Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 157 (13 Feb 2019)
Sequence version 2 (10 Oct 2003)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Inactive serine/threonine-protein kinase VRK3

Gene

VRK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.By similarity2 Publications

Caution

Inactive as a kinase due to its inability to bind ATP.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: InterPro
  • protein phosphatase binding Source: MGI
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandNucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202670 ERKs are inactivated

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8IV63

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive serine/threonine-protein kinase VRK3
Alternative name(s):
Serine/threonine-protein pseudokinase VRK3
Vaccinia-related kinase 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VRK3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105053.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18996 VRK3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IV63

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000105053

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134923990

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3430761

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VRK3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
45593724

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000868081 – 474Inactive serine/threonine-protein kinase VRK3Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei54PhosphoserineCombined sources1
Modified residuei55PhosphoserineCombined sources1
Modified residuei59PhosphoserineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IV63

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IV63

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IV63

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IV63

PeptideAtlas

More...
PeptideAtlasi
Q8IV63

PRoteomics IDEntifications database

More...
PRIDEi
Q8IV63

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70666
70667 [Q8IV63-2]
70668 [Q8IV63-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8IV63-1 [Q8IV63-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IV63

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IV63

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105053 Expressed in 220 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IV63 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IV63 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056489

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DUSP3 (By similarity). Interacts with RAN.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MAXP612442EBI-1058605,EBI-751711

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119394, 16 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IV63, 12 interactors

Molecular INTeraction database

More...
MINTi
Q8IV63

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000324636

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1474
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JIIX-ray2.00A/B146-474[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IV63

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IV63

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8IV63

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini166 – 457Protein kinasePROSITE-ProRule annotationAdd BLAST292

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi49 – 64Nuclear localization signal1 PublicationAdd BLAST16

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1164 Eukaryota
ENOG410XPGP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158111

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293191

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG047756

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IV63

KEGG Orthology (KO)

More...
KOi
K08816

Identification of Orthologs from Complete Genome Data

More...
OMAi
FQMACRL

Database of Orthologous Groups

More...
OrthoDBi
866200at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IV63

TreeFam database of animal gene trees

More...
TreeFami
TF106473

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR026870 Zinc_ribbon_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit
PF13240 zinc_ribbon_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IV63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MISFCPDCGK SIQAAFKFCP YCGNSLPVEE HVGSQTFVNP HVSSFQGSKR
60 70 80 90 100
GLNSSFETSP KKVKWSSTVT SPRLSLFSDG DSSESEDTLS SSERSKGSGS
110 120 130 140 150
RPPTPKSSPQ KTRKSPQVTR GSPQKTSCSP QKTRQSPQTL KRSRVTTSLE
160 170 180 190 200
ALPTGTVLTD KSGRQWKLKS FQTRDNQGIL YEAAPTSTLT CDSGPQKQKF
210 220 230 240 250
SLKLDAKDGR LFNEQNFFQR AAKPLQVNKW KKLYSTPLLA IPTCMGFGVH
260 270 280 290 300
QDKYRFLVLP SLGRSLQSAL DVSPKHVLSE RSVLQVACRL LDALEFLHEN
310 320 330 340 350
EYVHGNVTAE NIFVDPEDQS QVTLAGYGFA FRYCPSGKHV AYVEGSRSPH
360 370 380 390 400
EGDLEFISMD LHKGCGPSRR SDLQSLGYCM LKWLYGFLPW TNCLPNTEDI
410 420 430 440 450
MKQKQKFVDK PGPFVGPCGH WIRPSETLQK YLKVVMALTY EEKPPYAMLR
460 470
NNLEALLQDL RVSPYDPIGL PMVP
Length:474
Mass (Da):52,881
Last modified:October 10, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86B9B91050A7F0CC
GO
Isoform 2 (identifier: Q8IV63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-412: FVDKPG → LPWDSF
     413-474: Missing.

Note: No experimental confirmation available.
Show »
Length:412
Mass (Da):45,904
Checksum:iB8EA8340E4FB9824
GO
Isoform 3 (identifier: Q8IV63-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-96: Missing.

Note: No experimental confirmation available.
Show »
Length:424
Mass (Da):47,501
Checksum:iD17A379F153ED44E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYA8M0QYA8_HUMAN
Inactive serine/threonine-protein k...
VRK3
406Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R025M0R025_HUMAN
Inactive serine/threonine-protein k...
VRK3
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXD7M0QXD7_HUMAN
Inactive serine/threonine-protein k...
VRK3
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ79M0QZ79_HUMAN
Inactive serine/threonine-protein k...
VRK3
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R073M0R073_HUMAN
Inactive serine/threonine-protein k...
VRK3
362Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3H2M0R3H2_HUMAN
Inactive serine/threonine-protein k...
VRK3
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYG0M0QYG0_HUMAN
Inactive serine/threonine-protein k...
VRK3
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXV1M0QXV1_HUMAN
Inactive serine/threonine-protein k...
VRK3
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R200M0R200_HUMAN
Inactive serine/threonine-protein k...
VRK3
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX88M0QX88_HUMAN
Inactive serine/threonine-protein k...
VRK3
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti161K → E in AAP47180 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04129559S → F1 PublicationCorresponds to variant dbSNP:rs2033262Ensembl.1
Natural variantiVAR_041296105P → T1 PublicationCorresponds to variant dbSNP:rs11547882Ensembl.1
Natural variantiVAR_051682170S → P. Corresponds to variant dbSNP:rs11547881Ensembl.1
Natural variantiVAR_041297171F → L1 PublicationCorresponds to variant dbSNP:rs11547883Ensembl.1
Natural variantiVAR_051683188T → A. Corresponds to variant dbSNP:rs11879620Ensembl.1
Natural variantiVAR_041298268S → L1 PublicationCorresponds to variant dbSNP:rs10410075Ensembl.1
Natural variantiVAR_041299288C → Y1 PublicationCorresponds to variant dbSNP:rs10409482Ensembl.1
Natural variantiVAR_051684304H → L. Corresponds to variant dbSNP:rs35261919Ensembl.1
Natural variantiVAR_041300370R → C1 PublicationCorresponds to variant dbSNP:rs35331034Ensembl.1
Natural variantiVAR_041301371S → G1 PublicationCorresponds to variant dbSNP:rs56407496Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04340947 – 96Missing in isoform 3. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_008544407 – 412FVDKPG → LPWDSF in isoform 2. 1 Publication6
Alternative sequenceiVSP_008545413 – 474Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB031052 mRNA Translation: BAA90769.1
AF514788 mRNA Translation: AAP47180.1
AK292918 mRNA Translation: BAF85607.1
AK303010 mRNA Translation: BAG64141.1
AC011452 Genomic DNA No translation available.
BC023556 mRNA Translation: AAH23556.1
BC095449 mRNA Translation: AAH95449.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12791.1 [Q8IV63-1]
CCDS33076.1 [Q8IV63-3]
CCDS77334.1 [Q8IV63-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001020949.1, NM_001025778.1 [Q8IV63-3]
NP_001295349.1, NM_001308420.1 [Q8IV63-2]
NP_057524.3, NM_016440.3 [Q8IV63-1]
XP_005259028.1, XM_005258971.3 [Q8IV63-1]
XP_005259029.1, XM_005258972.3 [Q8IV63-3]
XP_006723300.1, XM_006723237.3 [Q8IV63-1]
XP_006723301.1, XM_006723238.3 [Q8IV63-3]
XP_011525325.1, XM_011527023.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.443330

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316763; ENSP00000324636; ENSG00000105053 [Q8IV63-1]
ENST00000377011; ENSP00000366210; ENSG00000105053 [Q8IV63-3]
ENST00000594092; ENSP00000472541; ENSG00000105053 [Q8IV63-2]
ENST00000594948; ENSP00000473171; ENSG00000105053 [Q8IV63-1]
ENST00000599538; ENSP00000469880; ENSG00000105053 [Q8IV63-1]
ENST00000601341; ENSP00000470156; ENSG00000105053 [Q8IV63-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51231

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51231

UCSC genome browser

More...
UCSCi
uc002prg.3 human [Q8IV63-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031052 mRNA Translation: BAA90769.1
AF514788 mRNA Translation: AAP47180.1
AK292918 mRNA Translation: BAF85607.1
AK303010 mRNA Translation: BAG64141.1
AC011452 Genomic DNA No translation available.
BC023556 mRNA Translation: AAH23556.1
BC095449 mRNA Translation: AAH95449.1
CCDSiCCDS12791.1 [Q8IV63-1]
CCDS33076.1 [Q8IV63-3]
CCDS77334.1 [Q8IV63-2]
RefSeqiNP_001020949.1, NM_001025778.1 [Q8IV63-3]
NP_001295349.1, NM_001308420.1 [Q8IV63-2]
NP_057524.3, NM_016440.3 [Q8IV63-1]
XP_005259028.1, XM_005258971.3 [Q8IV63-1]
XP_005259029.1, XM_005258972.3 [Q8IV63-3]
XP_006723300.1, XM_006723237.3 [Q8IV63-1]
XP_006723301.1, XM_006723238.3 [Q8IV63-3]
XP_011525325.1, XM_011527023.2
UniGeneiHs.443330

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JIIX-ray2.00A/B146-474[»]
ProteinModelPortaliQ8IV63
SMRiQ8IV63
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119394, 16 interactors
IntActiQ8IV63, 12 interactors
MINTiQ8IV63
STRINGi9606.ENSP00000324636

Chemistry databases

ChEMBLiCHEMBL3430761

PTM databases

iPTMnetiQ8IV63
PhosphoSitePlusiQ8IV63

Polymorphism and mutation databases

BioMutaiVRK3
DMDMi45593724

Proteomic databases

EPDiQ8IV63
jPOSTiQ8IV63
MaxQBiQ8IV63
PaxDbiQ8IV63
PeptideAtlasiQ8IV63
PRIDEiQ8IV63
ProteomicsDBi70666
70667 [Q8IV63-2]
70668 [Q8IV63-3]
TopDownProteomicsiQ8IV63-1 [Q8IV63-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51231
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316763; ENSP00000324636; ENSG00000105053 [Q8IV63-1]
ENST00000377011; ENSP00000366210; ENSG00000105053 [Q8IV63-3]
ENST00000594092; ENSP00000472541; ENSG00000105053 [Q8IV63-2]
ENST00000594948; ENSP00000473171; ENSG00000105053 [Q8IV63-1]
ENST00000599538; ENSP00000469880; ENSG00000105053 [Q8IV63-1]
ENST00000601341; ENSP00000470156; ENSG00000105053 [Q8IV63-3]
GeneIDi51231
KEGGihsa:51231
UCSCiuc002prg.3 human [Q8IV63-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51231
EuPathDBiHostDB:ENSG00000105053.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
VRK3
HGNCiHGNC:18996 VRK3
HPAiHPA056489
neXtProtiNX_Q8IV63
OpenTargetsiENSG00000105053
PharmGKBiPA134923990

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1164 Eukaryota
ENOG410XPGP LUCA
GeneTreeiENSGT00940000158111
HOGENOMiHOG000293191
HOVERGENiHBG047756
InParanoidiQ8IV63
KOiK08816
OMAiFQMACRL
OrthoDBi866200at2759
PhylomeDBiQ8IV63
TreeFamiTF106473

Enzyme and pathway databases

ReactomeiR-HSA-202670 ERKs are inactivated
SignaLinkiQ8IV63

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
VRK3 human
EvolutionaryTraceiQ8IV63

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51231

Protein Ontology

More...
PROi
PR:Q8IV63

Gene expression databases

BgeeiENSG00000105053 Expressed in 220 organ(s), highest expression level in right testis
ExpressionAtlasiQ8IV63 baseline and differential
GenevisibleiQ8IV63 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR026870 Zinc_ribbon_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF13240 zinc_ribbon_2, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVRK3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IV63
Secondary accession number(s): A6NEG5
, A8KA53, Q502Y2, Q9P2V8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: February 13, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again