UniProtKB - Q8IVC0 (Q8IVC0_HUMAN)
Protein
Submitted name:
Serpin peptidase inhibitor, clade D (Heparin cofactor), member 1
Gene
SERPIND1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- serine-type endopeptidase inhibitor activity Source: InterPro
GO - Biological processi
- blood coagulation Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Serpin peptidase inhibitor, clade D (Heparin cofactor), member 1Imported |
Gene namesi | Name:SERPIND1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5004308992 | 20 – 499 | Sequence analysisAdd BLAST | 480 |
Proteomic databases
PeptideAtlasi | Q8IVC0 |
PRIDEi | Q8IVC0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 135 – 496 | SERPINInterPro annotationAdd BLAST | 362 |
Sequence similaritiesi
Belongs to the serpin family.UniRule annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
OrthoDBi | 1124079at2759 |
Family and domain databases
CDDi | cd02047, HCII, 1 hit |
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR033831, HCII IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IVC0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKHSLNALLI FLIITSAWGG SKGPLDQLEK GGETAQSADP QWEQLNNKNL
60 70 80 90 100
SMPLLPADFH KENTVTNDWI PEGEEDDDYL DLEKIFSEDD DYIDIVDSLS
110 120 130 140 150
VSPTDSDVSA GNILQLFHGK SRIQRLNIVN AKFAFNLYRV LKDQVNTFDN
160 170 180 190 200
IFIAPVGIST AMGMISLGLK GETHEQVHSI LHFKDFVNAS SKYEITTIHN
210 220 230 240 250
LFRKLTHRLF RRNFGYTLRS VNDLYIQKQF PILLDFKTKV REYYFAEAQI
260 270 280 290 300
ADFSDPAFIS KTNNHIMKLT KGLIKDALEN IDPATQMMIL NCIYFKGSWV
310 320 330 340 350
NKFPVEMTHN HNFRLNEREV VKVSMMQTKG NFLAANDQEL DCDILQLEYV
360 370 380 390 400
GGISMLIVVP HKMSGMKTLE AQLTPGVVER WQKSMTNRTR EVLLPKFKLE
410 420 430 440 450
KNYNLVESLK LMGIRMLFDK NGNMAGISDQ RIAIDLFKHQ GTITVNEEGT
460 470 480 490
QATTVTTVGF MPLSTQVRFT VDRPFLFLIY EHRTSCLLFM GRVANPSRS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC035028 mRNA Translation: AAH35028.1 |
RefSeqi | NP_000176.2, NM_000185.3 |
Genome annotation databases
GeneIDi | 3053 |
KEGGi | hsa:3053 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC035028 mRNA Translation: AAH35028.1 |
RefSeqi | NP_000176.2, NM_000185.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q8IVC0 |
PRIDEi | Q8IVC0 |
Protocols and materials databases
DNASUi | 3053 |
Genome annotation databases
GeneIDi | 3053 |
KEGGi | hsa:3053 |
Organism-specific databases
CTDi | 3053 |
PharmGKBi | PA35053 |
Phylogenomic databases
OrthoDBi | 1124079at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3053, 12 hits in 843 CRISPR screens |
GenomeRNAii | 3053 |
Gene expression databases
Genevisiblei | Q8IVC0, HS |
Family and domain databases
CDDi | cd02047, HCII, 1 hit |
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR033831, HCII IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IVC0_HUMAN | |
Accessioni | Q8IVC0Primary (citable) accession number: Q8IVC0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |