UniProtKB - Q8IVA8 (Q8IVA8_HUMAN)
Protein
Submitted name:
Glutamate decarboxylase 1 (Brain, 67kDa)
Gene
GAD1
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
pyridoxal 5'-phosphateUniRule annotationARBA annotation
GO - Molecular functioni
- glutamate decarboxylase activity Source: UniProtKB
- pyridoxal phosphate binding Source: InterPro
GO - Biological processi
- carboxylic acid metabolic process Source: InterPro
Keywordsi
Molecular function | DecarboxylaseARBA annotation, Lyase |
Ligand | Pyridoxal phosphateUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Glutamate decarboxylase 1 (Brain, 67kDa)Imported |
Gene namesi | Name:GAD1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Pathology & Biotechi
Organism-specific databases
PharmGKBi | PA28507 |
Chemistry databases
DrugBanki | DB00114, Pyridoxal phosphate |
PTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 405 | N6-(pyridoxal phosphate)lysineUniRule annotation | 1 |
Proteomic databases
PeptideAtlasi | Q8IVA8 |
Interactioni
Subunit structurei
Homodimer.
ARBA annotationBinary interactionsi
Hide detailsQ8IVA8
With | #Exp. | IntAct |
---|---|---|
AGTRAP [Q6RW13] | 3 | EBI-10209663,EBI-741181 |
CMTM5 [Q96DZ9] | 3 | EBI-10209663,EBI-2548702 |
HAAO [P46952] | 3 | EBI-10209663,EBI-743215 |
Protein-protein interaction databases
IntActi | Q8IVA8, 3 interactors |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit |
InterProi | View protein in InterPro IPR002129, PyrdxlP-dep_de-COase IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR021115, Pyridoxal-P_BS |
Pfami | View protein in Pfam PF00282, Pyridoxal_deC, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00392, DDC_GAD_HDC_YDC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IVA8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSTPSSSA TSSNAGADPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF
60 70 80 90 100
LQRTNSLEEK SRLVSAFKER QSSKNLLSCE NSDRDARFRR TETDFSNLFA
110 120 130 140 150
RDLLPAKNGE EQTVQFLLEV VDILLNYVRK TFDRSTKVLD FHHPHQLLEG
160 170 180 190 200
MEGFNLELSD HPESLEQILV DCRDTLKYGV RTGHPRFFNQ LSTGLDIIGL
210 220 230 240 250
AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS SKDGDGIFSP
260 270 280 290 300
GGAISNMYSI MAARYKYFPE VKTKGMAAVP KLVLFTSEQS RYSIKKAGAA
310 320 330 340 350
LGFGTDNVIL IKCNERGEII PADFEAKILE AKQKGYVPFY VNATAGTTVY
360 370 380 390 400
GAFDPIQEIA DICEKYNLWL HVDAAWGGGL LMSRKHRHKL NGIERANSVT
410 420 430 440 450
WNPHKMMGVL LQCSAILVKE KGILQGCNQM CAGYLFQPDK QYDVSYDTGD
460 470 480 490 500
KAIQCGRHVD IFKFWLMWKA KGTVGFENQI NKCLELAEYL YAKIKNREEF
510 520 530 540 550
EMVFNGEPEH TNVCFWYIPQ SLRGVPDSPQ RREKLHKVAP KIKALMMESG
560 570 580 590
TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC037780 mRNA Translation: AAH37780.1 |
RefSeqi | NP_000808.2, NM_000817.2 |
Genome annotation databases
GeneIDi | 2571 |
KEGGi | hsa:2571 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC037780 mRNA Translation: AAH37780.1 |
RefSeqi | NP_000808.2, NM_000817.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q8IVA8, 3 interactors |
Chemistry databases
DrugBanki | DB00114, Pyridoxal phosphate |
Proteomic databases
PeptideAtlasi | Q8IVA8 |
Protocols and materials databases
DNASUi | 2571 |
Genome annotation databases
GeneIDi | 2571 |
KEGGi | hsa:2571 |
Organism-specific databases
CTDi | 2571 |
PharmGKBi | PA28507 |
Miscellaneous databases
BioGRID-ORCSi | 2571, 3 hits in 845 CRISPR screens |
ChiTaRSi | GAD1, human |
GenomeRNAii | 2571 |
Gene expression databases
Genevisiblei | Q8IVA8, HS |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit |
InterProi | View protein in InterPro IPR002129, PyrdxlP-dep_de-COase IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR021115, Pyridoxal-P_BS |
Pfami | View protein in Pfam PF00282, Pyridoxal_deC, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00392, DDC_GAD_HDC_YDC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IVA8_HUMAN | |
Accessioni | Q8IVA8Primary (citable) accession number: Q8IVA8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |