UniProtKB - Q8IVC4 (ZN584_HUMAN)
Protein
Zinc finger protein 584
Gene
ZNF584
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 159 – 181 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 214 – 236 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 242 – 264 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 270 – 292 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 320 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 326 – 348 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 404 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8IVC4 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 584 |
Gene namesi | Name:ZNF584 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000171574.17 |
HGNCi | HGNC:27318, ZNF584 |
neXtProti | NX_Q8IVC4 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 201514 |
OpenTargetsi | ENSG00000171574 |
PharmGKBi | PA134968861 |
Miscellaneous databases
Pharosi | Q8IVC4, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF584 |
DMDMi | 55976735 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047676 | 1 – 421 | Zinc finger protein 584Add BLAST | 421 |
Proteomic databases
MassIVEi | Q8IVC4 |
MaxQBi | Q8IVC4 |
PaxDbi | Q8IVC4 |
PeptideAtlasi | Q8IVC4 |
PRIDEi | Q8IVC4 |
ProteomicsDBi | 70680 |
PTM databases
iPTMneti | Q8IVC4 |
PhosphoSitePlusi | Q8IVC4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171574, Expressed in heart left ventricle and 169 other tissues |
ExpressionAtlasi | Q8IVC4, baseline and differential |
Genevisiblei | Q8IVC4, HS |
Organism-specific databases
HPAi | ENSG00000171574, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 128391, 2 interactors |
IntActi | Q8IVC4, 1 interactor |
STRINGi | 9606.ENSP00000306756 |
Miscellaneous databases
RNActi | Q8IVC4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 88 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 159 – 181 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 214 – 236 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 242 – 264 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 270 – 292 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 320 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 326 – 348 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 404 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163291 |
HOGENOMi | CLU_002678_0_9_1 |
InParanoidi | Q8IVC4 |
OMAi | PKQVKSC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8IVC4 |
TreeFami | TF337055 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 8 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q8IVC4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGEAEAQLD PSLQGLVMFE DVTVYFSREE WGLLNVTQKG LYRDVMLENF
60 70 80 90 100
ALVSSLGLAP SRSPVFTQLE DDEQSWVPSW VDVTPVSRAE ARRGFGLDGL
110 120 130 140 150
CRVEDERAHP EHLKSYRVIQ HQDTHSEGKP RRHTEHGAAF PPGSSCGQQQ
160 170 180 190 200
EVHVAEKLFK CSDCGKVFLK AFALLDHLIT HSEERPFRCP TGRSAFKKSA
210 220 230 240 250
HINPRKIHTG ETAHVCNECG KAFSYPSKLR KHQKVHTGIK PFKCSDCGKT
260 270 280 290 300
FNRKDALVLH QRIHTGERPY ECSKCGKTFS VLSTLIRHRK VHIGERPYEC
310 320 330 340 350
TECGKFFKYN NSFILHQRVH TGERPFECKQ CGKGYVTRSG LYQHWKVHTG
360 370 380 390 400
ERPYECSLCG KTFTTRSYRN RHQQFHTEER SYECTECGKA FKHSSTLLQH
410 420
KKVHTPERRQ EDRAHGKVVS C
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R0A3 | M0R0A3_HUMAN | Zinc finger protein 584 | ZNF584 | 376 | Annotation score: | ||
F6W0P0 | F6W0P0_HUMAN | Zinc finger protein 584 | ZNF584 | 145 | Annotation score: | ||
M0QZA3 | M0QZA3_HUMAN | Zinc finger protein 584 | ZNF584 | 93 | Annotation score: | ||
M0R2W6 | M0R2W6_HUMAN | Zinc finger protein 584 | ZNF584 | 32 | Annotation score: | ||
M0R3F5 | M0R3F5_HUMAN | Zinc finger protein 584 | ZNF584 | 29 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033579 | 142 | P → S. Corresponds to variant dbSNP:rs11668789Ensembl. | 1 | |
Natural variantiVAR_033580 | 301 | T → A1 PublicationCorresponds to variant dbSNP:rs7257872Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290068 mRNA Translation: BAF82757.1 BC033149 mRNA Translation: AAH33149.1 |
CCDSi | CCDS12979.1 |
RefSeqi | NP_001304931.1, NM_001318002.1 NP_775819.1, NM_173548.2 |
Genome annotation databases
Ensembli | ENST00000306910; ENSP00000306756; ENSG00000171574 |
GeneIDi | 201514 |
KEGGi | hsa:201514 |
UCSCi | uc002qsp.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290068 mRNA Translation: BAF82757.1 BC033149 mRNA Translation: AAH33149.1 |
CCDSi | CCDS12979.1 |
RefSeqi | NP_001304931.1, NM_001318002.1 NP_775819.1, NM_173548.2 |
3D structure databases
SMRi | Q8IVC4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128391, 2 interactors |
IntActi | Q8IVC4, 1 interactor |
STRINGi | 9606.ENSP00000306756 |
PTM databases
iPTMneti | Q8IVC4 |
PhosphoSitePlusi | Q8IVC4 |
Polymorphism and mutation databases
BioMutai | ZNF584 |
DMDMi | 55976735 |
Proteomic databases
MassIVEi | Q8IVC4 |
MaxQBi | Q8IVC4 |
PaxDbi | Q8IVC4 |
PeptideAtlasi | Q8IVC4 |
PRIDEi | Q8IVC4 |
ProteomicsDBi | 70680 |
Protocols and materials databases
Antibodypediai | 21593, 46 antibodies |
DNASUi | 201514 |
Genome annotation databases
Ensembli | ENST00000306910; ENSP00000306756; ENSG00000171574 |
GeneIDi | 201514 |
KEGGi | hsa:201514 |
UCSCi | uc002qsp.4, human |
Organism-specific databases
CTDi | 201514 |
DisGeNETi | 201514 |
EuPathDBi | HostDB:ENSG00000171574.17 |
GeneCardsi | ZNF584 |
HGNCi | HGNC:27318, ZNF584 |
HPAi | ENSG00000171574, Low tissue specificity |
neXtProti | NX_Q8IVC4 |
OpenTargetsi | ENSG00000171574 |
PharmGKBi | PA134968861 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163291 |
HOGENOMi | CLU_002678_0_9_1 |
InParanoidi | Q8IVC4 |
OMAi | PKQVKSC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8IVC4 |
TreeFami | TF337055 |
Enzyme and pathway databases
PathwayCommonsi | Q8IVC4 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 201514, 6 hits in 865 CRISPR screens |
ChiTaRSi | ZNF584, human |
GenomeRNAii | 201514 |
Pharosi | Q8IVC4, Tdark |
PROi | PR:Q8IVC4 |
RNActi | Q8IVC4, protein |
Gene expression databases
Bgeei | ENSG00000171574, Expressed in heart left ventricle and 169 other tissues |
ExpressionAtlasi | Q8IVC4, baseline and differential |
Genevisiblei | Q8IVC4, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 8 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN584_HUMAN | |
Accessioni | Q8IVC4Primary (citable) accession number: Q8IVC4 Secondary accession number(s): A8K203 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations