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Protein

Ras guanyl-releasing protein 3

Gene

RASGRP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) for Ras and Rap1.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi433 – 4441PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi462 – 4732PROSITE-ProRule annotationAdd BLAST12
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri494 – 544Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • MAPK cascade Source: Reactome
  • Ras protein signal transduction Source: Ensembl
  • small GTPase mediated signal transduction Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1169092 Activation of RAS in B cells
R-HSA-5673001 RAF/MAP kinase cascade

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8IV61

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras guanyl-releasing protein 3
Alternative name(s):
Calcium and DAG-regulated guanine nucleotide exchange factor III
Guanine nucleotide exchange factor for Rap1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RASGRP3
Synonyms:GRP3, KIAA0846
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000152689.17

Human Gene Nomenclature Database

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HGNCi
HGNC:14545 RASGRP3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609531 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IV61

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25780

Open Targets

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OpenTargetsi
ENSG00000152689

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134937092

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3638

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RASGRP3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34395670

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000688831 – 690Ras guanyl-releasing protein 3Add BLAST690

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8IV61

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8IV61

PeptideAtlas

More...
PeptideAtlasi
Q8IV61

PRoteomics IDEntifications database

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PRIDEi
Q8IV61

ProteomicsDB human proteome resource

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ProteomicsDBi
70665

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8IV61

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8IV61

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000152689 Expressed in 209 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

More...
CleanExi
HS_RASGRP3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IV61 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IV61 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA058937

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
DYNLL2Q96FJ23EBI-1047876,EBI-742371

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117315, 12 interactors

Protein interaction database and analysis system

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IntActi
Q8IV61, 5 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000384192

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q8IV61

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8IV61

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IV61

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 125N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST123
Domaini152 – 383Ras-GEFPROSITE-ProRule annotationAdd BLAST232
Domaini420 – 455EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini449 – 484EF-hand 2PROSITE-ProRule annotationAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RASGRP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri494 – 544Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IQ6M Eukaryota
ENOG410XTGZ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158843

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000293171

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG007513

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8IV61

KEGG Orthology (KO)

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KOi
K12362

Identification of Orthologs from Complete Genome Data

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OMAi
SFTDYQS

Database of Orthologous Groups

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OrthoDBi
355412at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8IV61

TreeFam database of animal gene trees

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TreeFami
TF312918

Family and domain databases

Conserved Domains Database

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CDDi
cd00029 C1, 1 hit
cd00051 EFh, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.840.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR020454 DAG/PE-bd
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002219 PE/DAG-bd
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR029645 RASGRP1/RASGRP3

The PANTHER Classification System

More...
PANTHERi
PTHR23113 PTHR23113, 1 hit
PTHR23113:SF178 PTHR23113:SF178, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00130 C1_1, 1 hit
PF13202 EF-hand_5, 2 hits
PF00617 RasGEF, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00008 DAGPEDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109 C1, 1 hit
SM00054 EFh, 2 hits
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF48366 SSF48366, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IV61-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSSGLGKAA TLDELLCTCI EMFDDNGELD NSYLPRIVLL MHRWYLSSTE
60 70 80 90 100
LAEKLLCMYR NATGESCNEF RLKICYFMRY WILKFPAEFN LDLGLIRMTE
110 120 130 140 150
EFREVASQLG YEKHVSLIDI SSIPSYDWMR RVTQRKKVSK KGKACLLFDH
160 170 180 190 200
LEPIELAEHL TFLEHKSFRR ISFTDYQSYV IHGCLENNPT LERSIALFNG
210 220 230 240 250
ISKWVQLMVL SKPTPQQRAE VITKFINVAK KLLQLKNFNT LMAVVGGLSH
260 270 280 290 300
SSISRLKETH SHLSSEVTKN WNEMTELVSS NGNYCNYRKA FADCDGFKIP
310 320 330 340 350
ILGVHLKDLI AVHVIFPDWT EENKVNIVKM HQLSVTLSEL VSLQNASHHL
360 370 380 390 400
EPNMDLINLL TLSLDLYHTE DDIYKLSLVL EPRNSKSQPT SPTTPNKPVV
410 420 430 440 450
PLEWALGVMP KPDPTVINKH IRKLVESVFR NYDHDHDGYI SQEDFESIAA
460 470 480 490 500
NFPFLDSFCV LDKDQDGLIS KDEMMAYFLR AKSQLHCKMG PGFIHNFQEM
510 520 530 540 550
TYLKPTFCEH CAGFLWGIIK QGYKCKDCGA NCHKQCKDLL VLACRRFARA
560 570 580 590 600
PSLSSGHGSL PGSPSLPPAQ DEVFEFPGVT AGHRDLDSRA ITLVTGSSRK
610 620 630 640 650
ISVRLQRATT SQATQTEPVW SEAGWGDSGS HTFPKMKSKF HDKAAKDKGF
660 670 680 690
AKWENEKPRV HAGVDVVDRG TEFELDQDEG EETRQDGEDG
Length:690
Mass (Da):78,332
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i747BBAA2CCAC2D12
GO
Isoform 2 (identifier: Q8IV61-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     388-388: Missing.

Show »
Length:689
Mass (Da):78,203
Checksum:iF7A5C6385E3E2530
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9K0P4C9K0P4_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWP0C9JWP0_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C352H7C352_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IYA5C9IYA5_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9C9C9J9C9_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JSS2C9JSS2_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA74869 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051901393T → A. Corresponds to variant dbSNP:rs13388394Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047371388Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB020653 mRNA Translation: BAA74869.2 Different initiation.
BX647990 mRNA No translation available.
AC020594 Genomic DNA Translation: AAY15037.1
CH471053 Genomic DNA Translation: EAX00432.1
CH471053 Genomic DNA Translation: EAX00433.1
CH471053 Genomic DNA Translation: EAX00434.1
BC027849 mRNA Translation: AAH27849.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46256.1 [Q8IV61-1]
CCDS54346.1 [Q8IV61-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001132960.1, NM_001139488.1 [Q8IV61-1]
NP_056191.1, NM_015376.2 [Q8IV61-2]
NP_733772.1, NM_170672.2 [Q8IV61-1]
XP_005264303.1, XM_005264246.3
XP_011531048.1, XM_011532746.2 [Q8IV61-1]
XP_011531049.1, XM_011532747.2
XP_011531050.2, XM_011532748.2 [Q8IV61-1]
XP_016859248.1, XM_017003759.1 [Q8IV61-1]
XP_016859249.1, XM_017003760.1
XP_016859250.1, XM_017003761.1 [Q8IV61-1]
XP_016859251.1, XM_017003762.1
XP_016859252.1, XM_017003763.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.143674

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000402538; ENSP00000385886; ENSG00000152689 [Q8IV61-1]
ENST00000403687; ENSP00000384192; ENSG00000152689 [Q8IV61-1]
ENST00000407811; ENSP00000383917; ENSG00000152689 [Q8IV61-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
25780

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25780

UCSC genome browser

More...
UCSCi
uc002rox.4 human [Q8IV61-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020653 mRNA Translation: BAA74869.2 Different initiation.
BX647990 mRNA No translation available.
AC020594 Genomic DNA Translation: AAY15037.1
CH471053 Genomic DNA Translation: EAX00432.1
CH471053 Genomic DNA Translation: EAX00433.1
CH471053 Genomic DNA Translation: EAX00434.1
BC027849 mRNA Translation: AAH27849.1
CCDSiCCDS46256.1 [Q8IV61-1]
CCDS54346.1 [Q8IV61-2]
RefSeqiNP_001132960.1, NM_001139488.1 [Q8IV61-1]
NP_056191.1, NM_015376.2 [Q8IV61-2]
NP_733772.1, NM_170672.2 [Q8IV61-1]
XP_005264303.1, XM_005264246.3
XP_011531048.1, XM_011532746.2 [Q8IV61-1]
XP_011531049.1, XM_011532747.2
XP_011531050.2, XM_011532748.2 [Q8IV61-1]
XP_016859248.1, XM_017003759.1 [Q8IV61-1]
XP_016859249.1, XM_017003760.1
XP_016859250.1, XM_017003761.1 [Q8IV61-1]
XP_016859251.1, XM_017003762.1
XP_016859252.1, XM_017003763.1
UniGeneiHs.143674

3D structure databases

ProteinModelPortaliQ8IV61
SMRiQ8IV61
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117315, 12 interactors
IntActiQ8IV61, 5 interactors
STRINGi9606.ENSP00000384192

Chemistry databases

BindingDBiQ8IV61
ChEMBLiCHEMBL3638

PTM databases

iPTMnetiQ8IV61
PhosphoSitePlusiQ8IV61

Polymorphism and mutation databases

BioMutaiRASGRP3
DMDMi34395670

Proteomic databases

MaxQBiQ8IV61
PaxDbiQ8IV61
PeptideAtlasiQ8IV61
PRIDEiQ8IV61
ProteomicsDBi70665

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
25780
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402538; ENSP00000385886; ENSG00000152689 [Q8IV61-1]
ENST00000403687; ENSP00000384192; ENSG00000152689 [Q8IV61-1]
ENST00000407811; ENSP00000383917; ENSG00000152689 [Q8IV61-2]
GeneIDi25780
KEGGihsa:25780
UCSCiuc002rox.4 human [Q8IV61-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25780
DisGeNETi25780
EuPathDBiHostDB:ENSG00000152689.17

GeneCards: human genes, protein and diseases

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GeneCardsi
RASGRP3

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0001961
HGNCiHGNC:14545 RASGRP3
HPAiHPA058937
MIMi609531 gene
neXtProtiNX_Q8IV61
OpenTargetsiENSG00000152689
PharmGKBiPA134937092

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQ6M Eukaryota
ENOG410XTGZ LUCA
GeneTreeiENSGT00940000158843
HOGENOMiHOG000293171
HOVERGENiHBG007513
InParanoidiQ8IV61
KOiK12362
OMAiSFTDYQS
OrthoDBi355412at2759
PhylomeDBiQ8IV61
TreeFamiTF312918

Enzyme and pathway databases

ReactomeiR-HSA-1169092 Activation of RAS in B cells
R-HSA-5673001 RAF/MAP kinase cascade
SIGNORiQ8IV61

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RASGRP3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RASGRP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25780

Protein Ontology

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PROi
PR:Q8IV61

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152689 Expressed in 209 organ(s), highest expression level in corpus callosum
CleanExiHS_RASGRP3
ExpressionAtlasiQ8IV61 baseline and differential
GenevisibleiQ8IV61 HS

Family and domain databases

CDDicd00029 C1, 1 hit
cd00051 EFh, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002219 PE/DAG-bd
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR029645 RASGRP1/RASGRP3
PANTHERiPTHR23113 PTHR23113, 1 hit
PTHR23113:SF178 PTHR23113:SF178, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF13202 EF-hand_5, 2 hits
PF00617 RasGEF, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00054 EFh, 2 hits
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRP3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IV61
Secondary accession number(s): D6W583, O94931, Q53SD7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2003
Last modified: January 16, 2019
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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