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Protein

NudC domain-containing protein 3

Gene

NUDCD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cilium assembly Source: GO_Central
  • developmental process Source: GO_Central
  • protein folding Source: GO_Central
  • protein localization to pericentriolar material Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
NudC domain-containing protein 3
Gene namesi
Name:NUDCD3
Synonyms:KIAA1068
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000015676.17
HGNCiHGNC:22208 NUDCD3
MIMi610296 gene
neXtProtiNX_Q8IVD9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi23386
OpenTargetsiENSG00000015676
PharmGKBiPA134989375

Polymorphism and mutation databases

BioMutaiNUDCD3
DMDMi145559509

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000579851 – 361NudC domain-containing protein 3Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IVD9
MaxQBiQ8IVD9
PaxDbiQ8IVD9
PeptideAtlasiQ8IVD9
PRIDEiQ8IVD9
ProteomicsDBi70681

PTM databases

iPTMnetiQ8IVD9
PhosphoSitePlusiQ8IVD9

Expressioni

Gene expression databases

BgeeiENSG00000015676
CleanExiHS_NUDCD3
GenevisibleiQ8IVD9 HS

Organism-specific databases

HPAiHPA019136
HPA019528
HPA019529

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116962, 60 interactors
CORUMiQ8IVD9
DIPiDIP-53643N
IntActiQ8IVD9, 126 interactors
STRINGi9606.ENSP00000347626

Structurei

Secondary structure

1361
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi179 – 185Combined sources7
Beta strandi191 – 195Combined sources5
Beta strandi198 – 204Combined sources7
Helixi212 – 214Combined sources3
Beta strandi215 – 219Combined sources5
Beta strandi221 – 229Combined sources9
Beta strandi231 – 244Combined sources14
Turni248 – 250Combined sources3
Beta strandi252 – 255Combined sources4
Beta strandi259 – 265Combined sources7
Beta strandi267 – 270Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGVNMR-A176-286[»]
ProteinModelPortaliQ8IVD9
SMRiQ8IVD9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IVD9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 277CSPROSITE-ProRule annotationAdd BLAST93

Phylogenomic databases

eggNOGiKOG2265 Eukaryota
ENOG410XQVU LUCA
GeneTreeiENSGT00530000063486
HOGENOMiHOG000036072
HOVERGENiHBG100537
InParanoidiQ8IVD9
OMAiQILYGAM
OrthoDBiEOG091G0BZ5
PhylomeDBiQ8IVD9
TreeFamiTF300147

Family and domain databases

CDDicd06495 p23_NUDCD3_like, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR037898 NudC_fam
IPR025934 NudC_N_dom
IPR027761 NUDCD3
IPR037905 p23_NUDCD3
PANTHERiPTHR12356 PTHR12356, 1 hit
PTHR12356:SF19 PTHR12356:SF19, 1 hit
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF14050 Nudc_N, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IVD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METGAAELYD QALLGILQHV GNVQDFLRVL FGFLYRKTDF YRLLRHPSDR
60 70 80 90 100
MGFPPGAAQA LVLQVFKTFD HMARQDDEKR RQELEEKIRR KEEEEAKTVS
110 120 130 140 150
AAAAEKEPVP VPVQEIEIDS TTELDGHQEV EKVQPPGPVK EMAHGSQEAE
160 170 180 190 200
APGAVAGAAE VPREPPILPR IQEQFQKNPD SYNGAVRENY TWSQDYTDLE
210 220 230 240 250
VRVPVPKHVV KGKQVSVALS SSSIRVAMLE ENGERVLMEG KLTHKINTES
260 270 280 290 300
SLWSLEPGKC VLVNLSKVGE YWWNAILEGE EPIDIDKINK ERSMATVDEE
310 320 330 340 350
EQAVLDRLTF DYHQKLQGKP QSHELKVHEM LKKGWDAEGS PFRGQRFDPA
360
MFNISPGAVQ F
Length:361
Mass (Da):40,822
Last modified:April 17, 2007 - v3
Checksum:i06B54758C395818A
GO

Sequence cautioni

The sequence AAH03691 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ96892 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB14855 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205V → L in AAH35014 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0540363T → P1 PublicationCorresponds to variant dbSNP:rs307007Ensembl.1
Natural variantiVAR_031709235R → C1 PublicationCorresponds to variant dbSNP:rs11550029Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004453 Genomic DNA Translation: AAQ96892.1 Sequence problems.
BC003691 mRNA Translation: AAH03691.1 Different initiation.
BC011673 mRNA Translation: AAH11673.2
BC035014 mRNA Translation: AAH35014.1
AB028991 mRNA Translation: BAA83020.1
AK024226 mRNA Translation: BAB14855.1 Different initiation.
CCDSiCCDS5490.2
RefSeqiNP_056147.2, NM_015332.3
UniGeneiHs.488171

Genome annotation databases

EnsembliENST00000355451; ENSP00000347626; ENSG00000015676
GeneIDi23386
KEGGihsa:23386
UCSCiuc003tkz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNUDC3_HUMAN
AccessioniPrimary (citable) accession number: Q8IVD9
Secondary accession number(s): Q9BTI3, Q9H7W9, Q9UPT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: April 17, 2007
Last modified: June 20, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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