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Protein

NudC domain-containing protein 3

Gene

NUDCD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • unfolded protein binding Source: GO_Central

GO - Biological processi

  • cilium assembly Source: GO_Central
  • developmental process Source: GO_Central
  • protein folding Source: GO_Central
  • protein localization to pericentriolar material Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NudC domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUDCD3
Synonyms:KIAA1068
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000015676.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22208 NUDCD3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610296 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IVD9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23386

Open Targets

More...
OpenTargetsi
ENSG00000015676

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134989375

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NUDCD3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145559509

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000579851 – 361NudC domain-containing protein 3Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei146PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IVD9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IVD9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IVD9

PeptideAtlas

More...
PeptideAtlasi
Q8IVD9

PRoteomics IDEntifications database

More...
PRIDEi
Q8IVD9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70681

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IVD9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IVD9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000015676 Expressed in 227 organ(s), highest expression level in frontal cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_NUDCD3

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IVD9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019136
HPA019528
HPA019529

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116962, 65 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8IVD9

Database of interacting proteins

More...
DIPi
DIP-53643N

Protein interaction database and analysis system

More...
IntActi
Q8IVD9, 126 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347626

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1361
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IVD9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IVD9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8IVD9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini185 – 277CSPROSITE-ProRule annotationAdd BLAST93

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2265 Eukaryota
ENOG410XQVU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158444

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000036072

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG100537

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IVD9

Identification of Orthologs from Complete Genome Data

More...
OMAi
QILYGAM

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0BZ5

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IVD9

TreeFam database of animal gene trees

More...
TreeFami
TF300147

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06495 p23_NUDCD3_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.790, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR037898 NudC_fam
IPR025934 NudC_N_dom
IPR027761 NUDCD3
IPR037905 p23_NUDCD3

The PANTHER Classification System

More...
PANTHERi
PTHR12356 PTHR12356, 1 hit
PTHR12356:SF19 PTHR12356:SF19, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04969 CS, 1 hit
PF14050 Nudc_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49764 SSF49764, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51203 CS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IVD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METGAAELYD QALLGILQHV GNVQDFLRVL FGFLYRKTDF YRLLRHPSDR
60 70 80 90 100
MGFPPGAAQA LVLQVFKTFD HMARQDDEKR RQELEEKIRR KEEEEAKTVS
110 120 130 140 150
AAAAEKEPVP VPVQEIEIDS TTELDGHQEV EKVQPPGPVK EMAHGSQEAE
160 170 180 190 200
APGAVAGAAE VPREPPILPR IQEQFQKNPD SYNGAVRENY TWSQDYTDLE
210 220 230 240 250
VRVPVPKHVV KGKQVSVALS SSSIRVAMLE ENGERVLMEG KLTHKINTES
260 270 280 290 300
SLWSLEPGKC VLVNLSKVGE YWWNAILEGE EPIDIDKINK ERSMATVDEE
310 320 330 340 350
EQAVLDRLTF DYHQKLQGKP QSHELKVHEM LKKGWDAEGS PFRGQRFDPA
360
MFNISPGAVQ F
Length:361
Mass (Da):40,822
Last modified:April 17, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06B54758C395818A
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH03691 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ96892 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB14855 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti205V → L in AAH35014 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0540363T → P1 PublicationCorresponds to variant dbSNP:rs307007Ensembl.1
Natural variantiVAR_031709235R → C1 PublicationCorresponds to variant dbSNP:rs11550029Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC004453 Genomic DNA Translation: AAQ96892.1 Sequence problems.
BC003691 mRNA Translation: AAH03691.1 Different initiation.
BC011673 mRNA Translation: AAH11673.2
BC035014 mRNA Translation: AAH35014.1
AB028991 mRNA Translation: BAA83020.1
AK024226 mRNA Translation: BAB14855.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5490.2

NCBI Reference Sequences

More...
RefSeqi
NP_056147.2, NM_015332.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.488171

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355451; ENSP00000347626; ENSG00000015676

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23386

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23386

UCSC genome browser

More...
UCSCi
uc003tkz.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004453 Genomic DNA Translation: AAQ96892.1 Sequence problems.
BC003691 mRNA Translation: AAH03691.1 Different initiation.
BC011673 mRNA Translation: AAH11673.2
BC035014 mRNA Translation: AAH35014.1
AB028991 mRNA Translation: BAA83020.1
AK024226 mRNA Translation: BAB14855.1 Different initiation.
CCDSiCCDS5490.2
RefSeqiNP_056147.2, NM_015332.3
UniGeneiHs.488171

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGVNMR-A176-286[»]
ProteinModelPortaliQ8IVD9
SMRiQ8IVD9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116962, 65 interactors
CORUMiQ8IVD9
DIPiDIP-53643N
IntActiQ8IVD9, 126 interactors
STRINGi9606.ENSP00000347626

PTM databases

iPTMnetiQ8IVD9
PhosphoSitePlusiQ8IVD9

Polymorphism and mutation databases

BioMutaiNUDCD3
DMDMi145559509

Proteomic databases

EPDiQ8IVD9
MaxQBiQ8IVD9
PaxDbiQ8IVD9
PeptideAtlasiQ8IVD9
PRIDEiQ8IVD9
ProteomicsDBi70681

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23386
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355451; ENSP00000347626; ENSG00000015676
GeneIDi23386
KEGGihsa:23386
UCSCiuc003tkz.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23386
DisGeNETi23386
EuPathDBiHostDB:ENSG00000015676.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NUDCD3
HGNCiHGNC:22208 NUDCD3
HPAiHPA019136
HPA019528
HPA019529
MIMi610296 gene
neXtProtiNX_Q8IVD9
OpenTargetsiENSG00000015676
PharmGKBiPA134989375

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2265 Eukaryota
ENOG410XQVU LUCA
GeneTreeiENSGT00940000158444
HOGENOMiHOG000036072
HOVERGENiHBG100537
InParanoidiQ8IVD9
OMAiQILYGAM
OrthoDBiEOG091G0BZ5
PhylomeDBiQ8IVD9
TreeFamiTF300147

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NUDCD3 human
EvolutionaryTraceiQ8IVD9

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NUDCD3_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23386

Protein Ontology

More...
PROi
PR:Q8IVD9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000015676 Expressed in 227 organ(s), highest expression level in frontal cortex
CleanExiHS_NUDCD3
GenevisibleiQ8IVD9 HS

Family and domain databases

CDDicd06495 p23_NUDCD3_like, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR037898 NudC_fam
IPR025934 NudC_N_dom
IPR027761 NUDCD3
IPR037905 p23_NUDCD3
PANTHERiPTHR12356 PTHR12356, 1 hit
PTHR12356:SF19 PTHR12356:SF19, 1 hit
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF14050 Nudc_N, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUDC3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IVD9
Secondary accession number(s): Q9BTI3, Q9H7W9, Q9UPT4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: April 17, 2007
Last modified: December 5, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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