Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 41 member 1

Gene

SLC41A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a magnesium transporter that is responsive to magnesium balance.1 Publication

GO - Molecular functioni

  • divalent inorganic cation transmembrane transporter activity Source: ParkinsonsUK-UCL
  • magnesium:sodium antiporter activity Source: ParkinsonsUK-UCL
  • magnesium ion transmembrane transporter activity Source: ParkinsonsUK-UCL
  • transmembrane transporter activity Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Biological processIon transport, Transport
LigandMagnesium

Enzyme and pathway databases

ReactomeiR-HSA-425410 Metal ion SLC transporters

Protein family/group databases

TCDBi1.A.26.2.1 the mg(2+) transporter-e (mgte) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 41 member 1
Gene namesi
Name:SLC41A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000133065.10
HGNCiHGNC:19429 SLC41A1
MIMi610801 gene
neXtProtiNX_Q8IVJ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi254428
OpenTargetsiENSG00000133065
PharmGKBiPA134889327

Polymorphism and mutation databases

BioMutaiSLC41A1
DMDMi152112285

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951111 – 513Solute carrier family 41 member 1Add BLAST513

Proteomic databases

EPDiQ8IVJ1
MaxQBiQ8IVJ1
PaxDbiQ8IVJ1
PeptideAtlasiQ8IVJ1
PRIDEiQ8IVJ1
ProteomicsDBi70715

PTM databases

iPTMnetiQ8IVJ1
PhosphoSitePlusiQ8IVJ1
SwissPalmiQ8IVJ1

Expressioni

Tissue specificityi

Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen.1 Publication

Gene expression databases

BgeeiENSG00000133065 Expressed in 189 organ(s), highest expression level in left ventricle myocardium
CleanExiHS_SLC41A1
ExpressionAtlasiQ8IVJ1 baseline and differential
GenevisibleiQ8IVJ1 HS

Organism-specific databases

HPAiHPA014721
HPA015138

Interactioni

Protein-protein interaction databases

BioGridi129036, 6 interactors
IntActiQ8IVJ1, 27 interactors
STRINGi9606.ENSP00000356105

Structurei

3D structure databases

ProteinModelPortaliQ8IVJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC41A transporter family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3788 Eukaryota
ENOG410XSTG LUCA
GeneTreeiENSGT00390000016816
HOGENOMiHOG000007017
HOVERGENiHBG057187
InParanoidiQ8IVJ1
KOiK15122
OMAiLSFHILW
OrthoDBiEOG091G08MB
PhylomeDBiQ8IVJ1
TreeFamiTF313647

Family and domain databases

InterProiView protein in InterPro
IPR006667 SLC41_membr_dom
IPR036739 SLC41_membr_dom_sf
PfamiView protein in Pfam
PF01769 MgtE, 2 hits
SUPFAMiSSF161093 SSF161093, 2 hits

Sequencei

Sequence statusi: Complete.

Q8IVJ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKPEPKDV HQLNGTGPSA SPCSSDGPGR EPLAGTSEFL GPDGAGVEVV
60 70 80 90 100
IESRANAKGV REEDALLENG SQSNESDDVS TDRGPAPPSP LKETSFSIGL
110 120 130 140 150
QVLFPFLLAG FGTVAAGMVL DIVQHWEVFQ KVTEVFILVP ALLGLKGNLE
160 170 180 190 200
MTLASRLSTA ANIGHMDTPK ELWRMITGNM ALIQVQATVV GFLASIAAVV
210 220 230 240 250
FGWIPDGHFS IPHAFLLCAS SVATAFIASL VLGMIMIGVI IGSRKIGINP
260 270 280 290 300
DNVATPIAAS LGDLITLALL SGISWGLYLE LNHWRYIYPL VCAFFVALLP
310 320 330 340 350
VWVVLARRSP ATREVLYSGW EPVIIAMAIS SVGGLILDKT VSDPNFAGMA
360 370 380 390 400
VFTPVINGVG GNLVAVQASR ISTFLHMNGM PGENSEQAPR RCPSPCTTFF
410 420 430 440 450
SPDVNSRSAR VLFLLVVPGH LVFLYTISCM QGGHTTLTLI FIIFYMTAAL
460 470 480 490 500
LQVLILLYIA DWMVHWMWGR GLDPDNFSIP YLTALGDLLG TGLLALSFHV
510
LWLIGDRDTD VGD
Length:513
Mass (Da):54,901
Last modified:July 10, 2007 - v2
Checksum:i2B6676F9C3AF6136
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3S → P in CAH56135 (PubMed:17974005).Curated1
Sequence conflicti196I → T in CAH56213 (PubMed:17974005).Curated1
Sequence conflicti204I → V in CAH56213 (PubMed:17974005).Curated1
Sequence conflicti207G → D in CAH56135 (PubMed:17974005).Curated1
Sequence conflicti217L → P in CAH56135 (PubMed:17974005).Curated1
Sequence conflicti272 – 275GISW → ASAG in CAD58404 (PubMed:12810078).Curated4
Sequence conflicti365A → T in CAE46028 (PubMed:17974005).Curated1
Sequence conflicti416V → A in CAD58404 (PubMed:12810078).Curated1
Sequence conflicti464V → A in CAH56135 (PubMed:17974005).Curated1
Sequence conflicti511V → A in CAH56135 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ514402 mRNA Translation: CAD58404.1
AL831974 mRNA Translation: CAH56217.1
AL832001 mRNA Translation: CAH56211.1
AL832362 mRNA Translation: CAH56213.1
BX641054 mRNA Translation: CAE46028.1
BX648979 mRNA Translation: CAH56135.1
CCDSiCCDS30988.1
RefSeqiNP_776253.3, NM_173854.5
XP_005245126.1, XM_005245069.2
UniGeneiHs.20274

Genome annotation databases

EnsembliENST00000367137; ENSP00000356105; ENSG00000133065
GeneIDi254428
KEGGihsa:254428
UCSCiuc001hdh.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ514402 mRNA Translation: CAD58404.1
AL831974 mRNA Translation: CAH56217.1
AL832001 mRNA Translation: CAH56211.1
AL832362 mRNA Translation: CAH56213.1
BX641054 mRNA Translation: CAE46028.1
BX648979 mRNA Translation: CAH56135.1
CCDSiCCDS30988.1
RefSeqiNP_776253.3, NM_173854.5
XP_005245126.1, XM_005245069.2
UniGeneiHs.20274

3D structure databases

ProteinModelPortaliQ8IVJ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129036, 6 interactors
IntActiQ8IVJ1, 27 interactors
STRINGi9606.ENSP00000356105

Protein family/group databases

TCDBi1.A.26.2.1 the mg(2+) transporter-e (mgte) family

PTM databases

iPTMnetiQ8IVJ1
PhosphoSitePlusiQ8IVJ1
SwissPalmiQ8IVJ1

Polymorphism and mutation databases

BioMutaiSLC41A1
DMDMi152112285

Proteomic databases

EPDiQ8IVJ1
MaxQBiQ8IVJ1
PaxDbiQ8IVJ1
PeptideAtlasiQ8IVJ1
PRIDEiQ8IVJ1
ProteomicsDBi70715

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367137; ENSP00000356105; ENSG00000133065
GeneIDi254428
KEGGihsa:254428
UCSCiuc001hdh.2 human

Organism-specific databases

CTDi254428
DisGeNETi254428
EuPathDBiHostDB:ENSG00000133065.10
GeneCardsiSLC41A1
H-InvDBiHIX0001523
HGNCiHGNC:19429 SLC41A1
HPAiHPA014721
HPA015138
MIMi610801 gene
neXtProtiNX_Q8IVJ1
OpenTargetsiENSG00000133065
PharmGKBiPA134889327
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3788 Eukaryota
ENOG410XSTG LUCA
GeneTreeiENSGT00390000016816
HOGENOMiHOG000007017
HOVERGENiHBG057187
InParanoidiQ8IVJ1
KOiK15122
OMAiLSFHILW
OrthoDBiEOG091G08MB
PhylomeDBiQ8IVJ1
TreeFamiTF313647

Enzyme and pathway databases

ReactomeiR-HSA-425410 Metal ion SLC transporters

Miscellaneous databases

ChiTaRSiSLC41A1 human
GenomeRNAii254428
PROiPR:Q8IVJ1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133065 Expressed in 189 organ(s), highest expression level in left ventricle myocardium
CleanExiHS_SLC41A1
ExpressionAtlasiQ8IVJ1 baseline and differential
GenevisibleiQ8IVJ1 HS

Family and domain databases

InterProiView protein in InterPro
IPR006667 SLC41_membr_dom
IPR036739 SLC41_membr_dom_sf
PfamiView protein in Pfam
PF01769 MgtE, 2 hits
SUPFAMiSSF161093 SSF161093, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiS41A1_HUMAN
AccessioniPrimary (citable) accession number: Q8IVJ1
Secondary accession number(s): Q63HJ4
, Q658Z5, Q659A4, Q6MZK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: September 12, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again