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Entry version 120 (02 Jun 2021)
Sequence version 1 (01 Mar 2003)
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Protein

LIX1-like protein

Gene

LIX1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • autophagosome maturation Source: GO_Central

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IVB5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LIX1-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LIX1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28715, LIX1L

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IVB5

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000271601.3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
128077

Open Targets

More...
OpenTargetsi
ENSG00000271601

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134915428

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IVB5, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LIX1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728055

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002328721 – 337LIX1-like proteinAdd BLAST337

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8IVB5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IVB5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IVB5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IVB5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IVB5

PeptideAtlas

More...
PeptideAtlasi
Q8IVB5

PRoteomics IDEntifications database

More...
PRIDEi
Q8IVB5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70679

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8IVB5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IVB5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IVB5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000271601, Expressed in gastrocnemius and 224 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IVB5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000271601, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126092, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IVB5, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000474487

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IVB5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IVB5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 64DisorderedSequence analysisAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi37 – 62Pro residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LIX1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR91, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005869

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_065651_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IVB5

Identification of Orthologs from Complete Genome Data

More...
OMAi
HPSRKIT

Database of Orthologous Groups

More...
OrthoDBi
1026341at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IVB5

TreeFam database of animal gene trees

More...
TreeFami
TF324035

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029270, LIX1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14954, LIX1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IVB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METMRAQRLQ PGVGTSGRGT LRALRPGVTG AAAATATPPA GPPPAPPPPA
60 70 80 90 100
PPPPPLLLSG APGLPLPPGA AGSPAVLREA VEAVVRSFAK HTQGYGRVNV
110 120 130 140 150
VEALQEFWQM KQSRGADLKN GALVVYEMVP SNSPPYVCYV TLPGGSCFGS
160 170 180 190 200
FQFCPTKAEA RRSAAKIALM NSVFNEHPSR RITDEFIEKS VSEALASFNG
210 220 230 240 250
NREEADNPNT GIGAFRFMLE SNKGKSMLEF QELMTVFQLL HWNGSLKAMR
260 270 280 290 300
ERQCSRQEVL AHYSHRALDD DIRHQMALDW VSREQSVPGA LSRELASTER
310 320 330
ELDEARLAGK ELRFHKEKKD ILVLAAGQLG NMHSSNC
Length:337
Mass (Da):36,563
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EC63B44AD5A744E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC035727 mRNA Translation: AAH35727.1
CR627381 mRNA Translation: CAH10478.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS72873.1

NCBI Reference Sequences

More...
RefSeqi
NP_714924.1, NM_153713.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000604000; ENSP00000474487; ENSG00000271601

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
128077

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:128077

UCSC genome browser

More...
UCSCi
uc001enr.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035727 mRNA Translation: AAH35727.1
CR627381 mRNA Translation: CAH10478.1
CCDSiCCDS72873.1
RefSeqiNP_714924.1, NM_153713.2

3D structure databases

SMRiQ8IVB5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126092, 10 interactors
IntActiQ8IVB5, 4 interactors
STRINGi9606.ENSP00000474487

PTM databases

iPTMnetiQ8IVB5
PhosphoSitePlusiQ8IVB5

Genetic variation databases

BioMutaiLIX1L
DMDMi74728055

Proteomic databases

EPDiQ8IVB5
jPOSTiQ8IVB5
MassIVEiQ8IVB5
MaxQBiQ8IVB5
PaxDbiQ8IVB5
PeptideAtlasiQ8IVB5
PRIDEiQ8IVB5
ProteomicsDBi70679
TopDownProteomicsiQ8IVB5

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
73360, 105 antibodies

The DNASU plasmid repository

More...
DNASUi
128077

Genome annotation databases

EnsembliENST00000604000; ENSP00000474487; ENSG00000271601
GeneIDi128077
KEGGihsa:128077
UCSCiuc001enr.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
128077
DisGeNETi128077

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LIX1L
HGNCiHGNC:28715, LIX1L
HPAiENSG00000271601, Low tissue specificity
neXtProtiNX_Q8IVB5
OpenTargetsiENSG00000271601
PharmGKBiPA134915428
VEuPathDBiHostDB:ENSG00000271601.3

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QR91, Eukaryota
GeneTreeiENSGT00390000005869
HOGENOMiCLU_065651_0_1_1
InParanoidiQ8IVB5
OMAiHPSRKIT
OrthoDBi1026341at2759
PhylomeDBiQ8IVB5
TreeFamiTF324035

Enzyme and pathway databases

PathwayCommonsiQ8IVB5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
128077, 8 hits in 988 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LIX1L, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
128077
PharosiQ8IVB5, Tdark

Protein Ontology

More...
PROi
PR:Q8IVB5
RNActiQ8IVB5, protein

Gene expression databases

BgeeiENSG00000271601, Expressed in gastrocnemius and 224 other tissues
GenevisibleiQ8IVB5, HS

Family and domain databases

InterProiView protein in InterPro
IPR029270, LIX1
PfamiView protein in Pfam
PF14954, LIX1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIX1L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IVB5
Secondary accession number(s): Q6AI36
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2003
Last modified: June 2, 2021
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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