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Entry version 134 (16 Oct 2019)
Sequence version 3 (30 Nov 2010)
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Protein

Neuron navigator 3

Gene

NAV3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate IL2 production by T-cells. May be involved in neuron regeneration.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuron navigator 3
Alternative name(s):
Pore membrane and/or filament-interacting-like protein 1
Steerin-3
Unc-53 homolog 3
Short name:
unc53H3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NAV3
Synonyms:KIAA0938, POMFIL1, STEERIN3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15998 NAV3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611629 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IVL0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration disrupting NAV3 has been found in patients with Sezary syndrome (PubMed:16166283). Translocation t(12;18)(q21;q21.2) (PubMed:16166283).1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
89795

Open Targets

More...
OpenTargetsi
ENSG00000067798

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31453

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IVL0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NAV3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104213

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002869761 – 2385Neuron navigator 3Add BLAST2385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1459PhosphoserineCombined sources1
Modified residuei1463PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IVL0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IVL0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IVL0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IVL0

PeptideAtlas

More...
PeptideAtlasi
Q8IVL0

PRoteomics IDEntifications database

More...
PRIDEi
Q8IVL0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70721 [Q8IVL0-1]
70722 [Q8IVL0-2]
70723 [Q8IVL0-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2059

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IVL0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IVL0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8IVL0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma.4 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000067798 Expressed in 178 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IVL0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IVL0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB037063
HPA032111
HPA032112

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124604, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IVL0, 4 interactors

Molecular INTeraction database

More...
MINTi
Q8IVL0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381007

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IVL0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini77 – 184Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili679 – 707Sequence analysisAdd BLAST29
Coiled coili1562 – 1653Sequence analysisAdd BLAST92
Coiled coili1794 – 1861Sequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi618 – 621Poly-Gln4
Compositional biasi1032 – 1560Ser-richAdd BLAST529
Compositional biasi1694 – 1699Poly-Lys6
Compositional biasi1867 – 1885Ser-richAdd BLAST19

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Nav/unc-53 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGVF Eukaryota
ENOG410XRG8 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158014

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293189

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IVL0

Identification of Orthologs from Complete Genome Data

More...
OMAi
SSLYSTX

Database of Orthologous Groups

More...
OrthoDBi
21830at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IVL0

TreeFam database of animal gene trees

More...
TreeFami
TF329881

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR039041 Nav/unc-53
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR12784 PTHR12784, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004 AAA, 1 hit
PF00307 CH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit
SM00033 CH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IVL0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVLGVASKL RQPAVGSKPV HTALPIPNLG TTGSQHCSSR PLELTETESS
60 70 80 90 100
MLSCQLALKS TCEFGEKKPL QGKAKEKEDS KIYTDWANHY LAKSGHKRLI
110 120 130 140 150
KDLQQDIADG VLLAEIIQII ANEKVEDING CPRSQSQMIE NVDVCLSFLA
160 170 180 190 200
ARGVNVQGLS AEEIRNGNLK AILGLFFSLS RYKQQQHHQQ QYYQSLVELQ
210 220 230 240 250
QRVTHASPPS EASQAKTQQD MQSSLAARYA TQSNHSGIAT SQKKPTRLPG
260 270 280 290 300
PSRVPAAGSS SKVQGASNLN RRSQSFNSID KNKPPNYANG NEKDSSKGPQ
310 320 330 340 350
SSSGVNGNVQ PPSTAGQPPA SAIPSPSASK PWRSKSMNVK HSATSTMLTV
360 370 380 390 400
KQSSTATSPT PSSDRLKPPV SEGVKTAPSG QKSMLEKFKL VNARTALRPP
410 420 430 440 450
QPPSSGPSDG GKDDDAFSES GEMEGFNSGL NSGGSTNSSP KVSPKLAPPK
460 470 480 490 500
AGSKNLSNKK SLLQPKEKEE KNRDKNKVCT EKPVKEEKDQ VTEMAPKKTS
510 520 530 540 550
KIASLIPKGS KTTAAKKESL IPSSSGIPKP GSKVPTVKQT ISPGSTASKE
560 570 580 590 600
SEKFRTTKGS PSQSLSKPIT MEKASASSCP APLEGREAGQ ASPSGSCTMT
610 620 630 640 650
VAQSSGQSTG NGAVQLPQQQ QHSHPNTATV APFIYRAHSE NEGTALPSAD
660 670 680 690 700
SCTSPTKMDL SYSKTAKQCL EEISGEDPET RRMRTVKNIA DLRQNLEETM
710 720 730 740 750
SSLRGTQISH STLETTFDST VTTEVNGRTI PNLTSRPTPM TWRLGQACPR
760 770 780 790 800
LQAGDAPSLG AGYPRSGTSR FIHTDPSRFM YTTPLRRAAV SRLGNMSQID
810 820 830 840 850
MSEKASSDLD MSSEVDVGGY MSDGDILGKS LRTDDINSGY MTDGGLNLYT
860 870 880 890 900
RSLNRIPDTA TSRDIIQRGV HDVTVDADSW DDSSSVSSGL SDTLDNISTD
910 920 930 940 950
DLNTTSSVSS YSNITVPSRK NTQLRTDSEK RSTTDETWDS PEELKKPEED
960 970 980 990 1000
FDSHGDAGGK WKTVSSGLPE DPEKAGQKAS LSVSQTGSWR RGMSAQGGAP
1010 1020 1030 1040 1050
SRQKAGTSAL KTPGKTDDAK ASEKGKAPLK GSSLQRSPSD AGKSSGDEGK
1060 1070 1080 1090 1100
KPPSGIGRST ATSSFGFKKP SGVGSSAMIT SSGATITSGS ATLGKIPKSA
1110 1120 1130 1140 1150
AIGGKSNAGR KTSLDGSQNQ DDVVLHVSSK TTLQYRSLPR PSKSSTSGIP
1160 1170 1180 1190 1200
GRGGHRSSTS SIDSNVSSKS AGATTSKLRE PTKIGSGRSS PVTVNQTDKE
1210 1220 1230 1240 1250
KEKVAVSDSE SVSLSGSPKS SPTSASACGA QGLRQPGSKY PDIASPTFRR
1260 1270 1280 1290 1300
LFGAKAGGKS ASAPNTEGVK SSSVMPSPST TLARQGSLES PSSGTGSMGS
1310 1320 1330 1340 1350
AGGLSGSSSP LFNKPSDLTT DVISLSHSLA SSPASVHSFT SGGLVWAANM
1360 1370 1380 1390 1400
SSSSAGSKDT PSYQSMTSLH TSSESIDLPL SHHGSLSGLT TGTHEVQSLL
1410 1420 1430 1440 1450
MRTGSVRSTL SESMQLDRNT LPKKGLRYTP SSRQANQEEG KEWLRSHSTG
1460 1470 1480 1490 1500
GLQDTGNQSP LVSPSAMSSS AAGKYHFSNL VSPTNLSQFN LPGPSMMRSN
1510 1520 1530 1540 1550
SIPAQDSSFD LYDDSQLCGS ATSLEERPRA ISHSGSFRDS MEEVHGSSLS
1560 1570 1580 1590 1600
LVSSTSSLYS TAEEKAHSEQ IHKLRRELVA SQEKVATLTS QLSANAHLVA
1610 1620 1630 1640 1650
AFEKSLGNMT GRLQSLTMTA EQKESELIEL RETIEMLKAQ NSAAQAAIQG
1660 1670 1680 1690 1700
ALNGPDHPPK DLRIRRQHSS ESVSSINSAT SHSSIGSGND ADSKKKKKKN
1710 1720 1730 1740 1750
WVNSRGSELR SSFKQAFGKK KSTKPPSSHS DIEELTDSSL PASPKLPHNA
1760 1770 1780 1790 1800
GDCGSASMKP SQSASASPLV WPPKKRQNGP VIYKHRSRIC ECTEAEAEII
1810 1820 1830 1840 1850
LQLKSELREK ELKLTDIRLE ALSSAHHLDQ IREAMNRMQN EIEILKAEND
1860 1870 1880 1890 1900
RLKAETGNTA KPTRPPSESS SSTSSSSSRQ SLGLSLNNLN ITEAVSSDIL
1910 1920 1930 1940 1950
LDDAGDATGH KDGRSVKIIV SISKGYGRAK DQKSQAYLIG SIGVSGKTKW
1960 1970 1980 1990 2000
DVLDGVIRRL FKEYVFRIDT STSLGLSSDC IASYCIGDLI RSHNLEVPEL
2010 2020 2030 2040 2050
LPCGYLVGDN NIITVNLKGV EENSLDSFVF DTLIPKPITQ RYFNLLMEHH
2060 2070 2080 2090 2100
RIILSGPSGT GKTYLANKLA EYVITKSGRK KTEDAIATFN VDHKSSKELQ
2110 2120 2130 2140 2150
QYLANLAEQC SADNNGVELP VVIILDNLHH VGSLSDIFNG FLNCKYNKCP
2160 2170 2180 2190 2200
YIIGTMNQGV SSSPNLELHH NFRWVLCANH TEPVKGFLGR YLRRKLIEIE
2210 2220 2230 2240 2250
IERNIRNNDL VKIIDWIPKT WHHLNSFLET HSSSDVTIGP RLFLPCPMDV
2260 2270 2280 2290 2300
EGSRVWFMDL WNYSLVPYIL EAVREGLQMY GKRTPWEDPS KWVLDTYPWS
2310 2320 2330 2340 2350
SATLPQESPA LLQLRPEDVG YESCTSTKEA TTSKHIPQTD TEGDPLMNML
2360 2370 2380
MKLQEAANYS STQSCDSEST SHHEDILDSS LESTL
Length:2,385
Mass (Da):255,648
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23706AF34D2018FA
GO
Isoform 2 (identifier: Q8IVL0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1767-1788: Missing.

Show »
Length:2,363
Mass (Da):253,022
Checksum:iA0725B26F7F45B0F
GO
Isoform 3 (identifier: Q8IVL0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1250-1426: Missing.
     1767-1788: Missing.

Show »
Length:2,186
Mass (Da):235,196
Checksum:iED7A149D6337D84A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YHA8H0YHA8_HUMAN
Neuron navigator 3
NAV3
1,258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI14H0YI14_HUMAN
Neuron navigator 3
NAV3
799Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFX5A0A2R8YFX5_HUMAN
Neuron navigator 3
NAV3
1,842Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZV4F8VZV4_HUMAN
Neuron navigator 3
NAV3
679Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GTC4A0A1B0GTC4_HUMAN
Neuron navigator 3
NAV3
440Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHX7H0YHX7_HUMAN
Neuron navigator 3
NAV3
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti677D → G in CAD32554 (PubMed:15158073).Curated1
Sequence conflicti924L → V in AAM73757 (PubMed:12079279).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03224945T → A1 PublicationCorresponds to variant dbSNP:rs10735309Ensembl.1
Natural variantiVAR_032250210S → W. Corresponds to variant dbSNP:rs34195711Ensembl.1
Natural variantiVAR_0322512200E → K in a patient with Sezary syndrome. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0252681250 – 1426Missing in isoform 3. 1 PublicationAdd BLAST177
Alternative sequenceiVSP_0252691767 – 1788Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ488201 mRNA Translation: CAD32554.1
AC073571 Genomic DNA No translation available.
AC073608 Genomic DNA No translation available.
AC078822 Genomic DNA No translation available.
AC090020 Genomic DNA No translation available.
AC138331 Genomic DNA No translation available.
AF397731 mRNA Translation: AAM73757.1
AB023155 mRNA Translation: BAA76782.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41815.1 [Q8IVL0-2]
CCDS66432.1 [Q8IVL0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001019554.1, NM_001024383.1 [Q8IVL0-1]
NP_055718.4, NM_014903.5 [Q8IVL0-2]
XP_011537246.1, XM_011538944.2 [Q8IVL0-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000397909; ENSP00000381007; ENSG00000067798 [Q8IVL0-1]
ENST00000536525; ENSP00000446132; ENSG00000067798 [Q8IVL0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
89795

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:89795

UCSC genome browser

More...
UCSCi
uc001syo.5 human [Q8IVL0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ488201 mRNA Translation: CAD32554.1
AC073571 Genomic DNA No translation available.
AC073608 Genomic DNA No translation available.
AC078822 Genomic DNA No translation available.
AC090020 Genomic DNA No translation available.
AC138331 Genomic DNA No translation available.
AF397731 mRNA Translation: AAM73757.1
AB023155 mRNA Translation: BAA76782.2
CCDSiCCDS41815.1 [Q8IVL0-2]
CCDS66432.1 [Q8IVL0-1]
RefSeqiNP_001019554.1, NM_001024383.1 [Q8IVL0-1]
NP_055718.4, NM_014903.5 [Q8IVL0-2]
XP_011537246.1, XM_011538944.2 [Q8IVL0-3]

3D structure databases

SMRiQ8IVL0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124604, 5 interactors
IntActiQ8IVL0, 4 interactors
MINTiQ8IVL0
STRINGi9606.ENSP00000381007

PTM databases

GlyConnecti2059
iPTMnetiQ8IVL0
PhosphoSitePlusiQ8IVL0
SwissPalmiQ8IVL0

Polymorphism and mutation databases

BioMutaiNAV3
DMDMi313104213

Proteomic databases

jPOSTiQ8IVL0
MassIVEiQ8IVL0
MaxQBiQ8IVL0
PaxDbiQ8IVL0
PeptideAtlasiQ8IVL0
PRIDEiQ8IVL0
ProteomicsDBi70721 [Q8IVL0-1]
70722 [Q8IVL0-2]
70723 [Q8IVL0-3]

Genome annotation databases

EnsembliENST00000397909; ENSP00000381007; ENSG00000067798 [Q8IVL0-1]
ENST00000536525; ENSP00000446132; ENSG00000067798 [Q8IVL0-2]
GeneIDi89795
KEGGihsa:89795
UCSCiuc001syo.5 human [Q8IVL0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
89795
DisGeNETi89795

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NAV3
HGNCiHGNC:15998 NAV3
HPAiCAB037063
HPA032111
HPA032112
MIMi611629 gene
neXtProtiNX_Q8IVL0
OpenTargetsiENSG00000067798
PharmGKBiPA31453

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGVF Eukaryota
ENOG410XRG8 LUCA
GeneTreeiENSGT00940000158014
HOGENOMiHOG000293189
InParanoidiQ8IVL0
OMAiSSLYSTX
OrthoDBi21830at2759
PhylomeDBiQ8IVL0
TreeFamiTF329881

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NAV3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
89795
PharosiQ8IVL0

Protein Ontology

More...
PROi
PR:Q8IVL0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000067798 Expressed in 178 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ8IVL0 baseline and differential
GenevisibleiQ8IVL0 HS

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR039041 Nav/unc-53
IPR027417 P-loop_NTPase
PANTHERiPTHR12784 PTHR12784, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF00307 CH, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAV3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IVL0
Secondary accession number(s): Q8NFW7, Q9Y2E7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 30, 2010
Last modified: October 16, 2019
This is version 134 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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