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Protein

Ras guanyl-releasing protein 3

Gene

RASGRP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) for Ras and Rap1.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi433 – 4441PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi462 – 4732PROSITE-ProRule annotationAdd BLAST12
Zinc fingeri494 – 544Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

GO - Biological processi

  • MAPK cascade Source: Reactome
  • Ras protein signal transduction Source: Ensembl
  • small GTPase mediated signal transduction Source: UniProtKB

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1169092 Activation of RAS in B cells
R-HSA-5673001 RAF/MAP kinase cascade
SIGNORiQ8IV61

Names & Taxonomyi

Protein namesi
Recommended name:
Ras guanyl-releasing protein 3
Alternative name(s):
Calcium and DAG-regulated guanine nucleotide exchange factor III
Guanine nucleotide exchange factor for Rap1
Gene namesi
Name:RASGRP3
Synonyms:GRP3, KIAA0846
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000152689.17
HGNCiHGNC:14545 RASGRP3
MIMi609531 gene
neXtProtiNX_Q8IV61

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi25780
OpenTargetsiENSG00000152689
PharmGKBiPA134937092

Chemistry databases

ChEMBLiCHEMBL3638

Polymorphism and mutation databases

BioMutaiRASGRP3
DMDMi34395670

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688831 – 690Ras guanyl-releasing protein 3Add BLAST690

Proteomic databases

MaxQBiQ8IV61
PaxDbiQ8IV61
PeptideAtlasiQ8IV61
PRIDEiQ8IV61
ProteomicsDBi70665

PTM databases

iPTMnetiQ8IV61
PhosphoSitePlusiQ8IV61

Expressioni

Gene expression databases

BgeeiENSG00000152689 Expressed in 209 organ(s), highest expression level in corpus callosum
CleanExiHS_RASGRP3
ExpressionAtlasiQ8IV61 baseline and differential
GenevisibleiQ8IV61 HS

Organism-specific databases

HPAiHPA058937

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DYNLL2Q96FJ23EBI-1047876,EBI-742371

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117315, 12 interactors
IntActiQ8IV61, 5 interactors
STRINGi9606.ENSP00000384192

Chemistry databases

BindingDBiQ8IV61

Structurei

3D structure databases

ProteinModelPortaliQ8IV61
SMRiQ8IV61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 125N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST123
Domaini152 – 383Ras-GEFPROSITE-ProRule annotationAdd BLAST232
Domaini420 – 455EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini449 – 484EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the RASGRP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri494 – 544Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQ6M Eukaryota
ENOG410XTGZ LUCA
GeneTreeiENSGT00880000137870
HOGENOMiHOG000293171
HOVERGENiHBG007513
InParanoidiQ8IV61
KOiK12362
OMAiSFTDYQS
OrthoDBiEOG091G03RN
PhylomeDBiQ8IV61
TreeFamiTF312918

Family and domain databases

CDDicd00029 C1, 1 hit
cd00051 EFh, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002219 PE/DAG-bd
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR029645 RASGRP1/RASGRP3
PANTHERiPTHR23113 PTHR23113, 1 hit
PTHR23113:SF178 PTHR23113:SF178, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF13202 EF-hand_5, 2 hits
PF00617 RasGEF, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00054 EFh, 2 hits
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IV61-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSSGLGKAA TLDELLCTCI EMFDDNGELD NSYLPRIVLL MHRWYLSSTE
60 70 80 90 100
LAEKLLCMYR NATGESCNEF RLKICYFMRY WILKFPAEFN LDLGLIRMTE
110 120 130 140 150
EFREVASQLG YEKHVSLIDI SSIPSYDWMR RVTQRKKVSK KGKACLLFDH
160 170 180 190 200
LEPIELAEHL TFLEHKSFRR ISFTDYQSYV IHGCLENNPT LERSIALFNG
210 220 230 240 250
ISKWVQLMVL SKPTPQQRAE VITKFINVAK KLLQLKNFNT LMAVVGGLSH
260 270 280 290 300
SSISRLKETH SHLSSEVTKN WNEMTELVSS NGNYCNYRKA FADCDGFKIP
310 320 330 340 350
ILGVHLKDLI AVHVIFPDWT EENKVNIVKM HQLSVTLSEL VSLQNASHHL
360 370 380 390 400
EPNMDLINLL TLSLDLYHTE DDIYKLSLVL EPRNSKSQPT SPTTPNKPVV
410 420 430 440 450
PLEWALGVMP KPDPTVINKH IRKLVESVFR NYDHDHDGYI SQEDFESIAA
460 470 480 490 500
NFPFLDSFCV LDKDQDGLIS KDEMMAYFLR AKSQLHCKMG PGFIHNFQEM
510 520 530 540 550
TYLKPTFCEH CAGFLWGIIK QGYKCKDCGA NCHKQCKDLL VLACRRFARA
560 570 580 590 600
PSLSSGHGSL PGSPSLPPAQ DEVFEFPGVT AGHRDLDSRA ITLVTGSSRK
610 620 630 640 650
ISVRLQRATT SQATQTEPVW SEAGWGDSGS HTFPKMKSKF HDKAAKDKGF
660 670 680 690
AKWENEKPRV HAGVDVVDRG TEFELDQDEG EETRQDGEDG
Length:690
Mass (Da):78,332
Last modified:March 1, 2003 - v1
Checksum:i747BBAA2CCAC2D12
GO
Isoform 2 (identifier: Q8IV61-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     388-388: Missing.

Show »
Length:689
Mass (Da):78,203
Checksum:iF7A5C6385E3E2530
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9K0P4C9K0P4_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
172Annotation score:
C9JWP0C9JWP0_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
113Annotation score:
C9IYA5C9IYA5_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
112Annotation score:
H7C352H7C352_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
138Annotation score:
C9J9C9C9J9C9_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
77Annotation score:
C9JSS2C9JSS2_HUMAN
Ras guanyl-releasing protein 3
RASGRP3
34Annotation score:

Sequence cautioni

The sequence BAA74869 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051901393T → A. Corresponds to variant dbSNP:rs13388394Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047371388Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020653 mRNA Translation: BAA74869.2 Different initiation.
BX647990 mRNA No translation available.
AC020594 Genomic DNA Translation: AAY15037.1
CH471053 Genomic DNA Translation: EAX00432.1
CH471053 Genomic DNA Translation: EAX00433.1
CH471053 Genomic DNA Translation: EAX00434.1
BC027849 mRNA Translation: AAH27849.1
CCDSiCCDS46256.1 [Q8IV61-1]
CCDS54346.1 [Q8IV61-2]
RefSeqiNP_001132960.1, NM_001139488.1 [Q8IV61-1]
NP_056191.1, NM_015376.2 [Q8IV61-2]
NP_733772.1, NM_170672.2 [Q8IV61-1]
XP_005264303.1, XM_005264246.3
XP_011531048.1, XM_011532746.2 [Q8IV61-1]
XP_011531049.1, XM_011532747.2
XP_011531050.2, XM_011532748.2 [Q8IV61-1]
XP_016859248.1, XM_017003759.1 [Q8IV61-1]
XP_016859249.1, XM_017003760.1
XP_016859250.1, XM_017003761.1 [Q8IV61-1]
XP_016859251.1, XM_017003762.1
XP_016859252.1, XM_017003763.1
UniGeneiHs.143674

Genome annotation databases

EnsembliENST00000402538; ENSP00000385886; ENSG00000152689 [Q8IV61-1]
ENST00000403687; ENSP00000384192; ENSG00000152689 [Q8IV61-1]
ENST00000407811; ENSP00000383917; ENSG00000152689 [Q8IV61-2]
GeneIDi25780
KEGGihsa:25780
UCSCiuc002rox.4 human [Q8IV61-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020653 mRNA Translation: BAA74869.2 Different initiation.
BX647990 mRNA No translation available.
AC020594 Genomic DNA Translation: AAY15037.1
CH471053 Genomic DNA Translation: EAX00432.1
CH471053 Genomic DNA Translation: EAX00433.1
CH471053 Genomic DNA Translation: EAX00434.1
BC027849 mRNA Translation: AAH27849.1
CCDSiCCDS46256.1 [Q8IV61-1]
CCDS54346.1 [Q8IV61-2]
RefSeqiNP_001132960.1, NM_001139488.1 [Q8IV61-1]
NP_056191.1, NM_015376.2 [Q8IV61-2]
NP_733772.1, NM_170672.2 [Q8IV61-1]
XP_005264303.1, XM_005264246.3
XP_011531048.1, XM_011532746.2 [Q8IV61-1]
XP_011531049.1, XM_011532747.2
XP_011531050.2, XM_011532748.2 [Q8IV61-1]
XP_016859248.1, XM_017003759.1 [Q8IV61-1]
XP_016859249.1, XM_017003760.1
XP_016859250.1, XM_017003761.1 [Q8IV61-1]
XP_016859251.1, XM_017003762.1
XP_016859252.1, XM_017003763.1
UniGeneiHs.143674

3D structure databases

ProteinModelPortaliQ8IV61
SMRiQ8IV61
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117315, 12 interactors
IntActiQ8IV61, 5 interactors
STRINGi9606.ENSP00000384192

Chemistry databases

BindingDBiQ8IV61
ChEMBLiCHEMBL3638

PTM databases

iPTMnetiQ8IV61
PhosphoSitePlusiQ8IV61

Polymorphism and mutation databases

BioMutaiRASGRP3
DMDMi34395670

Proteomic databases

MaxQBiQ8IV61
PaxDbiQ8IV61
PeptideAtlasiQ8IV61
PRIDEiQ8IV61
ProteomicsDBi70665

Protocols and materials databases

DNASUi25780
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402538; ENSP00000385886; ENSG00000152689 [Q8IV61-1]
ENST00000403687; ENSP00000384192; ENSG00000152689 [Q8IV61-1]
ENST00000407811; ENSP00000383917; ENSG00000152689 [Q8IV61-2]
GeneIDi25780
KEGGihsa:25780
UCSCiuc002rox.4 human [Q8IV61-1]

Organism-specific databases

CTDi25780
DisGeNETi25780
EuPathDBiHostDB:ENSG00000152689.17
GeneCardsiRASGRP3
H-InvDBiHIX0001961
HGNCiHGNC:14545 RASGRP3
HPAiHPA058937
MIMi609531 gene
neXtProtiNX_Q8IV61
OpenTargetsiENSG00000152689
PharmGKBiPA134937092
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ6M Eukaryota
ENOG410XTGZ LUCA
GeneTreeiENSGT00880000137870
HOGENOMiHOG000293171
HOVERGENiHBG007513
InParanoidiQ8IV61
KOiK12362
OMAiSFTDYQS
OrthoDBiEOG091G03RN
PhylomeDBiQ8IV61
TreeFamiTF312918

Enzyme and pathway databases

ReactomeiR-HSA-1169092 Activation of RAS in B cells
R-HSA-5673001 RAF/MAP kinase cascade
SIGNORiQ8IV61

Miscellaneous databases

ChiTaRSiRASGRP3 human
GeneWikiiRASGRP3
GenomeRNAii25780
PROiPR:Q8IV61
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152689 Expressed in 209 organ(s), highest expression level in corpus callosum
CleanExiHS_RASGRP3
ExpressionAtlasiQ8IV61 baseline and differential
GenevisibleiQ8IV61 HS

Family and domain databases

CDDicd00029 C1, 1 hit
cd00051 EFh, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002219 PE/DAG-bd
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR029645 RASGRP1/RASGRP3
PANTHERiPTHR23113 PTHR23113, 1 hit
PTHR23113:SF178 PTHR23113:SF178, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF13202 EF-hand_5, 2 hits
PF00617 RasGEF, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00054 EFh, 2 hits
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRP3_HUMAN
AccessioniPrimary (citable) accession number: Q8IV61
Secondary accession number(s): D6W583, O94931, Q53SD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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