
Mass (Da):268,167
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0AEDD1C1469A11A8
GO
Isoform 2 (identifier: Q8IVL1-2) [UniParc]FASTAAdd to basket
Also known as: RAINB1d

The sequence of this isoform differs from the canonical sequence as follows:
     256-278: Missing.
     1634-1666: Missing.

Show »
Length:2,432
Mass (Da):261,750
Checksum:i1CEC21B583BB5B36
GO
Isoform 3 (identifier: Q8IVL1-3) [UniParc]FASTAAdd to basket
Also known as: HELAD1L

The sequence of this isoform differs from the canonical sequence as follows:
     256-278: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Show »
Length:2,429
Mass (Da):261,408
Checksum:iFF906F1F4EB428B5
GO
Isoform 4 (identifier: Q8IVL1-4) [UniParc]FASTAAdd to basket
Also known as: HELAD1S

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MPAILVASKM...GSVENGFDTQ → MESVSESSQQQKRKPVIHGLEDQKR
     256-278: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Show »
Length:2,365
Mass (Da):254,978
Checksum:i000C16EB12682A2C
GO
Isoform 5 (identifier: Q8IVL1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-937: Missing.
     938-945: SLGLGDAD → MLWPRNLT
     1480-1501: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Show »
Length:1,493
Mass (Da):161,946
Checksum:i278DEF938E0D3DC2
GO
Isoform 6 (identifier: Q8IVL1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1578: Missing.
     1634-1666: Missing.
     1832-1834: Missing.

Show »
Length:874
Mass (Da):97,684
Checksum:iAEFA49541B2A2E94
GO
Isoform 7 (identifier: Q8IVL1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1896: Missing.

Show »
Length:592
Mass (Da):66,897
Checksum:i6B8F113F3C036820
GO
Isoform 8 (identifier: Q8IVL1-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MLWPRNLT

Show »
Length:2,408
Mass (Da):259,971
Checksum:i635AC30132928AF6
GO
Isoform 9 (identifier: Q8IVL1-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MAGTSAASSWGGGK

Show »
Length:2,414
Mass (Da):260,208
Checksum:iFF6423A81066C65B
GO
Isoform 10 (identifier: Q8IVL1-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MSVMLWRWEQNNTTMKL

Show »
Length:2,417
Mass (Da):261,109
Checksum:iDFBF27444A625EB2
GO
Isoform 11 (identifier: Q8IVL1-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MESVSESSQQQKRKPVIHGLEDQKR

Show »
Length:2,425
Mass (Da):261,866
Checksum:i5C153BF3E2FA6698
GO
Isoform 12 (identifier: Q8IVL1-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MQECDSKFFLPSGSNSGFTLLSNQ

Show »
Length:2,424
Mass (Da):261,579
Checksum:iA902C8AFDA1FA86E
GO
Isoform 13 (identifier: Q8IVL1-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MPAILVASKM...SGSVENGFDT → MAIDLYCGLACLWGIHEPR

Show »
Length:2,419
Mass (Da):261,102
Checksum:i98CA63F4C60A1573
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MTE8A0A0A0MTE8_HUMAN
Neuron navigator 2
NAV2
2,489Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTL4A0A0A0MTL4_HUMAN
Neuron navigator 2
NAV2
2,433Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNV5E9PNV5_HUMAN
Neuron navigator 2
NAV2
815Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLU3E9PLU3_HUMAN
Neuron navigator 2
NAV2
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISY2A0A3B3ISY2_HUMAN
Neuron navigator 2
NAV2
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92657 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB85038 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti100A → T in BAC00854 (PubMed:12214280).Curated1
Sequence conflicti100A → T in CAD32471 (PubMed:15158073).Curated1
Sequence conflicti259S → P in AAL96479 (PubMed:11904404).Curated1
Sequence conflicti259S → P in AAL96480 (PubMed:11904404).Curated1
Sequence conflicti259S → P in BAA92657 (PubMed:10718198).Curated1
Sequence conflicti282P → S in CAD32471 (PubMed:15158073).Curated1
Sequence conflicti1046T → M in BAB85038 (PubMed:14702039).Curated1
Sequence conflicti1173G → D in BAB85038 (PubMed:14702039).Curated1
Sequence conflicti1845Missing in AAH16054 (PubMed:16554811).Curated1
Sequence conflicti1939M → V in BAB85038 (PubMed:14702039).Curated1
Sequence conflicti2012E → G in BAA91965 (PubMed:14702039).Curated1
Sequence conflicti2053V → A in BAA91723 (PubMed:14702039).Curated1
Sequence conflicti2075L → V in BAB85038 (PubMed:14702039).Curated1
Sequence conflicti2296K → E in BAA91965 (PubMed:14702039).Curated1
Sequence conflicti2299E → K in BAB85038 (PubMed:14702039).Curated1
Sequence conflicti2395M → V in BAA91723 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029640109R → K2 PublicationsCorresponds to variant dbSNP:rs6483617Ensembl.1
Natural variantiVAR_029641491Q → H. Corresponds to variant dbSNP:rs16937251Ensembl.1
Natural variantiVAR_0296421041E → D1 PublicationCorresponds to variant dbSNP:rs3802799Ensembl.1
Natural variantiVAR_0296431077P → A6 PublicationsCorresponds to variant dbSNP:rs3802800Ensembl.1
Natural variantiVAR_0322522374V → I1 PublicationCorresponds to variant dbSNP:rs35891966Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0219241 – 1896Missing in isoform 7. 1 PublicationAdd BLAST1896
Alternative sequenceiVSP_0219251 – 1578Missing in isoform 6. 2 PublicationsAdd BLAST1578
Alternative sequenceiVSP_0219261 – 937Missing in isoform 5. 1 PublicationAdd BLAST937
Alternative sequenceiVSP_0219271 – 89MPAIL…GFDTQ → MESVSESSQQQKRKPVIHGL EDQKR in isoform 4. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_0219281 – 88MPAIL…NGFDT → MSVMLWRWEQNNTTMKL in isoform 10. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0219291 – 88MPAIL…NGFDT → MESVSESSQQQKRKPVIHGL EDQKR in isoform 11. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0219301 – 88MPAIL…NGFDT → MQECDSKFFLPSGSNSGFTL LSNQ in isoform 12. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0219311 – 88MPAIL…NGFDT → MAIDLYCGLACLWGIHEPR in isoform 13. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0219321 – 88MPAIL…NGFDT → MLWPRNLT in isoform 8. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0219331 – 88MPAIL…NGFDT → MAGTSAASSWGGGK in isoform 9. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_021934256 – 278Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST23
Alternative sequenceiVSP_021935938 – 945SLGLGDAD → MLWPRNLT in isoform 5. 1 Publication8
Alternative sequenceiVSP_0219361480 – 1501Missing in isoform 5. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0219371634 – 1666Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 5 PublicationsAdd BLAST33
Alternative sequenceiVSP_0219381832 – 1834Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 4 Publications3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF466143 mRNA Translation: AAL96479.1
AF466144 mRNA Translation: AAL96480.1
AB063115 mRNA Translation: BAC00853.1
AB063116 mRNA Translation: BAC00854.1
AJ488102 mRNA Translation: CAD32471.1
AJ488203 mRNA Translation: CAD32556.1
AJ488204 mRNA Translation: CAD32557.1
AJ488205 mRNA Translation: CAD32558.1
AJ488206 mRNA Translation: CAD32559.1
AJ488207 mRNA Translation: CAD32560.1
AJ488208 mRNA Translation: CAD32561.1
AB037840 mRNA Translation: BAA92657.3 Different initiation.
AK001495 mRNA Translation: BAA91723.1
AK001892 mRNA Translation: BAA91965.1
AK074287 mRNA Translation: BAB85038.1 Frameshift.
AC009549 Genomic DNA No translation available.
AC015684 Genomic DNA No translation available.
AC023950 Genomic DNA No translation available.
AC090662 Genomic DNA No translation available.
AC111163 Genomic DNA No translation available.
AC113193 Genomic DNA No translation available.
BC016054 mRNA Translation: AAH16054.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44552.1 [Q8IVL1-5]
CCDS53612.1 [Q8IVL1-4]
CCDS58126.1 [Q8IVL1-1]
CCDS7850.1 [Q8IVL1-3]
CCDS7851.2 [Q8IVL1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001104488.1, NM_001111018.1 [Q8IVL1-4]
NP_001104489.1, NM_001111019.2 [Q8IVL1-5]
NP_001231892.1, NM_001244963.1 [Q8IVL1-1]
NP_660093.2, NM_145117.4 [Q8IVL1-3]
NP_892009.3, NM_182964.5 [Q8IVL1-2]
XP_006718431.1, XM_006718368.3 [Q8IVL1-5]
XP_011518754.1, XM_011520452.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000349880; ENSP00000309577; ENSG00000166833 [Q8IVL1-3]
ENST00000360655; ENSP00000353871; ENSG00000166833 [Q8IVL1-4]
ENST00000396085; ENSP00000379394; ENSG00000166833 [Q8IVL1-2]
ENST00000396087; ENSP00000379396; ENSG00000166833 [Q8IVL1-1]
ENST00000533917; ENSP00000437316; ENSG00000166833 [Q8IVL1-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
89797

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:89797

UCSC genome browser

More...
UCSCi
uc001mpp.4, human [Q8IVL1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF466143 mRNA Translation: AAL96479.1
AF466144 mRNA Translation: AAL96480.1
AB063115 mRNA Translation: BAC00853.1
AB063116 mRNA Translation: BAC00854.1
AJ488102 mRNA Translation: CAD32471.1
AJ488203 mRNA Translation: CAD32556.1
AJ488204 mRNA Translation: CAD32557.1
AJ488205 mRNA Translation: CAD32558.1
AJ488206 mRNA Translation: CAD32559.1
AJ488207 mRNA Translation: CAD32560.1
AJ488208 mRNA Translation: CAD32561.1
AB037840 mRNA Translation: BAA92657.3 Different initiation.
AK001495 mRNA Translation: BAA91723.1
AK001892 mRNA Translation: BAA91965.1
AK074287 mRNA Translation: BAB85038.1 Frameshift.
AC009549 Genomic DNA No translation available.
AC015684 Genomic DNA No translation available.
AC023950 Genomic DNA No translation available.
AC090662 Genomic DNA No translation available.
AC111163 Genomic DNA No translation available.
AC113193 Genomic DNA No translation available.
BC016054 mRNA Translation: AAH16054.1
CCDSiCCDS44552.1 [Q8IVL1-5]
CCDS53612.1 [Q8IVL1-4]
CCDS58126.1 [Q8IVL1-1]
CCDS7850.1 [Q8IVL1-3]
CCDS7851.2 [Q8IVL1-2]
RefSeqiNP_001104488.1, NM_001111018.1 [Q8IVL1-4]
NP_001104489.1, NM_001111019.2 [Q8IVL1-5]
NP_001231892.1, NM_001244963.1 [Q8IVL1-1]
NP_660093.2, NM_145117.4 [Q8IVL1-3]
NP_892009.3, NM_182964.5 [Q8IVL1-2]
XP_006718431.1, XM_006718368.3 [Q8IVL1-5]
XP_011518754.1, XM_011520452.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YRNNMR-A90-197[»]
SMRiQ8IVL1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124606, 22 interactors
IntActiQ8IVL1, 12 interactors
STRINGi9606.ENSP00000379396

PTM databases

CarbonylDBiQ8IVL1
GlyConnecti1961, 13 N-Linked glycans (7 sites)
GlyGeniQ8IVL1, 6 sites, 2 N-linked glycans (1 site)
iPTMnetiQ8IVL1
PhosphoSitePlusiQ8IVL1

Polymorphism and mutation databases

BioMutaiNAV2
DMDMi308153582

Proteomic databases

EPDiQ8IVL1
jPOSTiQ8IVL1
MassIVEiQ8IVL1
MaxQBiQ8IVL1
PaxDbiQ8IVL1
PeptideAtlasiQ8IVL1
PRIDEiQ8IVL1
ProteomicsDBi70724 [Q8IVL1-1]
70725 [Q8IVL1-10]
70726 [Q8IVL1-11]
70727 [Q8IVL1-12]
70728 [Q8IVL1-13]
70729 [Q8IVL1-2]
70730 [Q8IVL1-3]
70731 [Q8IVL1-4]
70732 [Q8IVL1-5]
70733 [Q8IVL1-6]
70734 [Q8IVL1-7]
70735 [Q8IVL1-8]
70736 [Q8IVL1-9]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2148, 94 antibodies

Genome annotation databases

EnsembliENST00000349880; ENSP00000309577; ENSG00000166833 [Q8IVL1-3]
ENST00000360655; ENSP00000353871; ENSG00000166833 [Q8IVL1-4]
ENST00000396085; ENSP00000379394; ENSG00000166833 [Q8IVL1-2]
ENST00000396087; ENSP00000379396; ENSG00000166833 [Q8IVL1-1]
ENST00000533917; ENSP00000437316; ENSG00000166833 [Q8IVL1-5]
GeneIDi89797
KEGGihsa:89797
UCSCiuc001mpp.4, human [Q8IVL1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
89797
DisGeNETi89797
EuPathDBiHostDB:ENSG00000166833.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NAV2
HGNCiHGNC:15997, NAV2
HPAiENSG00000166833, Tissue enhanced (heart)
MIMi607026, gene
neXtProtiNX_Q8IVL1
OpenTargetsiENSG00000166833
PharmGKBiPA31452

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QPT3, Eukaryota
GeneTreeiENSGT00940000155663
HOGENOMiCLU_001002_1_1_1
InParanoidiQ8IVL1
KOiK19483
OrthoDBi21830at2759
PhylomeDBiQ8IVL1
TreeFamiTF329881

Enzyme and pathway databases

PathwayCommonsiQ8IVL1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
89797, 4 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NAV2, human
EvolutionaryTraceiQ8IVL1

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NAV2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
89797
PharosiQ8IVL1, Tbio

Protein Ontology

More...
PROi
PR:Q8IVL1
RNActiQ8IVL1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166833, Expressed in epithelium of mammary gland and 228 other tissues
ExpressionAtlasiQ8IVL1, baseline and differential
GenevisibleiQ8IVL1, HS

Family and domain databases

CDDicd00014, CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR039041, Nav/unc-53
IPR027417, P-loop_NTPase
PANTHERiPTHR12784, PTHR12784, 1 hit
PfamiView protein in Pfam
PF00307, CH, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM00033, CH, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
SSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAV2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IVL1
Secondary accession number(s): A6NEC1
, Q8IVK3, Q8IVK4, Q8IVK5, Q8IVK6, Q8IVK7, Q8IVK8, Q8NHC9, Q8NHD0, Q8TDE9, Q8TDF0, Q8TEB3, Q96B30, Q9NUZ6, Q9NVM7, Q9P2C8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 5, 2010
Last modified: August 12, 2020
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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