UniProtKB - Q8IVF4 (DYH10_HUMAN)
Protein
Dynein heavy chain 10, axonemal
Gene
DNAH10
Organism
Homo sapiens (Human)
Status
Functioni
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1832 – 1839 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 2113 – 2120 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 2455 – 2462 | ATPSequence analysis | 8 | |
Nucleotide bindingi | 2803 – 2810 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP-dependent microtubule motor activity, minus-end-directed Source: GO_Central
- dynein intermediate chain binding Source: GO_Central
- dynein light intermediate chain binding Source: GO_Central
GO - Biological processi
- microtubule-based movement Source: GO_Central
Keywordsi
Molecular function | Motor protein |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8IVF4 |
Names & Taxonomyi
Protein namesi | Recommended name: Dynein heavy chain 10, axonemalAlternative name(s): Axonemal beta dynein heavy chain 10 Ciliary dynein heavy chain 10 |
Gene namesi | Name:DNAH10 Synonyms:KIAA2017 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2941, DNAH10 |
MIMi | 605884, gene |
neXtProti | NX_Q8IVF4 |
VEuPathDBi | HostDB:ENSG00000197653.14 |
Subcellular locationi
Cytoskeleton
- cilium axoneme Curated
Cytoskeleton
- axoneme Source: GO_Central
- dynein complex Source: GO_Central
- microtubule Source: UniProtKB-KW
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 196385 |
OpenTargetsi | ENSG00000197653 |
PharmGKBi | PA27395 |
Miscellaneous databases
Pharosi | Q8IVF4, Tdark |
Genetic variation databases
BioMutai | DNAH10 |
DMDMi | 296439473 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000318938 | 1 – 4471 | Dynein heavy chain 10, axonemalAdd BLAST | 4471 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 1074 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q8IVF4 |
jPOSTi | Q8IVF4 |
MassIVEi | Q8IVF4 |
MaxQBi | Q8IVF4 |
PaxDbi | Q8IVF4 |
PeptideAtlasi | Q8IVF4 |
PRIDEi | Q8IVF4 |
ProteomicsDBi | 70691 [Q8IVF4-1] 70692 [Q8IVF4-2] |
PTM databases
GlyGeni | Q8IVF4, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q8IVF4 |
PhosphoSitePlusi | Q8IVF4 |
Expressioni
Tissue specificityi
Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain but not in adult heart.
Gene expression databases
Bgeei | ENSG00000197653, Expressed in oocyte and 142 other tissues |
ExpressionAtlasi | Q8IVF4, baseline and differential |
Genevisiblei | Q8IVF4, HS |
Organism-specific databases
HPAi | ENSG00000197653, Tissue enhanced (brain, epididymis, fallopian tube, lung, testis) |
Interactioni
Subunit structurei
Consists of at least two heavy chains and a number of intermediate and light chains.
GO - Molecular functioni
- dynein intermediate chain binding Source: GO_Central
- dynein light intermediate chain binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 128201, 9 interactors |
IntActi | Q8IVF4, 5 interactors |
STRINGi | 9606.ENSP00000386770 |
Miscellaneous databases
RNActi | Q8IVF4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 1221 – 1254 | TPR 1Add BLAST | 34 | |
Repeati | 2736 – 2769 | TPR 2Add BLAST | 34 | |
Repeati | 2771 – 2797 | TPR 3Add BLAST | 27 | |
Repeati | 3802 – 3837 | TPR 4Add BLAST | 36 | |
Repeati | 4074 – 4108 | TPR 5Add BLAST | 35 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 1793 | StemBy similarityAdd BLAST | 1793 | |
Regioni | 1794 – 2015 | AAA 1By similarityAdd BLAST | 222 | |
Regioni | 2075 – 2294 | AAA 2By similarityAdd BLAST | 220 | |
Regioni | 2417 – 2665 | AAA 3By similarityAdd BLAST | 249 | |
Regioni | 2765 – 3014 | AAA 4By similarityAdd BLAST | 250 | |
Regioni | 3029 – 3313 | StalkBy similarityAdd BLAST | 285 | |
Regioni | 3399 – 3629 | AAA 5By similarityAdd BLAST | 231 | |
Regioni | 3845 – 4062 | AAA 6By similarityAdd BLAST | 218 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 203 – 223 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 602 – 622 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1071 – 1106 | Sequence analysisAdd BLAST | 36 | |
Coiled coili | 1217 – 1245 | Sequence analysisAdd BLAST | 29 | |
Coiled coili | 2747 – 2770 | Sequence analysisAdd BLAST | 24 | |
Coiled coili | 3045 – 3131 | Sequence analysisAdd BLAST | 87 | |
Coiled coili | 3257 – 3327 | Sequence analysisAdd BLAST | 71 | |
Coiled coili | 3567 – 3638 | Sequence analysisAdd BLAST | 72 | |
Coiled coili | 4235 – 4260 | Sequence analysisAdd BLAST | 26 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1832 – 1839 | GPAGTGKT motif | 8 | |
Motifi | 1882 – 1888 | CFDEFNR motif | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 18 – 25 | Poly-Glu | 8 | |
Compositional biasi | 949 – 952 | Poly-Glu | 4 |
Domaini
Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).By similarity
Sequence similaritiesi
Belongs to the dynein heavy chain family.Curated
Keywords - Domaini
Coiled coil, Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG3595, Eukaryota |
GeneTreei | ENSGT00940000154642 |
HOGENOMi | CLU_000038_9_1_1 |
InParanoidi | Q8IVF4 |
OrthoDBi | 1492at2759 |
PhylomeDBi | Q8IVF4 |
TreeFami | TF316836 |
Family and domain databases
Gene3Di | 1.10.8.710, 1 hit 1.10.8.720, 1 hit 1.20.140.100, 1 hit 3.10.490.20, 1 hit 3.20.180.20, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR035699, AAA_6 IPR035706, AAA_9 IPR041658, AAA_lid_11 IPR042219, AAA_lid_11_sf IPR041589, DNAH3_AAA_lid_1 IPR042228, Dynein_2_C IPR042222, Dynein_2_N IPR043157, Dynein_AAA1S IPR041466, Dynein_AAA5_ext IPR041228, Dynein_C IPR043160, Dynein_C_barrel IPR024743, Dynein_HC_stalk IPR024317, Dynein_heavy_chain_D4_dom IPR004273, Dynein_heavy_D6_P-loop IPR013594, Dynein_heavy_dom-1 IPR013602, Dynein_heavy_dom-2 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF12774, AAA_6, 1 hit PF12780, AAA_8, 1 hit PF12781, AAA_9, 1 hit PF17857, AAA_lid_1, 1 hit PF18198, AAA_lid_11, 1 hit PF08385, DHC_N1, 2 hits PF08393, DHC_N2, 1 hit PF17852, Dynein_AAA_lid, 1 hit PF18199, Dynein_C, 1 hit PF03028, Dynein_heavy, 1 hit PF12777, MT, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 3 hits |
SUPFAMi | SSF52540, SSF52540, 4 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IVF4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVPEEVEVEI DEIPVLSEEG EEEEETYSQK VESVDKVRAK RVSLRTESLG
60 70 80 90 100
QPLNREDEEM DKEISEKLPS KRTAKHIMEK MHLHMLCTPL PEEFLDQNVV
110 120 130 140 150
FFLRNTKEAI SEATDMKEAM EIMPETLEYG IINANVLHFL KNIICQVFLP
160 170 180 190 200
ALSFNQHRTS TTVGVTSGEV SNSSEHESDL PPMPGEAVEY HSIQLIRDEF
210 220 230 240 250
LMNVQKFASN IQRTMQQLEG EIKLEMPIIS VEGEVSDLAA DPETVDILEQ
260 270 280 290 300
CVINWLNQIS TAVEAQLKKT PQGKGPLAEI EFWRERNATL SALHEQTKLP
310 320 330 340 350
IVRKVLDVIK ESDSMLVANL QPVFTELFKF HTEASDNVRF LSTVERYFKN
360 370 380 390 400
ITHGSGFHVV LDTIPAMMSA LRMVWIISRH YNKDERMIPL MERIAWEIAE
410 420 430 440 450
RVCRVVNLRT LFKENRASAQ SKTLEARNTL RLWKKAYFDT RAKIEASGRE
460 470 480 490 500
DRWEFDRKRL FERTDYMATI CQDLSDVLQI LEEFYNIFGP ELKAVTGDPK
510 520 530 540 550
RIDDVLCRVD GLVTPMENLT FDPFSIKSSQ FWKYVMDEFK IEVLIDIINK
560 570 580 590 600
IFVQNLENPP LYKNHPPVAG AIYWERSLFF RIKHTILRFQ EVQEILDSDR
610 620 630 640 650
GQEVKQKYLE VGRTMKEYED RKYEQWMEVT EQVLPALMKK SLLTKSSIAT
660 670 680 690 700
EEPSTLERGA VFAINFSPAL REIINETKYL EQLGFTVPEL ARNVALQEDK
710 720 730 740 750
FLRYTAGIQR MLDHYHMLIG TLNDAESVLL KDHSQELLRV FRSGYKRLNW
760 770 780 790 800
NSLGIGDYIT GCKQAIGKFE SLVHQIHKNA DDISSRLTLI EAINLFKYPA
810 820 830 840 850
AKSEEELPGV KEFFEHIERE RASDVDHMVR WYLAIGPLLT KVEGLVVHTN
860 870 880 890 900
TGKAPKLASY YKYWEKKIYE VLTKLILKNL QSFNSLILGN VPLFHTETIL
910 920 930 940 950
TAPEIILHPN TNEIDKMCFH CVRNCVEITK HFVRWMNGSC IECPPQKGEE
960 970 980 990 1000
EEVVIINFYN DISLNPQIIE QAVMIPQNVH RILINLMKYL QKWKRYRPLW
1010 1020 1030 1040 1050
KLDKAIVMEK FAAKKPPCVA YDEKLQFYSK IAYEVMRHPL IKDEHCIRLQ
1060 1070 1080 1090 1100
LRHLANTVQE NAKSWVISLG KLLNESAKEE LYNLHEEMEH LAKNLRKIPN
1110 1120 1130 1140 1150
TLEDLKFVLA TIAEIRSKSL VMELRYRDVQ ERYRTMAMYN LFPPDAEKEL
1160 1170 1180 1190 1200
VDKIESIWSN LFNDSVNVEH ALGDIKRTFT ELTRGEIMNY RVQIEEFAKR
1210 1220 1230 1240 1250
FYSEGPGSVG DDLDKGVELL GVYERELARH EKSRQELANA EKLFDLPITM
1260 1270 1280 1290 1300
YPELLKVQKE MSGLRMIYEL YEGLKVAKEE WSQTLWINLN VQILQEGIEG
1310 1320 1330 1340 1350
FLRALRKLPR PVRGLSVTYY LEAKMKAFKD SIPLLLDLKN EALRDRHWKE
1360 1370 1380 1390 1400
LMEKTSVFFE MTETFTLENM FAMELHKHTD VLNEIVTAAI KEVAIEKAVK
1410 1420 1430 1440 1450
EILDTWENMK FTVVKYCKGT QERGYILGSV DEIIQSLDDN TFNLQSISGS
1460 1470 1480 1490 1500
RFVGPFLQTV HKWEKTLSLI GEVIEIWMLV QRKWMYLESI FIGGDIRSQL
1510 1520 1530 1540 1550
PEEAKKFDNI DKVFKRIMGE TLKDPVIKRC CEAPNRLSDL QNVSEGLEKC
1560 1570 1580 1590 1600
QKSLNDYLDS KRNAFPRFFF ISDDELLSIL GSSDPLCVQE HMIKMYDNIA
1610 1620 1630 1640 1650
SLRFNDGDSG EKLVSAMISA EGEVMEFRKI LRAEGRVEDW MTAVLNEMRR
1660 1670 1680 1690 1700
TNRLITKEAI FRYCEDRSRV DWMLLYQGMV VLAASQVWWT WEVEDVFHKA
1710 1720 1730 1740 1750
QKGEKQAMKN YGRKMHRQID ELVTRITMPL SKNDRKKYNT VLIIDVHARD
1760 1770 1780 1790 1800
IVDSFIRGSI LEAREFDWES QLRFYWDREP DELNIRQCTG TFGYGYEYMG
1810 1820 1830 1840 1850
LNGRLVITPL TDRIYLTLTQ ALSMYLGGAP AGPAGTGKTE TTKDLAKALG
1860 1870 1880 1890 1900
LLCVVTNCGE GMDYRAVGKI FSGLAQCGAW GCFDEFNRID ASVLSVISSQ
1910 1920 1930 1940 1950
IQTIRNALIH QLTTFQFEGQ EISLDSRMGI FITMNPGYAG RTELPESVKA
1960 1970 1980 1990 2000
LFRPVVVIVP DLQQICEIML FSEGFLEAKT LAKKMTVLYK LAREQLSKQY
2010 2020 2030 2040 2050
HYDFGLRALK SVLVMAGELK RGSSDLREDV VLMRALRDMN LPKFVFEDVP
2060 2070 2080 2090 2100
LFLGLISDLF PGLDCPRVRY PDFNDAVEQV LEENGYAVLP IQVDKVVQMF
2110 2120 2130 2140 2150
ETMLTRHTTM VVGPTRGGKS VVINTLCQAQ TKLGLTTKLY ILNPKAVSVI
2160 2170 2180 2190 2200
ELYGILDPTT RDWTDGVLSN IFREINKPTD KKERKYILFD GDVDALWVEN
2210 2220 2230 2240 2250
MNSVMDDNRL LTLANGERIR LQAHCALLFE VGDLQYASPA TVSRCGMVYV
2260 2270 2280 2290 2300
DPKNLKYRPY WKKWVNQIPN KVEQYNLNSL FEKYVPYLMD VIVEGIVDGR
2310 2320 2330 2340 2350
QAEKLKTIVP QTDLNMVTQL AKMLDALLEG EIEDLDLLEC YFLEALYCSL
2360 2370 2380 2390 2400
GASLLEDGRM KFDEYIKRLA SLSTVDTEGV WANPGELPGQ LPTLYDFHFD
2410 2420 2430 2440 2450
NKRNQWVPWS KLVPEYIHAP ERKFINILVH TVDTTRTTWI LEQMVKIKQP
2460 2470 2480 2490 2500
VIFVGESGTS KTATTQNFLK NLSEETNIVL MVNFSSRTTS MDIQRNLEAN
2510 2520 2530 2540 2550
VEKRTKDTYG PPMGKRLLVF MDDMNMPRVD EYGTQQPIAL LKLLLEKGYL
2560 2570 2580 2590 2600
YDRGKELNCK SIRDLGFIAA MGKAGGGRNE VDPRFISLFS VFNVPFPSEE
2610 2620 2630 2640 2650
SLHLIYSSIL KGHTSTFHES IVAVSGKLTF CTLALYKNIV QDLPPTPSKF
2660 2670 2680 2690 2700
HYIFNLRDLS RVFNGLVLTN PERFQTVAQM VRVWRNECLR VFHDRLISET
2710 2720 2730 2740 2750
DKQLVQQHIG SLVVEHFKDD VEVVMRDPIL FGDFQMALHE GEPRIYEDIQ
2760 2770 2780 2790 2800
DYEAAKALFQ EILEEYNESN TKMNLVLFDD ALEHLTRVHR IIRMDRGHAL
2810 2820 2830 2840 2850
LVGVGGSGKQ SLSRLAAFTA SCEVFEILLS RGYSENSFRE DLKSLYLKLG
2860 2870 2880 2890 2900
IENKAMIFLF TDAHVAEEGF LELINNMLTS GIVPALFSEE EKESILSQIG
2910 2920 2930 2940 2950
QEALKQGMGP AKESVWQYFV NKSANNLHIV LGMSPVGDTL RTWCRNFPGM
2960 2970 2980 2990 3000
VNNTGIDWFM PWPPQALHAV AKSFLGYNPM IPAENIENVV KHVVLVHQSV
3010 3020 3030 3040 3050
DHYSQQFLQK LRRSNYVTPK NYLDFINTYS KLLDEKTQCN IAQCKRLDGG
3060 3070 3080 3090 3100
LDKLKEATIQ LDELNQKLAE QKIVLAEKSA ACEALLEEIA VNTAVAEEKK
3110 3120 3130 3140 3150
KLAEEKAMEI EEQNKVIAME KAEAETTLAE VMPILEAAKL ELQKLDKSDV
3160 3170 3180 3190 3200
TEIRSFAKPP KQVQTVCECI LIMKGYKELN WKTAKGVMSD PNFLRSLMEI
3210 3220 3230 3240 3250
DFDSITQSQV KNIKGLLKTL NTTTEEMEAV SKAGLGMLKF VEAVMGYCDV
3260 3270 3280 3290 3300
FREIKPKREK VARLERNFYL TKRELERIQN ELAAIQKELE TLGAKYEAAI
3310 3320 3330 3340 3350
LEKQKLQEEA EIMERRLIAA DKLISGLGSE NIRWLNDLDE LMHRRVKLLG
3360 3370 3380 3390 3400
DCLLCAAFLS YEGAFTWEFR DEMVNRIWQN DILEREIPLS QPFRLESLLT
3410 3420 3430 3440 3450
DDVEISRWGS QGLPPDELSV QNGILTTRAS RFPLCIDPQQ QALNWIKRKE
3460 3470 3480 3490 3500
EKNNLRVASF NDPDFLKQLE MSIKYGTPFL FRDVDEYIDP VIDNVLEKNI
3510 3520 3530 3540 3550
KVSQGRQFII LGDKEVDYDS NFRLYLNTKL ANPRYSPSVF GKAMVINYTV
3560 3570 3580 3590 3600
TLKGLEDQLL SVLVAYERRE LEEQREHLIQ ETSENKNLLK DLEDSLLREL
3610 3620 3630 3640 3650
ATSTGNMLDN VDLVHTLEET KSKATEVSEK LKLAEKTALD IDRLRDGYRP
3660 3670 3680 3690 3700
AARRGAILFF VLSEMALVNS MYQYSLIAFL EVFRLSLKKS LPDSILMKRL
3710 3720 3730 3740 3750
RNIMDTLTFS IYNHGCTGLF ERHKLLFSFN MTIKIEQAEG RVPQEELDFF
3760 3770 3780 3790 3800
LKGNISLEKS KRKKPCAWLS DQGWEDIILL SEMFSDNFGQ LPDDVENNQT
3810 3820 3830 3840 3850
VWQEWYDLDS LEQFPVPLGY DNNITPFQKL LILRCFRVDR VYRAVTDYVT
3860 3870 3880 3890 3900
VTMGEKYVQP PMISFEAIFE QSTPHSPIVF ILSPGSDPAT DLMKLAERSG
3910 3920 3930 3940 3950
FGGNRLKFLA MGQGQEKVAL QLLETAVARG QWLMLQNCHL LVKWLKDLEK
3960 3970 3980 3990 4000
SLERITKPHP DFRLWLTTDP TKGFPIGILQ KSLKVVTEPP NGLKLNMRAT
4010 4020 4030 4040 4050
YFKISHEMLD QCPHPAFKPL VYVLAFFHAV VQERRKFGKI GWNVYYDFNE
4060 4070 4080 4090 4100
SDFQVCMEIL NTYLTKAFQQ RDPRIPWGSL KYLIGEVMYG GRAIDSFDRR
4110 4120 4130 4140 4150
ILTIYMDEYL GDFIFDTFQP FHFFRNKEVD YKIPVGDEKE KFVEAIEALP
4160 4170 4180 4190 4200
LANTPEVFGL HPNAEIGYYT QAARDMWAHL LELQPQTGES SSGISRDDYI
4210 4220 4230 4240 4250
GQVAKEIENK MPKVFDLDQV RKRLGTGLSP TSVVLLQELE RFNKLVVRMT
4260 4270 4280 4290 4300
KSLAELQRAL AGEVGMSNEL DDVARSLFIG HIPNIWRRLA PDTLKSLGNW
4310 4320 4330 4340 4350
MVYFLRRFSQ YMLWVTESEP SVMWLSGLHI PESYLTALVQ ATCRKNGWPL
4360 4370 4380 4390 4400
DRSTLFTQVT KFQDADEVNE RAGQGCFVSG LYLEGADWDI EKGCLIKSKP
4410 4420 4430 4440 4450
KVLVVDLPIL KIIPIEAHRL KLQNTFRTPV YTTSMRRNAM GVGLVFEADL
4460 4470
FTTRHISHWV LQGVCLTLNS D
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1C7CYW8 | A0A1C7CYW8_HUMAN | Dynein heavy chain 10, axonemal | DNAH10 | 4,532 | Annotation score: | ||
A0A669KB38 | A0A669KB38_HUMAN | Dynein heavy chain 10, axonemal | DNAH10 | 4,589 | Annotation score: | ||
A0A0J9YY17 | A0A0J9YY17_HUMAN | Dynein heavy chain 10, axonemal | DNAH10 | 3,196 | Annotation score: | ||
H0YGZ2 | H0YGZ2_HUMAN | Dynein heavy chain 10, axonemal | DNAH10 | 319 | Annotation score: | ||
F5H515 | F5H515_HUMAN | Dynein heavy chain 10, axonemal | DNAH10 | 648 | Annotation score: | ||
A0A087WV07 | A0A087WV07_HUMAN | Dynein heavy chain 10, axonemal | DNAH10 | 970 | Annotation score: | ||
A0A096LNK1 | A0A096LNK1_HUMAN | Dynein heavy chain 10, axonemal | DNAH10 | 81 | Annotation score: | ||
A0A0J9YWH2 | A0A0J9YWH2_HUMAN | Dynein heavy chain 10, axonemal | DNAH10 | 84 | Annotation score: |
Sequence cautioni
The sequence BAC04579 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC86296 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1631 | L → V in BAC86296 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1631 | L → V in BAC23113 (Ref. 3) Curated | 1 | |
Sequence conflicti | 2046 | F → L in BAC86296 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 2132 – 2134 | KLG → NLS in BAC86296 (PubMed:14702039).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060135 | 167 | S → P. Corresponds to variant dbSNP:rs11057353EnsemblClinVar. | 1 | |
Natural variantiVAR_038916 | 480 | I → V1 PublicationCorresponds to variant dbSNP:rs10846559EnsemblClinVar. | 1 | |
Natural variantiVAR_060136 | 1724 | T → M. Corresponds to variant dbSNP:rs34934281EnsemblClinVar. | 1 | |
Natural variantiVAR_060137 | 1767 | D → E. Corresponds to variant dbSNP:rs7969937Ensembl. | 1 | |
Natural variantiVAR_060138 | 1865 | R → K. Corresponds to variant dbSNP:rs35685787Ensembl. | 1 | |
Natural variantiVAR_062177 | 1986 | T → M. Corresponds to variant dbSNP:rs33935373EnsemblClinVar. | 1 | |
Natural variantiVAR_060139 | 2403 | R → W. Corresponds to variant dbSNP:rs7977449Ensembl. | 1 | |
Natural variantiVAR_060140 | 2483 | N → S. Corresponds to variant dbSNP:rs11835416Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033518 | 1090 – 1095 | HLAKNL → VLNRCV in isoform 2. 1 Publication | 6 | |
Alternative sequenceiVSP_033519 | 1096 – 4471 | Missing in isoform 2. 1 PublicationAdd BLAST | 3376 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC079315 Genomic DNA No translation available. AC117503 Genomic DNA No translation available. AK095581 mRNA Translation: BAC04579.1 Different initiation. AK125475 mRNA Translation: BAC86173.1 AK125796 mRNA Translation: BAC86296.1 Different initiation. AB095937 mRNA Translation: BAC23113.2 AJ132089 mRNA Translation: CAA10562.1 |
CCDSi | CCDS9255.2 [Q8IVF4-1] |
RefSeqi | NP_997320.2, NM_207437.3 [Q8IVF4-1] |
Genome annotation databases
Ensembli | ENST00000638045; ENSP00000489675; ENSG00000197653 [Q8IVF4-1] |
GeneIDi | 196385 |
KEGGi | hsa:196385 |
UCSCi | uc001uft.5, human [Q8IVF4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC079315 Genomic DNA No translation available. AC117503 Genomic DNA No translation available. AK095581 mRNA Translation: BAC04579.1 Different initiation. AK125475 mRNA Translation: BAC86173.1 AK125796 mRNA Translation: BAC86296.1 Different initiation. AB095937 mRNA Translation: BAC23113.2 AJ132089 mRNA Translation: CAA10562.1 |
CCDSi | CCDS9255.2 [Q8IVF4-1] |
RefSeqi | NP_997320.2, NM_207437.3 [Q8IVF4-1] |
3D structure databases
SMRi | Q8IVF4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128201, 9 interactors |
IntActi | Q8IVF4, 5 interactors |
STRINGi | 9606.ENSP00000386770 |
PTM databases
GlyGeni | Q8IVF4, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q8IVF4 |
PhosphoSitePlusi | Q8IVF4 |
Genetic variation databases
BioMutai | DNAH10 |
DMDMi | 296439473 |
Proteomic databases
EPDi | Q8IVF4 |
jPOSTi | Q8IVF4 |
MassIVEi | Q8IVF4 |
MaxQBi | Q8IVF4 |
PaxDbi | Q8IVF4 |
PeptideAtlasi | Q8IVF4 |
PRIDEi | Q8IVF4 |
ProteomicsDBi | 70691 [Q8IVF4-1] 70692 [Q8IVF4-2] |
Protocols and materials databases
Antibodypediai | 52600, 15 antibodies |
Genome annotation databases
Ensembli | ENST00000638045; ENSP00000489675; ENSG00000197653 [Q8IVF4-1] |
GeneIDi | 196385 |
KEGGi | hsa:196385 |
UCSCi | uc001uft.5, human [Q8IVF4-1] |
Organism-specific databases
CTDi | 196385 |
DisGeNETi | 196385 |
GeneCardsi | DNAH10 |
HGNCi | HGNC:2941, DNAH10 |
HPAi | ENSG00000197653, Tissue enhanced (brain, epididymis, fallopian tube, lung, testis) |
MIMi | 605884, gene |
neXtProti | NX_Q8IVF4 |
OpenTargetsi | ENSG00000197653 |
PharmGKBi | PA27395 |
VEuPathDBi | HostDB:ENSG00000197653.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3595, Eukaryota |
GeneTreei | ENSGT00940000154642 |
HOGENOMi | CLU_000038_9_1_1 |
InParanoidi | Q8IVF4 |
OrthoDBi | 1492at2759 |
PhylomeDBi | Q8IVF4 |
TreeFami | TF316836 |
Enzyme and pathway databases
PathwayCommonsi | Q8IVF4 |
Miscellaneous databases
BioGRID-ORCSi | 196385, 18 hits in 873 CRISPR screens |
ChiTaRSi | DNAH10, human |
GenomeRNAii | 196385 |
Pharosi | Q8IVF4, Tdark |
PROi | PR:Q8IVF4 |
RNActi | Q8IVF4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197653, Expressed in oocyte and 142 other tissues |
ExpressionAtlasi | Q8IVF4, baseline and differential |
Genevisiblei | Q8IVF4, HS |
Family and domain databases
Gene3Di | 1.10.8.710, 1 hit 1.10.8.720, 1 hit 1.20.140.100, 1 hit 3.10.490.20, 1 hit 3.20.180.20, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR035699, AAA_6 IPR035706, AAA_9 IPR041658, AAA_lid_11 IPR042219, AAA_lid_11_sf IPR041589, DNAH3_AAA_lid_1 IPR042228, Dynein_2_C IPR042222, Dynein_2_N IPR043157, Dynein_AAA1S IPR041466, Dynein_AAA5_ext IPR041228, Dynein_C IPR043160, Dynein_C_barrel IPR024743, Dynein_HC_stalk IPR024317, Dynein_heavy_chain_D4_dom IPR004273, Dynein_heavy_D6_P-loop IPR013594, Dynein_heavy_dom-1 IPR013602, Dynein_heavy_dom-2 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF12774, AAA_6, 1 hit PF12780, AAA_8, 1 hit PF12781, AAA_9, 1 hit PF17857, AAA_lid_1, 1 hit PF18198, AAA_lid_11, 1 hit PF08385, DHC_N1, 2 hits PF08393, DHC_N2, 1 hit PF17852, Dynein_AAA_lid, 1 hit PF18199, Dynein_C, 1 hit PF03028, Dynein_heavy, 1 hit PF12777, MT, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 3 hits |
SUPFAMi | SSF52540, SSF52540, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DYH10_HUMAN | |
Accessioni | Q8IVF4Primary (citable) accession number: Q8IVF4 Secondary accession number(s): C9JMF5 Q8N761 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 10, 2021 | |
This is version 139 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families