MAP4K3

Functionⁱ

May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

1 Publication

Catalytic activityⁱ

ATP
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
L-seryl-[protein]
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Search chemical reactions in Rhea for this molecule.
=
ADP
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
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See the description of this molecule in ChEBI.
+
O-phospho-L-seryl-[protein]
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Search chemical reactions in Rhea for this molecule.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase."
  Diener K., Wang X.S., Chen C., Meyer C.F., Keesler G., Zukowski M., Tan T.-H., Yao Z.
  Proc. Natl. Acad. Sci. U.S.A. 94:9687-9692(1997) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-48.
EC:
2.7.11.1
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase."
  Diener K., Wang X.S., Chen C., Meyer C.F., Keesler G., Zukowski M., Tan T.-H., Yao Z.
  Proc. Natl. Acad. Sci. U.S.A. 94:9687-9692(1997) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-48.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
L-seryl-[protein]
L-serine residue
zoom
=
ADP
+
H⁺
+
O-phospho-L-seryl-[protein]
O-phospho-L-serine residue
zoom
ATP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
L-threonyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
=
ADP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
O-phospho-L-threonyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase."
  Diener K., Wang X.S., Chen C., Meyer C.F., Keesler G., Zukowski M., Tan T.-H., Yao Z.
  Proc. Natl. Acad. Sci. U.S.A. 94:9687-9692(1997) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-48.
EC:
2.7.11.1
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase."
  Diener K., Wang X.S., Chen C., Meyer C.F., Keesler G., Zukowski M., Tan T.-H., Yao Z.
  Proc. Natl. Acad. Sci. U.S.A. 94:9687-9692(1997) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-48.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
L-threonyl-[protein]
L-threonine residue
zoom
=
ADP
+
H⁺
+
O-phospho-L-threonyl-[protein]
O-phospho-L-threonine residue
zoom

Cofactorⁱ

Mg²⁺1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	45	ATPPROSITE-ProRule annotation	1
Binding siteⁱ	48	ATPPROSITE-ProRule annotation1 Publication	1
Active siteⁱ	136	Proton acceptorPROSITE-ProRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	22 – 30	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

PathwayCommonsⁱ	Q8IVH8
SignaLinkⁱ	Q8IVH8
SIGNORⁱ	Q8IVH8

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitogen-activated protein kinase kinase kinase kinase 3 (EC:2.7.11.1) Alternative name(s): Germinal center kinase-related protein kinase Short name: GLK MAPK/ERK kinase kinase kinase 3 Short name: MEK kinase kinase 3 Short name: MEKKK 3
Gene namesⁱ	Name:MAP4K3 Synonyms:RAB8IPL1
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6865, MAP4K3
MIMⁱ	604921, gene
neXtProtⁱ	NX_Q8IVH8
VEuPathDBⁱ	HostDB:ENSG00000011566.14

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	48	K → E: Loss of kinase activity and ability to activate JNK family. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8491
Open Targets More...OpenTargetsⁱ	ENSG00000011566
PharmGKBⁱ	PA30611

Miscellaneous databases

Pharosⁱ	Q8IVH8, Tchem

Pharosⁱ

Q8IVH8, Tchem

Chemistry databases

ChEMBLⁱ	CHEMBL5432
Drug and drug target database More...DrugBankⁱ	DB12010, Fostamatinib
DrugCentral More...DrugCentralⁱ	Q8IVH8
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2087

Genetic variation databases

BioMutaⁱ	MAP4K3
DMDMⁱ	29427817

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086277	1 – 894	Mitogen-activated protein kinase kinase kinase kinase 3Add BLAST		894

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	329	PhosphoserineBy similarity	1
Modified residueⁱ	398	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal More...CPTACⁱ	CPTAC-864 CPTAC-865
EPDⁱ	Q8IVH8
jPOSTⁱ	Q8IVH8
MassIVEⁱ	Q8IVH8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IVH8
PaxDbⁱ	Q8IVH8
PeptideAtlas More...PeptideAtlasⁱ	Q8IVH8
PRIDEⁱ	Q8IVH8
ProteomicsDBⁱ	70709 [Q8IVH8-1] 70710 [Q8IVH8-2] 70711 [Q8IVH8-3]

PTM databases

iPTMnetⁱ	Q8IVH8
PhosphoSitePlusⁱ	Q8IVH8
SwissPalmⁱ	Q8IVH8

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000011566, Expressed in kidney and 239 other tissues
ExpressionAtlasⁱ	Q8IVH8, baseline and differential
Genevisibleⁱ	Q8IVH8, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000011566, Low tissue specificity

HPAⁱ

ENSG00000011566, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation (By similarity).

By similarity

Binary interactionsⁱ

Hide details

Q8IVH8

With	#Exp.	IntAct
GRB2 [P62993]	2	EBI-1758170,EBI-401755
LCP2 [Q13094]	5	EBI-1758170,EBI-346946
PRKCQ [Q04759]	4	EBI-1758170,EBI-374762
Prkcq [Q02111] from Mus musculus.	4	EBI-1758170,EBI-2639157

Protein-protein interaction databases

BioGRIDⁱ	114063, 16 interactors
Database of interacting proteins More...DIPⁱ	DIP-48924N
IntActⁱ	Q8IVH8, 15 interactors
STRINGⁱ	9606.ENSP00000263881

Chemistry databases

BindingDBⁱ

Q8IVH8

Miscellaneous databases

RNActⁱ	Q8IVH8, protein

RNActⁱ

Q8IVH8, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	13 – 15	Combined sources	3
Beta strandⁱ	16 – 24	Combined sources	9
Beta strandⁱ	26 – 35	Combined sources	10
Turnⁱ	36 – 38	Combined sources	3
Beta strandⁱ	41 – 48	Combined sources	8
Helixⁱ	56 – 66	Combined sources	11
Beta strandⁱ	76 – 81	Combined sources	6
Beta strandⁱ	83 – 90	Combined sources	8
Helixⁱ	98 – 104	Combined sources	7
Helixⁱ	110 – 129	Combined sources	20
Beta strandⁱ	141 – 144	Combined sources	4
Beta strandⁱ	150 – 152	Combined sources	3
Helixⁱ	156 – 163	Combined sources	8
Helixⁱ	175 – 177	Combined sources	3
Helixⁱ	180 – 186	Combined sources	7
Helixⁱ	195 – 209	Combined sources	15
Turnⁱ	213 – 216	Combined sources	4
Helixⁱ	219 – 227	Combined sources	9
Turnⁱ	239 – 241	Combined sources	3
Helixⁱ	244 – 253	Combined sources	10
Turnⁱ	258 – 260	Combined sources	3
Helixⁱ	264 – 268	Combined sources	5
Helixⁱ	271 – 274	Combined sources	4
Helixⁱ	280 – 289	Combined sources	10
Helixⁱ	307 – 309	Combined sources	3

Show more details

3D structure databases

SMRⁱ	Q8IVH8
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	16 – 273	Protein kinasePROSITE-ProRule annotationAdd BLAST		258
Domainⁱ	556 – 867	CNHPROSITE-ProRule annotationAdd BLAST		312

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	410 – 536	DisorderedSequence analysisAdd BLAST		127

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	410 – 427	Basic and acidic residuesSequence analysisAdd BLAST	18
Compositional biasⁱ	448 – 462	Polar residuesSequence analysisAdd BLAST	15
Compositional biasⁱ	469 – 487	Pro residuesSequence analysisAdd BLAST	19
Compositional biasⁱ	494 – 516	Polar residuesSequence analysisAdd BLAST	23

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0576, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155483
InParanoidⁱ	Q8IVH8
OMAⁱ	RCPMSES
PhylomeDBⁱ	Q8IVH8
TreeFamⁱ	TF105121

Family and domain databases

InterProⁱ	View protein in InterPro IPR001180, CNH_dom IPR011009, Kinase-like_dom_sf IPR021160, MAPKKKK IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00780, CNH, 1 hit PF00069, Pkinase, 1 hit
PIRSFⁱ	PIRSF038172, MAPKKKK, 1 hit
SMARTⁱ	View protein in SMART SM00036, CNH, 1 hit SM00220, S_TKc, 1 hit
SUPFAMⁱ	SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50219, CNH, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 11 PublicationCurated (identifier: Q8IVH8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPGFDLSRR NPQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE 
        60         70         80         90        100
PGEDFAVVQQ EIIMMKDCKH PNIVAYFGSY LRRDKLWICM EFCGGGSLQD 
       110        120        130        140        150
IYHVTGPLSE LQIAYVSRET LQGLYYLHSK GKMHRDIKGA NILLTDNGHV 
       160        170        180        190        200
KLADFGVSAQ ITATIAKRKS FIGTPYWMAP EVAAVERKGG YNQLCDLWAV 
       210        220        230        240        250
GITAIELAEL QPPMFDLHPM RALFLMTKSN FQPPKLKDKM KWSNSFHHFV 
       260        270        280        290        300
KMALTKNPKK RPTAEKLLQH PFVTQHLTRS LAIELLDKVN NPDHSTYHDF 
       310        320        330        340        350
DDDDPEPLVA VPHRIHSTSR NVREEKTRSE ITFGQVKFDP PLRKETEPHH 
       360        370        380        390        400
ELPDSDGFLD SSEEIYYTAR SNLDLQLEYG QGHQGGYFLG ANKSLLKSVE 
       410        420        430        440        450
EELHQRGHVA HLEDDEGDDD ESKHSTLKAK IPPPLPPKPK SIFIPQEMHS 
       460        470        480        490        500
TEDENQGTIK RCPMSGSPAK PSQVPPRPPP PRLPPHKPVA LGNGMSSFQL 
       510        520        530        540        550
NGERDGSLCQ QQNEHRGTNL SRKEKKDVPK PISNGLPPTP KVHMGACFSK 
       560        570        580        590        600
VFNGCPLKIH CASSWINPDT RDQYLIFGAE EGIYTLNLNE LHETSMEQLF 
       610        620        630        640        650
PRRCTWLYVM NNCLLSISGK ASQLYSHNLP GLFDYARQMQ KLPVAIPAHK 
       660        670        680        690        700
LPDRILPRKF SVSAKIPETK WCQKCCVVRN PYTGHKYLCG ALQTSIVLLE 
       710        720        730        740        750
WVEPMQKFML IKHIDFPIPC PLRMFEMLVV PEQEYPLVCV GVSRGRDFNQ 
       760        770        780        790        800
VVRFETVNPN STSSWFTESD TPQTNVTHVT QLERDTILVC LDCCIKIVNL 
       810        820        830        840        850
QGRLKSSRKL SSELTFDFQI ESIVCLQDSV LAFWKHGMQG RSFRSNEVTQ 
       860        870        880        890 
EISDSTRIFR LLGSDRVVVL ESRPTDNPTA NSNLYILAGH ENSY

Length:894

Mass (Da):101,316

Last modified:March 1, 2003 - v1

Checksum:ⁱ6EB77BBB34E5B733

GO

Isoform 21 PublicationCurated (identifier: Q8IVH8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-12: MNPGFDLSRRNP → MA

« Hide

        10         20         30         40         50
MAQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE PGEDFAVVQQ 
        60         70         80         90        100
EIIMMKDCKH PNIVAYFGSY LRRDKLWICM EFCGGGSLQD IYHVTGPLSE 
       110        120        130        140        150
LQIAYVSRET LQGLYYLHSK GKMHRDIKGA NILLTDNGHV KLADFGVSAQ 
       160        170        180        190        200
ITATIAKRKS FIGTPYWMAP EVAAVERKGG YNQLCDLWAV GITAIELAEL 
       210        220        230        240        250
QPPMFDLHPM RALFLMTKSN FQPPKLKDKM KWSNSFHHFV KMALTKNPKK 
       260        270        280        290        300
RPTAEKLLQH PFVTQHLTRS LAIELLDKVN NPDHSTYHDF DDDDPEPLVA 
       310        320        330        340        350
VPHRIHSTSR NVREEKTRSE ITFGQVKFDP PLRKETEPHH ELPDSDGFLD 
       360        370        380        390        400
SSEEIYYTAR SNLDLQLEYG QGHQGGYFLG ANKSLLKSVE EELHQRGHVA 
       410        420        430        440        450
HLEDDEGDDD ESKHSTLKAK IPPPLPPKPK SIFIPQEMHS TEDENQGTIK 
       460        470        480        490        500
RCPMSGSPAK PSQVPPRPPP PRLPPHKPVA LGNGMSSFQL NGERDGSLCQ 
       510        520        530        540        550
QQNEHRGTNL SRKEKKDVPK PISNGLPPTP KVHMGACFSK VFNGCPLKIH 
       560        570        580        590        600
CASSWINPDT RDQYLIFGAE EGIYTLNLNE LHETSMEQLF PRRCTWLYVM 
       610        620        630        640        650
NNCLLSISGK ASQLYSHNLP GLFDYARQMQ KLPVAIPAHK LPDRILPRKF 
       660        670        680        690        700
SVSAKIPETK WCQKCCVVRN PYTGHKYLCG ALQTSIVLLE WVEPMQKFML 
       710        720        730        740        750
IKHIDFPIPC PLRMFEMLVV PEQEYPLVCV GVSRGRDFNQ VVRFETVNPN 
       760        770        780        790        800
STSSWFTESD TPQTNVTHVT QLERDTILVC LDCCIKIVNL QGRLKSSRKL 
       810        820        830        840        850
SSELTFDFQI ESIVCLQDSV LAFWKHGMQG RSFRSNEVTQ EISDSTRIFR 
       860        870        880 
LLGSDRVVVL ESRPTDNPTA NSNLYILAGH ENSY

Show »

Length:884

Mass (Da):100,133

Checksum:ⁱ14839222F5360166

GO

Isoform 31 PublicationCurated (identifier: Q8IVH8-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
352-372: Missing.

« Hide

        10         20         30         40         50
MNPGFDLSRR NPQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE 
        60         70         80         90        100
PGEDFAVVQQ EIIMMKDCKH PNIVAYFGSY LRRDKLWICM EFCGGGSLQD 
       110        120        130        140        150
IYHVTGPLSE LQIAYVSRET LQGLYYLHSK GKMHRDIKGA NILLTDNGHV 
       160        170        180        190        200
KLADFGVSAQ ITATIAKRKS FIGTPYWMAP EVAAVERKGG YNQLCDLWAV 
       210        220        230        240        250
GITAIELAEL QPPMFDLHPM RALFLMTKSN FQPPKLKDKM KWSNSFHHFV 
       260        270        280        290        300
KMALTKNPKK RPTAEKLLQH PFVTQHLTRS LAIELLDKVN NPDHSTYHDF 
       310        320        330        340        350
DDDDPEPLVA VPHRIHSTSR NVREEKTRSE ITFGQVKFDP PLRKETEPHH 
       360        370        380        390        400
ELDLQLEYGQ GHQGGYFLGA NKSLLKSVEE ELHQRGHVAH LEDDEGDDDE 
       410        420        430        440        450
SKHSTLKAKI PPPLPPKPKS IFIPQEMHST EDENQGTIKR CPMSGSPAKP 
       460        470        480        490        500
SQVPPRPPPP RLPPHKPVAL GNGMSSFQLN GERDGSLCQQ QNEHRGTNLS 
       510        520        530        540        550
RKEKKDVPKP ISNGLPPTPK VHMGACFSKV FNGCPLKIHC ASSWINPDTR 
       560        570        580        590        600
DQYLIFGAEE GIYTLNLNEL HETSMEQLFP RRCTWLYVMN NCLLSISGKA 
       610        620        630        640        650
SQLYSHNLPG LFDYARQMQK LPVAIPAHKL PDRILPRKFS VSAKIPETKW 
       660        670        680        690        700
CQKCCVVRNP YTGHKYLCGA LQTSIVLLEW VEPMQKFMLI KHIDFPIPCP 
       710        720        730        740        750
LRMFEMLVVP EQEYPLVCVG VSRGRDFNQV VRFETVNPNS TSSWFTESDT 
       760        770        780        790        800
PQTNVTHVTQ LERDTILVCL DCCIKIVNLQ GRLKSSRKLS SELTFDFQIE 
       810        820        830        840        850
SIVCLQDSVL AFWKHGMQGR SFRSNEVTQE ISDSTRIFRL LGSDRVVVLE 
       860        870 
SRPTDNPTAN SNLYILAGHE NSY

Show »

Length:873

Mass (Da):98,954

Checksum:ⁱ0C7D648387CFFE0C

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H5A3	F5H5A3_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase kinase 3, EC 2.7.11.1	MAP4K3	810	Annotation score:
F8WAZ1	F8WAZ1_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase kinase 3	MAP4K3	131	Annotation score:
V9GY95	V9GY95_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase kinase 3	MAP4K3	92	Annotation score:
H7C1A4	H7C1A4_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase kinase 3	MAP4K3	143	Annotation score:
F8WBC3	F8WBC3_HUMAN	Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase kinase 3	MAP4K3	44	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	392	N → D in AAC15472 (PubMed:9275185).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_040743	200	V → L1 PublicationCorresponds to variant dbSNP:rs35957290EnsemblClinVar.	1
Natural variantⁱVAR_040744	424	H → Q1 PublicationCorresponds to variant dbSNP:rs56317466Ensembl.	1
Natural variantⁱVAR_040745	669	T → S in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_007052	1 – 12	MNPGF…SRRNP → MA in isoform 2. 1 PublicationAdd BLAST		12
Alternative sequenceⁱVSP_007053	352 – 372	Missing in isoform 3. 1 PublicationAdd BLAST		21

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF000145 mRNA Translation: AAC15472.1 AF445413 AF445412 Genomic DNA Translation: AAN75849.1 AF445413 AF445412 Genomic DNA Translation: AAN75850.1 CH471053 Genomic DNA Translation: EAX00346.1 BC071579 mRNA Translation: AAH71579.1 AC007684 Genomic DNA Translation: AAF19240.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1803.1 [Q8IVH8-1] CCDS58707.1 [Q8IVH8-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001257354.1, NM_001270425.1 [Q8IVH8-3] NP_003609.2, NM_003618.3 [Q8IVH8-1]

Genome annotation databases

Ensemblⁱ	ENST00000263881; ENSP00000263881; ENSG00000011566 [Q8IVH8-1] ENST00000341681; ENSP00000345434; ENSG00000011566 [Q8IVH8-3]
GeneIDⁱ	8491
KEGGⁱ	hsa:8491
UCSC genome browser More...UCSCⁱ	uc002rro.4, human [Q8IVH8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q8IVH8	Mitogen-activated protein kinase kinase kinase kinase 3 (Fragment)		HUMAN		143	UniRef100_Q8IVH8
Q8IVH8-3	Mitogen-activated protein kinase kinase kinase kinase 3		HUMAN		810	UniRef100_F5H5A3

Protein	Similar proteins		Species	Score	Length	Source
Q8IVH8	Mitogen-activated protein kinase kinase kinase kinase 3		MOUSE		894	UniRef90_Q8IVH8
Mitogen-activated protein kinase kinase kinase kinase 3 (Fragment)		HUMAN		143
Mitogen-activated protein kinase kinase kinase kinase 3		PIG		1008
Non-specific serine/threonine protein kinase		PERMB		924
Mitogen-activated protein kinase kinase kinase kinase 3		FELCA		916
+505

Protein	Similar proteins		Species	Score	Length	Source
Q8IVH8	Mitogen-activated protein kinase kinase kinase kinase 3		MOUSE		894	UniRef50_Q8IVH8
Mitogen-activated protein kinase kinase kinase kinase 3		RAT		873
Mitogen-activated protein kinase kinase kinase kinase 3 (Fragment)		HUMAN		143
Mitogen-activated protein kinase kinase kinase kinase 3		PIG		1008
Non-specific serine/threonine protein kinase		PERMB		924
+704

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF000145 mRNA Translation: AAC15472.1 AF445413 AF445412 Genomic DNA Translation: AAN75849.1 AF445413 AF445412 Genomic DNA Translation: AAN75850.1 CH471053 Genomic DNA Translation: EAX00346.1 BC071579 mRNA Translation: AAH71579.1 AC007684 Genomic DNA Translation: AAF19240.1
CCDSⁱ	CCDS1803.1 [Q8IVH8-1] CCDS58707.1 [Q8IVH8-3]
RefSeqⁱ	NP_001257354.1, NM_001270425.1 [Q8IVH8-3] NP_003609.2, NM_003618.3 [Q8IVH8-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5J5T	X-ray	2.85	A	13-380	[»]
SMRⁱ	Q8IVH8
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	114063, 16 interactors
DIPⁱ	DIP-48924N
IntActⁱ	Q8IVH8, 15 interactors
STRINGⁱ	9606.ENSP00000263881

Chemistry databases

BindingDBⁱ	Q8IVH8
ChEMBLⁱ	CHEMBL5432
DrugBankⁱ	DB12010, Fostamatinib
DrugCentralⁱ	Q8IVH8
GuidetoPHARMACOLOGYⁱ	2087

PTM databases

iPTMnetⁱ	Q8IVH8
PhosphoSitePlusⁱ	Q8IVH8
SwissPalmⁱ	Q8IVH8

Genetic variation databases

BioMutaⁱ	MAP4K3
DMDMⁱ	29427817

Proteomic databases

CPTACⁱ	CPTAC-864 CPTAC-865
EPDⁱ	Q8IVH8
jPOSTⁱ	Q8IVH8
MassIVEⁱ	Q8IVH8
MaxQBⁱ	Q8IVH8
PaxDbⁱ	Q8IVH8
PeptideAtlasⁱ	Q8IVH8
PRIDEⁱ	Q8IVH8
ProteomicsDBⁱ	70709 [Q8IVH8-1] 70710 [Q8IVH8-2] 70711 [Q8IVH8-3]

Protocols and materials databases

Antibodypediaⁱ	29616, 350 antibodies
The DNASU plasmid repository More...DNASUⁱ	8491

Genome annotation databases

Ensemblⁱ	ENST00000263881; ENSP00000263881; ENSG00000011566 [Q8IVH8-1] ENST00000341681; ENSP00000345434; ENSG00000011566 [Q8IVH8-3]
GeneIDⁱ	8491
KEGGⁱ	hsa:8491
UCSCⁱ	uc002rro.4, human [Q8IVH8-1]

Organism-specific databases

CTDⁱ	8491
DisGeNETⁱ	8491
GeneCardsⁱ	MAP4K3
HGNCⁱ	HGNC:6865, MAP4K3
HPAⁱ	ENSG00000011566, Low tissue specificity
MIMⁱ	604921, gene
neXtProtⁱ	NX_Q8IVH8
OpenTargetsⁱ	ENSG00000011566
PharmGKBⁱ	PA30611
VEuPathDBⁱ	HostDB:ENSG00000011566.14
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0576, Eukaryota
GeneTreeⁱ	ENSGT00940000155483
InParanoidⁱ	Q8IVH8
OMAⁱ	RCPMSES
PhylomeDBⁱ	Q8IVH8
TreeFamⁱ	TF105121

Enzyme and pathway databases

PathwayCommonsⁱ	Q8IVH8
SignaLinkⁱ	Q8IVH8
SIGNORⁱ	Q8IVH8

Miscellaneous databases

BioGRID-ORCSⁱ	8491, 12 hits in 1028 CRISPR screens
ChiTaRSⁱ	MAP4K3, human
GenomeRNAiⁱ	8491
Pharosⁱ	Q8IVH8, Tchem
Protein Ontology More...PROⁱ	PR:Q8IVH8
RNActⁱ	Q8IVH8, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000011566, Expressed in kidney and 239 other tissues
ExpressionAtlasⁱ	Q8IVH8, baseline and differential
Genevisibleⁱ	Q8IVH8, HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001180, CNH_dom IPR011009, Kinase-like_dom_sf IPR021160, MAPKKKK IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS
Pfamⁱ	View protein in Pfam PF00780, CNH, 1 hit PF00069, Pkinase, 1 hit
PIRSFⁱ	PIRSF038172, MAPKKKK, 1 hit
SMARTⁱ	View protein in SMART SM00036, CNH, 1 hit SM00220, S_TKc, 1 hit
SUPFAMⁱ	SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50219, CNH, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	M4K3_HUMAN
Accessionⁱ	Q8IVH8Primary (citable) accession number: Q8IVH8 Secondary accession number(s): Q6IQ39 , Q8IVH7, Q9UDM5, Q9Y6R5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
	Last sequence update:	March 1, 2003
	Last modified:	June 2, 2021
	This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human and mouse protein kinases
Human and mouse protein kinases: classification and index
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q8IVH8 (M4K3_HUMAN)

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Mitogen-activated protein kinase kinase kinase kinase 3

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Keywords - PTMⁱ

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Keywords - Coding sequence diversityⁱ

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