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Entry version 142 (11 Dec 2019)
Sequence version 3 (05 Feb 2008)
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Protein

Ankyrin repeat domain-containing protein 18A

Gene

ANKRD18A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 18A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD18A
Synonyms:KIAA2015
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000180071.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23643 ANKRD18A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IVF6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
253650

Open Targets

More...
OpenTargetsi
ENSG00000180071

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134889624

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IVF6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKRD18A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166898074

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669121 – 992Ankyrin repeat domain-containing protein 18AAdd BLAST992

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IVF6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IVF6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IVF6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IVF6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IVF6

PeptideAtlas

More...
PeptideAtlasi
Q8IVF6

PRoteomics IDEntifications database

More...
PRIDEi
Q8IVF6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70698 [Q8IVF6-1]
72657

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IVF6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IVF6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000180071 Expressed in 90 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IVF6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IVF6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046346
HPA049923
HPA051288

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128979, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IVF6, 5 interactors

Molecular INTeraction database

More...
MINTi
Q8IVF6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000382610

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IVF6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IVF6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati67 – 96ANK 1Add BLAST30
Repeati100 – 129ANK 2Add BLAST30
Repeati133 – 162ANK 3Add BLAST30
Repeati166 – 195ANK 4Add BLAST30
Repeati199 – 228ANK 5Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili278 – 310Sequence analysisAdd BLAST33
Coiled coili378 – 618Sequence analysisAdd BLAST241
Coiled coili683 – 713Sequence analysisAdd BLAST31
Coiled coili743 – 899Sequence analysisAdd BLAST157

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164347

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000143452

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IVF6

Identification of Orthologs from Complete Genome Data

More...
OMAi
LTELLMC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IVF6

TreeFam database of animal gene trees

More...
TreeFami
TF333496

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom
IPR021885 DUF3496

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF14915 CCDC144C, 1 hit
PF12001 DUF3496, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IVF6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRKLFSFGRR LGQALLSSMD QEYAGPGYDI RDWELRKIHR AAIKGDAAEV
60 70 80 90 100
ERCLTRRFRD LDARDRKDRT VLHLACAHGR VQVVTLLLHR RCQIDICDRL
110 120 130 140 150
NRTPLMKAVH SQEEACAIVL LECGANPNIE DIYGNTALHY AVYNKGTSLA
160 170 180 190 200
ERLLSHHANI EALNKEGNTP LLFAINSRRQ HMVEFLLKNQ ANIHAVDNFK
210 220 230 240 250
RTALILAVQH NLSSIVTLLL QQNIRISSQD MFGQTAEDYA LCSDLRSIRQ
260 270 280 290 300
QILEHKNKML KNHLRNDNQE TAAMKPANLK KRKERAKAEH NLKVASEEKQ
310 320 330 340 350
ERLQRSENKQ PQDSQSYGKK KDAMYGNFML KKDIAMLKEE LYAIKNDSLR
360 370 380 390 400
KEKKYIQEIK SITEINANFE KSVRLNEKMI TKTVARYSQQ LNDLKAENAR
410 420 430 440 450
LNSELEKEKH NKERLEAEVE SLHSSLATAI NEYNEIVERK DLELVLWRAD
460 470 480 490 500
DVSRHEKMGS NISQLTDKNE LLTEQVHKAR VKFNTLKGKL RETRDALREK
510 520 530 540 550
TLALGSVQLD LRQAQHRIKE MKQMHPNGEA KESQSIGKQN SLEERIRQQE
560 570 580 590 600
LENLLLERQL EDARKEGDNK EIVINIHRDC LENGKEDLLE ERNKELMKEY
610 620 630 640 650
NYLKEKLLQC EKEKAEREVI VREFQEELVD HLKTFSISES PLEGTSHCHI
660 670 680 690 700
NLNETWTSKK KLFQVEIQPE EKHEEFRKLF ELISLLNYTA DQIRKKNREL
710 720 730 740 750
EEEATGYKKC LEMTINMLNA FANEDFSCHG DLNTDQLKMD ILFKKLKQKF
760 770 780 790 800
NDLVAEKEAV SSECVNLAKD NEVLHQELLS MRNVQEKCEK LEKDKKMLEE
810 820 830 840 850
EVLNLKTHME KDMVELGKLQ EYKSELDERA VQEIEKLEEI HLQKQAEYEK
860 870 880 890 900
QLEQLNKDNT ASLKKKELTL KDVECKFSKM KTAYEEVTTE LEEFKEAFAG
910 920 930 940 950
AVKANNSMSK KLMKSDKKIA VISTKLFTEK QRMKYFLSTL PTRPEPELPC
960 970 980 990
VENLNSIELN RKYIPKTAIR IPTSNPQTSN NCKNFLTEVL LC
Length:992
Mass (Da):115,597
Last modified:February 5, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26B05E166B7D6DD0
GO
Isoform 2 (identifier: Q8IVF6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-879: Missing.
     989-991: VLL → MELDRVEQII...QGPIAHPRHR

Show »
Length:205
Mass (Da):23,242
Checksum:i02C1568A8578518A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GN29R4GN29_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD18A
401Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH56266 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC23111 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti288Missing in AAH56266 (PubMed:15489334).Curated1
Sequence conflicti727S → N in BAC23111 (Ref. 1) Curated1
Sequence conflicti727S → N in AAI52435 (PubMed:15489334).Curated1
Sequence conflicti897A → V in BAC23111 (Ref. 1) Curated1
Sequence conflicti897A → V in AAI52435 (PubMed:15489334).Curated1
Sequence conflicti900G → A in BAC23111 (Ref. 1) Curated1
Sequence conflicti900G → A in AAI52435 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055507130E → K2 PublicationsCorresponds to variant dbSNP:rs1832313Ensembl.1
Natural variantiVAR_055508277A → E. Corresponds to variant dbSNP:rs632200Ensembl.1
Natural variantiVAR_055509484N → S. Corresponds to variant dbSNP:rs2996347Ensembl.1
Natural variantiVAR_055510688Y → C. Corresponds to variant dbSNP:rs2799163Ensembl.1
Natural variantiVAR_059118838E → D. Corresponds to variant dbSNP:rs12341435Ensembl.1
Natural variantiVAR_055511942T → I. Corresponds to variant dbSNP:rs11999308Ensembl.1
Natural variantiVAR_055512945E → D. Corresponds to variant dbSNP:rs12341435Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0569121 – 879Missing in isoform 2. 1 PublicationAdd BLAST879
Alternative sequenceiVSP_056913989 – 991VLL → MELDRVEQIITGTKKSFAML STCSRLLSFVESTAPRKHRR ALPIMRSLVPNRRTTVASTE SRTNRPGGVRSPGLQLEGTS TLQWEQGPIAHPRHR in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB095935 mRNA Translation: BAC23111.1 Different initiation.
AK093059 mRNA Translation: BAC04038.1
AL390726 Genomic DNA No translation available.
AL591543 Genomic DNA No translation available.
BC056266 mRNA Translation: AAH56266.1 Sequence problems.
BC152434 mRNA Translation: AAI52435.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55311.1 [Q8IVF6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_671728.2, NM_147195.3 [Q8IVF6-1]
XP_011516141.1, XM_011517839.2 [Q8IVF6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000399703; ENSP00000382610; ENSG00000180071 [Q8IVF6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
253650

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:253650

UCSC genome browser

More...
UCSCi
uc004abg.5 human [Q8IVF6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095935 mRNA Translation: BAC23111.1 Different initiation.
AK093059 mRNA Translation: BAC04038.1
AL390726 Genomic DNA No translation available.
AL591543 Genomic DNA No translation available.
BC056266 mRNA Translation: AAH56266.1 Sequence problems.
BC152434 mRNA Translation: AAI52435.1
CCDSiCCDS55311.1 [Q8IVF6-1]
RefSeqiNP_671728.2, NM_147195.3 [Q8IVF6-1]
XP_011516141.1, XM_011517839.2 [Q8IVF6-1]

3D structure databases

SMRiQ8IVF6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128979, 4 interactors
IntActiQ8IVF6, 5 interactors
MINTiQ8IVF6
STRINGi9606.ENSP00000382610

PTM databases

iPTMnetiQ8IVF6
PhosphoSitePlusiQ8IVF6

Polymorphism and mutation databases

BioMutaiANKRD18A
DMDMi166898074

Proteomic databases

EPDiQ8IVF6
jPOSTiQ8IVF6
MassIVEiQ8IVF6
MaxQBiQ8IVF6
PaxDbiQ8IVF6
PeptideAtlasiQ8IVF6
PRIDEiQ8IVF6
ProteomicsDBi70698 [Q8IVF6-1]
72657

Genome annotation databases

EnsembliENST00000399703; ENSP00000382610; ENSG00000180071 [Q8IVF6-1]
GeneIDi253650
KEGGihsa:253650
UCSCiuc004abg.5 human [Q8IVF6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
253650
DisGeNETi253650
EuPathDBiHostDB:ENSG00000180071.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ANKRD18A
HGNCiHGNC:23643 ANKRD18A
HPAiHPA046346
HPA049923
HPA051288
neXtProtiNX_Q8IVF6
OpenTargetsiENSG00000180071
PharmGKBiPA134889624

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000164347
HOGENOMiHOG000143452
InParanoidiQ8IVF6
OMAiLTELLMC
PhylomeDBiQ8IVF6
TreeFamiTF333496

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ANKRD18A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
253650
PharosiQ8IVF6 Tdark

Protein Ontology

More...
PROi
PR:Q8IVF6
RNActiQ8IVF6 protein

Gene expression databases

BgeeiENSG00000180071 Expressed in 90 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ8IVF6 baseline and differential
GenevisibleiQ8IVF6 HS

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom
IPR021885 DUF3496
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF14915 CCDC144C, 1 hit
PF12001 DUF3496, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAN18A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IVF6
Secondary accession number(s): A7MD11
, A8MVU5, Q5SY86, Q7Z468, Q8NA88
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: February 5, 2008
Last modified: December 11, 2019
This is version 142 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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