UniProtKB - Q8IVH2 (FOXP4_HUMAN)
Protein
Forkhead box protein P4
Gene
FOXP4
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor that represses lung-specific expression.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 307 – 332 | C2H2-typeAdd BLAST | 26 | |
DNA bindingi | 467 – 559 | Fork-headPROSITE-ProRule annotationAdd BLAST | 93 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8IVH2 |
Names & Taxonomyi
Protein namesi | Recommended name: Forkhead box protein P4Alternative name(s): Fork head-related protein-like A |
Gene namesi | Name:FOXP4 Synonyms:FKHLA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000137166.14 |
HGNCi | HGNC:20842, FOXP4 |
MIMi | 608924, gene |
neXtProti | NX_Q8IVH2 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 116113 |
OpenTargetsi | ENSG00000137166 |
PharmGKBi | PA134943098 |
Miscellaneous databases
Pharosi | Q8IVH2, Tbio |
Polymorphism and mutation databases
BioMutai | FOXP4 |
DMDMi | 46395887 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000091889 | 1 – 680 | Forkhead box protein P4Add BLAST | 680 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 52 | PhosphoserineCombined sources | 1 | |
Modified residuei | 86 | PhosphoserineCombined sources | 1 | |
Cross-linki | 175 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 246 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 378 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 554 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8IVH2 |
jPOSTi | Q8IVH2 |
MassIVEi | Q8IVH2 |
MaxQBi | Q8IVH2 |
PaxDbi | Q8IVH2 |
PeptideAtlasi | Q8IVH2 |
PRIDEi | Q8IVH2 |
ProteomicsDBi | 70705 [Q8IVH2-1] 70706 [Q8IVH2-2] 70707 [Q8IVH2-3] |
PTM databases
iPTMneti | Q8IVH2 |
PhosphoSitePlusi | Q8IVH2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000137166, Expressed in fundus of stomach and 210 other tissues |
ExpressionAtlasi | Q8IVH2, baseline and differential |
Genevisiblei | Q8IVH2, HS |
Organism-specific databases
HPAi | ENSG00000137166, Low tissue specificity |
Interactioni
Subunit structurei
Forms homodimers and heterodimers with FOXP1 and FOXP2. Dimerization is required for DNA-binding (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 125474, 19 interactors |
DIPi | DIP-59301N |
IntActi | Q8IVH2, 16 interactors |
MINTi | Q8IVH2 |
STRINGi | 9606.ENSP00000362151 |
Miscellaneous databases
RNActi | Q8IVH2, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 349 – 370 | Leucine-zipperAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 65 – 219 | Gln-richAdd BLAST | 155 |
Domaini
The leucine-zipper is required for dimerization and transcriptional repression.By similarity
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 307 – 332 | C2H2-typeAdd BLAST | 26 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG4385, Eukaryota |
GeneTreei | ENSGT00940000158700 |
HOGENOMi | CLU_019502_3_1_1 |
InParanoidi | Q8IVH2 |
OMAi | QNVTIPD |
OrthoDBi | 836427at2759 |
PhylomeDBi | Q8IVH2 |
TreeFami | TF326978 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032354, FOXP-CC IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16159, FOXP-CC, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IVH2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMVESASETI RSAPSGQNGV GSLSGQADGS SGGATGTTAS GTGREVTTGA
60 70 80 90 100
DSNGEMSPAE LLHFQQQQAL QVARQFLLQQ ASGLSSPGNN DSKQSASAVQ
110 120 130 140 150
VPVSVAMMSP QMLTPQQMQQ ILSPPQLQAL LQQQQALMLQ QLQEYYKKQQ
160 170 180 190 200
EQLHLQLLTQ QQAGKPQPKE ALGNKQLAFQ QQLLQMQQLQ QQHLLNLQRQ
210 220 230 240 250
GLVSLQPNQA SGPLQTLPQA AVCPTDLPQL WKGEGAPGQP AEDSVKQEGL
260 270 280 290 300
DLTGTAATAT SFAAPPKVSP PLSHHTLPNG QPTVLTSRRD SSSHEETPGS
310 320 330 340 350
HPLYGHGECK WPGCETLCED LGQFIKHLNT EHALDDRSTA QCRVQMQVVQ
360 370 380 390 400
QLEIQLAKES ERLQAMMAHL HMRPSEPKPF SQPLNPVPGS SSFSKVTVSA
410 420 430 440 450
ADSFPDGLVH PPTSAAAPVT PLRPPGLGSA SLHGGGPARR RSSDKFCSPI
460 470 480 490 500
SSELAQNHEF YKNADVRPPF TYASLIRQAI LETPDRQLTL NEIYNWFTRM
510 520 530 540 550
FAYFRRNTAT WKNAVRHNLS LHKCFVRVEN VKGAVWTVDE REYQKRRPPK
560 570 580 590 600
MTGSPTLVKN MISGLSYGAL NASYQAALAE SSFPLLNSPG MLNPGSASSL
610 620 630 640 650
LPLSHDDVGA PVEPLPSNGS SSPPRLSPPQ YSHQVQVKEE PAEAEEDRQP
660 670 680
GPPLGAPNPS ASGPPEDRDL EEELPGEELS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7ZBM3 | B7ZBM3_HUMAN | Forkhead box protein P4 | FOXP4 | 668 | Annotation score: | ||
A0A590UJX7 | A0A590UJX7_HUMAN | Forkhead box protein P4 | FOXP4 | 164 | Annotation score: | ||
A2A312 | A2A312_HUMAN | Forkhead box protein P4 | FOXP4 | 87 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036219 | 464 | A → T in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs867245225Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043034 | 141 – 142 | Missing in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_043465 | 220 | Missing in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_043466 | 384 – 395 | Missing in isoform 3. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB080747 mRNA Translation: BAC53809.1 AL139331 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04047.1 CH471081 Genomic DNA Translation: EAX04048.1 CH471081 Genomic DNA Translation: EAX04049.1 BC013030 mRNA Translation: AAH13030.2 BC040962 mRNA Translation: AAH40962.1 BC052803 mRNA Translation: AAH52803.1 |
CCDSi | CCDS34447.1 [Q8IVH2-1] CCDS34448.1 [Q8IVH2-2] CCDS4856.1 [Q8IVH2-3] |
RefSeqi | NP_001012426.1, NM_001012426.1 [Q8IVH2-1] NP_001012427.1, NM_001012427.1 [Q8IVH2-2] NP_612466.1, NM_138457.2 [Q8IVH2-3] |
Genome annotation databases
Ensembli | ENST00000307972; ENSP00000309823; ENSG00000137166 [Q8IVH2-1] ENST00000373057; ENSP00000362148; ENSG00000137166 [Q8IVH2-2] ENST00000373060; ENSP00000362151; ENSG00000137166 [Q8IVH2-1] ENST00000373063; ENSP00000362154; ENSG00000137166 [Q8IVH2-3] |
GeneIDi | 116113 |
KEGGi | hsa:116113 |
UCSCi | uc003oql.4, human [Q8IVH2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB080747 mRNA Translation: BAC53809.1 AL139331 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04047.1 CH471081 Genomic DNA Translation: EAX04048.1 CH471081 Genomic DNA Translation: EAX04049.1 BC013030 mRNA Translation: AAH13030.2 BC040962 mRNA Translation: AAH40962.1 BC052803 mRNA Translation: AAH52803.1 |
CCDSi | CCDS34447.1 [Q8IVH2-1] CCDS34448.1 [Q8IVH2-2] CCDS4856.1 [Q8IVH2-3] |
RefSeqi | NP_001012426.1, NM_001012426.1 [Q8IVH2-1] NP_001012427.1, NM_001012427.1 [Q8IVH2-2] NP_612466.1, NM_138457.2 [Q8IVH2-3] |
3D structure databases
SMRi | Q8IVH2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125474, 19 interactors |
DIPi | DIP-59301N |
IntActi | Q8IVH2, 16 interactors |
MINTi | Q8IVH2 |
STRINGi | 9606.ENSP00000362151 |
PTM databases
iPTMneti | Q8IVH2 |
PhosphoSitePlusi | Q8IVH2 |
Polymorphism and mutation databases
BioMutai | FOXP4 |
DMDMi | 46395887 |
Proteomic databases
EPDi | Q8IVH2 |
jPOSTi | Q8IVH2 |
MassIVEi | Q8IVH2 |
MaxQBi | Q8IVH2 |
PaxDbi | Q8IVH2 |
PeptideAtlasi | Q8IVH2 |
PRIDEi | Q8IVH2 |
ProteomicsDBi | 70705 [Q8IVH2-1] 70706 [Q8IVH2-2] 70707 [Q8IVH2-3] |
Protocols and materials databases
ABCDi | Q8IVH2, 2 sequenced antibodies |
Antibodypediai | 1453, 263 antibodies |
DNASUi | 116113 |
Genome annotation databases
Ensembli | ENST00000307972; ENSP00000309823; ENSG00000137166 [Q8IVH2-1] ENST00000373057; ENSP00000362148; ENSG00000137166 [Q8IVH2-2] ENST00000373060; ENSP00000362151; ENSG00000137166 [Q8IVH2-1] ENST00000373063; ENSP00000362154; ENSG00000137166 [Q8IVH2-3] |
GeneIDi | 116113 |
KEGGi | hsa:116113 |
UCSCi | uc003oql.4, human [Q8IVH2-1] |
Organism-specific databases
CTDi | 116113 |
DisGeNETi | 116113 |
EuPathDBi | HostDB:ENSG00000137166.14 |
GeneCardsi | FOXP4 |
HGNCi | HGNC:20842, FOXP4 |
HPAi | ENSG00000137166, Low tissue specificity |
MIMi | 608924, gene |
neXtProti | NX_Q8IVH2 |
OpenTargetsi | ENSG00000137166 |
PharmGKBi | PA134943098 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4385, Eukaryota |
GeneTreei | ENSGT00940000158700 |
HOGENOMi | CLU_019502_3_1_1 |
InParanoidi | Q8IVH2 |
OMAi | QNVTIPD |
OrthoDBi | 836427at2759 |
PhylomeDBi | Q8IVH2 |
TreeFami | TF326978 |
Enzyme and pathway databases
PathwayCommonsi | Q8IVH2 |
Miscellaneous databases
BioGRID-ORCSi | 116113, 12 hits in 865 CRISPR screens |
ChiTaRSi | FOXP4, human |
GeneWikii | FOXP4 |
GenomeRNAii | 116113 |
Pharosi | Q8IVH2, Tbio |
PROi | PR:Q8IVH2 |
RNActi | Q8IVH2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137166, Expressed in fundus of stomach and 210 other tissues |
ExpressionAtlasi | Q8IVH2, baseline and differential |
Genevisiblei | Q8IVH2, HS |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032354, FOXP-CC IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16159, FOXP-CC, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FOXP4_HUMAN | |
Accessioni | Q8IVH2Primary (citable) accession number: Q8IVH2 Secondary accession number(s): Q5W098 Q96E19 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations