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UniProtKB - Q8IVH2 (FOXP4_HUMAN)

Protein

Forkhead box protein P4

Gene

FOXP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor that represses lung-specific expression.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri307 – 332C2H2-typeAdd BLAST26
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi467 – 559Fork-headPROSITE-ProRule annotationAdd BLAST93

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Forkhead box protein P4
Alternative name(s):
Fork head-related protein-like A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FOXP4
Synonyms:FKHLA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000137166.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:20842 FOXP4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608924 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IVH2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		116113

Open Targets

More...OpenTargetsi		ENSG00000137166

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134943098

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FOXP4

Domain mapping of disease mutations (DMDM)

More...DMDMi		46395887

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000918891 – 680Forkhead box protein P4Add BLAST680

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki246Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki378Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei554PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IVH2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IVH2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IVH2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IVH2

PeptideAtlas

More...PeptideAtlasi		Q8IVH2

PRoteomics IDEntifications database

More...PRIDEi		Q8IVH2

ProteomicsDB human proteome resource

More...ProteomicsDBi		70705
70706 [Q8IVH2-2]
70707 [Q8IVH2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IVH2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IVH2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137166 Expressed in 194 organ(s), highest expression level in fundus of stomach

CleanEx database of gene expression profiles

More...CleanExi		HS_FOXP4

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IVH2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IVH2 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA007176

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers and heterodimers with FOXP1 and FOXP2. Dimerization is required for DNA-binding (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		125474, 17 interactors

Database of interacting proteins

More...DIPi		DIP-59301N

Protein interaction database and analysis system

More...IntActi		Q8IVH2, 13 interactors

Molecular INTeraction database

More...MINTi		Q8IVH2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000309823

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q8IVH2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IVH2

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni349 – 370Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi65 – 219Gln-richAdd BLAST155

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The leucine-zipper is required for dimerization and transcriptional repression.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri307 – 332C2H2-typeAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4385 Eukaryota
COG5025 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158700

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000092089

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG051657

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IVH2

KEGG Orthology (KO)

More...KOi		K09409

Identification of Orthologs from Complete Genome Data

More...OMAi		DEHEYQK

Database of Orthologous Groups

More...OrthoDBi		836427at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IVH2

TreeFam database of animal gene trees

More...TreeFami		TF326978

Family and domain databases

Conserved Domains Database

More...CDDi		cd00059 FH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001766 Fork_head_dom
IPR032354 FOXP-CC
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00250 Forkhead, 1 hit
PF16159 FOXP-CC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00053 FORKHEAD

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00339 FH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IVH2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMVESASETI RSAPSGQNGV GSLSGQADGS SGGATGTTAS GTGREVTTGA 
        60         70         80         90        100
DSNGEMSPAE LLHFQQQQAL QVARQFLLQQ ASGLSSPGNN DSKQSASAVQ 
       110        120        130        140        150
VPVSVAMMSP QMLTPQQMQQ ILSPPQLQAL LQQQQALMLQ QLQEYYKKQQ 
       160        170        180        190        200
EQLHLQLLTQ QQAGKPQPKE ALGNKQLAFQ QQLLQMQQLQ QQHLLNLQRQ 
       210        220        230        240        250
GLVSLQPNQA SGPLQTLPQA AVCPTDLPQL WKGEGAPGQP AEDSVKQEGL 
       260        270        280        290        300
DLTGTAATAT SFAAPPKVSP PLSHHTLPNG QPTVLTSRRD SSSHEETPGS 
       310        320        330        340        350
HPLYGHGECK WPGCETLCED LGQFIKHLNT EHALDDRSTA QCRVQMQVVQ 
       360        370        380        390        400
QLEIQLAKES ERLQAMMAHL HMRPSEPKPF SQPLNPVPGS SSFSKVTVSA 
       410        420        430        440        450
ADSFPDGLVH PPTSAAAPVT PLRPPGLGSA SLHGGGPARR RSSDKFCSPI 
       460        470        480        490        500
SSELAQNHEF YKNADVRPPF TYASLIRQAI LETPDRQLTL NEIYNWFTRM 
       510        520        530        540        550
FAYFRRNTAT WKNAVRHNLS LHKCFVRVEN VKGAVWTVDE REYQKRRPPK 
       560        570        580        590        600
MTGSPTLVKN MISGLSYGAL NASYQAALAE SSFPLLNSPG MLNPGSASSL 
       610        620        630        640        650
LPLSHDDVGA PVEPLPSNGS SSPPRLSPPQ YSHQVQVKEE PAEAEEDRQP 
       660        670        680
GPPLGAPNPS ASGPPEDRDL EEELPGEELS
Length:680
Mass (Da):73,488
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA63826ED85B24752
GO
Isoform 2 (identifier: Q8IVH2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-142: Missing.

Note: No experimental confirmation available.
Show »
Length:678
Mass (Da):73,247
Checksum:i987E8AB35DD70E40
GO
Isoform 3 (identifier: Q8IVH2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-220: Missing.
     384-395: Missing.

Note: No experimental confirmation available.
Show »
Length:667
Mass (Da):72,216
Checksum:i41ED0AF8996FE17F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZBM3B7ZBM3_HUMAN
Forkhead box protein P4
FOXP4
668Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A312A2A312_HUMAN
Forkhead box protein P4
FOXP4
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036219464A → T in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs867245225Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043034141 – 142Missing in isoform 2. 1 Publication2
Alternative sequenceiVSP_043465220Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_043466384 – 395Missing in isoform 3. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB080747 mRNA Translation: BAC53809.1
AL139331 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04047.1
CH471081 Genomic DNA Translation: EAX04048.1
CH471081 Genomic DNA Translation: EAX04049.1
BC013030 mRNA Translation: AAH13030.2
BC040962 mRNA Translation: AAH40962.1
BC052803 mRNA Translation: AAH52803.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34447.1 [Q8IVH2-1]
CCDS34448.1 [Q8IVH2-2]
CCDS4856.1 [Q8IVH2-3]

NCBI Reference Sequences

More...RefSeqi		NP_001012426.1, NM_001012426.1 [Q8IVH2-1]
NP_001012427.1, NM_001012427.1 [Q8IVH2-2]
NP_612466.1, NM_138457.2 [Q8IVH2-3]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.131436

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000307972; ENSP00000309823; ENSG00000137166 [Q8IVH2-1]
ENST00000373057; ENSP00000362148; ENSG00000137166 [Q8IVH2-2]
ENST00000373060; ENSP00000362151; ENSG00000137166 [Q8IVH2-1]
ENST00000373063; ENSP00000362154; ENSG00000137166 [Q8IVH2-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		116113

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:116113

UCSC genome browser

More...UCSCi		uc003oql.4 human [Q8IVH2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080747 mRNA Translation: BAC53809.1
AL139331 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04047.1
CH471081 Genomic DNA Translation: EAX04048.1
CH471081 Genomic DNA Translation: EAX04049.1
BC013030 mRNA Translation: AAH13030.2
BC040962 mRNA Translation: AAH40962.1
BC052803 mRNA Translation: AAH52803.1
CCDSiCCDS34447.1 [Q8IVH2-1]
CCDS34448.1 [Q8IVH2-2]
CCDS4856.1 [Q8IVH2-3]
RefSeqiNP_001012426.1, NM_001012426.1 [Q8IVH2-1]
NP_001012427.1, NM_001012427.1 [Q8IVH2-2]
NP_612466.1, NM_138457.2 [Q8IVH2-3]
UniGeneiHs.131436

3D structure databases

ProteinModelPortaliQ8IVH2
SMRiQ8IVH2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125474, 17 interactors
DIPiDIP-59301N
IntActiQ8IVH2, 13 interactors
MINTiQ8IVH2
STRINGi9606.ENSP00000309823

PTM databases

iPTMnetiQ8IVH2
PhosphoSitePlusiQ8IVH2

Polymorphism and mutation databases

BioMutaiFOXP4
DMDMi46395887

Proteomic databases

EPDiQ8IVH2
jPOSTiQ8IVH2
MaxQBiQ8IVH2
PaxDbiQ8IVH2
PeptideAtlasiQ8IVH2
PRIDEiQ8IVH2
ProteomicsDBi70705
70706 [Q8IVH2-2]
70707 [Q8IVH2-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		116113
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307972; ENSP00000309823; ENSG00000137166 [Q8IVH2-1]
ENST00000373057; ENSP00000362148; ENSG00000137166 [Q8IVH2-2]
ENST00000373060; ENSP00000362151; ENSG00000137166 [Q8IVH2-1]
ENST00000373063; ENSP00000362154; ENSG00000137166 [Q8IVH2-3]
GeneIDi116113
KEGGihsa:116113
UCSCiuc003oql.4 human [Q8IVH2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		116113
DisGeNETi116113
EuPathDBiHostDB:ENSG00000137166.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		FOXP4
HGNCiHGNC:20842 FOXP4
HPAiHPA007176
MIMi608924 gene
neXtProtiNX_Q8IVH2
OpenTargetsiENSG00000137166
PharmGKBiPA134943098

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4385 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00940000158700
HOGENOMiHOG000092089
HOVERGENiHBG051657
InParanoidiQ8IVH2
KOiK09409
OMAiDEHEYQK
OrthoDBi836427at2759
PhylomeDBiQ8IVH2
TreeFamiTF326978

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FOXP4 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FOXP4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		116113

Protein Ontology

More...PROi		PR:Q8IVH2

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000137166 Expressed in 194 organ(s), highest expression level in fundus of stomach
CleanExiHS_FOXP4
ExpressionAtlasiQ8IVH2 baseline and differential
GenevisibleiQ8IVH2 HS

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR032354 FOXP-CC
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF16159 FOXP-CC, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFOXP4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IVH2
Secondary accession number(s): Q5W098
, Q7Z7F8, Q8IW55, Q96E19
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: January 16, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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