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Protein

NUT family member 2A

Gene

NUTM2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NUT family member 2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUTM2A
Synonyms:FAM22A, KIAA2020
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000184923.12

Human Gene Nomenclature Database

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HGNCi
HGNC:23438 NUTM2A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IVF1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
728118

MalaCards human disease database

More...
MalaCardsi
NUTM2A

Open Targets

More...
OpenTargetsi
ENSG00000184923

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
213711 Endometrial stromal sarcoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134875735

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NUTM2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
269849751

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002660321 – 878NUT family member 2AAdd BLAST878

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IVF1

PeptideAtlas

More...
PeptideAtlasi
Q8IVF1

PRoteomics IDEntifications database

More...
PRIDEi
Q8IVF1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70686
70687 [Q8IVF1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IVF1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IVF1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184923 Expressed in 83 organ(s), highest expression level in prefrontal cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_FAM22A
HS_FAM22D

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IVF1 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q8IVF1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371126

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8IVF1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi278 – 285Poly-Pro8
Compositional biasi425 – 514Pro-richAdd BLAST90

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NUT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J94Q Eukaryota
ENOG4111C0H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00410000025793

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112470

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107898

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IVF1

Identification of Orthologs from Complete Genome Data

More...
OMAi
FINTRIA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G034P

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IVF1

TreeFam database of animal gene trees

More...
TreeFami
TF337728

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024310 NUT
IPR024309 NUT_N

The PANTHER Classification System

More...
PANTHERi
PTHR22879 PTHR22879, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12881 NUT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IVF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVKGPSGRS FCCESEGQFK SCLKRHTPSL LLPSSWKGNS GSCLMAKALH
60 70 80 90 100
RMSPTPNSCP LPLPLCRMSG VLCSRNLFTF KFSLFQLDSG ASGEPGHSLG
110 120 130 140 150
LTLGFSHCGN CQTAVVSAQP EGMASNGAYP ALGPGVTANP GTSLSVFTAL
160 170 180 190 200
PFTTPAPGPA HGPLLVTAGA PPGGPLVLST LPSTPLVTEQ DGCGPSGAGA
210 220 230 240 250
SNVFVQMRTE VGPVKAAQAQ TLVLTQAPLV WQAPGALCGG VVCPPPLLLA
260 270 280 290 300
AAPVVPVMAA QVVGGTQACE GGWSQGLPLP PPPPPAAQLP PIVSQGNAGP
310 320 330 340 350
WPQGAHGEGS LASSQAKAPP DDSCNPRSVY ENFRLWQHYK PLARRHLPQS
360 370 380 390 400
PDTEALSCFL IPVLRSLARR KPTMTLEEGL WRAMREWQHT SNFDRMIFYE
410 420 430 440 450
MAEKFLEFEA EEEMQIQKSQ WMKGPQCLPP PATPRLEPRG PPAPEVVKQP
460 470 480 490 500
VYLPSKAGPK APTACLPPPR PQRPVTKARR PPPRPHRRAE TKARLPPPRP
510 520 530 540 550
QRPAETKVPE EIPPEVVQEY VDIMEELLGP SLGATGEPEK QREEGEVKQP
560 570 580 590 600
QEEDWTPPDP GLLSYTDKLC SQKDFVTKVE AVIHPQFLEE LLSPDPQMDF
610 620 630 640 650
LALSQELEQE EGLTLAQLVE KRLLPLKEKQ HARAAPSRGT ARLDSSSSKF
660 670 680 690 700
AAGQGAERDV PVPQQGVGME TCPPQTTARD SQGRGRAHTG MARSKDSVVL
710 720 730 740 750
LGCQDSPGLR AARPTSPPQD HRPTCPGVGT KDALDLPGGS PVRESHGLAQ
760 770 780 790 800
GSSEEEELPS LAFLLGSQHK LLPWWLPQSP VPASGLLSPE KWGPQGTHQF
810 820 830 840 850
PSAERRGLNL APSPANKAKK RPLFGSLSPA EKTPHPGPGL RVSGEQSLTW
860 870
GLGGPSQSQK RKGDPLVSRK EKKQRCSQ
Length:878
Mass (Da):93,890
Last modified:November 24, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB65B88FE85A912A1
GO
Isoform 2 (identifier: Q8IVF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     618-629: LVEKRLLPLKEK → GAPSDAPGTDRC
     630-878: Missing.

Show »
Length:629
Mass (Da):67,315
Checksum:i99F74628C11E4481
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC23116 differs from that shown. Reason: Frameshift at position 83.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti47K → E in BAC23116 (Ref. 1) Curated1
Sequence conflicti160A → T in BAC23116 (Ref. 1) Curated1
Sequence conflicti546E → K in BAC23116 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034018618 – 629LVEKR…PLKEK → GAPSDAPGTDRC in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_034020630 – 878Missing in isoform 2. 1 PublicationAdd BLAST249

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB095940 mRNA Translation: BAC23116.1 Frameshift.
AL157893 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44452.1 [Q8IVF1-1]

NCBI Reference Sequences

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RefSeqi
NP_001009610.1, NM_001009610.1
NP_001092808.1, NM_001099338.1 [Q8IVF1-1]
XP_011538424.1, XM_011540122.2 [Q8IVF1-1]
XP_016872096.1, XM_017016607.1 [Q8IVF1-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.710565

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381689; ENSP00000371107; ENSG00000184923 [Q8IVF1-2]
ENST00000381707; ENSP00000371126; ENSG00000184923 [Q8IVF1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
728118
728130

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:728118
hsa:728130

UCSC genome browser

More...
UCSCi
uc001kek.4 human [Q8IVF1-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB095940 mRNA Translation: BAC23116.1 Frameshift.
AL157893 Genomic DNA No translation available.
CCDSiCCDS44452.1 [Q8IVF1-1]
RefSeqiNP_001009610.1, NM_001009610.1
NP_001092808.1, NM_001099338.1 [Q8IVF1-1]
XP_011538424.1, XM_011540122.2 [Q8IVF1-1]
XP_016872096.1, XM_017016607.1 [Q8IVF1-2]
UniGeneiHs.710565

3D structure databases

ProteinModelPortaliQ8IVF1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8IVF1, 1 interactor
STRINGi9606.ENSP00000371126

PTM databases

iPTMnetiQ8IVF1
PhosphoSitePlusiQ8IVF1

Polymorphism and mutation databases

BioMutaiNUTM2A
DMDMi269849751

Proteomic databases

PaxDbiQ8IVF1
PeptideAtlasiQ8IVF1
PRIDEiQ8IVF1
ProteomicsDBi70686
70687 [Q8IVF1-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381689; ENSP00000371107; ENSG00000184923 [Q8IVF1-2]
ENST00000381707; ENSP00000371126; ENSG00000184923 [Q8IVF1-1]
GeneIDi728118
728130
KEGGihsa:728118
hsa:728130
UCSCiuc001kek.4 human [Q8IVF1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
728118
728130
DisGeNETi728118
EuPathDBiHostDB:ENSG00000184923.12

GeneCards: human genes, protein and diseases

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GeneCardsi
NUTM2A
HGNCiHGNC:23438 NUTM2A
MalaCardsiNUTM2A
neXtProtiNX_Q8IVF1
OpenTargetsiENSG00000184923
Orphaneti213711 Endometrial stromal sarcoma
PharmGKBiPA134875735

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J94Q Eukaryota
ENOG4111C0H LUCA
GeneTreeiENSGT00410000025793
HOGENOMiHOG000112470
HOVERGENiHBG107898
InParanoidiQ8IVF1
OMAiFINTRIA
OrthoDBiEOG091G034P
PhylomeDBiQ8IVF1
TreeFamiTF337728

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8IVF1

Gene expression databases

BgeeiENSG00000184923 Expressed in 83 organ(s), highest expression level in prefrontal cortex
CleanExiHS_FAM22A
HS_FAM22D
GenevisibleiQ8IVF1 HS

Family and domain databases

InterProiView protein in InterPro
IPR024310 NUT
IPR024309 NUT_N
PANTHERiPTHR22879 PTHR22879, 1 hit
PfamiView protein in Pfam
PF12881 NUT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTM2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IVF1
Secondary accession number(s): A6NMX5, C9JDI1, Q5VZW1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 24, 2009
Last modified: December 5, 2018
This is version 100 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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